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Publications

2014
    Gilardi, F., Migliavacca, E., Naldi, A., Baruchet, M., Canella, D., Le Martelot, G., Guex, N., Desvergne, B.: Genome-wide analysis of SREBP1 activity around the clock reveals its combined dependency on nutrient and circadian signals. PLoS Genet 2014, 10:e1004155. URL

    Gilardi, F., Desvergne, B.: RXRs: Collegial Partners. Subcell Biochem 2014, 70:75-102. URL

2013
    Scholtysek, C., Katzenbeisser, J., Fu, H., Uderhardt, S., Ipseiz, N., Stoll, C., Zaiss, M. M., Stock, M., Donhauser, L., Bohm, C., Kleyer, A., Hess, A., Engelke, K., David, J. P., Djouad, F., Tuckermann, J. P., Desvergne, B., Schett, G., Kronke, G.: PPARbeta/delta governs Wnt signaling and bone turnover. Nat Med 2013, 19:608-13. URL

    Berger, H., Vegran, F., Chikh, M., Gilardi, F., Ladoire, S., Bugaut, H., Mignot, G., Chalmin, F., Bruchard, M., Derangere, V., Chevriaux, A., Rebe, C., Ryffel, B., Pot, C., Hichami, A., Desvergne, B., Ghiringhelli, F., Apetoh, L.: SOCS3 transactivation by PPARgamma prevents IL-17-driven cancer growth. Cancer Res 2013, 73:3578-90. URL

2012
    Nadra, K., Medard, J. J., Quignodon, L., Verheijen, M. H., Desvergne, B., Chrast, R.: Epineurial adipocytes are dispensable for Schwann cell myelination. J Neurochem 2012, 123:662-7. URL

    Nadra, K., Medard, J. J., Mul, J. D., Han, G. S., Gres, S., Pende, M., Metzger, D., Chambon, P., Cuppen, E., Saulnier-Blache, J. S., Carman, G. M., Desvergne, B., Chrast, R.: Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue. Mol Cell Biol 2012, 32:4794-810. URL

    Canella, D., Bernasconi, D., Gilardi, F., LeMartelot, G., Migliavacca, E., Praz, V., Cousin, P., Delorenzi, M., Hernandez, N., Cyclix Consortium*, *B. Desvergne is a member of the Cyclix Consortium: A multiplicity of factors contributes to selective RNA polymerase III occupancy of a subset of RNA polymerase III genes in mouse liver. Genome Res 2012, 22:666-80. URL

    Le Martelot, G., Canella, D., Symul, L., Migliavacca, E., Gilardi, F., Liechti, R., Martin, O., Harshman, K., Delorenzi, M., Desvergne, B., Herr, W., Deplancke, B., Schibler, U., Rougemont, J., Guex, N., Hernandez, N., Naef, F.: Genome-wide RNA polymerase II profiles and RNA accumulation reveal kinetics of transcription and associated epigenetic changes during diurnal cycles. PLoS Biol 2012, 10:e1001442. URL

    Brunner, J. M., Plattet, P., Doucey, M. A., Rosso, L., Curie, T., Montagner, A., Wittek, R., Vandelvelde, M., Zurbriggen, A., Hirling, H., Desvergne, B.: Morbillivirus Glycoprotein Expression Induces ER Stress, Alters Ca Homeostasis and Results in the Release of Vasostatin. PLoS One 2012, 7:e32803. URL

2011
    Yamamoto, H., Williams, E. G., Mouchiroud, L., Canto, C., Fan, W., Downes, M., Heligon, C., Barish, G. D., Desvergne, B., Evans, R. M., Schoonjans, K., Auwerx, J.: NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell 2011, 147:827-39. URL

    Casals-Casas, C., Desvergne, B.: Endocrine disruptors: from endocrine to metabolic disruption. Annu Rev Physiol 2011, 73:135-62. URL

2010
    Nadra, K., Quignodon, L., Sardella, C., Joye, E., Mucciolo, A., Chrast, R., Desvergne, B.: PPARgamma in placental angiogenesis. Endocrinology 2010, 151:4969-81. URL

    Peyrin-Biroulet, L., Beisner, J., Wang, G., Nuding, S., Oommen, S. T., Kelly, D., Parmentier-Decrucq, E., Dessein, R., Merour, E., Chavatte, P., Grandjean, T., Bressenot, A., Desreumaux, P., Colombel, J. F., Desvergne, B., Stange, E. F., Wehkamp, J., Chamaillard, M.: Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon. Proc Natl Acad Sci U S A 2010, 107:8772-7. URL

    Sanderson, L. M., Boekschoten, M. V., Desvergne, B., Muller, M., Kersten, S.: Transcriptional profiling reveals divergent roles of PPARalpha and PPARbeta/delta in regulation of gene expression in mouse liver. Physiol Genomics 2010, 41:42-52. URL

