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Christian Fankhauser, Professor

Christian Fankhauser received his PhD from the University of Lausanne in 1994 after carrying out his thesis at Swiss Institute for Experimental Cancer Research (ISREC) in the laboratory of Dr. Viesturs Simanis. He performed postdoctoral studies with Dr. Marty Yanofsky at UCSD then with Dr. Joanne Chory at The Salk Institute for Biological Studies in San Diego. He became a Swiss National Science Foundation Assistant Professor at the Department of Molecular Biology of the University of Geneva in 2000. He joined the Center for Integrative Genomics in January 2005, where he was appointed Associate Professor. In 2011 he was promoted to Professor.

Photoreceptors, phytochrome, light-regulated development, circadian clock, Arabidopsis thaliana

Research summary

Both genetic and environmental factors influence growth and development of any living organism. Plant development is very plastic and is constantly modulated by environmental fluctuations. Being photoautotrophic plants are particularly sensitive to their light environment. Light affects every major transition of the life cycle of a plant. To optimize growth according to ambient light conditions plants evolved several classes of photoreceptors including the UV-A/blue light sensing cryptochromes and phototropins and the phytochromes maximally absorbing red/far-red light. Genetic and photobiological studies suggest that the coordinated action of all these light receptors allows plants to fine-tune their development. We use molecular genetics in the model plant Arabidopsis thaliana to decipher the signaling events occurring upon photon capture.

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Christian Fankhhauser © Unil

Representative publications

M. Hersch, S. Lorrain, M. de Wit, M. Trevisan, K. Ljung, S. Bergmann, and C. Fankhauser: Light intensity modulates the regulatory network of the shade avoidance response in Arabidopsis. Proc Natl Acad Sci U S A, 2014. 111 (17): 6515-6520.URL

T. Preuten, T. Hohm, S. Bergmann, C. Fankhauser: Defining the site of light perception and initiation of phototropism in Arabidopsis. Curr Biol, 2013. 23:1934-8. URL

E. Demarsy, I. Schepens, K. Okajima, M. Hersch, S. Bergmann, J. Christie, K. Shimazaki, S. Tokutomi, and C. Fankhauser: Phytochrome Kinase Substrate 4 is phosphorylated by the phototropin 1 photoreceptor. EMBO J, 2012. 31(16): 3457-67. URL

C. Kami, M. Hersch, M. Trevisan, T. Genoud, A. Hiltbrunner, S. Bergmann, and C. Fankhauser: Nuclear phytochrome a signaling promotes phototropism in Arabidopsis. Plant Cell, 2012. 24 (2): 566-76. URL

P. Hornitschek, S. Lorrain, V. Zoete, O. Michielin, and C. Fankhauser: Inhibition of the shade avoidance response by formation of non-DNA binding bHLH heterodimers. EMBO J, 2009. 28 (24): 3893-902. URL

 

The effects of light on plant growth and development.

Almost all our food, feed, fuel and fiber ultimately derives from plants. Understanding the genetic and environmental factors modulating plant growth is thus of great importance. Plants growth ultimately depends on photosynthesis, the process during which light energy is harnessed for the synthesis of high energy reduced carbon compounds. In order to capture light, plants have evolved unique ways of building cells, tissues and organs, a highly diverse metabolism, and a life-long continuation of versatile growth and development. Given the central importance of light for growth, plants posses numerous photoreceptors enabling them to sense changes in the amount, quality (color), photoperiod and direction of light (Figure 1). Our main goal is to understand how light modulates plant growth and development in order to enable these sessile organisms to optimize their growth habit depending on the environmental conditions.

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Figure 1: The effect of light on plant growth and development. All higher plants possess several classes of photoreceptors. Phytochromes (phyA-phyE) sense red and far-red light. Three distinct photoreceptor families: phototropins (phot1 & phot2), cryptochromes (cry1 & cry2) and the Zeitlupes (ZTL, FKF1 & LKP2) sense UVA/blue light. UVB-receptors are currently unknown. These photoreceptors allow plants to sense the intensity, quality, periodicity (day-length) and direction of light. These photoreceptors control important developmental transitions (e.g. the induction of flowering). Cryptochrome and phytochromes also determine whether a seedling will adopt an etiolated development (after germination in the dark) or a photomorphogenic development when the seedling develops in the light. The etiolated mode of development allows the seedling to rapidly emerge from the soil into the light. Shade avoidance and phototropism are two important adaptive responses, which allow seedlings to optimize photosynthetic light capture. The list of Arabidopsis photoreceptors is presented on this Figure.
Christian Fankhauser © Unil

Molecular genetic studies in Arabidopsis have identified four photoreceptor families that are present in all higher plants. There are three classes of blue light sensors: cryptochromes, phototropins and members of the Zeitlupe family. In addition the phytochromes enable plants to sense red and far-red light (Figure 1). In Arabidopsis these families are composed of two cryptochromes (cry1 and cry2), two phototropins (phot1 and phot2), three Zeitlupe-like sensors (ZTL, FKF1 and LKP2) and five phytochromes (phyA-phyE). Given that we mostly study phytochrome and phototropin-mediated signal transduction those two photoreceptors are presented in more detail.

