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Ultrasound Imaging

Cardiac dimensions and function | Pulse-wave Doppler | Speckle-tracking | Vascular wall motion analysis | Other modalities
 

Cardiac dimensions and function

The platform has a high frequency ultrasound machine (Vevo 2100) specifically manufactured for use in mice and rats. This system was developed by VisualSonics in Toronto, Canada. The probes range from 30 to 80 MHz with very shallow focal lengths, allowing excellent visualization (around 30 microns). In particular, the analyses of cardiac dimensions (wall thickness, chamber width, etc.) along with cardiac function (ejection fraction, fractional shortening) can be rapidly obtained. All non-invasive transthoracic cardiac ultrasound in performed under light general isoflurane anesthesia.

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Long axis view of a mouse heart          M-Mode measurements

 

Long axis view of a mouse heart

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Pulse-wave Doppler

Pulsed-Wave Doppler Mode allows us to quantify the flow through the mitral or tricuspid valve
Tissue Doppler Mode allows us to track the motion of tissue, as mitral annulus

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Mitral Flow Mitral Annulus Velocity

 

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Speckle-tracking

CAF also proposes Speckle-traking imaging.

Speckle-traking imaging is a novel, non-Doppler-based technique used to detect myocardial wall motion (velocity, displacement) and myocardial deformation (strain and strain rate).

With the use of VevoStrain software, a value can be obtained which quantifies the velocity, the displacement, the strain and strain rate that is experienced by the selected area of myocardium. It allows for the comparison of one or several points along the left ventricule in parasternal long or short axis.

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Exemple of Speckle-traking in an infarcted heart.

 

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Vascular wall motion analysis

VevoVasc Analysis Software is a vascular strain analysis package that utilizes advanced speckle tracking algorithms on high-resolution ultrasound data to quantify vascular pathologies non-invasively and in vivo.

The software includes both qualitative and quantitative tools to study various vascular disease models.

1) Vessel Wall Tracking.

2) Vessel Stiffness Quantification Using Pulse Propagation Velocity.

3) Vessel Wall Analysis and Micro-Anatomy.

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Other modalities

Visualization of embryos in utero, neonatal echography, abdominal ultrasound, and tumor analysis. The system is also equipped with Power Doppler technology and 3D analysis.


 
Tumor surrounding an adrenal gland Three-dimensional view of a tumor (blue) into a kidney (red)

 

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CAF/EMIF, CHUV Rue du Bugnon 27 - CH-1005 Lausanne  - Switzerland  -  Tel. +41 21 31479 77
Swiss University