    Georgiadi, A., Lichtenstein, L., Degenhardt, T., Boekschoten, M. V., van Bilsen, M., Desvergne, B., Muller, M., Kersten, S.: Induction of cardiac Angptl4 by dietary fatty acids is mediated by peroxisome proliferator-activated receptor beta/delta and protects against fatty acid-induced oxidative stress. Circ Res 2010, 106:1712-21. URL

    Morgan, H., Beck, T., Blake, A., Gates, H., Adams, N., Debouzy, G., Leblanc, S., Lengger, C., Maier, H., Melvin, D., Meziane, H., Richardson, D., Wells, S. , White, J., Wood, J., *EUMODIC Consortium, De Angelis M.H., Brown, S.D., Hancock, J.M., Mallon, A.M.: EuroPhenome: a repository for high-throughput mouse phenotyping data. Nucleic Acids Res 2010, 38:577-85. *B.Desvergne is a member of the Eumodic Consortium. URL

    Feige, J. N., Gerber, A., Casals-Casas, C., Yang, Q., Winkler, C., Bedu, E., Bueno, M., Gelman, L., Auwerx, J., Gonzalez, F. J., Desvergne, B.: The Pollutant Diethylhexyl Phthalate Regulates Hepatic Energy Metabolism via Species-Specific PPARalpha-Dependent Mechanisms. Environ Health Perspect 2010, 118:234-41. URL

    Kapoor, A., Shintani, Y., Collino, M., Osuchowski, M. F., Busch, D., Patel, N. S., Sepodes, B., Castiglia, S., Fantozzi, R., Bishop-Bailey, D., Mota-Filipe, H., Yaqoob, M. M., Suzuki, K., Bahrami, S., Desvergne, B., Mitchell, J. A., Thiemermann, C.: Protective role of peroxisome proliferator-activated receptor-beta/delta in septic shock. Am J Respir Crit Care Med 2010, 182:1506-15. URL

    Harrington, L. S., Moreno, L., Reed, A., Wort, S. J., Desvergne, B., Garland, C., Zhao, L., Mitchell, J. A.: The PPARbeta/deltaAgonist GW0742 Relaxes Pulmonary Vessels and Limits Right Heart Hypertrophy in Rats with Hypoxia-Induced Pulmonary Hypertension. PLoS One 2010, 5:e9526. URL

2009
    Desvergne, B., Heligon, C.: Steroid hormone pulsing drives cyclic gene expression. Nat Cell Biol 2009, 11:1051-3. URL

    Sanderson, L. M., Degenhardt, T., Koppen, A., Kalkhoven, E., Desvergne, B., Muller, M., Kersten, S.: PPAR{beta}/{delta} but not PPAR{alpha} serves as plasma free fatty acid sensor in liver. Mol Cell Biol 2009, 29:6257-67. URL

    Desvergne, B., Feige, J. N., Casals-Casas, C.: PPAR-mediated activity of phthalates: A link to the obesity epidemic?. Mol Cell Endocrinol 2009, 304:43-8. URL

    Ali, F. Y., Hall, M. G., Desvergne, B., Warner, T. D., Mitchell, J. A.: PPAR{beta}/{delta} Agonists Modulate Platelet Function via a Mechanism Involving PPAR Receptors and Specific Association/Repression of PKC{alpha}. Arterioscler Thromb Vasc Biol 2009, 29:1871-3. URL

2008
    Desvergne, B.: PPARdelta/beta: the lobbyist switching macrophage allegiance in favor of metabolism. Cell Metab 2008, 7:467-9. URL

    Casals-Casas, C., Feige, J. N., Desvergne, B.: Interference of pollutants with PPARs: endocrine disruption meets metabolism. Int J Obes (Lond) 2008, 32 Suppl 6:S53-61. URL

    Rotman, N., Terreau-Haftek, Z., Lücke, S., Feige, J., Gelman, L., Desvergne, B., Wahli, W.: PPAR Disruption: Cellular Mechanisms and Physiological Consequences. CHIMIA 2008, 62:340-344. URL

    Hall*, M. G., Quignodon*, L., Desvergne, B.: Peroxisome Proliferator-Activated Receptor beta/delta in the Brain: Facts and Hypothesis. PPAR Res 2008, 2008:780452. URL

2007
    Wang, H., Xie, H., Sun, X., Tranguch, S., Zhang, H., Jia, X., Wang, D., Das, S. K., Desvergne, B., Wahli, W., Dubois, R. N., Dey, S. K.: Stage-specific integration of maternal and embryonic PPARdelta signaling is critical to pregnancy success. J Biol Chem 2007, 282:37770-82. URL

    Anghel, S. I., Bedu, E., Vivier, C. D., Descombes, P., Desvergne, B., Wahli, W.: Adipose tissue integrity as a prerequisite for systemic energy balance: a critical role for peroxisome proliferator-activated receptor gamma. J Biol Chem 2007, 282:29946-57. URL