The phytochromes

Phytochromes are synthesized as Pr (red-light absorbing); upon light excitation (red light is most effective) they are photo-transformed into Pfr (FR light absorbing), which is the active conformer. Light activation of the phytochromes triggers their accumulation in the nucleus where they mediate large changes in light-regulated gene expression (Figure 2). FR light leads to the rapid conversion of Pfr back to Pr, upon prolonged dark-treatment Pfr will spontaneously convert back to the inactive Pr conformer.

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Figure 2: Light controls the subcellular localization of the phytochromes.
(A) Schematic representation of the light-regulated accumulation of phytochrome. Phytochromes are synthesized in their red (R)-light absorbing form (Pr). Upon light absorption the Pr conformer is converted into its far-red (FR)-light absorbing form (Pfr) which rapidly accumulates in the nucleus where it rapidly modulates gene expression.
(B) Etiolated seedlings expressing a PHYA-GFP transgene shortly treated with light were analyzed by fluorescence microscopy. Note that phyA-GFP fluorescence is mostly confined to nuclei (one nucleus indicated with a white arrow) where it is found in nuclear bodies (nuclear substructures of unknown function).
Christian Fankhauser © Unil

Light-regulated gene expression is partly mediated by the conformation-specific interaction between phytochromes in their Pfr conformation and a family of bHLH class transcription factors known as PIFs (Phytochrome Interacting Factor). Photon capture by these photoreceptors induces a suite of developmental responses including seed germination, seedling de-etiolation, regulation of tropic growth, shade avoidance and the control of flowering time (Figures 1 and 3). Some light responses are specifically induced by a single phytochrome (for example only phyA can trigger the de-etiolation response under a dense canopy, Figure 4), but there are many examples where integration of signals emanating from multiple photoreceptors is required (e.g. multiple phytochromes regulate gene expression in response to red light).

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Figure 3: shade avoidance response in Arabidopsis.
Rosettes of Arabidopsis plants grown either in sun-mimicking or shade-mimicking light conditions. Note the elongated petioles and the pale green colour of the plant grown in the shade. The spectrum of sunlight (red) and of light under a dense canopy (green) is indicated below. Plants are particularly sensitive to the R/FR ratio, which is slightly above 1 in the sun and can drop as low as 0.1 under dense vegetational cover. The R/FR ratio has a direct impact of the phytochrome photo-equilibrium (Pfr/Ptot).
Christian Fankhauser © Unil

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Figure 4: The phytochrome A loss-of-function mutant (phyA) is blind to far-red light (FR).
A wild type (WT) and a phyA mutant grown in monochromatic far-red light. Note that the phyA mutants look like the wild type grown in the dark (D) as shown on the left of the image for comparison. Monochromatic FR light mimics the light condition encountered under deep vegetational cover.
Chrisitan Fankhauser © Unil

The phototropins

The phototropins control phototropism (Figure 5), leaf positioning, chloroplast movements and opening of stomata. This class of photoreceptors thus largely contribute to the optimization of photosynthesis. The phototropins are blue-light activated protein kinases composed of two light-sensing LOV domains and a carboxy-terminal protein kinase domain. Blue light liberates the kinase domain from the inhibitory action of the amino-terminus of the protein containing the photosensory LOV domains. While the initial molecular events triggered by blue light at the level of the photoreceptor are quite well understood, the subsequent steps in signal transduction are still poorly understood (e.g. what are the substrates of the light-activated phtotropins?). A limited number of phototropin signal transduction elements have currently been identified. Our laboratory has studied members of the PKS (Phytochrome Kinase Substrate) family which have been shown to interact with phot1 and are essential for normal phototropism.

