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    Lopez, M., Meier, D., Muller, A., Franken, P., Fujita, J., Fontana, A.: Tumor necrosis factor and transforming growth factor beta regulate clock genes by controlling the expression of the cold inducible RNA-binding protein (CIRBP). J Biol Chem 2014, 289:2736-44. URL


    Franken, P.: A role for clock genes in sleep homeostasis. Curr Opin Neurobiol 2013, 23:864-72. URL

    Vassalli, A., Dellepiane, J. M., Emmenegger, Y., Jimenez, S., Vandi, S., Plazzi, G., Franken, P., Tafti, M.: Electroencephalogram paroxysmal theta characterizes cataplexy in mice and children. Brain 2013, 136:1592-608. URL

    El Helou, J., Belanger-Nelson, E., Freyburger, M., Dorsaz, S., Curie, T., La Spada, F., Gaudreault, P. O., Beaumont, E., Pouliot, P., Lesage, F., Frank, M. G., Franken, P., Mongrain, V.: Neuroligin-1 links neuronal activity to sleep-wake regulation. Proc Natl Acad Sci U S A 2013, 110:9974-9. URL

    Saini, C., Liani, A., Curie, T., Gos, P., Kreppel, F., Emmenegger, Y., Bonacina, L., Wolf, J. P., Poget, Y. A., Franken, P., Schibler, U.: Real-time recording of circadian liver gene expression in freely moving mice reveals the phase-setting behavior of hepatocyte clocks. Genes Dev 2013, 27:1526-36. URL

    Gast, H., Muller, A., Lopez, M., Meier, D., Huber, R., Dechent, F., Prinz, M., Emmenegger, Y., Franken, P., Birchler, T., Fontana, A.: CD40 activation induces NREM sleep and modulates genes associated with sleep homeostasis. Brain Behav Immun 2013, 27:133-44. URL

    Mang, G. M., Franken, P.: Genetic Dissection of Sleep Homeostasis. Curr Top Behav Neurosci 2013, 5:2736-44. URL

    Curie, T., Mongrain, V., Dorsaz, S., Mang, G. M., Emmenegger, Y., Franken, P.: Homeostatic and circadian contribution to EEG and molecular state variables of sleep regulation. Sleep 2013, 36:311-23. URL


    Hinard, V., Mikhail, C., Pradervand, S., Curie, T., Houtkooper, R. H., Auwerx, J., Franken, P., Tafti, M.: Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures. J Neurosci 2012, 32:12506-17. URL

    Wimmer, R. D., Astori, S., Bond, C. T., Rovo, Z., Chatton, J. Y., Adelman, J. P., Franken, P., Luthi, A.: Sustaining sleep spindles through enhanced SK2-channel activity consolidates sleep and elevates arousal threshold. J Neurosci 2012, 32:13917-28. URL

    Hasan, S., Dauvilliers, Y., Mongrain, V., Franken, P., Tafti, M.: Age-related changes in sleep in inbred mice are genotype dependent. Neurobiol Aging 2012, 33:195 e13-26. URL

    Vienne, J., Lecciso, G., Constantinescu, I., Schwartz, S., Franken, P., Heinzer, R., Tafti, M.: Differential effects of sodium oxybate and baclofen on EEG, sleep, neurobehavioral performance, and memory. Sleep 2012, 35:1071-83. URL


    Astori, S., Wimmer, R. D., Prosser, H. M., Corti, C., Corsi, M., Liaudet, N., Volterra, A., Franken, P., Adelman, J. P., Luthi, A.: The CaV3.3 calcium channel is the major sleep spindle pacemaker in thalamus. Proc Natl Acad Sci U S A 2011, 108:13823-8. URL

    Mongrain, V., La Spada, F., Curie, T., Franken, P.: Sleep Loss Reduces the DNA-Binding of BMAL1, CLOCK, and NPAS2 to Specific Clock Genes in the Mouse Cerebral Cortex. PLoS One 2011, 6:e26622. URL


    Mongrain, V., Hernandez, S. A., Pradervand, S., Dorsaz, S., Curie, T., Hagiwara, G., Gip, P., Heller, H. C., Franken, P.: Separating the contribution of glucocorticoids and wakefulness to the molecular and electrophysiological correlates of sleep homeostasis. Sleep 2010, 33:1147-57. URL

    Vienne, J., Bettler, B., Franken, P., Tafti, M.: Differential effects of GABAB receptor subtypes, {gamma}-hydroxybutyric Acid, and Baclofen on EEG activity and sleep regulation. J Neurosci 2010, 30:14194-204. URL

