Publications réalisées avec la collaboration de la CAF:

BRAFV600E Overrides NOTCH Signaling in Thyroid Cancer

Florian Traversi, Amandine Stooss, Matthias S. Dettmer, and Roch-Philippe Charles

Thyroid. 2021 May;31(5):787-799. Epub 2020 Nov 12.https://doi.org/10.1089/thy.2019.0595

 

Inhibition of G-protein signalling in cardiac dysfunction of intellectual developmental disorder with cardiac arrhythmia (IDDCA) syndrome


Pasquelena De Nittis, Stephanie Efthymiou, Alexandre Sarre, Nicolas Guex, Jacqueline Chrast, Audrey Putoux, Tipu Sultan, Javeria Raza Alvi, Zia ur Rahman, Faisal Zafar, Nuzhat Rana, Fatima Rahman, Najwa Anwar, Shazia Maqbool, Maha S Zaki, Joseph G Gleeson, David Murphy, Hamid Galehdari, Gholamreza Shariati, Neda Mazaheri, Alireza Sedaghat, SYNAPS Study Group, Gaetan Lesca, Nicolas Chatron, Vincenzo Salpietro, Marilena Christoforou, Henry Houlden, William F Simonds, Thierry Pedrazzini, Reza Maroofian, Alexandre Reymond

Journal of Medical Genetics Published Online First: 10 November 2020. doi: 10.1136/jmedgenet-2020-107015

 

LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma LIN28B Control of EWS-FLI1 Stability.

 Tugba Keskin, Arnaud Bakaric, Patricia Waszy, Gaylor Boulay, Matteo Torsello, Sandrine Cornaz-Buros, Nadja Chevalier, Thibaud Geiser, Patricia Martin, Angela Volorio, Sowmya Iyer, Anupriya Kulkarni, Igor Letovanec, Stéphane Cherix, Gregory M Cote, Edwin Choy, Antonia Digklia, Michael Montemurro, Ivan Chebib, Petur G Nielsen, Angel M Carcaboso, Jaume Mora, Raffaele Renella, Mario L Suvà, Carlo Fusco, Paolo Provero, Miguel N Rivera, Nicolò Riggi, Ivan Stamenkovic

Cell Rep. 2020 Mar 31;30(13):4567-4583

 

Inhibition of the Hypoxia-Inducible Factor 1α-Induced Cardiospecific HERNA1 Enhance-Templated RNA Protects From Heart Disease.

Peter Mirtschink, Corinne Bischof, Minh-Duc Pham, Rahul Sharma, Sanjay Khadayate, Geetha Rossi, Niklaus Fankhauser, Shuyang Traub, Samuel Sossalla, Eman Hagag, Corinne Berthonneche, Alexandre Sarre, Sebastian N Stehr, Phillip Grote, Thierry Pedrazzini, Stefanie Dimmeler, Wilhelm Krek, Jaya Krishnan

Circulation. 2019 Jun 11;139(24):2778-2792

 

Reciprocal modulation of mesenchymal stem cells and tumor cells promotes lung cancer metastasis.

Giulia Fregni, Mathieu Quinodoz, Emely Möller, Joanna Vuille, Sabine Galland, Carlo Fusco, Patricia Martin, Igor Letovanec, Paolo Provero, Carlo Rivolta, Nicolo Riggi and Ivan Stamenkovic

EBioMedicine. 2018 Mar;29:128-145

 

Diverging effects of enalapril or eplerenone in primary prevention against doxorubicin-induced cardiotoxicity

Roger Hullin, Mélanie Métrich,  Alexandre Sarre,  Denis Basquin,  Marc Maillard, Julien Regamey, and  David Martin

Cardiovascular Research,  2018 Feb 1;114(2):272-281..

 

The long noncoding RNA Wisper controls cardiac fibrosis and remodeling.

Rudi Micheletti,  Isabelle Plaisance, Brian J. Abraham,  Alexandre Sarre,  Ching-Chia Ting, Michael Alexanian, Daniel Maric, Damien Maison, Mohamed Nemir, Richard A. Young, Blanche Schroen, Arantxa González,  Samir Ounzain,  and Thierry Pedrazzini

Sci. Transl. Med. 2017 Jun 21;9(395).

 

Comparative transcriptome profiling of the injured zebrafish and mouse hearts identifies miRNA-dependent repair pathways.

Stefania Crippa, Mohamed Nemir,  Samir Ounzain, Mark Ibberson, Corinne Berthonneche, Alexandre Sarre, Gaëlle Boisset, Damien Maison, Keith Harshman, Ioannis Xenarios, Dario Diviani, Daniel Schorderet, and Thierry Pedrazzini

Cardiovasc Res. 2016 May 1;110(1):73-84.

