English

Publications

2013
    Montagner, A., Delgado, M. B., Tallichet-Blanc, C., Chan, J. S., Sng, M. K., Mottaz, H., Degueurce, G., Lippi, Y., Moret, C., Baruchet, M., Antsiferova, M., Werner, S., Hohl, D., Saati, T. A., Farmer, P. J., Tan, N. S., Michalik, L., Wahli, W.: Src is activated by the nuclear receptor peroxisome proliferator-activated receptor beta/delta in ultraviolet radiation-induced skin cancer. EMBO Mol Med 2013,
    URL

    Barroso, E., del Valle, J., Porquet, D., Vieira Santos, A. M., Salvado, L., Rodriguez-Rodriguez, R., Gutierrez, P., Anglada-Huguet, M., Alberch, J., Camins, A., Palomer, X., Pallas, M., Michalik, L., Wahli, W., Vazquez-Carrera, M.: Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPARbeta/delta-null mice. Biochim Biophys Acta 2013, 1832:1241-8. URL

2012
    Serrano-Marco, L., Barroso, E., El Kochairi, I., Palomer, X., Michalik, L., Wahli, W., Vazquez-Carrera, M.: The peroxisome proliferator-activated receptor (PPAR) beta/delta agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells. Diabetologia 2012, 55:743-51. URL

    Wahli, W., Michalik, L.: PPARs at the crossroads of lipid signaling and inflammation. Trends Endocrinol Metab 2012, 23:351-63. URL

2011
    Montagner, A., Rando, G., Degueurce, G., Leuenberger, N., Michalik, L., Wahli, W.: New insights into the role of PPARs. Prostaglandins Leukot Essent Fatty Acids 2011, 85:235-43. URL

    Serrano-Marco, L., Rodriguez-Calvo, R., El Kochairi, I., Palomer, X., Michalik, L., Wahli, W., Vazquez-Carrera, M.: Activation of peroxisome proliferator-activated receptor-beta/-delta (PPAR-beta/-delta) ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes. Diabetes 2011, 60:1990-9. URL

    Alvarez-Guardia, D., Palomer, X., Coll, T., Serrano, L., Rodriguez-Calvo, R., Davidson, M. M., Merlos, M., El Kochairi, I., Michalik, L., Wahli, W., Vazquez-Carrera, M.: PPARbeta/delta activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells. Biochim Biophys Acta 2011, 1811:59-67. URL

    Garrido-Urbani, S., Jemelin, S., Deffert, C., Carnesecchi, S., Basset, O., Szyndralewiez, C., Heitz, F., Page, P., Montet, X., Michalik, L., Arbiser, J., Ruegg, C., Krause, K. H., Imhof, B. A.: Targeting vascular NADPH oxidase 1 blocks tumor angiogenesis through a PPARalpha mediated mechanism. PLoS One 2011, 6:e14665. URL

2010
    Morgan, H., Beck, T., Blake, A., Gates, H., Adams, N., Debouzy, G., Leblanc, S., Lengger, C., Maier, H., Melvin, D., Meziane, H., Richardson, D., Wells, S. , White, J., Wood, J., *EUMODIC Consortium, De Angelis M.H., Brown, S.D., Hancock, J.M., Mallon, A.M.: EuroPhenome: a repository for high-throughput mouse phenotyping data. Nucleic Acids Res 2010, 38:D577-85.*L.Michalik is a member of the Eumodic Consortium. URL

2009
    Plasari, G., Calabrese, A., Dusserre, Y., Gronostajski, R. M., McNair, A., Michalik, L., Mermod, N.: Nuclear Factor I-C links PDGF and TGF-{beta}1 signaling to skin wound healing progression. Mol Cell Biol 2009, 29:6006-17. URL

    Chong*, H. C., Tan*, M. J., Philippe, V., Tan, S. H., Tan, C. K., Ku, C. W., Goh, Y. Y., Wahli, W., Michalik, L., Tan, N. S.: Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing. J Cell Biol 2009, 184:817-31. URL

2008
    Rodriguez-Calvo, R., Serrano, L., Coll, T., Moullan, N., Sanchez, R. M., Merlos, M., Palomer, X., Laguna, J. C., Michalik, L., Wahli, W., Vazquez-Carrera, M.: Activation of peroxisome proliferator-activated receptor beta/delta inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2. Diabetes 2008, 57:2149-57. URL

    Michalik*, L., Wahli*, W.: PPARs Mediate Lipid Signaling in Inflammation and Cancer. PPAR Res 2008, 2008:134059. URL

    Michalik, L., Wahli, W.: Tissue repair and cancer control through PPARs and their coregulators In Nuclear Receptors Co-regulators and Human Disease Edited by B. O'Malley, R. Kumar; London, Singapore: World Scientific Publishing; 2008: 409-440.

