Cardiac dimensions and function
The platform has a high frequency ultrasound machine (Vevo 2100) specifically manufactured for use in mice and rats. This system was developed by VisualSonics in Toronto, Canada. The probes range from 30 to 80 MHz with very shallow focal lengths, allowing excellent visualization (around 30 microns). In particular, the analyses of cardiac dimensions (wall thickness, chamber width, etc.) along with cardiac function (ejection fraction, fractional shortening) can be rapidly obtained. All non-invasive transthoracic cardiac ultrasound in performed under light general isoflurane anesthesia.