Fisun Hamaratoglu, Professor SNF

Fisun Hamaratoglu received her PhD in 2007 from the Baylor College of Medicine for her work in the group of Georg Halder at the MD Anderson Cancer Center in Houston, USA. Her thesis work identified several upstream regulators, including the first receptor, of the Hippo tumor suppressor pathway. In 2008, she joined Markus Affolter’s laboratory at the Biozentrum, University of Basel, for her post-doctoral training, funded by HFSP, Marie Curie and Roche postdoctoral fellowships. In Basel, as part of the WingX.ch initiative, she established the fly wing as a model system to study scaling quantitatively and at a molecular level.

She joined the CIG in October 2013 as a Maître Assistant suppléant and is a Swiss National Science Foundation Professor since April 2014.

Keywords: scaling, growth control, morphogen, Hippo signaling, genetics, development, Drosophila.

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INTERVIEWRESEARCH REPORT 2015-2016

Research summary

What are the molecules that give animals their final size and shape? Over the years, developmental biologists have identified many molecules with key roles in pattern formation and size control. Several signaling pathways have emerged from this work including the Hippo and the Bone Morphogenetic Protein (BMP) pathways. Developing organs of all multi-cellular organisms, from flies to humans, grow and obtain their pattern simultaneously. How this coordination of growth and patterning is achieved is a long-standing question. Work in the Hamaratoglu Lab, using Drosophila genetics and quantitative approaches, aims to understand how the activities of the Hippo and BMP pathways are coordinated during development.

Representative publications

Hippo Reprograms the Transcriptional Response to Ras Signaling.
Pascual J*, Jacobs J*, Sansores-Garcia L, Natarajan M, Zeitlinger J, Aerts S§, Halder G§Hamaratoglu F§
Developmental Cell, 2017
*Equal contribution §Corresponding authors

 
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Ras Brakes for Hippo
Sumabat TM and Hariharan IK
Developmental Cell, 2017 
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Dpp/BMP signaling in flies: from molecules to biology.
Hamaratoglu F§, Affolter M, Pyrowolakis G.
Seminars in Cell and Developmental Biology. 2014 
§Corresponding author

Dpp signaling activity requires Pentagone to scale with tissue size in the growing Drosophila wing imaginal disc.
Hamaratoglu F, Morton de Lachapelle A*, Pyrowolakis G, Bergmann S§, Affolter M§. 
PLoS Biology, 2011 
*Equal contribution §Corresponding authors

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The Hippo tumor-suppressor pathway regulates apical-domain size in parallel to tissue growth.
Hamaratoglu F, Gajewski K, Sansores-Garcia L, Morrison C, Tao C, Halder G. 
Journal of Cell Science, 2009 

The tumour suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis.
Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H & Halder G. 
Nature Cell Biology, 2006 

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Contact

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Fisun Hamaratoglu

fisun.hamaratoglu@unil.ch

Tel: +41 21 692 4120

 

Administrative assistant

Stéphanie Scuderi
stephanie.scuderi@unil.ch
Tel: +41 21 692 3980

Génopode - CH-1015 Lausanne
Switzerland
Tel. +41 21 692 22 00
Fax +41 21 692 22 11