English

Publications

2013

 

 
    Ding, J., Loizides-Mangold, U., Rando, G., Zoete, V., Michielin, O., Reddy, J. K., Wahli, W., Riezman, H., Thorens, B.: The Peroxisomal Enzyme L-PBE Is Required to Prevent the Dietary Toxicity of Medium-Chain Fatty Acids. Cell Rep 2013, 5:248-58. URL

    Montagner, A., Delgado, M. B., Tallichet-Blanc, C., Chan, J. S., Sng, M. K., Mottaz, H., Degueurce, G., Lippi, Y., Moret, C., Baruchet, M., Antsiferova, M., Werner, S., Hohl, D., Saati, T. A., Farmer, P. J., Tan, N. S., Michalik, L., Wahli, W.: Src is activated by the nuclear receptor peroxisome proliferator-activated receptor beta/delta in ultraviolet radiation-induced skin cancer. EMBO Mol Med 2013,
    URL

    Constantin, N., Wahli, W.: Nutrigenomic foods: What will we be eating tomorrow? Nutrafoods 2013, 12:3-12. URL

    Barroso, E., del Valle, J., Porquet, D., Vieira Santos, A. M., Salvado, L., Rodriguez-Rodriguez, R., Gutierrez, P., Anglada-Huguet, M., Alberch, J., Camins, A., Palomer, X., Pallas, M., Michalik, L., Wahli, W., Vazquez-Carrera, M.: Tau hyperphosphorylation and increased BACE1 and RAGE levels in the cortex of PPARbeta/delta-null mice. Biochim Biophys Acta 2013, 1832:1241-8. URL

    Tan, N. S., Wahli, W.: Studying wound repair in the mouse. Current Protocols in Mouse Biology 2013, 3:171-185. URL

    Rotman, N., Guex, N., Gouranton, E., Wahli, W.: PPARbeta Interprets a Chromatin Signature of Pluripotency to Promote Embryonic Differentiation at Gastrulation. PLoS One 2013, 8:e83300. URL

    Constantin, N., Wahli, W.: Disease prevention through nutrition. Pan European Networks: Science & Technology 2013, 8:240-241. URL

    Chappuis, S., Ripperger, J. A., Schnell, A., Rando, G., Jud, C., Wahli, W., Albrecht, U.: Role of the circadian clock gene Per2 in adaptation to cold temperature. Mol Metab 2013, 2:184-93. URL


2012

 

 
    Iglesias, J., Barg, S., Vallois, D., Lahiri, S., Roger, C., Yessoufou, A., Pradevand, S., McDonald, A., Bonal, C., Reimann, F., Gribble, F., Debril, M. B., Metzger, D., Chambon, P., Herrera, P., Rutter, G. A., Prentki, M., Thorens, B., Wahli, W.: PPARbeta/delta affects pancreatic beta cell mass and insulin secretion in mice. J Clin Invest 2012, 122:4105-17. URL

    Serrano-Marco, L., Barroso, E., El Kochairi, I., Palomer, X., Michalik, L., Wahli, W., Vazquez-Carrera, M.: The peroxisome proliferator-activated receptor (PPAR) beta/delta agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells. Diabetologia 2012, 55:743-51. URL

    Wahli, W., Michalik, L.: PPARs at the crossroads of lipid signaling and inflammation. Trends Endocrinol Metab 2012, 23:351-63. URL

    Ge, X., Vajjala, A., McFarlane, C., Wahli, W., Sharma, M., Kambadur, R.: Lack of Smad3 signaling leads to impaired skeletal muscle regeneration. Am J Physiol Endocrinol Metab 2012, 303:E90-E102. URL

    Lahiri, S., Wahli, W.: Peroxisome proliferator-activated receptor β/δ: a master regulator of metabolic pathways in skeletal muscle. Hormone Molecular Biology and Clinical Investigation 2012, 4:565–573. URL

    Bonala, S., Lokireddy, S., Arigela, H., Teng, S., Wahli, W., Sharma, M., McFarlane, C., Kambadur, R.: Peroxisome proliferator-activated receptor beta/delta induces myogenesis by modulating myostatin activity. J Biol Chem 2012, 287:12935-51. URL

    Montagner, A., Wahli, W.: Contributions of peroxisome proliferator-activated receptor β/δ to skin health and disease. Biomolecular Concepts 2012, 4:53-64. URL

    Woldt, E., Terrand, J., Mlih, M., Matz, R. L., Bruban, V., Coudane, F., Foppolo, S., El Asmar, Z., Chollet, M. E., Ninio, E., Bednarczyk, A., Thierse, D., Schaeffer, C., Van Dorsselaer, A., Boudier, C., Wahli, W., Chambon, P., Metzger, D., Herz, J., Boucher, P.: The nuclear hormone receptor PPARgamma counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells. Nat Commun 2012, 3:1077. URL

    Kostadinova, R., Montagner, A., Gouranton, E., Fleury, S., Guillou, H., Dombrowicz, D., Desreumaux, P., Wahli, W.: GW501516-activated PPARbeta/delta promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation. Cell Biosci 2012, 2:34. URL


2011

 

 
    El Kochairi, I., Montagner, A., Rando, G., Lohmann, C., Matter, C. M., Wahli, W.: Beneficial effects of combinatorial micronutrition on body fat and atherosclerosis in mice. Cardiovasc Res 2011, 91:732-41. URL

    Montagner, A., Rando, G., Degueurce, G., Leuenberger, N., Michalik, L., Wahli, W.: New insights into the role of PPARs. Prostaglandins Leukot Essent Fatty Acids 2011, 85:235-43. URL

    Ge, X., McFarlane, C., Vajjala, A., Lokireddy, S., Ng, Z. H., Tan, C. K., Tan, N. S., Wahli, W., Sharma, M., Kambadur, R.: Smad3 signaling is required for satellite cell function and myogenic differentiation of myoblasts. Cell Res 2011, 21:1591-604. URL

    Gachon, F., Leuenberger, N., Claudel, T., Gos, P., Jouffe, C., Fleury Olela, F., de Mollerat du Jeu, X., Wahli, W., Schibler, U.: Proline- and acidic amino acid-rich basic leucine zipper proteins modulate peroxisome proliferator-activated receptor alpha (PPARalpha) activity. Proc Natl Acad Sci U S A 2011, 108:4794-9. URL

    Serrano-Marco, L., Rodriguez-Calvo, R., El Kochairi, I., Palomer, X., Michalik, L., Wahli, W., Vazquez-Carrera, M.: Activation of peroxisome proliferator-activated receptor-beta/-delta (PPAR-beta/-delta) ameliorates insulin signaling and reduces SOCS3 levels by inhibiting STAT3 in interleukin-6-stimulated adipocytes. Diabetes 2011, 60:1990-9. URL

    Tan, C. K., Leuenberger, N., Tan, M. J., Yan, Y. W., Chen, Y., Kambadur, R., Wahli, W., Tan, N. S.: Smad3 deficiency in mice protects against insulin resistance and obesity induced by a high-fat diet. Diabetes 2011, 60:464-76. URL

    Alvarez-Guardia, D., Palomer, X., Coll, T., Serrano, L., Rodriguez-Calvo, R., Davidson, M. M., Merlos, M., El Kochairi, I., Michalik, L., Wahli, W., Vazquez-Carrera, M.: PPARbeta/delta activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells. Biochim Biophys Acta 2011, 1811:59-67. URL

    Hensler, M., Bardova, K., Macek Jilkova, Z., Wahli, W., Meztger, D., Chambon, P., Kopecky, J., Flachs, P.: The inhibition of fat cell proliferation by n-3 fatty acids in dietary obese mice. Lipids Health Dis 2011, 10:128. URL

    Rando, G., Wahli, W.: Sex differences in nuclear receptor-regulated liver metabolic pathways. Biochim Biophys Acta 2011, 1812:964-73. URL

    Kulozik, P., Jones, A., Mattijssen, F., Rose, A. J., Reimann, A., Strzoda, D., Kleinsorg, S., Raupp, C., Kleinschmidt, J., Muller-Decker, K., Wahli, W., Sticht, C., Gretz, N., von Loeffelholz, C., Stockmann, M., Pfeiffer, A., Stohr, S., Dallinga-Thie, G. M., Nawroth, P. P., Berriel Diaz, M., Herzig, S.: Hepatic deficiency in transcriptional cofactor TBL1 promotes liver steatosis and hypertriglyceridemia. Cell Metab 2011, 13:389-400. URL

    Deblon, N., Veyrat-Durebex, C., Bourgoin, L., Caillon, A., Bussier, A. L., Petrosino, S., Piscitelli, F., Legros, J. J., Geenen, V., Foti, M., Wahli, W., Di Marzo, V., Rohner-Jeanrenaud, F.: Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats. PLoS One 2011, 6:e25565. URL


2010

 

 
    Vegiopoulos, A., Muller-Decker, K., Strzoda, D., Schmitt, I., Chichelnitskiy, E., Ostertag, A., Berriel Diaz, M., Rozman, J., Hrabe de Angelis, M., Nusing, R. M., Meyer, C. W., Wahli, W., Klingenspor, M., Herzig, S.: Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science 2010, 328:1158-61. URL

    Rotman, N., Wahli, W.: PPAR modulation of kinase-linked receptor signaling in physiology and disease. Physiology (Bethesda) 2010, 25:176-85. URL

    Yessoufou, A., Wahli, W.: Multifaceted roles of peroxisome proliferator-activated receptors (PPARs) at the cellular and whole organism levels. Swiss Med Wkly 2010, 140:w13071. URL

    Morgan, H., Beck, T., Blake, A., Gates, H., Adams, N., Debouzy, G., Leblanc, S., Lengger, C., Maier, H., Melvin, D., Meziane, H., Richardson, D., Wells, S. , White, J., Wood, J., *EUMODIC Consortium, De Angelis M.H., Brown, S.D., Hancock, J.M., Mallon, A.M.: EuroPhenome: a repository for high-throughput mouse phenotyping data. Nucleic Acids Research 2010, 38:577-85. *W.Wahli is a member of the Eumodic Consortium.

