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Liliane Michalik, MER

CATHERINE GAILLOUD © UNIL Liliane Michalik received her PhD from the University Louis Pasteur of Strasbourg in 1993, for work on microtubule-associated proteins in the group of Jean-François Launay, INSERM. In 1994, she joined the group of Walter Wahli at UNIL for her post-doctoral training, during which she initiated a research project aimed at elucidating the roles of the nuclear hormone receptors PPARs in skin homeostasis and repair. Between 1996 and 2002, she persued her research in the same field as Maître Assistant, then Maître d’Enseignement et de Recherche at UNIL. She arrived at the Center for Integrative Genomics in 2003 as Maître d'Enseignement et de Recherche, and is MER-privat docent since 2008.

skin repair, UV induced skin cancer, angiogenesis, peroxisome proliferator-activated receptors

Research Summary

Transcriptional control of tissue repair, carcinogenesis and angiogenesis

Due to its peripheral localization, the skin is prone to be damaged, for instance by mechanical injury or UV radiations. In response to an injury, a cascade of events is initiated, which is aimed at repairing the damage in a life saving process, but which does not lead to complete regeneration. Damage provoked by UVB exposure initiates an inflammatory and DNA repair response, and leads to tumour development after long-term chronic exposure. The murine skin is a valuable model that is widely used to study organ repair and tumour development, two situations that share many cellular and molecular similarities.

We are interested in the transcriptional control of skin wound healing and UVB-induced carcinogenesis by the nuclear hormone receptor PPARs. Using genetically modified mice, various organ and cell culture models, as well as genomic approaches, we study PPAR functions in inflammation, epithelial homeostasis, epithelium-mesenchyme interactions, and angiogenesis.

Representative Publications

Chong*, H.C., Tan*, M.J., Philippe, V., Tan, S.H., Tan, C.K., Ku, C.W., Goh, Y.Y., Wahli, W., Michalik, L., and Tan, N.S. 2009. Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing. J Cell Biol 184:817-831.

Plasari, G., Calabrese, A., Dusserre, Y., Gronostajski, R.M., McNair, A., Michalik, L., and Mermod, N. 2009. Nuclear factor I-C links platelet-derived growth factor and transforming growth factor beta1 signaling to skin wound healing progression. Mol Cell Biol 29:6006-6017.

Tan, N.S., Icre, G., Montagner, A., Bordier-ten-Heggeler, B., Wahli, W., and Michalik, L. 2007. The nuclear hormone receptor peroxisome proliferator-activated receptor beta/delta potentiates cell chemotactism, polarization, and migration. Mol Cell Biol 27:7161-7175

Michalik, L., and Wahli, W. 2006. Involvement of PPAR nuclear receptors in tissue injury and wound repair. J Clin Invest 116:598-606.

Michalik, L., Feige, J.N., Gelman, L., Pedrazzini, T., Keller, H., Desvergne, B., and Wahli, W. 2005. Selective expression of a dominant-negative form of peroxisome proliferator-activated receptor in keratinocytes leads to impaired epidermal healing. Mol Endocrinol 19:2335-2348.

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