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Fisun Hamaratoglu, Professor SNF

Fisun Hamaratoglu received her PhD in 2007 from the Baylor College of Medicine for her work in the group of Georg Halder at the MD Anderson Cancer Center in Houston, USA. Her thesis work identified several upstream regulators, including the first receptor, of the Hippo tumor suppressor pathway. In 2008, she joined Markus Affolter’s laboratory at the Biozentrum, University of Basel, for her post-doctoral training, funded by HFSP, Marie Curie and Roche postdoctoral fellowships. In Basel, as part of the WingX.ch initiative, she established the fly wing as a model system to study scaling quantitatively and at a molecular level.

She joined the CIG in October 2013 as a Maître Assistant suppléant and is a Swiss National Science Foundation Professor since April 2014.

Keywords: scaling, growth control, morphogen, Hippo signaling, genetics, development, Drosophila.

Research summary

What are the molecules that give animals their final size and shape? Over the years, developmental biologists have identified many molecules with key roles in pattern formation and size control. Several signaling pathways have emerged from this work including the Hippo and the Bone Morphogenetic Protein (BMP) pathways. Developing organs of all multi-cellular organisms, from flies to humans, grow and obtain their pattern simultaneously. How this coordination of growth and patterning is achieved is a long-standing question. Work in the Hamaratoglu Lab, using Drosophila genetics and quantitative approaches, aims to understand how the activities of the Hippo and BMP pathways are coordinated during development.

Representative publications

Hippo Reprograms the Transcriptional Response to Ras Signaling.
Pascual J*, Jacobs J*, Sansores-Garcia L, Natarajan M, Zeitlinger J, Aerts S§, Halder G§Hamaratoglu F§
Developmental Cell, 2017
*Equal contribution §Corresponding authors

 
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Ras Brakes for Hippo
Sumabat TM and Hariharan IK
Developmental Cell, 2017 
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Dpp/BMP signaling in flies: from molecules to biology.
Hamaratoglu F§, Affolter M, Pyrowolakis G.
Seminars in Cell and Developmental Biology. 2014 
§Corresponding author

Dpp signaling activity requires Pentagone to scale with tissue size in the growing Drosophila wing imaginal disc.
Hamaratoglu F, Morton de Lachapelle A*, Pyrowolakis G, Bergmann S§, Affolter M§. 
PLoS Biology, 2011 
*Equal contribution §Corresponding authors

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The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth.
Hamaratoglu F, Gajewski K, Sansores-Garcia L, Morrison C, Tao C, Halder G. 
Journal of Cell Science, 2009 

The tumour suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis.
Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H & Halder G. 
Nature Cell Biology, 2006 

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Publications

 
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olga-resize200x147.png Olga Klipa

Olga obtained her Master’s degree in Cytology, Histology and Developmental Biology at National University of Kyiv (Ukraine) in 2012. Then, she continued her research at the Institute of Molecular Biology and Genetics NAS of Ukraine where she worked on a project concerning PI3K/mTOR/S6K signaling pathway for two years. She joined the Hamaratoglu Lab as a PhD student in September 2014.

 

simone-resize200x237.jpg Simone Mumbauer

Simone obtained her Master’s Degree in Molecular Biosciences from Ruprecht-Karls-Universität in Heidelberg, Germany in 2013. In her Master’s thesis she investigated the role of endocytic mechanisms regulating apical plasma membrane morphogenesis in the laboratory of Stefano De Renzis at the EMBL. While working in several fly labs, including the lab of Anne Ephrussi and Ingrid Lohmann, she lost her heart to Developmental Biology and fell in love with Drosophila. Therefore the Hamaratoglu Lab is the perfect place for her to study the dynamic aspects of Hippo signaling in Drosophila. Simone joined the lab in July 2014 as a PhD student.

 

Justine.jpeg Justine Pascual

Justine Pascual obtained her Master’s Degree at the IUP Bioengineering at Paul Sabatier University in Toulouse in 2010 after her training at Novartis (Basel). She worked in Oncology Department at Actelion (Basel) and two years at the EPFL before joining the lab and the fly world in April 2014.

 

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Contact

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Fisun Hamaratoglu

fisun.hamaratoglu@unil.ch

Tel: +41 21 692 4120

 

Administrative assistant

Stéphanie Scuderi
stephanie.scuderi@unil.ch
Tel: +41 21 692 3980

CH-1015 Lausanne  - Switzerland  -  Tel. +41 21 692 22 00  -  Fax +41 21 692 22 11
Swiss University