    Leuenberger, N., Wahli, W.: PPARα, a key regulator of hepatic energy homeostasis in health and disease In Signaling Pathways in Liver Diseases Edited by Dufour, J.F., Clavien, P.A.; Heidelberg: Springer-Verlag GmbH & Co KG; 2010: 305-315.


2009

 

 
    Leuenberger, N., Pradervand, S., Wahli, W.: Sumoylated PPARalpha mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice. J Clin Invest 2009, 119:3138-48. URL

    Lohmann, C., Schafer, N., von Lukowicz, T., Sokrates Stein, M. A., Boren, J., Rutti, S., Wahli, W., Donath, M. Y., Luscher, T. F., Matter, C. M.: Atherosclerotic mice exhibit systemic inflammation in periadventitial and visceral adipose tissue, liver, and pancreatic islets. Atherosclerosis 2009, 207:360-7. URL

    Chong*, H. C., Tan*, M. J., Philippe, V., Tan, S. H., Tan, C. K., Ku, C. W., Goh, Y. Y., Wahli, W., Michalik, L., Tan, N. S.: Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing. J Cell Biol 2009, 184:817-31. URL

    Rotman, N., Wahli, W.: Fatty acid synthesis and PPARalpha hand in hand. Chem Biol 2009, 16:801-2. URL

    Wahli, W., Constantin, N.: La nutrigénomique, un défi médico-socio-économique. Swiss Medical Forum 2009, 9:242-245. URL

    Demers, A., Caron, V., Rodrigue-Way, A., Wahli, W., Ong, H., Tremblay, A.: A concerted kinase interplay identifies PPARgamma as a molecular target of ghrelin signaling in macrophages. PLoS One 2009, 4:e7728. URL


2008

 

 
    Brawand, D., Wahli*, W., Kaessmann*, H.: Loss of egg yolk genes in mammals and the origin of lactation and placentation. PLoS Biol 2008, 6:e63. URL

    Wahli, W.: PPAR gamma: ally and foe in bone metabolism. Cell Metab 2008, 7:188-90. URL

    Wahli, W.: A gut feeling of the PXR, PPAR and NF-kappaB connection. J Intern Med 2008, 263:613-9. URL

    Rodriguez-Calvo, R., Serrano, L., Coll, T., Moullan, N., Sanchez, R. M., Merlos, M., Palomer, X., Laguna, J. C., Michalik, L., Wahli, W., Vazquez-Carrera, M.: Activation of peroxisome proliferator-activated receptor beta/delta inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2. Diabetes 2008, 57:2149-57. URL

    Rotman, N., Terreau-Haftek, Z., Lücke, S., Feige, J., Gelman, L., Desvergne, B., Wahli, W.: PPAR Disruption: Cellular Mechanisms and Physiological Consequences. CHIMIA 2008, 62:340-344. URL

    Wahli, W.: Nutrition, gestion de l'énergie et surpoids: que font donc nos gènes ? In Nouveaux Cahiers Volume 3. Edited by IJSLA; 2008: 44-78.

    Michalik*, L., Wahli*, W.: PPARs Mediate Lipid Signaling in Inflammation and Cancer. PPAR Res 2008, 2008:134059. URL

    Michalik, L., Wahli, W.: Tissue repair and cancer control through PPARs and their coregulators In Nuclear Receptors Co-regulators and Human Disease Edited by B. O'Malley, R. Kumar; London, Singapore: World Scientific Publishing; 2008: 409-440.

    Jahoor, A, Patel, R, Bryan, R, Do, C, Krier, J, Watters, C, Wahli, W, Li, G, Williams, SC, Rumbaugh, KP: PPAR mediate host cell pro-inflammatory responses to P. aeruginosa autoinducer. Journal of Bacteriology 2008, 190:4408-4415..


2007

 

 
    Wang, H., Xie, H., Sun, X., Tranguch, S., Zhang, H., Jia, X., Wang, D., Das, S. K., Desvergne, B., Wahli, W., Dubois, R. N., Dey, S. K.: Stage-specific integration of maternal and embryonic PPARdelta signaling is critical to pregnancy success. J Biol Chem 2007, 282:37770-82. URL

    Anghel, S. I., Bedu, E., Vivier, C. D., Descombes, P., Desvergne, B., Wahli, W.: Adipose tissue integrity as a prerequisite for systemic energy balance: a critical role for peroxisome proliferator-activated receptor gamma. J Biol Chem 2007, 282:29946-57. URL

    Tan, N. S., Icre, G., Montagner, A., Bordier-ten-Heggeler, B., Wahli, W., Michalik, L.: The nuclear hormone receptor peroxisome proliferator-activated receptor beta/delta potentiates cell chemotactism, polarization, and migration. Mol Cell Biol 2007, 27:7161-75. URL

    Michalik, L., Wahli, W.: Guiding ligands to nuclear receptors. Cell 2007, 129:649-51. URL

    Stienstra, R., Mandard, S., Tan, N. S., Wahli, W., Trautwein, C., Richardson, T. A., Lichtenauer-Kaligis, E., Kersten, S., Muller, M.: The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver. J Hepatol 2007, 46:869-77.. URL

    Mandard, S., Stienstra, R., Escher, P., Tan, N. S., Kim, I., Gonzalez, F. J., Wahli, W., Desvergne, B., Muller, M., Kersten, S.: Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors. Cell Mol Life Sci 2007, 64:1145-57. URL

    Indra, A. K., Castaneda, E., Antal, M. C., Jiang, M., Messaddeq, N., Meng, X., Loehr, C. V., Gariglio, P., Kato, S., Wahli, W., Desvergne, B., Metzger, D., Chambon, P.: Malignant transformation of DMBA/TPA-induced papillomas and nevi in the skin of mice selectively lacking retinoid-X-receptor alpha in epidermal keratinocytes. J Invest Dermatol 2007, 127:1250-60. URL

    Michalik*, L., Zoete*, V., Krey, G., Grosdidier, A., Gelman, L., Chodanowski, P., Feige, J. N., Desvergne, B., Wahli**, W., Michielin**, O.: Combined simulation and mutagenesis analyses reveal the involvement of key residues for peroxisome proliferator-activated receptor alpha helix 12 dynamic behavior. J Biol Chem 2007, 282:9666-77. URL

    Feige, J. N., Gelman, L., Rossi, D., Zoete, V., Metivier, R., Tudor, C., Anghel, S. I., Grosdidier, A., Lathion, C., Engelborghs, Y., Michielin, O., Wahli, W., Desvergne, B.: The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis. J Biol Chem 2007, 282:19152-66. URL

    Berry*, A., Balard*, P., Coste, A., Olagnier, D., Lagane, C., Authier, H., Benoit-Vical, F., Lepert, J. C., Seguela, J. P., Magnaval, J. F., Chambon, P., Metzger, D., Desvergne, B., Wahli, W., Auwerx, J., Pipy, B.: IL-13 induces expression of CD36 in human monocytes through PPARgamma activation. Eur J Immunol 2007, 37:1642-52. URL

    Anghel, S. I., Wahli, W.: Fat poetry: a kingdom for PPARgamma. Cell Res 2007, 17:486-511. URL

    Tudor, C., Feige, J. N., Pingali, H., Lohray, V. B., Wahli, W., Desvergne, B., Engelborghs, Y., Gelman, L.: Association with coregulators is the major determinant governing peroxisome proliferator-activated receptor mobility in living cells. J Biol Chem 2007, 282:4417-26 . URL

    Michalik*, L., Wahli*, W*.: Peroxisome proliferator-activated receptors (PPARs) in skin health, repair and disease. Biochim Biophys Acta 2007, 1771:991-8 . URL

    Michalik, L., Wahli, W.: Roles of the peroxisome proliferators-activated receptor (PPAR) alpha and beta/delta in skin wound healing. International Congress Series 2007, 1302:45-52.


2006

 

 
    Knauf, C., Rieusset, J., Foretz, M., Cani, P. D., Uldry, M., Hosokawa, M., Martinez, E., Bringart, M., Waget, A., Kersten, S., Desvergne, B., Gremlich, S., Wahli, W., Seydoux, J., Delzenne, N. M., Thorens, B., Burcelin, R.: Peroxisome proliferator-activated receptor-alpha-null mice have increased white adipose tissue glucose utilization, GLUT4, and fat mass: Role in liver and brain. Endocrinology 2006, 147:4067-78. URL

    Icre, G., Wahli, W., Michalik, L.: Functions of the peroxisome proliferator-activated receptor (PPAR) alpha and beta in skin homeostasis, epithelial repair, and morphogenesis. J Investig Dermatol Symp Proc 2006, 11:30-5. URL

    Schuler, M., Ali, F., Chambon, C., Duteil, D., Bornert, J. M., Tardivel, A., Desvergne, B., Wahli, W., Chambon, P., Metzger, D.: PGC1alpha expression is controlled in skeletal muscles by PPARbeta, whose ablation results in fiber-type switching, obesity, and type 2 diabetes. Cell Metab 2006, 4:407-14. URL

    Michalik, L., Wahli, W.: Involvement of PPAR nuclear receptors in tissue injury and wound repair. J Clin Invest 2006, 116:598-606. URL

    Feige, J. N., Gelman, L., Michalik, L., Desvergne, B., Wahli, W.: From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions. Prog Lipid Res 2006, 45:120-59. URL

    Mandard, S., Zandbergen, F., van Straten, E., Wahli, W., Kuipers, F., Muller, M., Kersten, S.: The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated with lipoproteins and governs plasma lipid levels and adiposity. J Biol Chem 2006, 281:934-44. URL

    Ali, F. Y., Egan, K., FitzGerald, G. A., Desvergne, B., Wahli, W., Bishop-Bailey, D., Warner, T. D., Mitchell, J. A.: Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts. Am J Respir Cell Mol Biol 2006, 34:242-6. URL