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Figure 5: phototropism in an Arabidopsis seedling.
An Arabidopsis seedling is photographed at hourly intervals following irradiation with unilateral blue light (light direction is indicated with an arrow). Note that within 2 hours of unilateral blue light asymmetric growth in the hypocotyl elongation zone leads to phototropism.
Christian Fankhauser © Unil

Main research areas

We perform our research with the model plant Arabidopsis thaliana. We combine molecular genetics, genome-wide expression studies, cell biology, biochemistry and imaging of growth processes in Arabidopsis to address the following specific aims:

  1. Identify the molecular determinants leading to the specificity of phyA. Unlike other phytochromes, phyA can mediate light responses under conditions where the vast majority of the phytochrome is in its inactive Pr state (Figure 4). This correlates with the unique ability of phyA to accumulate in the nucleus in far-red light (mimicking light under a dense canopy).
  2. Determine the mechanisms by which the phytochromes control PIF-mediated growth responses. We mostly concentrate our attention on the role of PIF4 and PIF5 in the regulation of growth during the shade avoidance response (Figure 6). We study the mechanisms by which the phytochromes regulate PIF activity and search for PIF target genes.

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Figure 6: A model for the regulation of shade avoidance by the phytochromes and PIF (Phytochrome Interacting Factor) bHLH-class transcription factors.
Phytochromes are synthesized in their Pr conformation (PrB for phytochrome B in its Pr conformation). Upon light activation they are converted to their active Pfr conformation (PfrB for phytochrome B in its Pfr conformation), which accumulates in the nucleus. In sunlight characterized by a high R/FR ratio (see figure 3) the phytochromes are mostly in their Pfr conformation. Pfr specifically interacts with PIF transcription factors leading to their proteolytic degradation. In the shade, which leads to a reduction of the R/FR ratio, the phytochrome photo-equilibrium is pushed towards the Pr conformer. PrB no longer interacts with PIF transcription factors leading to their accumulation and transcription of shade marker genes.
Christian Fankhauser © Unil

  1. Uncover the mode of action of PKS (Phytochrome Kinase Substrate) proteins in the control hypocotyl growth orientation and other phototropin-mediated responses (e.g. leaf flattening and positioning). Proper positioning of the stem and leaves is of central importance for the plant in order to optimize photosynthetic light capture. PKS proteins are involved both in phytochrome and phototropin signalling and may thus allow us to understand how these two photoreceptors co-ordinately control this growth response. Phototropism requires asymmetric growth of the shaded and lit sides of the hypocotyl. An important goal is to understand how this light response ultimately leads to asymmetric distribution of the plant hormone auxin, which is required for directional growth. Interestingly PKS4 is specifically expressed in the hypocotyl elongation zone, which undergoes asymmetric elongation during tropic growth (Figure 7).

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Figure 7: PKS4 is specifically expressed in the hypocotyl elongation zone.
GUS staining of 4-day-old etiolated PKS4pro:GUS lines. This expression pattern is particularly interesting given that these are the cells undergoing asymmetric elongation during tropic growth responses. Note that pks4 mutants have phototropic defects.
Christian Fankhauser © Unil


In press |  2016 |  2015 |  2014 |  2013 |  2012 |  2011 |  2010 |  2009 |  2008 |  2007 |  2006 |  2005 |  2004 |  2003 |  2002 |  2001 |  2000 |  1999 |  1998 |  1997 |  1996 |  1995 |  1994 |  1993 |  1992 |  1991 |  Thèses (doctorat) | 
 