    Pialat, J. B., Cho, T. H., Beuf, O., Joye, E., Moucharaffie, S., Langlois, J. B., Nemoz, C., Janier, M., Berthezene, Y., Nighoghossian, N., Desvergne, B., Wiart, M.: MRI monitoring of focal cerebral ischemia in peroxisome proliferator-activated receptor (PPAR)-deficient mice. NMR Biomed 2007, 20:335-42. URL

    Mandard, S., Stienstra, R., Escher, P., Tan, N. S., Kim, I., Gonzalez, F. J., Wahli, W., Desvergne, B., Muller, M., Kersten, S.: Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors. Cell Mol Life Sci 2007, 64:1145-57. URL

    Indra, A. K., Castaneda, E., Antal, M. C., Jiang, M., Messaddeq, N., Meng, X., Loehr, C. V., Gariglio, P., Kato, S., Wahli, W., Desvergne, B., Metzger, D., Chambon, P.: Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes. J Invest Dermatol 2007, 127:1250-60. URL

    Michalik*, L., Zoete*, V., Krey, G., Grosdidier, A., Gelman, L., Chodanowski, P., Feige, J. N., Desvergne, B., Wahli**, W., Michielin**, O.: Combined simulation and mutagenesis analyses reveal the involvement of key residues for peroxisome proliferator-activated receptor alpha helix 12 dynamic behavior. J Biol Chem 2007, 282:9666-77. URL

    Feige, J. N., Gelman, L., Rossi, D., Zoete, V., Metivier, R., Tudor, C., Anghel, S. I., Grosdidier, A., Lathion, C., Engelborghs, Y., Michielin, O., Wahli, W., Desvergne, B.: The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis. J Biol Chem 2007, 282:19152-66. URL

    Bedu, E., Desplanches, D., Pequignot, J., Bordier, B., Desvergne, B.: Double gene deletion reveals the lack of cooperation between PPARalpha and PPARbeta in skeletal muscle. Biochem Biophys Res Commun 2007, 357:877-81. URL

    Desvergne, B.: Retinaldehyde: more than meets the eye. Nat Med 2007, 13:671-3. URL

    Berry*, A., Balard*, P., Coste, A., Olagnier, D., Lagane, C., Authier, H., Benoit-Vical, F., Lepert, J. C., Seguela, J. P., Magnaval, J. F., Chambon, P., Metzger, D., Desvergne, B., Wahli, W., Auwerx, J., Pipy, B.: IL-13 induces expression of CD36 in human monocytes through PPARgamma activation. Eur J Immunol 2007, 37:1642-52. URL

    Tudor, C., Feige, J. N., Pingali, H., Lohray, V. B., Wahli, W., Desvergne, B., Engelborghs, Y., Gelman, L.: Association with coregulators is the major determinant governing peroxisome proliferator-activated receptor mobility in living cells. J Biol Chem 2007, 282:4417-26 . URL

    Gelman, L., Feige, J. N., Desvergne, B.: Molecular basis of selective PPARgamma modulation for the treatment of Type 2 diabetes. Biochim Biophys Acta 2007, 1771:1094-107. URL

    Desvergne, B.: PPARs special issue: anchoring the present to explore the future. Biochim Biophys Acta 2007, 1771:913-4. URL

    Desvergne, B.: RXR: From Partnership to Leadership in Metabolic Regulations. Vitam Horm 2007, 75:1-32. URL

2006
    Knauf, C., Rieusset, J., Foretz, M., Cani, P. D., Uldry, M., Hosokawa, M., Martinez, E., Bringart, M., Waget, A., Kersten, S., Desvergne, B., Gremlich, S., Wahli, W., Seydoux, J., Delzenne, N. M., Thorens, B., Burcelin, R.: Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain. Endocrinology 2006, 147:4067-78. URL

    Schuler, M., Ali, F., Chambon, C., Duteil, D., Bornert, J. M., Tardivel, A., Desvergne, B., Wahli, W., Chambon, P., Metzger, D.: PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes. Cell Metab 2006, 4:407-14. URL

    Feige, J. N., Gelman, L., Michalik, L., Desvergne, B., Wahli, W.: From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Prog Lipid Res 2006, 45:120-59. URL

    Ali, F. Y., Egan, K., FitzGerald, G. A., Desvergne, B., Wahli, W., Bishop-Bailey, D., Warner, T. D., Mitchell, J. A.: Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts. Am J Respir Cell Mol Biol 2006, 34:242-6. URL

    Wang, D., Wang, H., Guo, Y., Ning, W., Katkuri, S., Wahli, W., Desvergne, B., Dey, S. K., DuBois, R. N.: Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Proc Natl Acad Sci U S A 2006, 103:19069-74. URL

    Varnat, F., Heggeler, B. B., Grisel, P., Boucard, N., Corthesy-Theulaz, I., Wahli, W., Desvergne, B.: PPARbeta/delta regulates paneth cell differentiation via controlling the hedgehog signaling pathway. Gastroenterology 2006, 131:538-53. URL

    Nadra, K., Anghel, S. I., Joye, E., Tan, N. S., Basu-Modak, S., Trono, D., Wahli, W., Desvergne, B.: Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta. Mol Cell Biol 2006, 26:3266-81. URL

    Desvergne, B., Michalik, L., Wahli, W.: Transcriptional regulation of metabolism. Physiol Rev 2006, 86:465-514. URL

    Varnat, F., Michalik, L., Desvergne, B., Wahli, W.: PPARs: lipid sensors that regulate cell differentiation processes In Nutritional Genomics: Impact on Health and Disease Edited by Brigelius-Flohé, R. , Joost, H.G.; Weinheim: Wiley-VCH Verlag GmbH & Co; 2006: 117-131.