    Wang, D., Wang, H., Guo, Y., Ning, W., Katkuri, S., Wahli, W., Desvergne, B., Dey, S. K., DuBois, R. N.: Crosstalk between peroxisome proliferator-activated receptor delta and VEGF stimulates cancer progression. Proc Natl Acad Sci U S A 2006, 103:19069-74. URL

    Michalik, L., Auwerx, J., Berger, J. P., Chatterjee, V. K., Glass, C. K., Gonzalez, F. J., Grimaldi, P. A., Kadowaki, T., Lazar, M. A., O'Rahilly, S., Palmer, C. N., Plutzky, J., Reddy, J. K., Spiegelman, B. M., Staels, B., Wahli, W.: International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacol Rev 2006, 58:726-41. URL

    Avallone, R., Demers, A., Rodrigue-Way, A., Bujold, K., Harb, D., Anghel, S., Wahli, W., Marleau, S., Ong, H., Tremblay, A.: A growth hormone-releasing peptide that binds scavenger receptor CD36 and ghrelin receptor up-regulates sterol transporters and cholesterol efflux in macrophages through a peroxisome proliferator-activated receptor gamma-dependent pathway. Mol Endocrinol 2006, 20:3165-78. URL

    Varnat, F., Heggeler, B. B., Grisel, P., Boucard, N., Corthesy-Theulaz, I., Wahli, W., Desvergne, B.: PPARbeta/delta regulates paneth cell differentiation via controlling the hedgehog signaling pathway. Gastroenterology 2006, 131:538-53. URL

    Canaple, L., Rambaud, J., Dkhissi-Benyahya, O., Rayet, B., Tan, N. S., Michalik, L., Delaunay, F., Wahli, W., Laudet, V.: Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock. Mol Endocrinol 2006, 20:1715-27. URL

    Nadra, K., Anghel, S. I., Joye, E., Tan, N. S., Basu-Modak, S., Trono, D., Wahli, W., Desvergne, B.: Differentiation of trophoblast giant cells and their metabolic functions are dependent on peroxisome proliferator-activated receptor beta/delta. Mol Cell Biol 2006, 26:3266-81. URL

    Desvergne, B., Michalik, L., Wahli, W.: Transcriptional regulation of metabolism. Physiol Rev 2006, 86:465-514. URL

    Varnat, F., Michalik, L., Desvergne, B., Wahli, W.: PPARs: lipid sensors that regulate cell differentiation processes In Nutritional Genomics: Impact on Health and Disease Edited by Brigelius-Flohé, R. , Joost, H.G.; Weinheim: Wiley-VCH Verlag GmbH & Co; 2006: 117-131.

    Rotman, N., Michalik, L., Desvergne, B., Wahli, W.: PPARs in fetal and early postnatal development In Nuclear receptors in development (Advances in Developmental Biology Series, Vol.16) Edited by R. Taneja , PM Wassarman; Elsevier; 2006: 33-49.

    Michalik, L., Wahli, W.: PPARs and colon cancers : A curse or a cure? In Recent Advances in Gastrointestinal Carcinogenesis Edited by H. Bamba, S. Ota; Trivandrum: Transworld Research Network; 2006: 145-161.

    Lathion, C., Michalik, L., Wahli, W.: Physiological ligands of PPARs in inflammation and lipid homeostasis. Future Lipidology 2006, 1:191-201.

    Gelman, L., Feige, J. N., Tudor, C., Engelborghs, Y., Wahli, W., Desvergne, B.: Integrating nuclear receptor mobility in models of gene regulation. Nucl Recept Signal 2006, 4:e010. URL


2005

 

 
    Michalik, L., Feige, J. N., Gelman, L., Pedrazzini, T., Keller, H., Desvergne, B., Wahli, W.: Selective expression of a dominant-negative form of peroxisome proliferator-activated receptor in keratinocytes leads to impaired epidermal healing. Mol Endocrinol 2005, 19:2335-48. URL

    Feige, J. N., Sage, D., Wahli, W., Desvergne, B., Gelman, L.: PixFRET, an ImageJ plug-in for FRET calculation that can accommodate variations in spectral bleed-throughs. Microsc Res Tech 2005, 68:51-8. URL

    Mutch, D. M., Wahli, W., Williamson, G.: Nutrigenomics and nutrigenetics: the emerging faces of nutrition. Faseb J 2005, 19:1602-16. URL

    Di-Poi, N., Desvergne, B., Michalik, L., Wahli, W.: Transcriptional repression of peroxisome proliferator-activated receptor beta/delta in murine keratinocytes by CCAAT/enhancer-binding proteins. J Biol Chem 2005, 280:38700-10. URL

    Eumorphia_Consortium, Authors_from_the_CIG: , Wahli, W., Delgado, MB., Desvergne, B., Michalik, L., Bedu, E.: EMPReSS: standardised phenotype screens for functional annotation of the mouse genome. Nat Genet 2005, 37:1155. URL

    Tan, N. S., Michalik, L., Desvergne, B., Wahli, W.: Genetic- or transforming growth factor-beta 1-induced changes in epidermal peroxisome proliferator-activated receptor beta/delta expression dictate wound repair kinetics. J Biol Chem 2005, 280:18163-70. URL

    Feige, J. N., Gelman, L., Tudor, C., Engelborghs, Y., Wahli, W., Desvergne, B.: Fluorescence imaging reveals the nuclear behavior of peroxisome proliferator-activated receptor/retinoid X receptor heterodimers in the absence and presence of ligand. J Biol Chem 2005, 280:17880-90. URL

    Planavila, A., Rodriguez-Calvo, R., Jove, M., Michalik, L., Wahli, W., Laguna, J. C., Vazquez-Carrera, M.: Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes. Cardiovasc Res 2005, 65:832-41. URL

    Di-Poi, N., Ng, C. Y., Tan, N. S., Yang, Z., Hemmings, B. A., Desvergne, B., Michalik, L., Wahli, W.: Epithelium-mesenchyme interactions control the activity of peroxisome proliferator-activated receptor beta/delta during hair follicle development. Mol Cell Biol 2005, 25:1696-712. URL

    Genolet, R., Kersten, S., Braissant, O., Mandard, S., Tan, N. S., Bucher, P., Desvergne, B., Michalik, L., Wahli, W.: Promoter rearrangements cause species-specific hepatic regulation of the glyoxylate reductase/hydroxypyruvate reductase gene by the peroxisome proliferator-activated receptor alpha. J Biol Chem 2005, 280:24143-52. URL

    Metzger, D., Imai, T., Jiang, M., Takukawa, R., Desvergne, B., Wahli, W., Chambon, P.: Functional role of RXRs and PPARgamma in mature adipocytes. Prostaglandins Leukot Essent Fatty Acids 2005, 73:51-8. URL

    Gremlich, S., Nolan, C., Roduit, R., Burcelin, R., Peyot, M. L., Delghingaro-Augusto, V., Desvergne, B., Michalik, L., Prentki, M., Wahli, W.: Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation. Endocrinology 2005, 146:375-82. URL

    Tan, N. S., Michalik, L., Desvergne, B., Wahli, W.: Multiple expression control mechanisms of peroxisome proliferator-activated receptors and their target genes. J Steroid Biochem Mol Biol 2005, 93:99-105. URL

    Skrtic, S., Carlsson, L., Ljungberg, A., Linden, D., Michalik, L., Wahli, W., Oscarsson, J.: Decreased expression of peroxisome proliferator-activated receptor alpha and liver fatty acid binding protein after partial hepatectomy of rats and mice. Liver Int 2005, 25:33-40. URL

    Zandbergen, F., Mandard, S., Escher, P., Tan, N. S., Patsouris, D., Jatkoe, T., Rojas-Caro, S., Madore, S., Wahli, W., Tafuri, S., Muller, M., Kersten, S.: The G0/G1 switch gene 2 is a novel PPAR target gene. Biochem J 2005, 392:313-24. URL

    Yang, Z. Z., Tschopp, O., Di-Poi, N., Bruder, E., Baudry, A., Dummler, B., Wahli, W., Hemmings, B. A.: Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice. Mol Cell Biol 2005, 25:10407-18. URL

    Debril, M. B., Dubuquoy, L., Feige, J. N., Wahli, W., Desvergne, B., Auwerx, J., Gelman, L.: Scaffold attachment factor B1 directly interacts with nuclear receptors in living cells and represses transcriptional activity. J Mol Endocrinol 2005, 35:503-17. URL

    Letavernier, E., Perez, J., Joye, E., Bellocq, A., Fouqueray, B., Haymann, J. P., Heudes, D., Wahli, W., Desvergne, B., Baud, L.: Peroxisome proliferator-activated receptor beta/delta exerts a strong protection from ischemic acute renal failure. J Am Soc Nephrol 2005, 16:2395-402. URL

    Bedu, E., Wahli, W., Desvergne, B.: Peroxisome proliferator-activated receptor beta/delta as a therapeutic target for metabolic diseases. Expert Opin Ther Targets 2005, 9:861-73. URL

    Rousseaux, C., Lefebvre, B., Dubuquoy, L., Lefebvre, P., Romano, O., Auwerx, J., Metzger, D., Wahli, W., Desvergne, B., Naccari, G. C., Chavatte, P., Farce, A., Bulois, P., Cortot, A., Colombel, J. F., Desreumaux, P.: Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma. J Exp Med 2005, 201:1205-15. URL

    Sellers, J. A., Hou, L., Schoenberg, D. R., Batistuzzo de Medeiros, S. R., Wahli, W., Shelness, G. S.: Microsomal triglyceride transfer protein promotes the secretion of Xenopus laevis vitellogenin A1. J Biol Chem 2005, 280:13902-5. URL

    Gelman, L., Michalik, L., Desvergne, B., Wahli, W.: Kinase signaling cascades that modulate peroxisome proliferator-activated receptors. Curr Opin Cell Biol 2005, 17:216-22. URL

    Kostadinova, R., Wahli, W., Michalik, L.: PPARs in diseases: control mechanisms of inflammation. Curr Med Chem 2005, 12:2995-3009. URL

    Genolet, R, Michalik, L, Wahli, W: Peroxisome Proliferator Activated Receptors In Signaling pathways in liver diseases Edited by Dufour, J-F, Clavien, P-A; Berlin, Heidelberg, New York: Springer; 2005: 267-280.