    Schughart, K.: SYSGENET: a meeting report from a new European network for systems genetics. Mamm Genome 2010, 21:331-6. URL


    Franken, P., Kopp, C., Landolt, H. P., Luthi, A.: The functions of sleep. Eur J Neurosci 2009, 29:1739-40. URL

    Franken, P., Dijk, D. J.: Circadian clock genes and sleep homeostasis. Eur J Neurosci 2009, 29:1820-9. URL

    Tsai, J. W., Hannibal, J., Hagiwara, G., Colas, D., Ruppert, E., Ruby, N. F., Heller, H. C., Bourgin, P., Franken, P.: Melanopsin as a sleep modulator: circadian gating of the direct effects of light on sleep and altered sleep homeostasis in Opn4(-/-) mice. PLoS Biol 2009, 7:e1000125. URL

    Hasan, S., Pradervand, S., Ahnaou, A., Drinkenburg, W., Tafti, M., Franken, P.: How to keep the brain awake? The complex molecular pharmacogenetics of wake promotion. Neuropsychopharmacology 2009, 34:1625-40. URL

    Gregory, A.M., Franken, P.: Genetic approaches to the problem of sleep In Current Advances in Sleep Biology Edited by Frank, M.G:; New York: Nova Science Publishers; 2009: 41-61.

    Franken*, P., Langmesser*, S., Feil, S., Emmenegger, Y., Albrecht, U., Feil, R.: cGMP-dependent protein kinase type I is implicated in the regulation of the timing and quality of sleep and wakefulness. PLoS ONE 2009, 4:e4238. URL

    Franken, P.: Understanding sleep through genetic analysis. Front Neurosci 2009, 3:416-7.


    Cueni, L., Canepari, M., Lujan, R., Emmenegger, Y., Watanabe, M., Bond, C. T., Franken, P., Adelman, J. P., Luthi, A.: T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites. Nat Neurosci 2008, 11:683-92. URL

    Wisor, J. P., Pasumarthi, R. K., Gerashchenko, D., Thompson, C. L., Pathak, S., Sancar, A., Franken, P., Lein, E. S., Kilduff, T. S.: Sleep deprivation effects on circadian clock gene expression in the cerebral cortex parallel electroencephalographic differences among mouse strains. J Neurosci 2008, 28:7193-201. URL

    Franken, P. : Sleep homeostasis In Encyclopedia of Neuroscience Edited by Binder, M.D., Hirokawa, N., Windhorst, U.; Berlin, Heidelberg, New York: Springer; 2008: 3721-3725.

    Andretic, R., Franken, P., Tafti, M.: Genetics of sleep. Annu Rev Genet 2008, 42:361-88. URL


    Franken, P.: The quality of waking and process S. Sleep 2007, 30:126-7. URL

    O'Hara, B. F., Ding, J., Bernat, R. L., Franken, P.: Genomic and proteomic approaches towards an understanding of sleep. CNS Neurol Disord Drug Targets 2007, 6:71-81. URL

    Flores, A. E., Flores, J. E., Deshpande, H., Picazo, J. A., Xie, X. S., Franken, P., Heller, H. C., Grahn, D. A., O'Hara, B. F.: Pattern recognition of sleep in rodents using piezoelectric signals generated by gross body movements. IEEE Trans Biomed Eng 2007, 54:225-33. URL

    Maret, S., Dorsaz, S., Gurcel, L., Pradervand, S., Petit, B., Pfister, C., Hagenbuchle, O., O'Hara, B. F., Franken, P., Tafti, M.: Homer1a is a core brain molecular correlate of sleep loss. Proc Natl Acad Sci U S A 2007, 104:20090-5. URL

    Tafti, M., Franken, P.: Molecular analysis of sleep. Cold Spring Harb Symp Quant Biol 2007, 72:573-8. URL

    Franken, P., Thomason, R., Heller, H. C., O'Hara, B. F.: A non-circadian role for clock-genes in sleep homeostasis: a strain comparison. BMC Neurosci 2007, 8:87. URL


    Franken, P., Dudley, C. A., Estill, S. J., Barakat, M., Thomason, R., O'Hara, B. F., McKnight, S. L.: NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: genotype and sex interactions. Proc Natl Acad Sci U S A 2006, 103:7118-23. URL

    Franken, P., Gip, P., Hagiwara, G., Ruby, N. F., Heller, H. C.: Glycogen content in the cerebral cortex increases with sleep loss in C57BL/6J mice. Neurosci Lett 2006, 402:176-9. URL