    Varnat, F., Desvergne, B.: Authors Reply-PPARbeta/delta regulates paneth cell differentiation via controlling the hedgehog signaling pathway. Gastroenterology 2006, 131:1658-9.

    Rotman, N., Michalik, L., Desvergne, B., Wahli, W.: PPARs in fetal and early postnatal development In Nuclear receptors in development (Advances in Developmental Biology Series, Vol.16) Edited by R. Taneja , PM Wassarman; Elsevier; 2006: 33-49.

    Gelman, L., Feige, J. N., Tudor, C., Engelborghs, Y., Wahli, W., Desvergne, B.: Integrating nuclear receptor mobility in models of gene regulation. Nucl Recept Signal 2006, 4:e010. URL

2005
    Michalik, L., Feige, J. N., Gelman, L., Pedrazzini, T., Keller, H., Desvergne, B., Wahli, W.: Selective expression of a dominant-negative form of peroxisome proliferator-activated receptor in keratinocytes leads to impaired epidermal healing. Mol Endocrinol 2005, 19:2335-48. URL

    Feige, J. N., Sage, D., Wahli, W., Desvergne, B., Gelman, L.: PixFRET, an ImageJ plug-in for FRET calculation that can accommodate variations in spectral bleed-throughs. Microsc Res Tech 2005, 68:51-8. URL

    Di-Poi, N., Desvergne, B., Michalik, L., Wahli, W.: Transcriptional repression of peroxisome proliferator-activated receptor beta/delta in murine keratinocytes by CCAAT/enhancer-binding proteins. J Biol Chem 2005, 280:38700-10. URL

    Eumorphia_Consortium, Authors_from_the_CIG: , Wahli, W., Delgado, MB., Desvergne, B., Michalik, L., Bedu, E.: EMPReSS: standardised phenotype screens for functional annotation of the mouse genome. Nat Genet 2005, 37:1155. URL

    Tan, N. S., Michalik, L., Desvergne, B., Wahli, W.: Genetic- or transforming growth factor-beta 1-induced changes in epidermal peroxisome proliferator-activated receptor beta/delta expression dictate wound repair kinetics. J Biol Chem 2005, 280:18163-70. URL

    Feige, J. N., Gelman, L., Tudor, C., Engelborghs, Y., Wahli, W., Desvergne, B.: Fluorescence imaging reveals the nuclear behavior of peroxisome proliferator-activated receptor/retinoid X receptor heterodimers in the absence and presence of ligand. J Biol Chem 2005, 280:17880-90. URL

    Di-Poi, N., Ng, C. Y., Tan, N. S., Yang, Z., Hemmings, B. A., Desvergne, B., Michalik, L., Wahli, W.: Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development. Mol Cell Biol 2005, 25:1696-712. URL

    Genolet, R., Kersten, S., Braissant, O., Mandard, S., Tan, N. S., Bucher, P., Desvergne, B., Michalik, L., Wahli, W.: Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate reductase/hydroxypyruvate reductase gene by the peroxisome proliferator-activated receptor alpha. J Biol Chem 2005, 280:24143-52. URL

    Metzger, D., Imai, T., Jiang, M., Takukawa, R., Desvergne, B., Wahli, W., Chambon, P.: Functional role of RXRs and PPARgamma in mature adipocytes. Prostaglandins Leukot Essent Fatty Acids 2005, 73:51-8. URL

    Gremlich, S., Nolan, C., Roduit, R., Burcelin, R., Peyot, M. L., Delghingaro-Augusto, V., Desvergne, B., Michalik, L., Prentki, M., Wahli, W.: Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation. Endocrinology 2005, 146:375-82. URL

    Tan, N. S., Michalik, L., Desvergne, B., Wahli, W.: Multiple expression control mechanisms of peroxisome proliferator-activated receptors and their target genes. J Steroid Biochem Mol Biol 2005, 93:99-105. URL

    Debril, M. B., Dubuquoy, L., Feige, J. N., Wahli, W., Desvergne, B., Auwerx, J., Gelman, L.: Scaffold attachment factor B1 directly interacts with nuclear receptors in living cells and represses transcriptional activity. J Mol Endocrinol 2005, 35:503-17. URL