2004

 

 
    Wang, D., Wang, H., Shi, Q., Katkuri, S., Walhi, W., Desvergne, B., Das, S. K., Dey, S. K., DuBois, R. N.: Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer Cell 2004, 6:285-95. URL

    Auwerx, J., Avner, P., Baldock, R., Ballabio, A., Balling, R., Barbacid, M., Berns, A., Bradley, A., Brown, S., Carmeliet, P., Chambon, P., Cox, R., Davidson, D., Davies, K., Duboule, D., Forejt, J., Granucci, F., Hastie, N., de Angelis, M. H., Jackson, I., Kioussis, D., Kollias, G., Lathrop, M., Lendahl, U., Malumbres, M., von Melchner, H., Muller, W., Partanen, J., Ricciardi-Castagnoli, P., Rigby, P., Rosen, B., Rosenthal, N., Skarnes, B., Stewart, A. F., Thornton, J., Tocchini-Valentini, G., Wagner, E., Wahli, W., Wurst, W.: The European dimension for the mouse genome mutagenesis program. Nat Genet 2004, 36:925-7. URL

    Tan, N. S., Michalik, L., Di-Poi, N., Ng, C. Y., Mermod, N., Roberts, A. B., Desvergne, B., Wahli, W.: Essential role of Smad3 in the inhibition of inflammation-induced PPARbeta/delta expression. Embo J 2004, 23:4211-21. URL

    Rieusset, J., Seydoux, J., Anghel, S. I., Escher, P., Michalik, L., Soon Tan, N., Metzger, D., Chambon, P., Wahli, W., Desvergne, B.: Altered growth in male peroxisome proliferator-activated receptor gamma (PPARgamma) heterozygous mice: involvement of PPARgamma in a negative feedback regulation of growth hormone action. Mol Endocrinol 2004, 18:2363-77. URL

    Di-Poi, N., Michalik, L., Desvergne, B., Wahli, W.: Functions of peroxisome proliferator-activated receptors (PPAR) in skin homeostasis. Lipids 2004, 39:1093-9. URL

    Ijpenberg, A., Tan, N. S., Gelman, L., Kersten, S., Seydoux, J., Xu, J., Metzger, D., Canaple, L., Chambon, P., Wahli, W., Desvergne, B.: In vivo activation of PPAR target genes by RXR homodimers. Embo J 2004, 23:2083-91. URL

    Imai, T., Takakuwa, R., Marchand, S., Dentz, E., Bornert, J. M., Messaddeq, N., Wendling, O., Mark, M., Desvergne, B., Wahli, W., Chambon, P., Metzger, D.: Peroxisome proliferator-activated receptor gamma is required in mature white and brown adipocytes for their survival in the mouse. Proc Natl Acad Sci U S A 2004, 101:4543-7. URL

    Mutch, D. M., Anderle, P., Fiaux, M., Mansourian, R., Vidal, K., Wahli, W., Williamson, G., Roberts, M. A.: Regional variations in ABC transporter expression along the mouse intestinal tract. Physiol Genomics 2004, 17:11-20. URL

    Desvergne, B., Michalik, L., Wahli, W.: Be fit or be sick: peroxisome proliferator-activated receptors are down the road. Mol Endocrinol 2004, 18:1321-32. URL

    Patsouris, D., Mandard, S., Voshol, P. J., Escher, P., Tan, N. S., Havekes, L. M., Koenig, W., Marz, W., Tafuri, S., Wahli, W., Muller, M., Kersten, S.: PPARalpha governs glycerol metabolism. J Clin Invest 2004, 114:94-103. URL

    Sanguino, E., Ramon, M., Michalik, L., Wahli, W., Alegret, M., Sanchez, R. M., Vazquez-Carrera, M., Laguna, J. C.: Lack of hypotriglyceridemic effect of gemfibrozil as a consequence of age-related changes in rat liver PPARalpha. Biochem Pharmacol 2004, 67:157-66. URL

    Michalik, L., Desvergne, B., Wahli, W.: Peroxisome-proliferator-activated receptors and cancers: complex stories. Nat Rev Cancer 2004, 4:61-70. URL

    Jove, M., Salla, J., Planavila, A., Cabrero, A., Michalik, L., Wahli, W., Laguna, J. C., Vazquez-Carrera, M.: Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone. J Lipid Res 2004, 45:113-23. URL

    Tan, N. S., Michalik, L., Di-Poi, N., Desvergne, B., Wahli, W.: Critical roles of the nuclear receptor PPARbeta (peroxisome-proliferator-activated receptor beta) in skin wound healing. Biochem Soc Trans 2004, 32:97-102. URL

    Tan, N. S., Michalik, L., Desvergne, B., Wahli, W.: Peroxisome proliferator-activated receptor-beta as a target for wound healing drugs. Expert Opin Ther Targets 2004, 8:39-48. URL

    Genolet, R., Wahli, W., Michalik, L.: PPARs as drug targets to modulate inflammatory responses?. Curr Drug Targets Inflamm Allergy 2004, 3:361-75. URL

    Mandard, S., Zandbergen, F., Tan, N. S., Escher, P., Patsouris, D., Koenig, W., Kleemann, R., Bakker, A., Veenman, F., Wahli, W., Muller, M., Kersten, S.: The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF/PGAR/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment. J Biol Chem 2004, 279:34411-20. URL

    Mao-Qiang, M., Fowler, A. J., Schmuth, M., Lau, P., Chang, S., Brown, B. E., Moser, A. H., Michalik, L., Desvergne, B., Wahli, W., Li, M., Metzger, D., Chambon, P. H., Elias, P. M., Feingold, K. R.: Peroxisome-proliferator-activated receptor (PPAR)-gamma activation stimulates keratinocyte differentiation. J Invest Dermatol 2004, 123:305-12. URL

    Wang, D., Wang, H., Shi, Q., Katkuri, S., Wahli, W., Desvergne, B., Das, S.K., Dey, S.K., DuBois, R.N.: Prostaglandin E(2) promotes colorectal adenoma growth via transactivation of the nuclear peroxisome proliferator-activated receptor delta. Cancer cell 2004, 6:285-95.

    Wahli, W., Michalik, L., Desvergne, B.: PPARs in health and disease : central roles in energy homeostasis and tissue repair. BIO 2004, 11:26-31.

    Kersten, S., Escher, P., Tafuri, S., Wahli, W.: Understanding the coordinated effects of PPARs on lipid metabolism using microarrays In Unraveling Lipid Metabolism with Microarrays Taylor and Francis Books, CRC Press; 2004: 249-263.


2003

 

 
    Jackson, L., Wahli, W., Michalik, L., Watson, S. A., Morris, T., Anderton, K., Bell, D. R., Smith, J. A., Hawkey, C. J., Bennett, A. J.: Potential role for peroxisome proliferator activated receptor (PPAR) in preventing colon cancer. Gut 2003, 52:1317-22. URL

    Di-Poi, N., Michalik, L., Tan, N. S., Desvergne, B., Wahli, W.: The anti-apoptotic role of PPARbeta contributes to efficient skin wound healing. J Steroid Biochem Mol Biol 2003, 85:257-65. URL

    Jalouli, M., Carlsson, L., Ameen, C., Linden, D., Ljungberg, A., Michalik, L., Eden, S., Wahli, W., Oscarsson, J.: Sex difference in hepatic peroxisome proliferator-activated receptor alpha expression: influence of pituitary and gonadal hormones. Endocrinology 2003, 144:101-9. URL

    Hellemans, K., Michalik, L., Dittie, A., Knorr, A., Rombouts, K., De Jong, J., Heirman, C., Quartier, E., Schuit, F., Wahli, W., Geerts, A.: Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells. Gastroenterology 2003, 124:184-201. URL

    Hellemans, K., Rombouts, K., Quartier, E., Dittie, A. S., Knorr, A., Michalik, L., Rogiers, V., Schuit, F., Wahli, W., Geerts, A.: PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation. J Lipid Res 2003, 44:280-95. URL

    Michalik, L., Desvergne, B., Wahli, W.: Peroxisome proliferator-activated receptors beta/delta: emerging roles for a previously neglected third family member. Curr Opin Lipidol 2003, 14:129-35. URL

    Tan, N. S., Michalik, L., Desvergne, B., Wahli, W.: Peroxisome proliferator-activated receptor (PPAR)-beta as a target for wound healing drugs: what is possible?. Am J Clin Dermatol 2003, 4:523-30. URL

    Michalik, L., Tan, N. S., Wahli, W., Desvergne, B.: PPARs: nuclear receptors involved in the control of inflammation In Cellular proteins and their fatty acids in health and disease Volume Chapter 24. Edited by Duttaroy, AK , Spener, F; Weinheim: Wiley VCH; 2003: 419-435.