In Press
de Wit M., Costa Galvão V., Fankhauser C., In Press. Light-Mediated Hormonal Regulation of Plant Growth and Development. Annual Review of Plant Biology . [DOI] [Pubmed]
2016
Fankhauser C., Batschauer A., 2016. Shadow on the Plant: A Strategy to Exit. Cell 164(1-2) pp. 15-17. [DOI] [Pubmed]
Fankhauser C., Batschauer A., 2016. Shadow on the Plant: A Strategy to Exit. Cell 164(1-2) pp. 15-17. [DOI] [Web of Science] [Pubmed]
2015
Fankhauser C., Christie J.M., 2015. Plant Phototropic Growth. Current Biology 25(9) pp. R384-R389. [DOI] [Web of Science] [Pubmed]
Galvão V.C., Fankhauser C., 2015. Sensing the light environment in plants: photoreceptors and early signaling steps. Current Opinion in Neurobiology 34 pp. 46-53. [DOI] [Web of Science] [Pubmed]
Preuten T., Blackwood L., Christie J.M., Fankhauser C., 2015. Lipid anchoring of Arabidopsis phototropin 1 to assess the functional significance of receptor internalization: should I stay or should I go? New Phytologist 206(3) pp. 1038-1050. [DOI] [Web of Science] [Pubmed]
2014
de Wit M., Lorrain S., Fankhauser C., 2014. Auxin-mediated plant architectural changes in response to shade and high temperature. Physiologia Plantarum 151(1) pp. 13-24. [DOI] [Web of Science] [Pubmed]
Dornbusch T., Michaud O., Xenarios I., Fankhauser C., 2014. Differentially phased leaf growth and movements in Arabidopsis depend on coordinated circadian and light regulation. Plant Cell 26(10) pp. 3911-3921. [DOI] [Web of Science] [Pubmed]
Hersch M., Lorrain S., de Wit M., Trevisan M., Ljung K., Bergmann S., Fankhauser C., 2014. Light intensity modulates the regulatory network of the shade avoidance response in Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America 111(17) pp. 6515-6520. [DOI] [Web of Science] [Pubmed]
Hohm T., Demarsy E., Quan C., Allenbach Petrolati L., Preuten T., Vernoux T., Bergmann S., Fankhauser C., 2014. Plasma membrane H+-ATPase regulation is required for auxin gradient formation preceding phototropic growth. Molecular Systems Biology 10(9) p. 751. [Web of Science] [Pubmed]
Kami C., Allenbach L., Zourelidou M., Ljung K., Schütz F., Isono E., Watahiki M.K., Yamamoto K.T., Schwechheimer C., Fankhauser C., 2014. Reduced phototropism in pks mutants may be due to altered auxin-regulated gene expression or reduced lateral auxin transport. Plant Journal 77(3) pp. 393-403. [DOI] [Web of Science] [Pubmed]
2013
Debrieux D., Trevisan M., Fankhauser C., 2013. Conditional Involvement of CONSTITUTIVE PHOTOMORPHOGENIC1 in the Degradation of Phytochrome A. Plant Physiology 161(4) pp. 2136-2145. [DOI] [Web of Science] [Pubmed]
Goyal A., Szarzynska B., Fankhauser C., 2013. Phototropism: at the crossroads of light-signaling pathways. Trends in Plant Science 18(7) pp. 393-401. [DOI] [Web of Science] [Pubmed]
Hohm T., Preuten T., Fankhauser C., 2013. Phototropism: Translating light into directional growth. American Journal of Botany 100(1) pp. 47-59. [DOI] [Web of Science] [Pubmed]
Medzihradszky M., Bindics J., Adám E., Viczián A., Klement E., Lorrain S., Gyula P., Mérai Z., Fankhauser C., Medzihradszky K.F. et al., 2013. Phosphorylation of Phytochrome B Inhibits Light-Induced Signaling via Accelerated Dark Reversion in Arabidopsis. Plant Cell 25(2) pp. 535-544. [DOI] [Web of Science] [Pubmed]
Preuten T., Hohm T., Bergmann S., Fankhauser C., 2013. Defining the site of light perception and initiation of phototropism in Arabidopsis. Current Biology 23(19) pp. 1934-1938. [DOI] [Web of Science] [Pubmed]
Willige B.C., Ahlers S., Zourelidou M., Barbosa I.C., Demarsy E., Trevisan M., Davis P.A., Roelfsema M.R., Hangarter R., Fankhauser C. et al., 2013. D6PK AGCVIII Kinases Are Required for Auxin Transport and Phototropic Hypocotyl Bending in Arabidopsis. Plant Cell 25(5) pp. 1674-1688. [DOI] [Web of Science] [Pubmed]
Yamashino T., Nomoto Y., Lorrain S., Miyachi M., Ito S., Nakamichi N., Fankhauser C., Mizuno T., 2013. Verification at the protein level of the PIF4-mediated external coincidence model for the temperature-adaptive photoperiodic control of plant growth in Arabidopsis thaliana. Plant Signaling and Behavior 8(3) pp. e23390. [Document] [DOI] [Pubmed]