    Letavernier, E., Perez, J., Joye, E., Bellocq, A., Fouqueray, B., Haymann, J. P., Heudes, D., Wahli, W., Desvergne, B., Baud, L.: Peroxisome proliferator-activated receptor beta/delta exerts a strong protection from ischemic acute renal failure. J Am Soc Nephrol 2005, 16:2395-402. URL

    Bedu, E., Wahli, W., Desvergne, B.: Peroxisome proliferator-activated receptor beta/delta as a therapeutic target for metabolic diseases. Expert Opin Ther Targets 2005, 9:861-73. URL

    Rousseaux, C., Lefebvre, B., Dubuquoy, L., Lefebvre, P., Romano, O., Auwerx, J., Metzger, D., Wahli, W., Desvergne, B., Naccari, G. C., Chavatte, P., Farce, A., Bulois, P., Cortot, A., Colombel, J. F., Desreumaux, P.: Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma. J Exp Med 2005, 201:1205-15. URL

    Gelman, L., Michalik, L., Desvergne, B., Wahli, W.: Kinase signaling cascades that modulate peroxisome proliferator-activated receptors. Curr Opin Cell Biol 2005, 17:216-22. URL

2004
    Wang, D., Wang, H., Shi, Q., Katkuri, S., Walhi, W., Desvergne, B., Das, S. K., Dey, S. K., DuBois, R. N.: Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer Cell 2004, 6:285-95. URL

    Tan, N. S., Michalik, L., Di-Poi, N., Ng, C. Y., Mermod, N., Roberts, A. B., Desvergne, B., Wahli, W.: Essential role of Smad3 in the inhibition of inflammation-induced PPARbeta/delta expression. Embo J 2004, 23:4211-21. URL

    Rieusset, J., Seydoux, J., Anghel, S. I., Escher, P., Michalik, L., Soon Tan, N., Metzger, D., Chambon, P., Wahli, W., Desvergne, B.: Altered growth in male peroxisome proliferator-activated receptor gamma (PPARgamma) heterozygous mice: involvement of PPARgamma in a negative feedback regulation of growth hormone action. Mol Endocrinol 2004, 18:2363-77. URL

    Di-Poi, N., Michalik, L., Desvergne, B., Wahli, W.: Functions of peroxisome proliferator-activated receptors (PPAR) in skin homeostasis. Lipids 2004, 39:1093-9. URL

    Ijpenberg, A., Tan, N. S., Gelman, L., Kersten, S., Seydoux, J., Xu, J., Metzger, D., Canaple, L., Chambon, P., Wahli, W., Desvergne, B.: In vivo activation of PPAR target genes by RXR homodimers. Embo J 2004, 23:2083-91. URL

    Imai, T., Takakuwa, R., Marchand, S., Dentz, E., Bornert, J. M., Messaddeq, N., Wendling, O., Mark, M., Desvergne, B., Wahli, W., Chambon, P., Metzger, D.: Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse. Proc Natl Acad Sci U S A 2004, 101:4543-7. URL

    Desvergne, B., Michalik, L., Wahli, W.: Be fit or be sick: peroxisome proliferator-activated receptors are down the road. Mol Endocrinol 2004, 18:1321-32. URL

    Michalik, L., Desvergne, B., Wahli, W.: Peroxisome-proliferator-activated receptors and cancers: complex stories. Nat Rev Cancer 2004, 4:61-70. URL

    Tan, N. S., Michalik, L., Di-Poi, N., Desvergne, B., Wahli, W.: Critical roles of the nuclear receptor PPARbeta (peroxisome-proliferator-activated receptor beta) in skin wound healing. Biochem Soc Trans 2004, 32:97-102. URL

    Tan, N. S., Michalik, L., Desvergne, B., Wahli, W.: Peroxisome proliferator-activated receptor-beta as a target for wound healing drugs. Expert Opin Ther Targets 2004, 8:39-48. URL

    Mao-Qiang, M., Fowler, A. J., Schmuth, M., Lau, P., Chang, S., Brown, B. E., Moser, A. H., Michalik, L., Desvergne, B., Wahli, W., Li, M., Metzger, D., Chambon, P. H., Elias, P. M., Feingold, K. R.: Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation. J Invest Dermatol 2004, 123:305-12. URL

    Wahli, W., Michalik, L., Desvergne, B.: PPARs in health and disease : central roles in energy homeostasis and tissue repair. BIO 2004, 11:26-31.

2003
    Di-Poi, N., Michalik, L., Tan, N. S., Desvergne, B., Wahli, W.: The anti-apoptotic role of PPARbeta contributes to efficient skin wound healing. J Steroid Biochem Mol Biol 2003, 85:257-65. URL

    Michalik, L., Desvergne, B., Wahli, W.: Peroxisome proliferator-activated receptors beta/delta: emerging roles for a previously neglected third family member. Curr Opin Lipidol 2003, 14:129-35. URL

    Tan, N. S., Michalik, L., Desvergne, B., Wahli, W.: Peroxisome proliferator-activated receptor (PPAR)-beta as a target for wound healing drugs: what is possible?. Am J Clin Dermatol 2003, 4:523-30. URL

    Michalik, L., Tan, N. S., Wahli, W., Desvergne, B.: PPARs: nuclear receptors involved in the control of inflammation In Cellular proteins and their fatty acids in health and disease Volume Chapter 24. Edited by Duttaroy, AK , Spener, F; Weinheim: Wiley VCH; 2003: 419-435.

