Prof. Christian S. Hardtke

Writes papers and research grants, teaches plant biology, suggests experiments.

- Full Professor at the University of Lausanne since 2010

- Director of the Plant Molecular Biology Department since 2009

- Associate Professor at the University of Lausanne since 2004

- Assistant Professor at McGill University from 2001 to 2005

- Human Frontier Science Program post-doctoral fellow at Yale University from 1998 to 2000

- Post-doctoral associate at the University of Toronto in 1998

- Ph.D. (Dr. rer. nat.) from the University of Munich in 1997

Scientific publications

46. Eavan Dorcey, Antia Rodriguez-Villalon, Paula Salinas, Luca Santuari, Sylvain Pradervand, Keith Harshman and Christian S. Hardtke (2012): Context-dependent dual role of SKI8 homologs in mRNA synthesis and turnover. PLoS Genetics, Vol. 8: e1002652.

45. David Pacheco-Villalobos and Christian S. Hardtke (2012): Natural genetic variation of root system architecture from Arabidopsis to Brachypodium: towards adaptive value. Philosophical Transactions of the Royal Society B, Vol. 367: pp. 1552-1558.

44. Luca Santuari, Emanuele Scacchi, Antia Rodriguez-Villalon, Paula Salinas, Esther M.N. Dohmann, Geraldine Brunoud, Teva Vernoux, Richard S. Smith and Christian S. Hardtke (2011): Positional information by differential endocytosis splits auxin response to drive Arabidopsis root meristem growth. Current Biology, Vol. 21: pp. 1918-1923.

43. Laura Ragni, Kaisa Nieminen, David Pacheco-Villalobos, Richard Sibout, Claus Schwechheimer and Christian S. Hardtke (2011): A direct stimulatory role of mobile gibberellin in Arabidopsis hypocotyl xylem expansion. The Plant Cell, Vol. 23: pp. 1322-1336.

42. Martial Sankar, Karen S. Osmont, Jacub Rolcik, Bojan Gujas, Danuse Tarkowska, Miroslav Strnad, Ioannis Xenarios and Christian S. Hardtke (2011): A qualitative continuous model of cellular auxin and brassinosteroid signaling and their crosstalk. Bioinformatics, Vol. 27, pp. 1404-1412.

41. Stephen Depuydt and Christian S. Hardtke (2011): Hormone Signalling Crosstalk in Plant Growth Regulation. Current Biology, Vol. 21: pp. R365-R373.

40. Christian S. Hardtke and Kaisa Nieminen (2011): Advances in identifying and exploiting natural genetic variation. Plant biotechnology and agriculture: Prospects for the 21st century, pp. 195-205.

39. Emanuele Scacchi, Paula Salinas, Bojan Gujas, Luca Santuari, Naden Krogan, Laura Ragni, Thomas Berleth and Christian S. Hardtke (2010): Spatio-temporal sequence of cross-regulatory events in root meristem growth. Proceedings of the National Academy of Sciences U.S.A., Vol. 107: pp. 22734-22739.

38. Luca Santuari and Christian S. Hardtke (2010): The case for resequencing studies of Arabidopsis thaliana accessions: mining the dark matter of natural genetic variation. Faculty of 1000 Reports, Vol 2: pp. 85.

37. Julien Beuchat, Emanuele Scacchi, Danuse Tarkowska, Laura Ragni, Miroslav Strnad and Christian S. Hardtke (2010): BRX promotes Arabidopsis shoot growth. New Phytologist, Vol. 188: pp. 23-29.

36. Julien Beuchat, Shuwei Li, Laura Ragni, Chikako Shindo, Michael H. Kohn and Christian S. Hardtke (2010): A hyperactive QTL allele of Arabidopsis BRX contributes to natural variation in root growth vigor. Proceedings of the National Academy of Sciences U.S.A., Vol. 107: pp. 8475-8480.

35. Luca Santuari, Sylvain Pradervand, Amelia-Maria Amiguet-Vercher, Jerome Thomas, Eavan Dorcey, Keith Harshman, Ioannis Xenarios, Thomas E. Juenger and Christian S. Hardtke (2010): Substantial deletion overlap among divergent Arabidopsis genomes revealed by intersection of short reads and tiling arrays. Genome Biology, Vol. 11: pp. R4.