    Maret, S., Franken, P., Dauvilliers, Y., Ghyselinck, N. B., Chambon, P., Tafti, M.: Retinoic acid signaling affects cortical synchrony during sleep. Science 2005, 310:111-3. URL

    Xie, X., Dumas, T., Tang, L., Brennan, T., Reeder, T., Thomas, W., Klein, R. D., Flores, J., O'Hara, B. F., Heller, H. C., Franken, P.: Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice. Brain Res 2005, 1052:212-21. URL

    Dijk, D.J. , Franken, P. : Interaction of sleep homeostasis and circadian rhythmicity: dependent or independent systems? In Principles and practice of sleep medecine Edited by Kryger, M.H., Roth T., Dement W.; Philadelphia, PA: Saunders/Elsevier; 2005: 418–434.


    Larkin, J. E., Yokogawa, T., Heller, H. C., Franken, P., Ruby, N. F.: Homeostatic regulation of sleep in arrhythmic Siberian hamsters. Am J Physiol Regul Integr Comp Physiol 2004, 287:R104-11. URL

    Tafti, M., Franken, P.: Genetics of delta and theta activities during sleep: Deficiency in short-chain fatty acid -oxidation affects theta oscillations during sleep. Sleep Biol Rhythms 2004, 2:34-5.

    Dauvilliers, Y., Franken, P., Tafti, M.: Genetic regulation of sleep In Sleep: Circuits and Function Edited by Luppi CRC Press; 2004: 123-44.


    Franken, P., Tafti, M.: Genetics of sleep and sleep disorders. Front Biosci 2003, 8:e381-97. URL

    Dudley, C. A., Erbel-Sieler, C., Estill, S. J., Reick, M., Franken, P., Pitts, S., McKnight, S. L.: Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Science 2003, 301:379-83. URL

    Tafti, M., Petit, B., Chollet, D., Neidhart, E., de Bilbao, F., Kiss, J. Z., Wood, P. A., Franken, P.: Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep. Nat Genet 2003, 34:320-5. URL

    Shaw, P. J., Franken, P.: Perchance to dream: solving the mystery of sleep through genetic analysis. J Neurobiol 2003, 54:179-202. URL

    Franken, P., Gip, P., Hagiwara, G., Ruby, N. F., Heller, H. C.: Changes in brain glycogen after sleep deprivation vary with genotype. Am J Physiol Regul Integr Comp Physiol 2003, 285:R413-9. URL


    Tafti, M., Franken, P.: Invited review: genetic dissection of sleep. J Appl Physiol 2002, 92:1339-47. URL

    Franken, P.: Long-term vs. short-term processes regulating REM sleep. J Sleep Res 2002, 11:17-28. URL

    Wisor, J. P., O'Hara, B. F., Terao, A., Selby, C. P., Kilduff, T. S., Sancar, A., Edgar, D. M., Franken, P.: A role for cryptochromes in sleep regulation. BMC Neurosci 2002, 3:20. URL

    Ruby, N. F., Brennan, T. J., Xie, X., Cao, V., Franken, P., Heller, H. C., O'Hara, B. F.: Role of melanopsin in circadian responses to light. Science 2002, 298:2211-3. URL

    Larkin, J. E., Franken, P., Heller, H. C.: Loss of circadian organization of sleep and wakefulness during hibernation. Am J Physiol Regul Integr Comp Physiol 2002, 282:R1086-95.

    Franken, P.: Debating how REM sleep is regulated (and by what). Journal of Sleep Research 2002, 11:31-33. URL


    Chollet, D., Franken, P., Raffin, Y., Henrotte, J. G., Widmer, J., Malafosse, A., Tafti, M.: Magnesium involvement in sleep: genetic and nutritional models. Behav Genet 2001, 31:413-25. URL

    Franken, P., Chollet, D., Tafti, M.: The homeostatic regulation of sleep need is under genetic control. J Neurosci 2001, 21:2610-21. URL


    Franken, P., Lopez-Molina, L., Marcacci, L., Schibler, U., Tafti, M.: The transcription factor DBP affects circadian sleep consolidation and rhythmic EEG activity. J Neurosci 2000, 20:617-25. URL

    Chollet, D., Franken, P., Raffin, Y., Malafosse, A., Widmer, J., Tafti, M.: Blood and brain magnesium in inbred mice and their correlation with sleep quality. Am J Physiol Regul Integr Comp Physiol 2000, 279:R2173-8. URL


    Franken, P., Malafosse, A., Tafti, M.: Genetic determinants of sleep regulation in inbred mice. Sleep 1999, 22:155-69. URL