2012
Demarsy E., Schepens I., Okajima K., Hersch M., Bergmann S., Christie J., Shimazaki K., Tokutomi S., Fankhauser C., 2012. Phytochrome Kinase Substrate 4 is phosphorylated by the phototropin 1 photoreceptor. EMBO Journal 31(16) pp. 3457-3467. [DOI] [Web of Science] [Pubmed]
Dornbusch T., Lorrain S., Kuznetsov D., Fortier A., Liechti R., Xenarios I., Fankhauser C., 2012. Measuring the diurnal pattern of leaf hyponasty and growth in Arabidopsis - a novel phenotyping approach using laser scanning. Functional Plant Biology 39(10-11) pp. 860-869. [DOI] [Web of Science]
Hornitschek P., Kohnen M.V., Lorrain S., Rougemont J., Ljung K., López-Vidriero I., Franco-Zorrilla J.M., Solano R., Trevisan M., Pradervand S. et al., 2012. Phytochrome interacting factors 4 and 5 control seedling growth in changing light conditions by directly controlling auxin signaling. Plant Journal 71(5) pp. 699-711. [DOI] [Web of Science] [Pubmed]
Kami C., Hersch M., Trevisan M., Genoud T., Hiltbrunner A., Bergmann S., Fankhauser C., 2012. Nuclear phytochrome a signaling promotes phototropism in Arabidopsis. Plant Cell 24(2) pp. 566-576. [DOI] [Web of Science] [Pubmed]
Lee K.P., Piskurewicz U., Turečková V., Carat S., Chappuis R., Strnad M., Fankhauser C., Lopez-Molina L., 2012. Spatially and genetically distinct control of seed germination by phytochromes A and B. Genes and Development 26(17) pp. 1984-1996. [DOI] [Web of Science] [Pubmed]
Lorrain S., Fankhauser C., 2012. Plant development: should I stop or should I grow? Current Biology 22(16) pp. R645-R647. [DOI] [Web of Science] [Pubmed]
Radotić K., Roduit C., Simonović J., Hornitschek P., Fankhauser C., Mutavd?ić D., Steinbach G., Dietler G., Kasas S., 2012. Atomic Force Microscopy Stiffness Tomography on Living Arabidopsis thaliana Cells Reveals the Mechanical Properties of Surface and Deep Cell-Wall Layers during Growth. Biophysical Journal 103(3) pp. 386-394. [DOI] [Web of Science] [Pubmed]
2011
Ding Z., Galván-Ampudia C.S., Demarsy E., Łangowski Ł., Kleine-Vehn J., Fan Y., Morita M.T., Tasaka M., Fankhauser C., Offringa R. et al., 2011. Light-mediated polarization of the PIN3 auxin transporter for the phototropic response in Arabidopsis. Nature Cell Biology 13(4) pp. 447-452. [DOI] [Web of Science] [Pubmed]
Fankhauser C., Ulm R., 2011. Light-regulated interactions with SPA proteins underlie cryptochrome-mediated gene expression. Genes and Development 25(10) pp. 1004-1009. [DOI] [Web of Science] [Pubmed]
Foreman J., Johansson H., Hornitschek P., Josse E.M., Fankhauser C., Halliday K.J., 2011. Light receptor action is critical for maintaining plant biomass at warm ambient temperatures. Plant Journal 65(3) pp. 441-452. [DOI] [Web of Science] [Pubmed]
Gallego-Bartolomé J., Kami C., Fankhauser C., Alabadí D., Blázquez M.A., 2011. A hormonal regulatory module that provides flexibility to tropic responses. Plant Physiology 156(4) pp. 1819-1825. [DOI] [Web of Science] [Pubmed]
2010
de Carbonnel M., Davis P., Roelfsema M.R., Inoue S., Schepens I., Lariguet P., Geisler M., Shimazaki K., Hangarter R., Fankhauser C., 2010. The Arabidopsis PHYTOCHROME KINASE SUBSTRATE2 protein is a phototropin signaling element that regulates leaf flattening and leaf positioning. Plant Physiology 152(3) pp. 1391-1405. [DOI] [Web of Science] [Pubmed]
Debrieux D., Fankhauser C., 2010. Light-induced degradation of phyA is promoted by transfer of the photoreceptor into the nucleus. Plant Molecular Biology 73(6) pp. 687-695. [DOI] [Web of Science] [Pubmed]
Kami C., Lorrain S., Hornitschek P., Fankhauser C., 2010. Light-regulated plant growth and development. Current Topics in Developmental Biology 91 pp. 29-66. [DOI] [Web of Science] [Pubmed]
2009
Demarsy E., Fankhauser C., 2009. Higher plants use LOV to perceive blue light. Current Opinion in Plant Biology 12(1) pp. 69-74. [DOI] [Web of Science] [Pubmed]
Hornitschek P., Lorrain S., Zoete V., Michielin O., Fankhauser C., 2009. Inhibition of the shade avoidance response by formation of non-DNA binding bHLH heterodimers. EMBO journal 28(24) pp. 3893-3902. [DOI] [Web of Science] [Pubmed]