 

Cardiac mTOR complex 2 preserves ventricular function in pressure-overload hypertrophy.

 

Pankaj Shende, Lifen Xu, Christian Morandi, Laura Pentassuglia, Philippe Heim, Sonia Lebboukh, Corinne Berthonneche, ThierryPedrazzini, Beat A. Kaufmann, Michael N. Hall, Markus A. Rüegg, Marijke Brink

 

Cardiovasc Res. 2016 Jan 1;109(1):103-14.

 

An Intact Small Animal Model of Myocardial Ischemia-Reperfusion: Characterization of Metabolic Changes by Hyperpolarized 13C MR Spectroscopy.

Hikari A.I. Yoshihara,  Jessica A.M. Bastiaansen,  Corinne Berthonneche,  Arnaud Comment,  Jurg Schwitter

Am J Physiol Heart Circ Physiol. 2015 Dec 15;309(12):H2058-66

 

Jagged1 intracellular domain-mediated inhibition of Notch1 signaling regulates cardiac homeostasis in the postnatal heart.

Mélanie Metrich, April Bezdek Pomey, Corinne Berthonneche, Alexandre Sarre, Mohamed Nemir, Thierry Pedrazzini

Cardiovasc Res. 2015 Oct 1;108(1):74-86

 

HIF-driven SF3B1 induces KHK-C to enforce fructolysis and heart disease.

 

Peter Mirtschink, Jaya Krishnan, Fiona Grimm, Alexandre Sarre, Manuel Hörl, Melis Kayikci, Niklaus Fankhauser, Yann Christinat, Cédric Cortijo, Owen Feehan, Ana Vukolic, Samuel Sossalla, Sebastian N. Stehr, Jernej Ule, Nicola Zamboni, Thierry Pedrazzini and Wilhelm Krek.

Nature. 2015 Jun 25;522(7557):444-9

 

No development of hypertension in the hyperuricemic liver-Glut9 knockout mouse.

 

Frederic Preitner, Anabela Pimentel, Salima Metref, Corinne Berthonneche, Alexandre Sarre, Catherine Moret, Samuel Rotman, Gabriel Centeno, Dmitri Firsov and Bernard Thorens.

Kidney Int. 2015 May;87(5):940-7.

 

Targeting cancer stem-like cells as an approach to defeating cellular heterogeneity in Ewing's sarcoma.

Sandrine Cornaz-Buros, Nicolo Riggi, Claudio DeVito, Alexandre Sarre, Igor Letovanec, Paolo Provero, Ivan Stamenkovic.

Cancer Res. 2014 Nov 15;74(22):6610-22.

 

Functional importance of cardiac enhancer-associated noncoding RNAs in heart development and disease.

Samir Ounzain, Iole Pezzuto, Rudi Micheletti, Frédéric Burdet, Razan Sheta, Mohamed Nemir, Christine Gonzales, Alexandre Sarre, Michael Alexanian, Matthew J. Blow, Dalit May, Rory Johnson, Jérome Dauvillier, Len A. Pennacchio, Thierry Pedrazzini.

J Mol Cell Cardiol. 2014 Nov;76:55-70

 

Genome-wide profiling of the cardiac transcriptome after myocardial infarction identifies novel heart-specific long non-coding RNAs.


Samir Ounzain; Rudi Micheletti; Tal Beckmann; Blanche Schroen; Michael Alexanian; Iole Pezzuto; Stefania Crippa; Mohamed Nemir; Alexandre Sarre; Rory Johnson; Jérome Dauvillier; Frédéric Burdet; Mark Ibberson; Roderic Guigo; Ioannis Xenarios; Stephane Heymans; Thierry Pedrazzini


Eur Heart J. 2015 Feb 7;36(6):353-68a.

 

Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells

Gisèle Montavon,  Nicolas Jauquier,  Aurélie Coulon, Michel Peuchmaur, Marjorie Flahaut, Katia Balmas Bourloud, Pu Yan, Olivier Delattre, Lukas Sommer, Jean-Marc Joseph, Isabelle Janoueix-Lerosey,6 Nicole Gross, and Annick Mühlethaler-Mottet

Oncotarget. 2014 Jun; 5(12): 4452–4466.

 

A-Kinase Anchoring Protein Lbc Coordinates a p38 Activating Signaling Complex Controlling Compensatory Cardiac Hypertrophy.

Irene Pérez López, Luca Cariolato, Darko Maric, Ludovic Gillet, Hugues Abriel and Dario Diviani.

Mol Cell Biol. 2013 Aug;33(15):2903-17

 

Nitric oxide synthase 2 is required for conversion of pro-fibrogenic inflammatory CD133(+) progenitors into F4/80(+) macrophages in experimental autoimmune myocarditis.