2002
    Di-Poi, N., Tan, N. S., Michalik, L., Wahli, W., Desvergne, B.: Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway. Mol Cell 2002, 10:721-33. URL

    Rieusset, J., Touri, F., Michalik, L., Escher, P., Desvergne, B., Niesor, E., Wahli, W.: A new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesity and antidiabetic activity. Mol Endocrinol 2002, 16:2628-44. URL

    Fauconnet, S., Lascombe, I., Chabannes, E., Adessi, G. L., Desvergne, B., Wahli, W., Bittard, H.: Differential regulation of vascular endothelial growth factor expression by peroxisome proliferator-activated receptors in bladder cancer cells. J Biol Chem 2002, 277:23534-43. URL

    Tan, N. S., Shaw, N. S., Vinckenbosch, N., Liu, P., Yasmin, R., Desvergne, B., Wahli, W., Noy, N.: Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription. Mol Cell Biol 2002, 22:5114-27. URL

    Guissouma, H., Dupre, S. M., Becker, N., Jeannin, E., Seugnet, I., Desvergne, B., Demeneix, B. A.: Feedback on hypothalamic TRH transcription is dependent on thyroid hormone receptor N terminus. Mol Endocrinol 2002, 16:1652-66. URL

    Michalik, L., Desvergne, B., Dreyer, C., Gavillet, M., Laurini, R. N., Wahli, W.: PPAR expression and function during vertebrate development. Int J Dev Biol 2002, 46:105-14. URL

    Rodondi, N., Darioli, R., Ramelet, A. A., Hohl, D., Lenain, V., Perdrix, J., Wietlisbach, V., Riesen, W. F., Walther, T., Medinger, L., Nicod, P., Desvergne, B., Mooser, V.: High risk for hyperlipidemia and the metabolic syndrome after an episode of hypertriglyceridemia during 13-cis retinoic acid therapy for acne: a pharmacogenetic study. Ann Intern Med 2002, 136:582-9. URL

    Kersten, S., Desvergne, B., Wahli, W.: Peroxisome Proliferator Activated Receptor alpha coordinates intermediary metabolism during fasting In PPARs : fom basic science to clinical applications Volume 18. Edited by J-C Fruchart, A-M Gotto , R Paoletti, B Staels; Dordrecht, Boston, London: Kluwers Academic Publishers; 2002: 1-4.

    Desvergne, B., Michalik, L., Wahli, W.: Sensors for metabolic control : A regulatory network of nuclear receptors In Hormone signaling Edited by Goffin, V. , Kelly, P. A. ; Norwell: Kluwer Academic Publishers; 2002: 283-304.

2001
    Kersten, S., Mandard, S., Escher, P., Gonzalez, F. J., Tafuri, S., Desvergne, B., Wahli, W.: The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism. Faseb J 2001, 15:1971-8. URL

    Escher, P., Braissant, O., Basu-Modak, S., Michalik, L., Wahli, W., Desvergne, B.: Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology 2001, 142:4195-202. URL

    Canaple, L., Nurdin, N., Angelova, N., Hunkeler, D., Desvergne, B.: Development of a coculture model of encapsulated cells. Ann N Y Acad Sci 2001, 944:350-61. URL

    Canaple, L., Nurdin, N., Angelova, N., Saugy, D., Hunkeler, D., Desvergne, B.: Maintenance of primary murine hepatocyte functions in multicomponent polymer capsules--in vitro cryopreservation studies. J Hepatol 2001, 34:11-8. URL

    Tan, N. S., Michalik, L., Noy, N., Yasmin, R., Pacot, C., Heim, M., Fluhmann, B., Desvergne, B., Wahli, W.: Critical roles of PPAR beta/delta in keratinocyte response to inflammation. Genes Dev 2001, 15:3263-77. URL

    Michalik, L., Desvergne, B., Tan, N. S., Basu-Modak, S., Escher, P., Rieusset, J., Peters, J. M., Kaya, G., Gonzalez, F. J., Zakany, J., Metzger, D., Chambon, P., Duboule, D., Wahli, W.: Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice. J Cell Biol 2001, 154:799-814. URL

    Desreumaux, P., Dubuquoy, L., Nutten, S., Peuchmaur, M., Englaro, W., Schoonjans, K., Derijard, B., Desvergne, B., Wahli, W., Chambon, P., Leibowitz, M. D., Colombel, J. F., Auwerx, J.: Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies. J Exp Med 2001, 193:827-38. URL

    Rieusset, J., Wahli, W., Desvergne, B.: Les récepteurs nucéaires PPARs (Peroxisome Proliferator Activated Receptors) : Trois isotypes pour de multiples fonctions. Médecine Thérapeutique Endocrinologie 2001, 3:4-12.