34. Sébastien Haye and Christian S. Hardtke (2009): The Roundtable on Sustainable Biofuels: plant scientist input needed. Trends in Plant Science, Vol. 14: pp. 409-412.

33. Emanuele Scacchi, Karen S. Osmont, Julien Beuchat, Paula Salinas, Marisa Navarrete-Gómez, Marina Trigueros, Cristina Ferrándiz and Christian S. Hardtke (2009): Dynamic, auxin-responsive plasma membrane to nucleus movement of Arabidopsis BRX. Development, Vol. 136: pp. 2059-2067.

32. Stephanie Plantegenet, Johann Weber, Darlene R. Goldstein, Georg Zeller, Cindy Nussbaumer, Jerome Thomas, Detlef Weigel, Keith Harshman and Christian S. Hardtke (2009): Comprehensive analysis of Arabidopsis expression level polymorphisms with simple inheritance. Molecular Systems Biology, 5, 242.

31. Americo Rodrigues, Julia Santiago, Silvia Rubio, Angela Saez, Karen S. Osmont, Jose Gadea, Christian S. Hardtke and Pedro L. Rodriguez (2009): The short-rooted phenotype of the brevis radix mutant partly reflects root ABA hypersensitivity. Plant Physiology, Vol. 149: pp. 1917-28.

30. Chikako Shindo, Giorgina Bernasconi and Christian S. Hardtke (2008): Intra-specific competition reveals conditional fitness effects of single gene polymorphism at the Arabidopsis root growth regulator BRX. New Phytologist, Vol. 180: pp. 71-80.

29. Karen S. Osmont and Christian S. Hardtke (2008): The topless plant developmental phenotype explained! Genome Biology, Vol. 9: pp. 219-222.

28. Richard Sibout, Stephanie Plantegenet and Christian S. Hardtke (2008): Flowering as a condition for xylem expansion in Arabidopsis hypocotyl & root. Current Biology, Vol. 18: pp. 458-463.

27. Christian S. Hardtke and Keiko U. Torii (2008): Plant growth and development - the new wave. Current Opinions in Plant Biology, Vol. 11: pp. 1-3.

26. Christian S. Hardtke, Eavan Dorcey, Karen S. Osmont and Richard Sibout (2007): Phytohormone collaboration: zooming in on auxin-brassinosteroid interactions. Trends in Cell Biology, Vol. 17: pp. 485-492.

25. Christian S. Hardtke (2007): Transcriptional auxin-brassinosteroid crosstalk: who's talking? BioEssays, Vol. 29: pp. 1115-1123.

24. Karen S. Osmont, Richard Sibout and Christian S. Hardtke (2007): Hidden Branches: Developments in Root System Architecture. Annual Review of Plant Biology, Vol. 58: pp. 93-113.

23. Chikako Shindo, Giorgina Bernasconi and Christian S. Hardtke (2007): Natural genetic variation in Arabidopsis: tools, traits and prospects for Evolutionary Ecology. Annals of Botany, Vol. 99: pp. 1043-1054.

22. Richard Sibout, Poornima Sukuma, Chamari Hettiarachchi, Magnus Holm, Gloria K. Muday and Christian S. Hardtke (2006): Opposite root growth phenotypes of hy5 vs. hy5 hyh mutants correlate with increased constitutive auxin signaling. PLoS Genetics, Vol. 2: pp. 1898-1911, e202.

21. Céline F. Mouchel, Karen S. Osmont and Christian S. Hardtke (2006): BRX mediates feedback between brassinosteroid levels and auxin signalling in root growth. Nature, Vol. 443: pp. 458-461.

20. Georgette C. Briggs, Karen S. Osmont, Chikako Shindo, Richard Sibout and Christian S. Hardtke (2006): Unequal genetic redundancies in Arabidopsis - a neglected phenomenon? Trends in Plant Sciences, Vol. 11: pp. 492-498.

19. Georgette C. Briggs, Céline F. Mouchel and Christian S. Hardtke (2006): Characterization of the plant-specific BRX gene family reveals limited genetic redundancy despite high sequence conservation. Plant Physiology, Vol. 140: pp. 1306-1316.

18. Christian S. Hardtke (2006): Root development - branching into novel spheres. Current Opinions in Plant Biology, Vol. 9: pp. 66-71.