2002

 

 
    Di-Poi, N., Tan, N. S., Michalik, L., Wahli, W., Desvergne, B.: Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway. Mol Cell 2002, 10:721-33. URL

    Rieusset, J., Touri, F., Michalik, L., Escher, P., Desvergne, B., Niesor, E., Wahli, W.: A new selective peroxisome proliferator-activated receptor gamma antagonist with antiobesity and antidiabetic activity. Mol Endocrinol 2002, 16:2628-44. URL

    Hihi, A. K., Michalik, L., Wahli, W.: PPARs: transcriptional effectors of fatty acids and their derivatives. Cell Mol Life Sci 2002, 59:790-8. URL

    Fauconnet, S., Lascombe, I., Chabannes, E., Adessi, G. L., Desvergne, B., Wahli, W., Bittard, H.: Differential regulation of vascular endothelial growth factor expression by peroxisome proliferator-activated receptors in bladder cancer cells. J Biol Chem 2002, 277:23534-43. URL

    Tan, N. S., Shaw, N. S., Vinckenbosch, N., Liu, P., Yasmin, R., Desvergne, B., Wahli, W., Noy, N.: Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription. Mol Cell Biol 2002, 22:5114-27. URL

    Michalik, L., Desvergne, B., Dreyer, C., Gavillet, M., Laurini, R. N., Wahli, W.: PPAR expression and function during vertebrate development. Int J Dev Biol 2002, 46:105-14. URL

    Wahli, W.: Peroxisome proliferator-activated receptors (PPARs): from metabolic control to epidermal wound healing. Swiss Med Wkly 2002, 132:83-91. URL

    Ciana, P., Vegeto, E., Beato, M., Chambon, P., Gustafsson, J. A., Parker, M., Wahli, W., Maggi, A.: Looking at nuclear receptors from the heights of Erice. Workshop on nuclear receptor structure and function. EMBO Rep 2002, 3:125-9. URL

    Kersten, S., Desvergne, B., Wahli, W.: Peroxisome Proliferator Activated Receptor alpha coordinates intermediary metabolism during fasting In PPARs : fom basic science to clinical applications Volume 18. Edited by J-C Fruchart, A-M Gotto , R Paoletti, B Staels; Dordrecht, Boston, London: Kluwers Academic Publishers; 2002: 1-4.

    Desvergne, B., Michalik, L., Wahli, W.: Sensors for metabolic control : A regulatory network of nuclear receptors In Hormone signaling Edited by Goffin, V. , Kelly, P. A. ; Norwell: Kluwer Academic Publishers; 2002: 283-304.


2001

 

 
    Kersten, S., Mandard, S., Escher, P., Gonzalez, F. J., Tafuri, S., Desvergne, B., Wahli, W.: The peroxisome proliferator-activated receptor alpha regulates amino acid metabolism. Faseb J 2001, 15:1971-8. URL

    Escher, P., Braissant, O., Basu-Modak, S., Michalik, L., Wahli, W., Desvergne, B.: Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology 2001, 142:4195-202. URL

    Komar, C. M., Braissant, O., Wahli, W., Curry, T. E., Jr.: Expression and localization of PPARs in the rat ovary during follicular development and the periovulatory period. Endocrinology 2001, 142:4831-8. URL

    Tan, N. S., Michalik, L., Noy, N., Yasmin, R., Pacot, C., Heim, M., Fluhmann, B., Desvergne, B., Wahli, W.: Critical roles of PPAR beta/delta in keratinocyte response to inflammation. Genes Dev 2001, 15:3263-77. URL

    Michalik, L., Desvergne, B., Tan, N. S., Basu-Modak, S., Escher, P., Rieusset, J., Peters, J. M., Kaya, G., Gonzalez, F. J., Zakany, J., Metzger, D., Chambon, P., Duboule, D., Wahli, W.: Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice. J Cell Biol 2001, 154:799-814. URL

    Poirier, H., Niot, I., Monnot, M. C., Braissant, O., Meunier-Durmort, C., Costet, P., Pineau, T., Wahli, W., Willson, T. M., Besnard, P.: Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine. Biochem J 2001, 355:481-8. URL

    Desreumaux, P., Dubuquoy, L., Nutten, S., Peuchmaur, M., Englaro, W., Schoonjans, K., Derijard, B., Desvergne, B., Wahli, W., Chambon, P., Leibowitz, M. D., Colombel, J. F., Auwerx, J.: Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies. J Exp Med 2001, 193:827-38. URL

    Rieusset, J., Wahli, W., Desvergne, B.: Les récepteurs nucéaires PPARs (Peroxisome Proliferator Activated Receptors) : Trois isotypes pour de multiples fonctions. Médecine Thérapeutique Endocrinologie 2001, 3:4-12.


2000

 

 
    Kersten, S., Mandard, S., Tan, N. S., Escher, P., Metzger, D., Chambon, P., Gonzalez, F. J., Desvergne, B., Wahli, W.: Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. J Biol Chem 2000, 275:28488-93. URL

    Robyr, D., Gegonne, A., Wolffe, A. P., Wahli, W.: Determinants of vitellogenin B1 promoter architecture. HNF3 and estrogen responsive transcription within chromatin. J Biol Chem 2000, 275:28291-300. URL

    Kersten, S., Desvergne, B., Wahli, W.: Roles of PPARs in health and disease. Nature 2000, 405:421-4. URL

    Escher, P., Wahli, W.: Peroxisome proliferator-activated receptors: insight into multiple cellular functions. Mutat Res 2000, 448:121-38. URL

    Robyr, D., Wolffe, A. P., Wahli, W.: Nuclear hormone receptor coregulators in action: diversity for shared tasks. Mol Endocrinol 2000, 14:329-47. URL

    ten Heggeler-Bordier, B., Muller, S., Monestier, M., Wahli, W.: An immuno-electron microscopical analysis of transcribing multinucleosomal templates: what happens to the histones?. J Mol Biol 2000, 299:853-8. URL

    Lascombe, I., Beffa, D., Ruegg, U., Tarradellas, J., Wahli, W.: Estrogenic activity assessment of environmental chemicals using in vitro assays: identification of two new estrogenic compounds. Environ Health Perspect 2000, 108:621-9. URL

    Lazennec, G., Canaple, L., Saugy, D., Wahli, W.: Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators. Mol Endocrinol 2000, 14:1962-75. URL

    Michalik, L., Desvergne, B., Wahli, W.: Les bases moléculaires de l'obésité : vers de nouvelles thérapeutiques ?. Médecines Sciences 2000, 16:1030-1039.

    Michalik, L., Desvergne, B., Basu-Modak, S., Tan, N. S., Wahli, W.: Nuclear hormone receptors and mouse skin homeostasis: implication of PPARbeta. Horm Res 2000, 54:263-8. URL

    Kersten, S., Wahli, W.: Peroxisome proliferator activated receptor agonists In New approches to drug development Volume 89. Basel: Birkhaüser Publishers; 2000: 141-51.


1999

 

 
    Bernard, P., Goudonnet, H., Artur, Y., Desvergne, B., Wahli, W.: Activation of the mouse TATA-less and human TATA-containing UDP-glucuronosyltransferase 1A1 promoters by hepatocyte nuclear factor 1. Mol Pharmacol 1999, 56:526-36. URL

    Desvergne, B., Wahli, W.: Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 1999, 20:649-88. URL

    Di Croce, L., Okret, S., Kersten, S., Gustafsson, J. A., Parker, M., Wahli, W., Beato, M.: Steroid and nuclear receptors. Villefranche-sur-Mer, France, May 25-27, 1999. Embo J 1999, 18:6201-10. URL

    Kersten, S., Seydoux, J., Peters, J. M., Gonzalez, F. J., Desvergne, B., Wahli, W.: Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest 1999, 103:1489-98. URL

    Basu-Modak, S., Braissant, O., Escher, P., Desvergne, B., Honegger, P., Wahli, W.: Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures. J Biol Chem 1999, 274:35881-8. URL

    Michalik, L., Wahli, W.: Peroxisome proliferator-activated receptors: three isotypes for a multitude of functions. Curr Opin Biotechnol 1999, 10:564-70. URL

    Devchand, P. R., Hihi, A. K., Perroud, M., Schleuning, W. D., Spiegelman, B. M., Wahli, W.: Chemical probes that differentially modulate PPARalpha and BLTR, nuclear and cell surface receptors for leukotriene B(4). J Biol Chem 1999, 274:23341-8. URL

    Wahli, W., Kersten, S., Devchand, P., Desvergne, B.: PPARα : cross-talk with membrane receptors and control of energy homeostasis In Common Diseases - Genetic and Pathogenic Aspects of Multifactorial Diseases Volume 1181. Edited by H. Imura, M Kasuga , K. Nakao; 1999: 159-167.

    Wahli, W., Devchand, P. R., IJpenberg, A., Desvergne, B.: Fatty acids, eicosanoids, and hypolipidemic agents regulate gene expression through direct binding to peroxisome proliferator-activated receptors. Adv Exp Med Biol 1999, 447:199-209. URL

    Kersten, S., Wahli, W.: Adopting orphans : finding ligands In Nuclear Receptors : A Practical Approach Edited by D. Picard; Oxford: Oxford University Press; 1999: 71-93.

    Hihi, A. K., Wahli, W.: Structure and function of the estrogen receptor In Estrogens and antiestrogens I. Handbook of Experimental Pharmacolog Volume 135/I. Edited by Springer Verlag; Heilderberg: 1999: 111-126.

    Devchand, P. R., Ijpenberg, A., Devergne, B., Wahli, W.: PPARs: nuclear receptors for fatty acids, eicosanoids, and xenobiotics. Adv Exp Med Biol 1999, 469:231-6. URL


1998

 

 
    Tsai-Pflugfelder, M., Gasser, S. M., Wahli, W.: Functional interaction between the estrogen receptor and CTF1: analysis of the vitellogenin gene B1 promoter in yeast. Mol Endocrinol 1998, 12:1525-41. URL

    Marilley, D., Robyr, D., Schild-Poulter, C., Wahli, W.: Regulation of the vitellogenin gene B1 promoter after transfer into hepatocytes in primary cultures. Mol Cell Endocrinol 1998, 141:79-93. URL

    Braissant, O., Wahli, W.: Differential expression of peroxisome proliferator-activated receptor-alpha, -beta, and -gamma during rat embryonic development. Endocrinology 1998, 139:2748-54. URL

    Cattley, R. C., DeLuca, J., Elcombe, C., Fenner-Crisp, P., Lake, B. G., Marsman, D. S., Pastoor, T. A., Popp, J. A., Robinson, D. E., Schwetz, B., Tugwood, J., Wahli, W.: Do peroxisome proliferating compounds pose a hepatocarcinogenic hazard to humans?. Regul Toxicol Pharmacol 1998, 27:47-60. URL

    Desvergne, B., IJpenberg, A., Devchand, P. R., Wahli, W.: The peroxisome proliferator-activated receptors at the cross-road of diet and hormonal signalling. J Steroid Biochem Mol Biol 1998, 65:65-74. URL

    Devchand, P., Wahli, W.: Leukotriene B4 : agonist for the fat regulator PPARα In Leukotrienes : New Concepts and Targets for Therapy Edited by Rodger, I. , Botting, J. , Dahlén, S.-E. ; London: William Harvey Press; 1998: 119-124.

