Obesity and adipose tissue dysfunction are associated with the accumulation of lipids in non-adipose tissues. The so-called ectopic fat deposition in liver (hepatic steatosis) and muscle (intramyocellular lipids) often associates with insulin resistance.
Lipids are extracted by the Folch method. Parameters that can be measured include :
- Triglycerides, Total cholesterol, Free fatty acids.
- Optional: Cholesterol esters (with an additional purification step).
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See also: Body lipid content.
Minehira, K., Young, SG., Villanueva, CJ., Yetukuri, L., Oresic, M., Hellerstein, MK., Farese, RV. Jr, Horton, JD., Preitner, F., Thorens, B., and Tappy, L. Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res. 49(9):2038-44, 2008