Lorrain S., Trevisan M., Pradervand S., Fankhauser C., 2009. Phytochrome interacting factors 4 and 5 redundantly limit seedling de-etiolation in continuous far-red light. The Plant Journal 60(3) pp. 449-461. [DOI] [Web of Science] [Pubmed]
Stephenson P.G., Fankhauser C., Terry M.J., 2009. PIF3 is a repressor of chloroplast development. Proceedings of the National Academy of Sciences of the United States of America 106(18) pp. 7654-7659. [DOI] [Web of Science] [Pubmed]
2008
Boccalandro H.E., De Simone S.N., Bergmann-Honsberger A., Schepens I., Fankhauser C., Casal J.J., 2008. PHYTOCHROME KINASE SUBSTRATE1 regulates root phototropism and gravitropism. Plant Physiology 146(1) pp. 108-115. [DOI] [Web of Science] [Pubmed]
de Lucas M., Davière J.M., Rodríguez-Falcón M., Pontin M., Iglesias-Pedraz J.M., Lorrain S., Fankhauser C., Blázquez M.A., Titarenko E., Prat S., 2008. A molecular framework for light and gibberellin control of cell elongation. Nature 451(7177) pp. 480-484. [DOI] [Web of Science] [Pubmed]
Fankhauser C., Chen M., 2008. Transposing phytochrome into the nucleus. Trends in Plant Science 13(11) pp. 596-601. [DOI] [Web of Science] [Pubmed]
Fiechter V., Cameroni E., Cerutti L., De V. C., Barral Y., Fankhauser C., 2008. The evolutionary conserved BER1 gene is involved in microtubule stability in yeast. Current Genetics 53(2) pp. 107-115. [DOI] [Web of Science] [Pubmed]
Genoud T., Santa Cruz M.T., Kulisic T., Sparla F., Fankhauser C., Métraux J.P., 2008. The protein phosphatase 7 regulates phytochrome signaling in Arabidopsis. PloS one 3(7) pp. e2699. [Document] [DOI] [Web of Science] [Pubmed]
Genoud T., Schweizer F., Tscheuschler A., Debrieux D., Casal J.J., Schäfer E., Hiltbrunner A., Fankhauser C., 2008. FHY1 mediates nuclear import of the light-activated phytochrome A photoreceptor. PLoS genetics 4(8) pp. e1000143. [Document] [DOI] [Web of Science] [Pubmed]
Lorrain S., Allen T., Duek P. D., Whitelam G. C., Fankhauser C., 2008. Phytochrome-mediated inhibition of shade avoidance involves degradation of growth-promoting bHLH transcription factors. Plant Journal 53(2) pp. 312-323. [Document] [DOI] [Web of Science] [Pubmed]
Schepens I., Boccalandro H. E., Kami C., Casal J. J., Fankhauser C., 2008. PHYTOCHROME KINASE SUBSTRATE4 modulates phytochrome-mediated control of hypocotyl growth orientation. Plant Physiology 147(2) pp. 661-671. [DOI] [Web of Science] [Pubmed]
2007
Nozue K., Covington M.F., Duek P.D., Lorrain S., Fankhauser C., Harmer S.L., Maloof J.N., 2007. Rhythmic growth explained by coincidence between internal and external cues. Nature 448(7151) pp. 358-361. [DOI] [Web of Science] [Pubmed]
Trupkin S.A., Debrieux D., Hiltbrunner A., Fankhauser C., Casal J.J., 2007. The serine-rich N-terminal region of Arabidopsis phytochrome A is required for protein stability. Plant Molecular Biology 63(5) pp. 669-678. [DOI] [Web of Science] [Pubmed]
2006
Fankhauser C., Bowler C., 2006. Biochemical and molecular analysis of signaling components. pp. 379-406 in Schäfer E., Nagy F. (eds.) Photomorphogenesis in Plants and Bacteria. 3rd ed., Springer, Dordrecht.
Fankhauser C., Lorrain S., 2006. Quand les plantes sortent de l'ombre. Pour la science 349 pp. 68-73.
Lariguet P., Schepens I., Hodgson D., Pedmale U.V., Trevisan M., Kami C., de Carbonnel M., Alonso J.M., Ecker J.R., Liscum E. et al., 2006. PHYTOCHROME KINASE SUBSTRATE 1 is a phototropin 1 binding protein required for phototropism. Proceedings of the National Academy of Sciences of the United States of America 103(26) pp. 10134-10139. [DOI] [Web of Science] [Pubmed]
Lorrain S., Genoud T., Fankhauser C., 2006. Let there be light in the nucleus! Current Opinion in Plant Biology 9(5) pp. 509-514. [DOI] [Web of Science] [Pubmed]
2005
Duek P.D., Fankhauser C., 2005. bHLH class transcription factors take centre stage in phytochrome signalling. Trends in Plant Science 10(2) pp. 51-54. [DOI] [Web of Science] [Pubmed]