2000
    Kersten, S., Mandard, S., Tan, N. S., Escher, P., Metzger, D., Chambon, P., Gonzalez, F. J., Desvergne, B., Wahli, W.: Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. J Biol Chem 2000, 275:28488-93. URL

    Kersten, S., Desvergne, B., Wahli, W.: Roles of PPARs in health and disease. Nature 2000, 405:421-4. URL

    Nurdin, N., Canaple, L., Bartkowiak, A., Desvergne, B., Hunkeler, D.: Capsule permeability via polymer and protein ingress/egress. J. App. Polym. Sci. 2000, 75:1165-1175.

    Michalik, L., Desvergne, B., Wahli, W.: Les bases moléculaires de l'obésité : vers de nouvelles thérapeutiques ?. Médecines Sciences 2000, 16:1030-1039.

    Michalik, L., Desvergne, B., Basu-Modak, S., Tan, N. S., Wahli, W.: Nuclear hormone receptors and mouse skin homeostasis: implication of PPARbeta. Horm Res 2000, 54:263-8. URL

1999
    Bernard, P., Goudonnet, H., Artur, Y., Desvergne, B., Wahli, W.: Activation of the mouse TATA-less and human TATA-containing UDP-glucuronosyltransferase 1A1 promoters by hepatocyte nuclear factor 1. Mol Pharmacol 1999, 56:526-36. URL

    Desvergne, B., Wahli, W.: Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 1999, 20:649-88. URL

    Bartkowiak, A., Canaple, L., Ceausoglu, I., Nurdin, N., Renken, A., Rindisbacher, L., Wandrey, C., Desvergne, B., Hunkeler, D.: New multicomponent capsules for immunoisolation. Ann N Y Acad Sci 1999, 875:135-45. URL

    Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., Wahli, W.: Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest 1999, 103:1489-98. URL

    Basu-Modak, S., Braissant, O., Escher, P., Desvergne, B., Honegger, P., Wahli, W.: Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures. J Biol Chem 1999, 274:35881-8. URL

    Wahli, W., Kersten, S., Devchand, P., Desvergne, B.: PPARα : cross-talk with membrane receptors and control of energy homeostasis In Common Diseases - Genetic and Pathogenic Aspects of Multifactorial Diseases Volume 1181. Edited by H. Imura, M Kasuga , K. Nakao; 1999: 159-167.

    Wahli, W., Devchand, P. R., IJpenberg, A., Desvergne, B.: Fatty acids, eicosanoids, and hypolipidemic agents regulate gene expression through direct binding to peroxisome proliferator-activated receptors. Adv Exp Med Biol 1999, 447:199-209. URL

1998
    Jeannin, E., Robyr, D., Desvergne, B.: Transcriptional regulatory patterns of the myelin basic protein and malic enzyme genes by the thyroid hormone receptors alpha1 and beta1. J Biol Chem 1998, 273:24239-48. URL

    Desvergne, B., IJpenberg, A., Devchand, P. R., Wahli, W.: The peroxisome proliferator-activated receptors at the cross-road of diet and hormonal signalling. J Steroid Biochem Mol Biol 1998, 65:65-74. URL

1997
    Juge-Aubry, C., Pernin, A., Favez, T., Burger, A. G., Wahli, W., Meier, C. A., Desvergne, B.: DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5'-flanking region. J Biol Chem 1997, 272:25252-9. URL

    Desvergne, B., Favez, T.: The major transcription initiation site of the SV40 late promoter is a potent thyroid hormone response element. Nucleic Acids Res 1997, 25:1774-81. URL

    Masmoudi, T., Hihi, A. K., Vazquez, M., Artur, Y., Desvergne, B., Wahli, W., Goudonnet, H.: Transcriptional regulation by triiodothyronine of the UDP-glucuronosyltransferase family 1 gene complex in rat liver. Comparison with induction by 3-methylcholanthrene. J Biol Chem 1997, 272:17171-5. URL

    Ijpenberg, A., Jeannin, E., Wahli, W., Desvergne, B.: Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor heterodimer binding to DNA. A functional analysis of the malic enzyme gene PPAR response element. J Biol Chem 1997, 272:20108-17. URL

1996
    Lemberger, T., Saladin, R., Vazquez, M., Assimacopoulos, F., Staels, B., Desvergne, B., Wahli, W., Auwerx, J.: Expression of the peroxisome proliferator-activated receptor alpha gene is stimulated by stress and follows a diurnal rhythm. J Biol Chem 1996, 271:1764-9. URL

    Lemberger, T., Desvergne, B., Wahli, W.: Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology. Annu Rev Cell Dev Biol 1996, 12:335-63. URL

    Desvergne, B.: Book review of Peroxisome proliferation and its role in carcinogenesis. ISSX Newsletter 1996, 16:

1995
    Wahli, W., Braissant, O., Desvergne, B.: Peroxisome proliferator activated receptors: transcriptional regulators of adipogenesis, lipid metabolism and more. Chem Biol 1995, 2:261-6. URL

    Desvergne, B., Wahli, W.: PPAR: a key nuclear factor in nutrient/gene interactions ? In Inducible transcription Volume 1. Edited by Baeuerle, P. ; Boston: Birkhäuser; 1995: 142-176.