2007
    Tan, N. S., Icre, G., Montagner, A., Bordier-ten-Heggeler, B., Wahli, W., Michalik, L.: The nuclear hormone receptor peroxisome proliferator-activated receptor beta/delta potentiates cell chemotactism, polarization, and migration. Mol Cell Biol 2007, 27:7161-75. URL

    Michalik, L., Wahli, W.: Guiding ligands to nuclear receptors. Cell 2007, 129:649-51. URL

    Michalik*, L., Zoete*, V., Krey, G., Grosdidier, A., Gelman, L., Chodanowski, P., Feige, J. N., Desvergne, B., Wahli**, W., Michielin**, O.: Combined simulation and mutagenesis analyses reveal the involvement of key residues for peroxisome proliferator-activated receptor alpha helix 12 dynamic behavior. J Biol Chem 2007, 282:9666-77. URL

    Michalik*, L., Wahli*, W*.: Peroxisome proliferator-activated receptors (PPARs) in skin health, repair and disease. Biochim Biophys Acta 2007, 1771:991-8 . URL

    Michalik, L., Wahli, W.: Roles of the peroxisome proliferators-activated receptor (PPAR) alpha and beta/delta in skin wound healing. International Congress Series 2007, 1302:45-52.

2006
    Icre, G., Wahli, W., Michalik, L.: Functions of the peroxisome proliferator-activated receptor (PPAR) alpha and beta in skin homeostasis, epithelial repair, and morphogenesis. J Investig Dermatol Symp Proc 2006, 11:30-5. URL

    Michalik, L., Wahli, W.: Involvement of PPAR nuclear receptors in tissue injury and wound repair. J Clin Invest 2006, 116:598-606. URL

    Feige, J. N., Gelman, L., Michalik, L., Desvergne, B., Wahli, W.: From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Prog Lipid Res 2006, 45:120-59. URL

    Michalik, L., Auwerx, J., Berger, J. P., Chatterjee, V. K., Glass, C. K., Gonzalez, F. J., Grimaldi, P. A., Kadowaki, T., Lazar, M. A., O'Rahilly, S., Palmer, C. N., Plutzky, J., Reddy, J. K., Spiegelman, B. M., Staels, B., Wahli, W.: International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev 2006, 58:726-41. URL

    Canaple, L., Rambaud, J., Dkhissi-Benyahya, O., Rayet, B., Tan, N. S., Michalik, L., Delaunay, F., Wahli, W., Laudet, V.: Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock. Mol Endocrinol 2006, 20:1715-27. URL

    Desvergne, B., Michalik, L., Wahli, W.: Transcriptional regulation of metabolism. Physiol Rev 2006, 86:465-514. URL

    Varnat, F., Michalik, L., Desvergne, B., Wahli, W.: PPARs: lipid sensors that regulate cell differentiation processes In Nutritional Genomics: Impact on Health and Disease Edited by Brigelius-Flohé, R. , Joost, H.G.; Weinheim: Wiley-VCH Verlag GmbH & Co; 2006: 117-131.

    Rotman, N., Michalik, L., Desvergne, B., Wahli, W.: PPARs in fetal and early postnatal development In Nuclear receptors in development (Advances in Developmental Biology Series, Vol.16) Edited by R. Taneja , PM Wassarman; Elsevier; 2006: 33-49.

    Michalik, L., Wahli, W.: PPARs and colon cancers : A curse or a cure? In Recent Advances in Gastrointestinal Carcinogenesis Edited by H. Bamba, S. Ota; Trivandrum: Transworld Research Network; 2006: 145-161.

    Lathion, C., Michalik, L., Wahli, W.: Physiological ligands of PPARs in inflammation and lipid homeostasis. Future Lipidology 2006, 1:191-201.