Hiltbrunner A., Viczián A., Bury E., Tscheuschler A., Kircher S., Tóth R., Honsberger A., Nagy F., Fankhauser C., Schäfer E., 2005. Nuclear accumulation of the phytochrome A photoreceptor requires FHY1. Current Biology 15(23) pp. 2125-2130. [DOI] [Web of Science] [Pubmed]
Lariguet P., Fankhauser C., 2005. The effect of the light and gravity on hypocotyl growth orientation. pp. 277-284 in Wada M., Shimazaki K., Iino M. (eds.) Light Sensing in Plants. Springer, Tokyo. [DOI]
2004
Casal J.J., Fankhauser C., Coupland G., Blázquez M.A., 2004. Signalling for developmental plasticity. Trends in Plant Science 9(6) pp. 309-314. [DOI] [Web of Science] [Pubmed]
Chen M., Chory J., Fankhauser C., 2004. Light signal transduction in higher plants. Annual Review of Genetics 38 pp. 87-117. [DOI] [Web of Science] [Pubmed]
Fankhauser C., Casal J.J., 2004. Phenotypic characterization of a photomorphogenic mutant. Plant Journal 39(5) pp. 747-760. [DOI] [Web of Science] [Pubmed]
Schepens I., Duek P., Fankhauser C., 2004. Phytochrome-mediated light signalling in Arabidopsis. Current Opinion in Plant Biology 7(5) pp. 564-569. [DOI] [Web of Science] [Pubmed]
Sineshchekov V., Fankhauser C., 2004. PKS1 and PKS2 affect the phyA state in etiolated Arabidopsis seedlings. Photochemical and Photobiological Sciences 3(6) pp. 608-611. [DOI] [Web of Science] [Pubmed]
2003
Halliday K.J., Fankhauser C., 2003. Phytochrome-hormonal signalling networks. New Phytologist 157(3) pp. 449-463. [DOI] [Web of Science]
Lariguet P., Boccalandro H.E., Alonso J.M., Ecker J.R., Chory J., Casal J.J., Fankhauser C., 12-2003. A growth regulatory loop that provides homeostasis to phytochrome a signaling. Plant Cell 15(12) pp. 2966-2978. [DOI] [Web of Science] [Pubmed]
Staiger D., Allenbach L., Salathia N., Fiechter V., Davis S.J., Millar A.J., Chory J., Fankhauser C., 01-2003. The Arabidopsis SRR1 gene mediates phyB signaling and is required for normal circadian clock function. Genes and Development 17(2) pp. 256-268. [DOI] [Web of Science] [Pubmed]
2002
2001
Fankhauser C., 2001. Genetics of Photomorphogenesis in Plants. pp. 1454-1458 in Brenner S., Miller J.H. (eds.) Encyclopedia of Genetics. Academic Press, New York. [DOI]
Fankhauser C., 04-2001. The phytochromes, a family of red/far-red absorbing photoreceptors. Journal of Biological Chemistry 276(15) pp. 11453-11456. [DOI] [Web of Science] [Pubmed]
Liu X.L., Covington M.F., Fankhauser C., Chory J., Wagner D.R., 06-2001. ELF3 encodes a circadian clock-regulated nuclear protein that functions in an Arabidopsis PHYB signal transduction pathway. Plant Cell 13(6) pp. 1293-1304. [Web of Science] [Pubmed]
Zhao Y., Christensen S.K., Fankhauser C., Cashman J.R., Cohen J.D., Weigel D., Chory J., 01-2001. A role for flavin monooxygenase-like enzymes in auxin biosynthesis. Science 291(5502) pp. 306-309. [DOI] [Web of Science] [Pubmed]
2000
Fankhauser C., 12-2000. Phytochromes as light-modulated protein kinases. Seminars in Cell and Developmental Biology 11(6) pp. 467-473. [DOI] [Web of Science] [Pubmed]
Fankhauser C., Chory J., 09-2000. RSF1, an Arabidopsis locus implicated in phytochrome A signaling. Plant physiology 124(1) pp. 39-45. [DOI] [Web of Science] [Pubmed]
Neff M.M., Fankhauser C., Chory J., 02-2000. Light: an indicator of time and place. Genes and Development 14(3) pp. 257-271. [DOI] [Web of Science] [Pubmed]
Spiegelman J.I., Mindrinos M.N., Fankhauser C., Richards D., Lutes J., Chory J., Oefner P.J., 12-2000. Cloning of the Arabidopsis RSF1 gene by using a mapping strategy based on high-density DNA arrays and denaturing high-performance liquid chromatography. Plant Cell 12(12) pp. 2485-2498. [Web of Science] [Pubmed]
Utzig S., Fankhauser C., Simanis V., 2000. Periodic accumulation of cdc15 mRNA is not necessary for septation in Schizosaccharomyces pombe. Journal of Molecular Biology 302(4) pp. 751-759. [DOI] [Web of Science] [Pubmed]
Weigel D., Ahn J.H., Blázquez M.A., Borevitz J.O., Christensen S.K., Fankhauser C., Ferrándiz C., Kardailsky I., Malancharuvil E.J., Neff M.M. et al., 04-2000. Activation tagging in Arabidopsis. Plant physiology 122(4) pp. 1003-1013. [DOI] [Web of Science] [Pubmed]