    Desvergne, B., Wahli, W.: PPAR : A key factor in nutrient/gene interactions In Inducible Transcription Volume 1. Edited by Baeuerle, P. ; Boston, Basel, Berlin: Birkhäuser; 1995: 142-176.

1994
    Lemberger, T., Staels, B., Saladin, R., Desvergne, B., Auwerx, J., Wahli, W.: Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids. J Biol Chem 1994, 269:24527-30. URL

    Lazar, J., Desvergne, B., Zimmerman, E. C., Zimmer, D. B., Magnuson, M. A., Nikodem, V. M.: A role for intronic sequences on expression of thyroid hormone receptor alpha gene. J Biol Chem 1994, 269:20352-9. URL

    Desvergne, B.: How do thyroid hormone receptors bind to structurally diverse response elements?. Mol Cell Endocrinol 1994, 100:125-31. URL

1992
    Farsetti, A., Desvergne, B., Hallenbeck, P., Robbins, J., Nikodem, V. M.: Characterization of myelin basic protein thyroid hormone response element and its function in the context of native and heterologous promoter. J Biol Chem 1992, 267:15784-8. URL

1991
    Desvergne, B., Petty, K. J., Nikodem, V. M.: Functional characterization and receptor binding studies of the malic enzyme thyroid hormone response element. J Biol Chem 1991, 266:1008-13. URL

    Farsetti, A., Mitsuhashi, T., Desvergne, B., Robbins, J., Nikodem, V. M.: Molecular basis of thyroid hormone regulation of myelin basic protein gene expression in rodent brain. J Biol Chem 1991, 266:23226-32. URL

1990
    Petty, K. J., Desvergne, B., Mitsuhashi, T., Nikodem, V. M.: Identification of a thyroid hormone response element in the malic enzyme gene. J Biol Chem 1990, 265:7395-400. URL

    Nikodem, V. M., Petty, K. J., Mitsuhashi, T., Desvergne, B.: Structure and mechanism of action of thyroid hormone receptors In The Thyroid Gland Edited by Greer MA; New-York: Raven Press; 1990: 307-321.

1989
    Desvergne, B., Baffet, G., Loyer, P., Rissel, M., Lescoat, G., Guguen-Guillouzo, C., Brissot, P.: Chronic iron overload inhibits protein secretion by adult rat hepatocytes maintained in long-term primary culture. Eur J Cell Biol 1989, 49:162-70. URL

    Lescoat, G., Jouanolle, H., Desvergne, B., Pasdeloup, N., Kneip, B., Deugnier, Y., Guillouzo, A., Brissot, P.: Effects of iron overload on transferrin secretion by cultured fetal rat hepatocytes. Biol Cell 1989, 65:221-9. URL

    Lescoat, G., Desvergne, B., Loreal, O., Pasdeloup, N., Deugnier, Y., Bourel, M., Brissot, P.: Modulation of albumin secretion by ornithine alpha-ketoglutarate in adult rat hepatocyte cultures and a human hepatoma cell line (HepG2). Ann Nutr Metab 1989, 33:252-60. URL

1988
    Lescoat, G., Loreal, O., Desvergne, B., Pasdeloup, N., Deugnier, Y., Brissot, P.: Effect of ornithine on transferrin secretion of rat and human hepatocyte cultures. Liver 1988, 8:360-5. URL

    Etienne, P. L., Baffet, G., Desvergne, B., Boisnard-Rissel, M., Glaise, D., Guguen-Guillouzo, C.: Transient expression of c-fos and constant expression of c-myc in freshly isolated and cultured normal adult rat hepatocytes. Oncogene Res 1988, 3:255-62. URL

1987
    Jouanolle, H., Lescoat, G., Desvergne, B., Deugnier, Y., Brissot, P., Bourel, M.: [Iron overload of the liver and protein synthesis. Progress made through experimental models]. Ann Gastroenterol Hepatol (Paris) 1987, 23:269-72. URL

    Brissot, P., Farjanel, J., Bourel, D., Campion, J. P., Guillouzo, A., Rattner, A., Deugnier, Y., Desvergne, B., Ferrand, B., Simon, M., et al.,: Chronic liver iron overload in the baboon by ferric nitrilotriacetate. Morphologic and functional changes with special reference to collagen synthesis enzymes. Dig Dis Sci 1987, 32:620-7. URL
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