Lluis Fajas Coll, Professor

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Metabolic reprogramming is a hallmark of normal physiological homeostasis, but also of pathological conditions such as cancer. Metabolic pathways are temporary orchestrated to satisfy the shifting demands of growth, proliferation, and differentiation. Growing evidences exist about the regulatory crosstalk between metabolic pathways, cell cycle progression and cell division: our laboratory, among others, has shown that cancer-cell metabolism is reprogrammed through the regulation of metabolic enzymes by various cell cycle regulators. Moreover, we have demonstrated that some of these cell cycle regulators, like the pRB-cdk4-E2F1 pathway, control metabolism of adult non-proliferative cells, and that their activity is altered especially under pathological conditions contributing to obesity and diabetes.

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INTERVIEW

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Prof. Lluis Fajas Coll

Group leader

 

Administrative assistant

Carine Dovat
carine.dovat@unil.ch
Tel: +41 21 692 4110

Génopode - CH-1015 Lausanne
Switzerland
Tel. +41 21 692 22 00
Fax +41 21 692 22 11