2005
    Michalik, L., Feige, J. N., Gelman, L., Pedrazzini, T., Keller, H., Desvergne, B., Wahli, W.: Selective expression of a dominant-negative form of peroxisome proliferator-activated receptor in keratinocytes leads to impaired epidermal healing. Mol Endocrinol 2005, 19:2335-48. URL

    Di-Poi, N., Desvergne, B., Michalik, L., Wahli, W.: Transcriptional repression of peroxisome proliferator-activated receptor beta/delta in murine keratinocytes by CCAAT/enhancer-binding proteins. J Biol Chem 2005, 280:38700-10. URL

    Eumorphia_Consortium, Authors_from_the_CIG: , Wahli, W., Delgado, MB., Desvergne, B., Michalik, L., Bedu, E.: EMPReSS: standardised phenotype screens for functional annotation of the mouse genome. Nat Genet 2005, 37:1155. URL

    Tan, N. S., Michalik, L., Desvergne, B., Wahli, W.: Genetic- or transforming growth factor-beta 1-induced changes in epidermal peroxisome proliferator-activated receptor beta/delta expression dictate wound repair kinetics. J Biol Chem 2005, 280:18163-70. URL

    Planavila, A., Rodriguez-Calvo, R., Jove, M., Michalik, L., Wahli, W., Laguna, J. C., Vazquez-Carrera, M.: Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes. Cardiovasc Res 2005, 65:832-41. URL

    Di-Poi, N., Ng, C. Y., Tan, N. S., Yang, Z., Hemmings, B. A., Desvergne, B., Michalik, L., Wahli, W.: Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development. Mol Cell Biol 2005, 25:1696-712. URL

    Genolet, R., Kersten, S., Braissant, O., Mandard, S., Tan, N. S., Bucher, P., Desvergne, B., Michalik, L., Wahli, W.: Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate reductase/hydroxypyruvate reductase gene by the peroxisome proliferator-activated receptor alpha. J Biol Chem 2005, 280:24143-52. URL

    Gremlich, S., Nolan, C., Roduit, R., Burcelin, R., Peyot, M. L., Delghingaro-Augusto, V., Desvergne, B., Michalik, L., Prentki, M., Wahli, W.: Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation. Endocrinology 2005, 146:375-82. URL

    Tan, N. S., Michalik, L., Desvergne, B., Wahli, W.: Multiple expression control mechanisms of peroxisome proliferator-activated receptors and their target genes. J Steroid Biochem Mol Biol 2005, 93:99-105. URL

    Skrtic, S., Carlsson, L., Ljungberg, A., Linden, D., Michalik, L., Wahli, W., Oscarsson, J.: Decreased expression of peroxisome proliferator-activated receptor alpha and liver fatty acid binding protein after partial hepatectomy of rats and mice. Liver Int 2005, 25:33-40. URL

    Gelman, L., Michalik, L., Desvergne, B., Wahli, W.: Kinase signaling cascades that modulate peroxisome proliferator-activated receptors. Curr Opin Cell Biol 2005, 17:216-22. URL

    Kostadinova, R., Wahli, W., Michalik, L.: PPARs in diseases: control mechanisms of inflammation. Curr Med Chem 2005, 12:2995-3009. URL

    Genolet, R, Michalik, L, Wahli, W: Peroxisome Proliferator Activated Receptors In Signaling pathways in liver diseases Edited by Dufour, J-F, Clavien, P-A; Berlin, Heidelberg, New York: Springer; 2005: 267-280.

2004
    Tan, N. S., Michalik, L., Di-Poi, N., Ng, C. Y., Mermod, N., Roberts, A. B., Desvergne, B., Wahli, W.: Essential role of Smad3 in the inhibition of inflammation-induced PPARbeta/delta expression. Embo J 2004, 23:4211-21. URL

    Rieusset, J., Seydoux, J., Anghel, S. I., Escher, P., Michalik, L., Soon Tan, N., Metzger, D., Chambon, P., Wahli, W., Desvergne, B.: Altered growth in male peroxisome proliferator-activated receptor gamma (PPARgamma) heterozygous mice: involvement of PPARgamma in a negative feedback regulation of growth hormone action. Mol Endocrinol 2004, 18:2363-77. URL

    Di-Poi, N., Michalik, L., Desvergne, B., Wahli, W.: Functions of peroxisome proliferator-activated receptors (PPAR) in skin homeostasis. Lipids 2004, 39:1093-9. URL

