Computational Biology & Cancer Genomics group
Research in our group focuses on computational and system biology approaches to study functional interrelationships between molecular alterations selected in cancer. Computational biology studies focus on the design and development of systematic approaches to nominate candidate functional alterations from molecular profiles of human tumors, how these events are mutually dependent and what are the therapeutic implications of these dependencies. Along these lines current projects investigate recurrent epigenetic modifications in cancer, mutually exclusive and concurrent alterations between and within tumors, and associations between oncogenic signatures and therapeutic response in cancer cell lines. Cancer genomics studies focus instead on the molecular profiling and analyses of tumor cohorts to characterize their genetic bases and discover potential therapeutic vulnerabilities. Ongoing projects are conducted in collaboration with the TCGA consortium, of which our group is a member, and internal collaborations with groups within the Swiss Cancer Center Lausanne (SCCL). Here, areas of interest include, but are not limited to, skin cutaneous melanoma and breast cancer.