    Tafti, M., Chollet, D., Valatx, J. L., Franken, P.: Quantitative trait loci approach to the genetics of sleep in recombinant inbred mice. J Sleep Res 1999, 8 Suppl 1:37-43. URL

    Franken, P., Cao, V., Heller, H. C., Miller, J. D.: The glutamate induced phase shift in the SCN slice: a two pulse study. Brain Res 1999, 818:34-40. URL


    Franken, P., Malafosse, A., Tafti, M.: Genetic variation in EEG activity during sleep in inbred mice. Am J Physiol 1998, 275:R1127-37. URL


    Tafti, M., Franken, P., Kitahama, K., Malafosse, A., Jouvet, M., Valatx, J. L.: Localization of candidate genomic regions influencing paradoxical sleep in mice. Neuroreport 1997, 8:3755-8. URL


    Ruby, N. F., Saran, A., Kang, T., Franken, P., Heller, H. C.: Siberian hamsters free run or become arrhythmic after a phase delay of the photocycle. Am J Physiol 1996, 271:R881-90. URL


    Franken, P., Tobler, I., Borbely, A. A.: Varying photoperiod in the laboratory rat: profound effect on 24-h sleep pattern but no effect on sleep homeostasis. Am J Physiol 1995, 269:R691-701.

    Gao, B. O., Franken, P., Tobler, I., Borbely, A. A.: Effect of elevated ambient temperature on sleep, EEG spectra, and brain temperature in the rat. Am J Physiol 1995, 268:R1365-73.


    Franken, P., Dijk, D. J., Tobler, I., Borbely, A. A.: High-frequency components of the rat electrocorticogram are modulated by the vigilance states. Neurosci Lett 1994, 167:89-92. URL

    Deboer, T., Franken, P., Tobler, I.: Sleep and cortical temperature in the Djungarian hamster under baseline conditions and after sleep deprivation. J Comp Physiol [A] 1994, 174:145-55. URL

    Tobler, I., Franken, P., Gao, B., Jaggi, K., Borbély, A. A.: Sleep deprivation in the rat at different ambient temperatures: effect on sleep, EEG spectra and brain temperature. Archives Italiennes de Biologie 1994, 132:39-52.

    Tobler, I., Franken, P., Alföldi, P., Borbély, A. A.: Room light impairs sleep in the albino rat. Behavioural Brain Research 1994, 63:205-11.


    Tobler, I., Franken, P., Jaggi, K.: Vigilance states, EEG spectra, and cortical temperature in the guinea pig. American Journal of Physiology 1993, 264:R1125-32. URL

    Tobler, I., Franken, P.: Sleep homeostasis in the guinea pig: similar response to sleep deprivation in the light and dark period. Neuroscience Letters 1993, 164:105-8. URL

    Franken, P., Tobler, I., Borbély, A. A.: Effects of 12-h sleep deprivation and of 12-h cold exposure on sleep regulation and cortical temperature in the rat. Physiology and Behavior 1993, 54:885-94.


    Franken, P., Tobler, I., Borbely, A. A.: Sleep and waking have a major effect on the 24-hr rhythm of cortical temperature in the rat. J Biol Rhythms 1992, 7:341-52.

    Tobler, I. I., Franken, P., Trachsel, L., Borbely, A. A.: Models of sleep regulation in mammals. J Sleep Res 1992, 1:125-127.

    Franken, P., Tobler, I., Borbély, A. A.: Cortical temperature and EEG slow-wave activity in the rat: analysis of vigilance state related changes. Pflugers Archiv. European Journal of Physiology 1992, 420:500-7.


    Alfoldi, P., Franken, P., Tobler, I., Borbely, A. A.: Short light-dark cycles influence sleep stages and EEG power spectra in the rat. Behav Brain Res 1991, 43:125-31. URL

    Franken, P., Dijk, D. J., Tobler, I., Borbely, A. A.: Sleep deprivation in rats: effects on EEG power spectra, vigilance states, and cortical temperature. Am J Physiol 1991, 261:R198-208. URL

    Franken, P., Tobler, I., Borbély, A. A.: Sleep homeostasis in the rat: simulation of the time course of EEG slow-wave activity [published erratum appears in Neurosci Lett 1991 Nov 11;132(2):279]. Neuroscience Letters 1991, 130:141-4.


    Tobler, I., Franken, P., Scherschlicht, R.: Sleep and EEG spectra in the rabbit under baseline conditions and following sleep deprivation. Physiology and Behavior 1990, 48:121-9.
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