    Desvergne, B., Michalik, L., Wahli, W.: Be fit or be sick: peroxisome proliferator-activated receptors are down the road. Mol Endocrinol 2004, 18:1321-32. URL

    Sanguino, E., Ramon, M., Michalik, L., Wahli, W., Alegret, M., Sanchez, R. M., Vazquez-Carrera, M., Laguna, J. C.: Lack of hypotriglyceridemic effect of gemfibrozil as a consequence of age-related changes in rat liver PPARalpha. Biochem Pharmacol 2004, 67:157-66. URL

    Michalik, L., Desvergne, B., Wahli, W.: Peroxisome-proliferator-activated receptors and cancers: complex stories. Nat Rev Cancer 2004, 4:61-70. URL

    Jove, M., Salla, J., Planavila, A., Cabrero, A., Michalik, L., Wahli, W., Laguna, J. C., Vazquez-Carrera, M.: Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone. J Lipid Res 2004, 45:113-23. URL

    Tan, N. S., Michalik, L., Di-Poi, N., Desvergne, B., Wahli, W.: Critical roles of the nuclear receptor PPARbeta (peroxisome-proliferator-activated receptor beta) in skin wound healing. Biochem Soc Trans 2004, 32:97-102. URL

    Tan, N. S., Michalik, L., Desvergne, B., Wahli, W.: Peroxisome proliferator-activated receptor-beta as a target for wound healing drugs. Expert Opin Ther Targets 2004, 8:39-48. URL

    Genolet, R., Wahli, W., Michalik, L.: PPARs as drug targets to modulate inflammatory responses?. Curr Drug Targets Inflamm Allergy 2004, 3:361-75. URL

    Mao-Qiang, M., Fowler, A. J., Schmuth, M., Lau, P., Chang, S., Brown, B. E., Moser, A. H., Michalik, L., Desvergne, B., Wahli, W., Li, M., Metzger, D., Chambon, P. H., Elias, P. M., Feingold, K. R.: Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation. J Invest Dermatol 2004, 123:305-12. URL

    Wahli, W., Michalik, L., Desvergne, B.: PPARs in health and disease : central roles in energy homeostasis and tissue repair. BIO 2004, 11:26-31.

2003
    Jackson, L., Wahli, W., Michalik, L., Watson, S. A., Morris, T., Anderton, K., Bell, D. R., Smith, J. A., Hawkey, C. J., Bennett, A. J.: Potential role for peroxisome proliferator activated receptor (PPAR) in preventing colon cancer. Gut 2003, 52:1317-22. URL

    Di-Poi, N., Michalik, L., Tan, N. S., Desvergne, B., Wahli, W.: The anti-apoptotic role of PPARbeta contributes to efficient skin wound healing. J Steroid Biochem Mol Biol 2003, 85:257-65. URL

    Jalouli, M., Carlsson, L., Ameen, C., Linden, D., Ljungberg, A., Michalik, L., Eden, S., Wahli, W., Oscarsson, J.: Sex difference in hepatic peroxisome proliferator-activated receptor alpha expression: influence of pituitary and gonadal hormones. Endocrinology 2003, 144:101-9. URL

    Hellemans, K., Michalik, L., Dittie, A., Knorr, A., Rombouts, K., De Jong, J., Heirman, C., Quartier, E., Schuit, F., Wahli, W., Geerts, A.: Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells. Gastroenterology 2003, 124:184-201. URL

    Hellemans, K., Rombouts, K., Quartier, E., Dittie, A. S., Knorr, A., Michalik, L., Rogiers, V., Schuit, F., Wahli, W., Geerts, A.: PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation. J Lipid Res 2003, 44:280-95. URL

    Michalik, L., Desvergne, B., Wahli, W.: Peroxisome proliferator-activated receptors beta/delta: emerging roles for a previously neglected third family member. Curr Opin Lipidol 2003, 14:129-35. URL

    Tan, N. S., Michalik, L., Desvergne, B., Wahli, W.: Peroxisome proliferator-activated receptor (PPAR)-beta as a target for wound healing drugs: what is possible?. Am J Clin Dermatol 2003, 4:523-30. URL

    Michalik, L., Tan, N. S., Wahli, W., Desvergne, B.: PPARs: nuclear receptors involved in the control of inflammation In Cellular proteins and their fatty acids in health and disease Volume Chapter 24. Edited by Duttaroy, AK , Spener, F; Weinheim: Wiley VCH; 2003: 419-435.

