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Research : The structure and function of genomes and their evolution

A major challenge in genomics is to understand the organization and evolution of genomes from closely and distantly related organisms. What are the differences among genomes, and which of these differences determine disease development in humans or set, for example, humans and other primates apart?

Alexandre Reymond and colleagues focus on the characterization of genome strucutre during evolution and on the study of haploinsufficiency and its links to certain syndromes. Their recent studies provide a better understanding of the Williams-Beuren Sysndrome

Henrik Kaessmann and colleagues compare the entire human genome to those of various primates : the apes, which are our closest evolutionary relatives, and non-hominoid primates. Their studies have identified a gene specific to hominoids that supports high neurotransmitter flux, as well as a nuber of other young human genes, often with functions in the male germline.

 

Alexandre Reymond

Henrik Kaessmann


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