    Braissant, O., Wahli, W.: A simplified in situ hybridization protocol using non-radioactively labelled probes to detect abundant and rare mRNAs on tissue sections. Biochemica 1998, 1:10-16.


1997

 

 
    Juge-Aubry, C., Pernin, A., Favez, T., Burger, A. G., Wahli, W., Meier, C. A., Desvergne, B.: DNA binding properties of peroxisome proliferator-activated receptor subtypes on various natural peroxisome proliferator response elements. Importance of the 5'-flanking region. J Biol Chem 1997, 272:25252-9. URL

    Nunez, S. B., Medin, J. A., Braissant, O., Kemp, L., Wahli, W., Ozato, K., Segars, J. H.: Retinoid X receptor and peroxisome proliferator-activated receptor activate an estrogen responsive gene independent of the estrogen receptor. Mol Cell Endocrinol 1997, 127:27-40. URL

    Krey, G., Braissant, O., L'Horset, F., Kalkhoven, E., Perroud, M., Parker, M. G., Wahli, W.: Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol Endocrinol 1997, 11:779-91. URL

    Batistuzzo de Medeiros, S. R., Krey, G., Hihi, A. K., Wahli, W.: Functional interactions between the estrogen receptor and the transcription activator Sp1 regulate the estrogen-dependent transcriptional activity of the vitellogenin A1 io promoter. J Biol Chem 1997, 272:18250-60. URL

    Masmoudi, T., Hihi, A. K., Vazquez, M., Artur, Y., Desvergne, B., Wahli, W., Goudonnet, H.: Transcriptional regulation by triiodothyronine of the UDP-glucuronosyltransferase family 1 gene complex in rat liver. Comparison with induction by 3-methylcholanthrene. J Biol Chem 1997, 272:17171-5. URL

    Keller, H., Devchand, P. R., Perroud, M., Wahli, W.: PPAR alpha structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents. Biol Chem 1997, 378:651-5. URL

    Ijpenberg, A., Jeannin, E., Wahli, W., Desvergne, B.: Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor heterodimer binding to DNA. A functional analysis of the malic enzyme gene PPAR response element. J Biol Chem 1997, 272:20108-17. URL

    Poirier, H., Braissant, O., Niot, I., Wahli, W., Besnard, P.: 9-cis-retinoic acid enhances fatty acid-induced expression of the liver fatty acid-binding protein gene. FEBS Lett 1997, 412:480-4. URL

    Willson, T. M., Wahli, W.: Peroxisome proliferator-activated receptor agonists. Curr Opin Chem Biol 1997, 1:235-41. URL

    Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., Lehmann, J. M.: Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc Natl Acad Sci U S A 1997, 94:4318-23. URL

    Keller, H., Wahli, W.: Steroid hormone and related receptors In Principles of Medical Biology, Molecular and Cellular Endocrinology Volume 10A. Edited by Bittar, E.E. , Bittar, N. ; Greenwich, USA: JAI Press Inc.; 1997: 255-296.

    Devchand, P., Wahli, W.: Tempting fate with fat In Hormones and Signalling Volume 1. Edited by Academic Press; 1997: 235-256.


1996

 

 
    Shalev, A., Siegrist-Kaiser, C. A., Yen, P. M., Wahli, W., Burger, A. G., Chin, W. W., Meier, C. A.: The peroxisome proliferator-activated receptor alpha is a phosphoprotein: regulation by insulin. Endocrinology 1996, 137:4499-502. URL

    Devchand, P. R., Keller, H., Peters, J. M., Vazquez, M., Gonzalez, F. J., Wahli, W.: The PPARalpha-leukotriene B4 pathway to inflammation control. Nature 1996, 384:39-43. URL

    Lemberger, T., Saladin, R., Vazquez, M., Assimacopoulos, F., Staels, B., Desvergne, B., Wahli, W., Auwerx, J.: Expression of the peroxisome proliferator-activated receptor alpha gene is stimulated by stress and follows a diurnal rhythm. J Biol Chem 1996, 271:1764-9. URL

    Braissant, O., Foufelle, F., Scotto, C., Dauca, M., Wahli, W.: Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology 1996, 137:354-66. URL

    Lemberger, T., Braissant, O., Juge-Aubry, C., Keller, H., Saladin, R., Staels, B., Auwerx, J., Burger, A. G., Meier, C. A., Wahli, W.: PPAR tissue distribution and interactions with other hormone-signaling pathways. Ann N Y Acad Sci 1996, 804:231-51. URL

    Lemberger, T., Desvergne, B., Wahli, W.: Peroxisome proliferator-activated receptors: a nuclear receptor signaling pathway in lipid physiology. Annu Rev Cell Dev Biol 1996, 12:335-63. URL


1995

 

 
    Roulet, E., Armentero, M. T., Krey, G., Corthesy, B., Dreyer, C., Mermod, N., Wahli, W.: Regulation of the DNA-binding and transcriptional activities of Xenopus laevis NFI-X by a novel C-terminal domain. Mol Cell Biol 1995, 15:5552-62. URL

    Mahfoudi, A., Roulet, E., Dauvois, S., Parker, M. G., Wahli, W.: Specific mutations in the estrogen receptor change the properties of antiestrogens to full agonists. Proc Natl Acad Sci U S A 1995, 92:4206-10. URL

    Wahli, W., Braissant, O., Desvergne, B.: Peroxisome proliferator activated receptors: transcriptional regulators of adipogenesis, lipid metabolism and more. Chem Biol 1995, 2:261-6. URL

    ten Heggeler-Bordier, B., Schild-Poulter, C., Chapel, S., Wahli, W.: Fate of linear and supercoiled multinucleosomic templates during transcription. Embo J 1995, 14:2561-9. URL

    Juge-Aubry, C. E., Gorla-Bajszczak, A., Pernin, A., Lemberger, T., Wahli, W., Burger, A. G., Meier, C. A.: Peroxisome proliferator-activated receptor mediates cross-talk with thyroid hormone receptor by competition for retinoid X receptor. Possible role of a leucine zipper-like heptad repeat. J Biol Chem 1995, 270:18117-22. URL

    Keller, H., Givel, F., Perroud, M., Wahli, W.: Signaling cross-talk between peroxisome proliferator-activated receptor/retinoid X receptor and estrogen receptor through estrogen response elements. Mol Endocrinol 1995, 9:794-804. URL

    Krey, G., Mahfoudi, A., Wahli, W.: Functional interactions of peroxisome proliferator-activated receptor, retinoid-X receptor, and Sp1 in the transcriptional regulation of the acyl-coenzyme-A oxidase promoter. Mol Endocrinol 1995, 9:219-31. URL

    Alevizopoulos, A., Dusserre, Y., Tsai-Pflugfelder, M., von der Weid, T., Wahli, W., Mermod, N.: A proline-rich TGF-beta-responsive transcriptional activator interacts with histone H3. Genes Dev 1995, 9:3051-66. URL

    Schoonjans, K., Watanabe, M., Suzuki, H., Mahfoudi, A., Krey, G., Wahli, W., Grimaldi, P., Staels, B., Yamamoto, T., Auwerx, J.: Induction of the acyl-coenzyme A synthetase gene by fibrates and fatty acids is mediated by a peroxisome proliferator response element in the C promoter. J Biol Chem 1995, 270:19269-76. URL

    Jansen, J. H., Mahfoudi, A., Rambaud, S., Lavau, C., Wahli, W., Dejean, A.: Multimeric complexes of the PML-retinoic acid receptor alpha fusion protein in acute promyelocytic leukemia cells and interference with retinoid and peroxisome-proliferator signaling pathways. Proc Natl Acad Sci U S A 1995, 92:7401-5. URL

    Nunez, S. B., Medin, J. A., Keller, H., Wang, K., Ozato, K., Wahli, W., Segars, J.: Retinoid X receptor beta and peroxisome proliferator-activated receptor activate an estrogen response element. Recent Prog Horm Res 1995, 50:409-16. URL

    Krey, G., Keller, H., Mahfoudi, A., Wahli, W.: PPARs : Nuclear hormone receptors controlling peroxisomal fatty acid β-oxidation In Functions and Biogenesis of Peroxisomes in Relation to Human Disease Edited by R.J.A. Wanders, R.B.H. Schutgens , H.F. Tabak; North-Holland, Amsterdam, Oxford, New York, Tokyo: 1995: 167-200.

    Desvergne, B., Wahli, W.: PPAR : A key factor in nutrient/gene interactions In Inducible Transcription Volume 1. Edited by Baeuerle, P. ; Boston, Basel, Berlin: Birkhäuser; 1995: 142-176.

    Desvergne, B., Wahli, W.: PPAR: a key nuclear factor in nutrient/gene interactions ? In Inducible transcription Volume 1. Edited by Baeuerle, P. ; Boston: Birkhäuser; 1995: 142-176.