2002
    Di-Poi, N., Tan, N. S., Michalik, L., Wahli, W., Desvergne, B.: Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway. Mol Cell 2002, 10:721-33. URL

    Rieusset, J., Touri, F., Michalik, L., Escher, P., Desvergne, B., Niesor, E., Wahli, W.: A new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesity and antidiabetic activity. Mol Endocrinol 2002, 16:2628-44. URL

    Hihi, A. K., Michalik, L., Wahli, W.: PPARs: transcriptional effectors of fatty acids and their derivatives. Cell Mol Life Sci 2002, 59:790-8. URL

    Michalik, L., Desvergne, B., Dreyer, C., Gavillet, M., Laurini, R. N., Wahli, W.: PPAR expression and function during vertebrate development. Int J Dev Biol 2002, 46:105-14. URL

    Desvergne, B., Michalik, L., Wahli, W.: Sensors for metabolic control : A regulatory network of nuclear receptors In Hormone signaling Edited by Goffin, V. , Kelly, P. A. ; Norwell: Kluwer Academic Publishers; 2002: 283-304.

2001
    Escher, P., Braissant, O., Basu-Modak, S., Michalik, L., Wahli, W., Desvergne, B.: Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology 2001, 142:4195-202. URL

    Tan, N. S., Michalik, L., Noy, N., Yasmin, R., Pacot, C., Heim, M., Fluhmann, B., Desvergne, B., Wahli, W.: Critical roles of PPAR beta/delta in keratinocyte response to inflammation. Genes Dev 2001, 15:3263-77. URL

    Michalik, L., Desvergne, B., Tan, N. S., Basu-Modak, S., Escher, P., Rieusset, J., Peters, J. M., Kaya, G., Gonzalez, F. J., Zakany, J., Metzger, D., Chambon, P., Duboule, D., Wahli, W.: Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice. J Cell Biol 2001, 154:799-814. URL

2000
    Michalik, L., Desvergne, B., Wahli, W.: Les bases moléculaires de l'obésité : vers de nouvelles thérapeutiques ?. Médecines Sciences 2000, 16:1030-1039.

    Michalik, L., Desvergne, B., Basu-Modak, S., Tan, N. S., Wahli, W.: Nuclear hormone receptors and mouse skin homeostasis: implication of PPARbeta. Horm Res 2000, 54:263-8. URL

1999
    Michalik, L., Wahli, W.: Peroxisome proliferator-activated receptors: three isotypes for a multitude of functions. Curr Opin Biotechnol 1999, 10:564-70. URL

1998
    Vanier, M. T., Neuville, P., Michalik, L., Launay, J. F.: Expression of specific tau exons in normal and tumoral pancreatic acinar cells. J Cell Sci 1998, 111 ( Pt 10):1419-32. URL

1995
    Michalik, L., Neuville, P., Vanier, M. T., Launay, J. F.: Pancreatic tau related maps: biochemical and immunofluorescence analysis in a tumoral cell line. Mol Cell Biochem 1995, 143:107-12. URL

    Neuville, P., Vanier, M. T., Michalik, L., Launay, J. F.: In situ localization with digoxigenin-labelled probes of tau-related mRNAs in the rat pancreas. Histochem J 1995, 27:565-74. URL

1993
    Neuville, P., Michalik, L., Launay, J. F.: Identification of a microtubule-binding domain sequence in pancreatic messenger RNAs. Biochim Biophys Acta 1993, 1181:317-20. URL

    Michalik, L., Neuville, P., Vanier, M. T., Launay, J. F.: Biochemical and immunochemical identification of a microtubule-binding protein from bovine pancreas. Cell Motil Cytoskeleton 1993, 25:381-90. URL

1992
    Michalik, L., Vanier, M. T., Launay, J. F.: Characterization of a 67 kDa microtubule-binding protein in the pancreas from different species. Biochim Biophys Acta 1992, 1116:269-73. URL

1991
    Michalik, L., Vanier, M. T., Launay, J. F.: Microtubule affinity chromatography: a new technique for isolating microtubule-binding proteins from rat pancreas. Cell Mol Biol 1991, 37:805-11. URL


Search:
 in this site:
   
   
   
 Rechercher

Génopode - CH-1015 Lausanne  - Switzerland  -  Phone +41 21 692 39 00  -  Fax  +41 21 692 39 05