Przemyslaw Blyszczuk, Corinne Berthonneche, Silvia Behnke, Marcel Glönkler, Holger Moch, Thierry Pedrazzini, Thomas F. Lüscher, Urs Eriksson and Gabriela Kania

Cardiovasc Res. 2013 Feb 1;97(2):219-29

 

The Notch pathway controls fibrotic and regenerative repair in the adult heart.

Mohamed Nemir, Mélanie Metrich, Isabelle Plaisance, Mario Lepore, Steeve Cruchet, Corinne Berthonneche, Alexandre Sarre, Freddy Radtke and Thierry Pedrazzini.

Eur Heart J. 2014 Aug 21;35(32):2174-85

 

Cardiac dysfunction and impaired compensatory response to pressure overload in mice deficient in stem cell antigen-1.

Nathalie Rosenblatt-Velin, Sandy Ogay, Allison Felley, William L. Stanford, and Thierry Pedrazzini.

FASEB J. 2012 Jan; 26(1):229-39

 

Involvement of the CXCR7/CXCR4/CXCL12 Axis in the Malignant Progression of Human Neuroblastoma

Julie Liberman, Hervé Sartelet, Marjorie Flahaut, Annick Mühlethaler-Mottet, Aurélie Coulon, Carine Nyalendo, Gilles Vassal, Jean-Marc Joseph, and Nicole Gross.

PLoS One. 2012; 7(8): e43665.

 

Isolation of cardiovascular precursor cells from the human fetal heart.

Christine Gonzales, Nina D. Ullrich, Stefan Gerber, Corinne Berthonneche, Ernst Niggli, and Thierry Pedrazzini.

Tissue Engineering Part A. January 2012, 18(1-2): 198-207.

 

Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice.

Pankaj Shende, Isabelle Plaisance, Christian Morandi, Corinne Pellieux, Corinne Berthonneche, Francesco Zorzato, Jaya Krishnan, René Lerch, Michael N. Hall, Markus A. Rüegg, Thierry Pedrazzini, and Marijke Brink.

 Circulation. 2011; 123(10):1073-82.

 

Proangiogenic factor PlGF programs CD11b(+) myelomonocytes in breast cancer during differentiation of their hematopoietic progenitors.

Julien Laurent, Eveline Faes-van't Hull, Cedric Touvrey, François Kuonen, Qiang Lan, Girieca Lorusso, Marie-Agnès Doucey, Laura Ciarloni, Natsuko Imaizumi, Gian Carlo Alghisi, Ernesta Fagiani, Khalil Zaman, Roger Stupp, Masabumi Shibuya, Jean-François Delaloye, Gerhard Christofori and Curzio Ruegg

Cancer Res. 2011; 71(11):3781-91.

 

Functional Sphere Profiling Reveals the Complexity of Neuroblastoma Tumor-Initiating Cell Model.

Aurélie Coulon, Marjorie Flahaut, Annick Muhlethaler-Mottet, Roland Meier, Julie Liberman, Katia Balmas-Bourloud, Katya Nardou, Stéphane Tercier, Jean-Marc Joseph, Lukas Sommer and Nicole Gross

Neoplasia. 2011; 13(10):991-1004.

 

Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy.

Przemyslaw Blyszczuk,  Gabriela Kania, Thomas Dieterle, Rene R. Marty, Alan Valaperti, Corinne Berthonneche, Thierry Pedrazzini, Christoph T. Berger, Stephan Dirnhofer, Christian M. Matter, Josef M. Penninger, Thomas F. Lüscher, Urs Eriksson.

Circ Res. 2009; 105(9):912-20

 

Activation of a HIF1α-PPARγ Axis Underlies the Integration of Glycolytic and Lipid Anabolic Pathways in Pathologic Cardiac Hypertrophy

Jaya Krishnan, Marianne Suter, Renata Windak, Tatiana Krebs, Allison Felley, Christophe Montessuit, Malgorzata Tokarska-Schlattner, Ellen Aasum, Anna Bogdanova, Evelyne Perriard, Jean-Claude Perriard, Terje Larsen, Thierry Pedrazzini, Wilhelm Krek.

Cell Metab. 2009; 9(6):512-24

 

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

C. Florian Bentzinger, Klaas Romanino, Dimitri Cloëtta, Shuo Lin, Joseph B. Mascarenhas, Filippo Oliveri, Jinyu Xia,  Emilio Casanova, Céline F. Costa, Marijke Brink, Francesco Zorzato, Michael N. Hall, Markus A. Rüegg.

Cell Metab. 2008;8(5):343-4.

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Centre Hospitalier Universitaire Vaudois (CHUV)