1994

 

 
    Lemberger, T., Staels, B., Saladin, R., Desvergne, B., Auwerx, J., Wahli, W.: Regulation of the peroxisome proliferator-activated receptor alpha gene by glucocorticoids. J Biol Chem 1994, 269:24527-30. URL

    Claret, F. X., Chapel, S., Garces, J., Tsai-Pflugfelder, M., Bertholet, C., Shapiro, D. J., Wittek, R., Wahli, W.: Two functional forms of the Xenopus laevis estrogen receptor translated from a single mRNA species. J Biol Chem 1994, 269:14047-55. URL

    Marilley, D., Mahfoudi, A., Wahli, W.: Gene transfer into Xenopus hepatocytes: transcriptional regulation by members of the nuclear receptor superfamily. Mol Cell Endocrinol 1994, 101:227-36. URL

    Cardinaux, J. R., Chapel, S., Wahli, W.: Complex organization of CTF/NF-I, C/EBP, and HNF3 binding sites within the promoter of the liver-specific vitellogenin gene. J Biol Chem 1994, 269:32947-56. URL

    Green, S., Wahli, W.: Peroxisome proliferator-activated receptors: finding the orphan a home. Mol Cell Endocrinol 1994, 100:149-53. URL

    Ellinger-Ziegelbauer, H., Hihi, A. K., Laudet, V., Keller, H., Wahli, W., Dreyer, C.: FTZ-F1-related orphan receptors in Xenopus laevis: transcriptional regulators differentially expressed during early embryogenesis. Mol Cell Biol 1994, 14:2786-97. URL


1993

 

 
    Keller, H., Dreyer, C., Medin, J., Mahfoudi, A., Ozato, K., Wahli, W.: Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers. Proc Natl Acad Sci U S A 1993, 90:2160-4. URL

    Keller, H., Mahfoudi, A., Dreyer, C., Hihi, A. K., Medin, J., Ozato, K., Wahli, W.: Peroxisome proliferator-activated receptors and lipid metabolism. Ann N Y Acad Sci 1993, 684:157-73. URL

    Schild, C., Claret, F. X., Wahli, W., Wolffe, A. P.: A nucleosome-dependent static loop potentiates estrogen-regulated transcription from the Xenopus vitellogenin B1 promoter in vitro. Embo J 1993, 12:423-33. URL

    Krey, G., Keller, H., Mahfoudi, A., Medin, J., Ozato, K., Dreyer, C., Wahli, W.: Xenopus peroxisome proliferator activated receptors: genomic organization, response element recognition, heterodimer formation with retinoid X receptor and activation by fatty acids. J Steroid Biochem Mol Biol 1993, 47:65-73. URL

    Segars, J. H., Marks, M. S., Hirschfeld, S., Driggers, P. H., Martinez, E., Grippo, J. F., Brown, M., Wahli, W., Ozato, K.: Inhibition of estrogen-responsive gene activation by the retinoid X receptor beta: evidence for multiple inhibitory pathways. Mol Cell Biol 1993, 13:2258-68. URL

    Wahli, W.: Fatty acids control gene expression through members of the nuclear receptor superfamily In Schering Lecturer's Publication Volume 18. Schering Lecturer's Publication; 1993: 1-24.

    Keller, H., Wahli, W.: Peroxisome Proliferator-Activated Receptors. A link between endocrinology and nutrition ?. Trends in Endocrinology and Metabolism 1993, 4:291-296.

    Dreyer, C., Keller, H., Mahfoudi, A., Laudet, V., Krey, G., Wahli, W.: Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR). Biol Cell 1993, 77:67-76. URL


1992

 

 
    Dreyer, C., Krey, G., Keller, H., Givel, F., Helftenbein, G., Wahli, W.: Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors. Cell 1992, 68:879-87. URL

    ten Heggeler-Bordier, B., Wahli, W., Adrian, M., Stasiak, A., Dubochet, J.: The apical localization of transcribing RNA polymerases on supercoiled DNA prevents their rotation around the template. Embo J 1992, 11:667-72. URL

    Ourednik, W, Wahli, W., Van der Loos, H: The developing mouse whiskerpad : pattern formation at the periphery of a highly organized somatosensory pathway In Development of the Central Nervous System in Vertebrates Volume 234. Edited by S.C. Sharma and A.M. Goffinet, NATO ASI SERIES; Plenum Press; 1992: 145-165.


1991

 

 
    Lebeau, M. C., Alvarez-Bolado, G., Wahli, W., Catsicas, S.: PCR driven DNA-DNA competitive hybridization: a new method for sensitive differential cloning. Nucleic Acids Res 1991, 19:4778. URL

    Lebeau, M. C., Alvarez-Bolado, G., Braissant, O., Wahli, W., Catsicas, S.: Ribosomal protein L27 is identical in chick and rat. Nucleic Acids Res 1991, 19:1337. URL

    Wahli, W., Martinez, E.: Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression. Faseb J 1991, 5:2243-9. URL

    Martinez, E., Dusserre, Y., Wahli, W., Mermod, N.: Synergistic transcriptional activation by CTF/NF-I and the estrogen receptor involves stabilized interactions with a limiting target factor. Mol Cell Biol 1991, 11:2937-45. URL

    Martinez, E., Givel, F., Wahli, W.: A common ancestor DNA motif for invertebrate and vertebrate hormone response elements. Embo J 1991, 10:263-8. URL

    Corthesy, B., Corthesy-Theulaz, I., Cardinaux, J. R., Wahli, W.: A liver protein fraction regulating hormone-dependent in vitro transcription from the vitellogenin genes induces their expression in Xenopus oocytes. Mol Endocrinol 1991, 5:159-69. URL

    ten Heggeler-Bordier, B., Wahli, W.: Electron microscopy visualization of protein-DNA complexes In A Laboratory Guide to In Vitro Studies of Protein-DNA Interactions Volume 5. Edited by Birkhäuser, BioMethods ; Basel, Boston, Berlin: 1991: 153-161.

    Martinez, E., Wahli, W.: Characterization of hormone response elements In Nuclear Hormone Receptors Edited by M.G. Parker ; London: Academic Press; 1991: 125-153.


1990

 

 
    Corthesy, B., Claret, F. X., Wahli, W.: Estrogen receptor level determines sex-specific in vitro transcription from the Xenopus vitellogenin promoter. Proc Natl Acad Sci U S A 1990, 87:7878-82. URL

    Adrian, M., ten Heggeler-Bordier, B., Wahli, W., Stasiak, A. Z., Stasiak, A., Dubochet, J.: Direct visualization of supercoiled DNA molecules in solution. Embo J 1990, 9:4551-4. URL

    Corthesy, B., Leonnard, P., Wahli, W.: Transcriptional potentiation of the vitellogenin B1 promoter by a combination of both nucleosome assembly and transcription factors: an in vitro dissection. Mol Cell Biol 1990, 10:3926-33. URL

    Theulaz, I., Wahli, W.: Preparation of nuclear extract from Xenopus oocytes injected with an expression vector encoding a transcription factor and functional analysis of the newly synthesized protein. DNA and Protein Engineering Techniques 1990, 2:65-68.

    Corthesy, B., Wahli, W.: A protocol for the preparation of nuclear extracts capable of estrogen-dependent in vitro transcription.. DNA and Protein Engineering Techniques 1990, 2:68-71.


1989

 

 
    Tremea, F., Batistuzzo de Medeiros, S. R., ten Heggeler-Bordier, B., Germond, J. E., Seiler-Tuyns, A., Wahli, W.: Identification of two steroid-responsive promoters of different strength controlled by the same estrogen-responsive element in the 5'-end region of the Xenopus laevis vitellogenin gene A1. Mol Endocrinol 1989, 3:1596-609. URL

    Haefliger, D. N., Moskaitis, J. E., Schoenberg, D. R., Wahli, W.: Amphibian albumins as members of the albumin, alpha-fetoprotein, vitamin D-binding protein multigene family. J Mol Evol 1989, 29:344-54. URL

    Martinez, E., Wahli, W.: Cooperative binding of estrogen receptor to imperfect estrogen-responsive DNA elements correlates with their synergistic hormone-dependent enhancer activity. Embo J 1989, 8:3781-91. URL

    Corthesy, B., Cardinaux, J. R., Claret, F. X., Wahli, W.: A nuclear factor I-like activity and a liver-specific repressor govern estrogen-regulated in vitro transcription from the Xenopus laevis vitellogenin B1 promoter. Mol Cell Biol 1989, 9:5548-62. URL

    Wahli, W., Martinez, E., Corthesy, B., Cardinaux, J. R.: cis- and trans-acting elements of the estrogen-regulated vitellogenin gene B1 of Xenopus laevis. J Steroid Biochem 1989, 34:17-32. URL


1988

 

 
    Seiler-Tuyns, A., Merillat, A. M., Haefliger, D. N., Wahli, W.: The human estrogen receptor can regulate exogenous but not endogenous vitellogenin gene promoters in a Xenopus cell line. Nucleic Acids Res 1988, 16:8291-305. URL

    Green, S., Kumar, V., Theulaz, I., Wahli, W., Chambon, P.: The N-terminal DNA-binding 'zinc finger' of the oestrogen and glucocorticoid receptors determines target gene specificity. Embo J 1988, 7:3037-44. URL

    ten Heggler-Bordier, B., Claret, F. X., Wahli, W.: Immuno-electron microscopic identification of human estrogen receptor-DNA complexes at the estrogen-responsive element and in the first intron of a Xenopus vitellogenin gene. J Mol Biol 1988, 204:217-20. URL

    Corthesy, B., Hipskind, R., Theulaz, I., Wahli, W.: Estrogen-dependent in vitro transcription from the vitellogenin promoter in liver nuclear extracts. Science 1988, 239:1137-9. URL

    Theulaz, I., Hipskind, R., ten Heggeler-Bordier, B., Green, S., Kumar, V., Chambon, P., Wahli, W.: Expression of human estrogen receptor mutants in Xenopus oocytes: correlation between transcriptional activity and ability to form protein-DNA complexes. Embo J 1988, 7:1653-60. URL

    Shapiro, D. J., Sharp, P. A., Wahli, W. W., Keller, M. J.: A high-efficiency HeLa cell nuclear transcription extract. DNA 1988, 7:47-55. URL

    Wahli, W.: Evolution and expression of vitellogenin genes. Trends Genet 1988, 4:227-32. URL

    Wahli, W., Seiler-Tuyns, A., Theulaz, I., Corthesy, B.: Mise en activité sélective d'un gène par une hormone. UNI Lausanne 1988, 54:22-25.