1999
Fankhauser C., Chory J., 02-1999. Light receptor kinases in plants! Current Biology 9(4) pp. R123-R126. [DOI] [Web of Science] [Pubmed]
Fankhauser C., Yeh K.C., Lagarias J.C., Zhang H., Elich T.D., Chory J., 05-1999. PKS1, a substrate phosphorylated by phytochrome that modulates light signaling in Arabidopsis. Science 284(5419) pp. 1539-1541. [DOI] [Web of Science] [Pubmed]
1998
Jarvis P., Chen L.J., Li H., Peto C.A., Fankhauser C., Chory J., 10-1998. An Arabidopsis mutant defective in the plastid general protein import apparatus. Science 282(5386) pp. 100-103. [DOI] [Web of Science] [Pubmed]
1997
Fankhauser C., Chory J., 1997. Light control of plant development. Annual Review of Cell and Developmental Biology 13 pp. 203-229. [DOI] [Web of Science] [Pubmed]
1996
Chory J., Chatterjee M., Cook R.K., Elich T., Fankhauser C., Li J., Nagpal P., Neff M., Pepper A., Poole D. et al., 10-1996. From seed germination to flowering, light controls plant development via the pigment phytochrome. Proceedings of the National Academy of Sciences of the United States of America 93(22) pp. 12066-12071. [DOI] [Web of Science] [Pubmed]
Sohrmann M., Fankhauser C., Brodbeck C., Simanis V., 11-1996. The dmf1/mid1 gene is essential for correct positioning of the division septum in fission yeast. Genes and Development 10(21) pp. 2707-2719. [DOI] [Web of Science] [Pubmed]
1995
Fankhauser C., Reymond A., Cerutti L., Utzig S., Hofmann K., Simanis V., 1995. The S. pombe cdc15 gene is a key element in the reorganization of F-actin at mitosis. Cell 82(3) pp. 435-444. [DOI] [Web of Science] [Pubmed]
1994
Fankhauser C., Simanis V., 03-1994. Cold fission: splitting the pombe cell at room temperature. Trends in Cell Biology 4(3) pp. 96-101. [DOI] [Pubmed]
Fankhauser C., Simanis V., 07-1994. The cdc7 protein kinase is a dosage dependent regulator of septum formation in fission yeast. EMBO Journal 13(13) pp. 3011-3019. [Web of Science] [Pubmed]
1993
Fankhauser C., Simanis V., 05-1993. The Schizosaccharomyces pombe cdc14 gene is required for septum formation and can also inhibit nuclear division. Molecular biology of the cell 4(5) pp. 531-539. [Web of Science] [Pubmed]
1992
Courtot C., Fankhauser C., Simanis V., Lehner C.F., 10-1992. The Drosophila cdc25 homolog twine is required for meiosis. Development 116(2) pp. 405-416. [Web of Science] [Pubmed]
Marks J., Fankhauser C., Simanis V., 04-1992. Genetic interactions in the control of septation in Schizosaccharomyces pombe. Journal of cell science 101 ( Pt 4) pp. 801-808. [Web of Science] [Pubmed]
1991
Fankhauser C., Izaurralde E., Adachi Y., Wingfield P., Laemmli U.K., 1991. Specific complex of human immunodeficiency virus type 1 rev and nucleolar B23 proteins: dissociation by the Rev response element. Molecular and Cellular Biology 11(5) pp. 2567-2575. [Document] [Web of Science] [Pubmed]
Phd thesis
Hornitschek-Thielan P., 2011. Mechanism of HFR1 function in adaptive growth responses in "Arabidopsis thaliana". 142 p., Université de Lausanne, Faculté de biologie et médecine, Fankhauser C. (dir.).
de Carbonnel M., 08-2009. PKS2: A link between phototropin signalling and auxin transport - a study on how plants sense and respond to light. 205 p., Université de Lausanne, Faculté de biologie et médecine, Fankhauser C. (dir.). [Document]
Debrieux D., 2009. Looking for factors involved in the light-dependent degradation of phytochrome A. 137 p., Université de Lausanne, Faculté de biologie et médecine, Frankhauser C. (dir.).
Fiechter V., 2007. Study of the SRR1-gene family in Arabidopsis, yeast and mouse cells. 101 p., Université de Lausanne, Faculté de biologie et médecine, Fankhauser C. (dir.).
 
 
 
 
 
 
 

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Christian Fankhauser

christian.fankhauser@unil.ch

Tel: +41 21 692 3941

 

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Nathalie Clerc
nathalie.clerc@unil.ch
Tel: +41 21 692 3920

CH-1015 Lausanne  - Switzerland  -  Tel. +41 21 692 22 00  -  Fax +41 21 692 22 11
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