17. Céline F. Mouchel, Georgette C. Briggs and Christian S. Hardtke (2004): Natural genetic variation in Arabidopsis identifies BREVIS RADIX, a novel regulator of cell proliferation and elongation in the root. Genes & Development, Vol. 18: pp. 700-714.

16. Corinne P. Cluis, Céline F. Mouchel and Christian S. Hardtke (2004): The Arabidopsis transcription factor HY5 integrates light and hormone signaling pathways. The Plant Journal, Vol. 38: pp. 332-347.

15. Christian S. Hardtke, Wenzislava Ckurshumova, Danielle P. Vidaurre, Sasha A. Singh, George Stamatiou, Shiv B. Tiwari, Gretchen Hagen, Tom J. Guilfoyle and Thomas Berleth (2004): Overlapping and non-redundant functions of the Arabidopsis Auxin Response Factors MONOPTEROS and NONPHOTOTROPIC HYPOCOTYL 4. Development, Vol. 131: pp. 1089-1100.

14. Christian S. Hardtke, 2003: Gibberellin Signaling: GRASs Growing Roots. Current Biology, Vol. 13: pp. R366-R367.

13. Peter Kosarev, Klaus F.X. Mayer and Christian S. Hardtke (2002): Evaluation and classification of RING finger domains encoded by the Arabidopsis genome. Genome Biology, Vol. 3: pp. 16.1-16.12.

12. Christian S. Hardtke, Haruko Okamoto, Chatanika Stoop-Myer and Xing-Wang Deng (2002): Biochemical evidence for ubiquitin ligase activity of the COP1 interacting protein CIP8. The Plant Journal, Vol. 30: pp. 385-394.

11. Magnus Holm, Christian S. Hardtke, Rachelle Gaudet and Xing-Wang Deng (2001): Identification of a structural motif that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1. The EMBO Journal, Vol. 20: pp. 118-127.

10. Christian S. Hardtke and Xing-Wang Deng (2000): The cell biology of the COP/DET/FUS proteins. Regulating proteolysis in photomorphogenesis and beyond? Plant Physiology, Vol. 124: pp. 1548-1557.

9. Christian S. Hardtke, Kazuhito Gohda, Mark T. Osterlund, Tokitaka Oyama, Kiyotaka Okada and Xing-Wang Deng (2000): HY5 stability and activity in Arabidopsis is regulated by a phosphorylation in its COP1 binding domain. The EMBO Journal, Vol. 19: pp. 4997-5006.

8. Mark T. Osterlund, Christian S. Hardtke, Ning Wei and Xing-Wang Deng (2000): Targeted destabilization of HY5 during light-regulated development of Arabidopsis. Nature, Vol. 405: pp. 462-466.

7. Thomas Berleth, Jim Mattsson and Christian S. Hardtke (2000): Vascular continuity and auxin signals. Trends in Plant Sciences, Vol. 5: pp. 387-393.

6. Thomas Berleth, Jim Mattsson and Christian S. Hardtke (2000): Vascular continuity, cell axialization and auxin. Plant Growth Regulation, Vol. 32: pp. 173-185.

5. Christian S. Hardtke and Thomas Berleth (1998): The Arabidopsis gene MONOPTEROS encodes a transcription factor mediating embryo axis formation and vascular development. The EMBO Journal, Vol. 17: pp. 1405-1411.

4. Thomas Berleth, Christian S. Hardtke, Gerhard K.H. Przemeck and Judith Müller (1996): Mutational analysis of root initiation in the Arabidopsis embryo. Plant and Soil, Vol. 187: pp. 1-9.

3. Christian S. Hardtke and Thomas Berleth (1996): Genetic and contig map of a 2200-kb region encompassing 5.5 cM on chromosome 1 of Arabidopsis thaliana. Genome, Vol. 39: pp. 1086-1092.

2. Christian S. Hardtke, Judith Müller and Thomas Berleth (1996): Genetic similarity among Arabidopsis thaliana ecotypes estimated from DNA sequence comparison. Plant Molecular Biology, Vol. 32: pp. 915-922.

1. Gerhard K.H. Przemeck, Jim Mattsson, Christian S. Hardtke, Z. Renée Sung and Thomas Berleth (1996): Studies on the role of the Arabidopsis gene MONOPTEROS in vascular development and plant cell axialization. Planta, Vol. 200: pp. 229-237.

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