    Wahli, W.: Le génie génétique et les biotechnologies au service de l'homme. Semailles et moissons 1988, 100:8-12.

    Wahli, W.: La vie : objet de laboratoire ?. Actes 1988, 83:6-11.


1987

 

 
    Nardelli, D., Gerber-Huber, S., van het Schip, F. D., Gruber, M., Ab, G., Wahli, W.: Vertebrate and nematode genes coding for yolk proteins are derived from a common ancestor. Biochemistry 1987, 26:6397-402. URL

    Nardelli, D., van het Schip, F. D., Gerber-Huber, S., Haefliger, J. A., Gruber, M., Ab, G., Wahli, W.: Comparison of the organization and fine structure of a chicken and a Xenopus laevis vitellogenin gene. J Biol Chem 1987, 262:15377-85. URL

    Gerber-Huber, S., Nardelli, D., Haefliger, J. A., Cooper, D. N., Givel, F., Germond, J. E., Engel, J., Green, N. M., Wahli, W.: Precursor-product relationship between vitellogenin and the yolk proteins as derived from the complete sequence of a Xenopus vitellogenin gene. Nucleic Acids Res 1987, 15:4737-60. URL

    Haefliger, J. A., Tschopp, J., Nardelli, D., Wahli, W., Kocher, H. P., Tosi, M., Stanley, K. K.: Complementary DNA cloning of complement C8 beta and its sequence homology to C9. Biochemistry 1987, 26:3551-6. URL

    ten Heggeler-Bordier, B., Hipskind, R., Seiler-Tuyns, A., Martinez, E., Corthesy, B., Wahli, W.: Electron microscopic visualization of protein-DNA interactions at the estrogen responsive element and in the first intron of the Xenopus laevis vitellogenin gene. Embo J 1987, 6:1715-20. URL

    Martinez, E., Givel, F., Wahli, W.: The estrogen-responsive element as an inducible enhancer: DNA sequence requirements and conversion to a glucocorticoid-responsive element. Embo J 1987, 6:3719-27. URL

    Cooper, D. N., Gerber-Huber, S., Nardelli, D., Schubiger, J. L., Wahli, W.: The distribution of the dinucleotide CpG and cytosine methylation in the vitellogenin gene family. J Mol Evol 1987, 25:107-15. URL


1986

 

 
    Schubiger, J. L., Wahli, W.: Transposition of a bacterial IS3 element into a Xenopus Vi-element. Nucleic Acids Res 1986, 14:7814. URL

    Seiler-Tuyns, A., Walker, P., Martinez, E., Merillat, A. M., Givel, F., Wahli, W.: Identification of estrogen-responsive DNA sequences by transient expression experiments in a human breast cancer cell line. Nucleic Acids Res 1986, 14:8755-70. URL

    Schubiger, J. L., Wahli, W.: Linkage arrangement in the vitellogenin gene family of Xenopus laevis as revealed by gene segregation analysis. Nucleic Acids Res 1986, 14:8723-34. URL


1985

 

 
    ten Heggeler, B., Wahli, W.: Visualization of RNA polymerase II ternary transcription complexes formed in vitro on a Xenopus laevis vitellogenin gene. Embo J 1985, 4:2269-73. URL

    Schubiger, J. L., Germond, J. E., ten Heggeler, B., Wahli, W.: The Vi element. A transposon-like repeated DNA sequence interspersed in the vitellogenin locus of Xenopus laevis. J Mol Biol 1985, 186:491-503. URL

    Zoll, B., Arnemann, J., Krawczak, M., Cooper, D. N., Pescia, G., Wahli, W., Steinbach, P., Schmidtke, J.: Evidence against close linkage of the loci for fraXq of Martin-Bell syndrome and for factor IX. Hum Genet 1985, 71:122-6. URL

    Wahli, W., Ryffel, G. U.: Xenopus vitellogenin genes. Oxf Surv Eukaryot Genes 1985, 2:96-120. URL


1984

 

 
    Knowland, J., Theulaz, I., Wright, C. V., Wahli, W.: Injection of partially purified estrogen receptor protein from Xenopus liver nuclei into oocytes activates the silent vitellogenin locus. Proc Natl Acad Sci U S A 1984, 81:5777-81. URL

    Walker, P., Germond, J. E., Brown-Luedi, M., Givel, F., Wahli, W.: Sequence homologies in the region preceding the transcription initiation site of the liver estrogen-responsive vitellogenin and apo-VLDLII genes. Nucleic Acids Res 1984, 12:8611-26. URL

    Germond, J. E., Walker, P., ten Heggeler, B., Brown-Luedi, M., de Bony, E., Wahli, W.: Evolution of vitellogenin genes: comparative analysis of the nucleotide sequences downstream of the transcription initiation site of four Xenopus laevis and one chicken gene. Nucleic Acids Res 1984, 12:8595-609. URL


1983

 

 
    Ryffel, G. U., Muellener, D. B., Gerber-Huber, S., Wyler, T., Wahli, W.: Scattering of repetitive DNA sequences in the albumin and vitellogenin gene loci of Xenopus laevis. Nucleic Acids Res 1983, 11:7701-16. URL

    Germond, J. E., ten Heggeler, B., Schubiger, J. L., Walker, P., Westley, B., Wahli, W.: Vitellogenin B2 gene in Xenopus laevis: isolation, in vitro transcription and relation to other vitellogenin genes. Nucleic Acids Res 1983, 11:2979-97. URL

    Walker, P., Brown-Luedi, M., Germond, J. E., Wahli, W., Meijlink, F. C., van het Schip, A. D., Roelink, H., Gruber, M., Ab, G.: Sequence homologies within the 5' end region of the estrogen-controlled vitellogenin gene in Xenopus and chicken. Embo J 1983, 2:2271-9. URL

    Ryffel, G. U., Wahli, W.: Regulation and structure of the vitellogenin genes In Eucaryotic genes : Their structure, activity and regulation Edited by Butterworths; London: 1983: 329-341.


1982

 

 
    Wahli, W., Germond, J. E., ten Heggeler, B., May, F. E.: Vitellogenin genes A1 and B1 are linked in the Xenopus laevis genome. Proc Natl Acad Sci U S A 1982, 79:6832-6. URL

    Wahli, W.: Analyses critiques de l'expression génétique. Dialectica 1982, 36:71-81.


1981

 

 
    Ryffel, G. U., Muellener, D. B., Wyler, T., Wahli, W., Weber, R.: Transcription of single-copy vitellogenin gene of Xenopus involves expression of middle repetitive DNA. Nature 1981, 291:429-31. URL

    Wahli, W., Dawid, I. B., Ryffel, G. U., Weber, R.: Vitellogenesis and the vitellogenin gene family. Science 1981, 212:298-304. URL


1980

 

 
    Wahli, W., Dawid, I. B., Wyler, T., Weber, R., Ryffel, G. U.: Comparative analysis of the structural organization of two closely related vitellogenin genes in X. laevis. Cell 1980, 20:107-17. URL

    Wahli, W., Dawid, I. B.: Isolation of two closely related vitellogenin genes, including their flanking regions, from a Xenopus laevis gene library. Proc Natl Acad Sci U S A 1980, 77:1437-41. URL

    Felber, B. K., Maurhofer, S., Jaggi, R. B., Wyler, T., Wahli, W., Ryffel, G. U., Weber, R.: Isolation and translation in vitro of four related vitellogenin mRNAs of estrogen-stimulated Xenopus laevis. Eur J Biochem 1980, 105:17-24. URL


1979

 

 
    Wahli, W., Dawid, I. B., Wyler, T., Jaggi, R. B., Weber, R., Ryffel, G. U.: Vitellogenin in Xenopus laevis is encoded in a small family of genes. Cell 1979, 16:535-49. URL

    Dawid, I. B., Wahli, W.: Application of recombinant DNA technology to questions of developmental biology: a review. Dev Biol 1979, 69:305-28. URL


1978

 

 
    Wahli, W., Wyler, T., Weber, R., Ryffel, G. U.: Electron-microscopic demonstration of terminal and internal initiation sites for cDNA synthesis on vitellogenin mRNA. Eur J Biochem 1978, 86:225-34. URL

    Wahli, W., Ryffel, G. U., Wyler, T., Jaggi, F. B., Weber, R., Dawid, I. B.: Cloning and characterization of synthetic sequences from the Xenopus iaevis vitellogenin structural gene. Dev Biol 1978, 67:371-83. URL

    Wahli, W., Abraham, I., Weber, R.: Retention of the differentiated state by larval Xenopus liver cells in primary culture. Wilhelm Roux's Archives 1978,
    235-248. URL

    Wahli, W.: The vitellogenin gene in Xenopus laevis In Carnegie Institution Year Book Volume 77. 1978: 95-103.


1977

 

 
    Ryffel, G. U., Wahli, W., Weber, R.: Quantitation of vitellogenin messenger RNA in the liver of male Xenopus toads during primary and secondary stimulation by estrogen. Cell 1977, 11:213-21. URL

    Wahli, W. , Weber, R.: Factors promoting the establishment of primary cultures of liver cells from Xenopus larvae. Wilhelm Roux's Archives 1977,
    347-360. URL

    Wahli, W.: Untersuchungen über die Oestrogen-abhängige Synthese von Vitellogenin messenger RNA in der Leber von Xenopus laevis. 1977, Thesis:


1976

 

 
    Wahli, W., Wyler, T., Weber, R., Ryffel, G. U.: Size, complexity and abundance of a specific poly(A)-containing RNA of liver from male Xenopus induced to vitellogenin synthesis by estrogen. Eur J Biochem 1976, 66:457-65. URL


Search:
 in this site:
   
   
   
 Rechercher

Génopode - CH-1015 Lausanne  - Switzerland  -  Phone +41 21 692 39 00  -  Fax  +41 21 692 39 05