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Yok-Ai Que<br>MER, Chef de projet

| Research Interests | Curriculum vitae | Publications
 

Research theme: Microbial pathogenesis

Research Interests

  • Endocarditis & Endovascular infections
  • Pathogenesis of Gram-positive Infections
  • Staphylococcal Diseases
  • Sepsis & Critical Care

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Curriculum vitae

Present Position

  Maître d'Enseignement et de Recherche (MER), Department of Fundamental Microbiology, University of Lausanne, Switzerland

Education

01/1997-10/2000 MD-PhD, Infectious Diseases Laboratory, Prs. MP. Glauser & Ph. Moreillon, University of Lausanne, Switzerland
01/1999 MD, Infectious Diseases Laboratory, Prs. MP. Glauser & Ph. Moreillon, University of Lausanne, Switzerland
12/1996 Swiss Federal Diploma of Physician, University of Lausanne, Swizerland
09/1990-12/1996 Medical School, University of Lausanne, Switzerland
06/1990 Bachelor of Science, Collège de l'Abbaye de St-Maurice, Switzerland

Internships and Residencies

Attending Physician

01/2007 Department of adult critical care medicine, Pr. René Chioléro, CHUV, Lausanne

Resident

02/2006-12/2006 Department of adult critical care medicine, Pr. René Chioléro, CHUV, Lausanne
04/2005-02/2006  Critical care medicine, Surgical Patients, Pr. René Chioléro, CHUV, Lausanne
04/2003-04/2005 Critical care medicine, Medical Patients, Pr. MD Schaller, CHUV, Lausanne

Clinical Fellow

10/2002-03/2003 Immunology, Prs. Pantaleo et Spertini, CHUV, Lausanne
07/2002-09/2002 Infectious diseases, Pr. Francioli, CHUV, Lausanne
01/2002-06/2002 Critical care medicine, Medical Patients, Pr. MD Schaller, CHUV, Lausanne
07/2001-12/2001 Emergency medicine, Pr. Yersin, CHUV, Lausanne
04/2001-06/2001 Cardiology, Pr. Kappenberger, CHUV, Lausanne
10/2000-03/2001 Internal Medicine, Pr. Burkhardt, CHUV, Lausanne

Licensure and Certification

2006 Specialist FMH, Board in Critical care medicine
2001 PhD, University of Lausanne, Switzerland
1999 MD, University of Lausanne, Switzerland
1996 Swiss Federal Diploma of Physician, University of Lausanne, Switzerland
1990 Bachelor of Science, Collège de l'Abbaye de St-Maurice, Switzerland

Academic Appointments

01/2007 Maître d'enseignement et de recherche

Hospital Appointments

01/2007 Attending Physician

Honors and Distinctions

2001 Prize of the Société Académique Vaudoise, with mention Lauréat de l'Université, for the PhD degree, University of Lausanne
2000 ICAAC Program Committee Award, 40th ICCAC, Toronto, September 2000
1999 Faculty prize for the MD degree, University of Lausanne
1997 Prize of the city of Ecublens for the Diploma in Medicine, University of Lausanne

 

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Publications

Peer-reviewed publications

  • Que Y-A., Entenza J-M., Francioli P., Moreillon P., The impact of penicillinase on cefamandole treatment and prophylaxis of experimental endocarditis due to methicillin-resistant Staphylococcus aureus, Journal of Infectious Diseases, 1998 ;77 :146-154.

  • Que Y-A., Haefliger J-A., Francioli P., Moreillon P., Expression of Staphylococcus aureus Clumping-factor A in Lactococcus lactis subsp. cremoris using a new shuttle vector. Infection and Immunity, 2000 ;68 :3516-3522.

  • Sinha B., Francois P.,. Que Y-A, Hussain M., Heilmann C., Moreillon P., Lew D.P., Krause K-H., Peters G., Herrmann M. Heterologously expressed Staphylococcus aureus fibronectin-binding proteins are sufficient for invasion of host cells. Infection and Immunity, 2000 ; 68:6871-8.

  • Que Y-A., Francois P., Haefliger J-A., Entenza J-M., Vaudaux P., Moreillon P. Reassessing the role of Staphylococcus aureus clumping-factor and fibronectin-binding protein by expression in Lactococcus lactis. Infection and Immunity ; 69:6296-302, 2001.

  • Cottagnoud P., Entenza J-M., Cottagnoud M., Que Y-A., Moreillon P., Tauber MG. Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae. BMC Microbiology 1(1):9, 2001.

  • Entenza J-M., Que Y-A., Vouillamoz J., Glauser M-P., Moreillon P. Efficacies of moxifloxacin, ciprofloxacin, and vancomycin against experimental endocarditis due to methicillin-resistant Staphylococcus aureus expressing various degrees of ciprofloxacin resistance. Antimicrobial Agents Chemotherapy. 45(11):3076-83, 2001.

  • Que Y-A., Haefliger J-A., Francois P., Entenza J-M., Shina B., Hermann M., Vaudaux P., Francioli P., Moreillon P. The Staphylococcus aureus Fibronectin-binding protein A - but not Clumping-factor - is sufficient for endothelium invasion in experimental endocarditis. Journal of experimental medicine. 201(10) :1627-35, 2005.

  • Aellen S., Que Y-A., Guignard B., Haenni M., Moreillon P. Detection of Live and Antibiotic-Killed Bacteria by Quantitative Real-Time PCR of Specific Fragments of Ribosomal RNA. Antimicrobial Agents Chemotherapy. 50(6) :1913-20, 2006.

  • Widmer E, Que, Y-A., Entenza JM, Moreillon P. New concepts in the pathophysiology of infective endocarditis. Current Infectious Disease Report. 8(4) :271-9, 2006.

  • Que Y-A., Muller O., Liaudet L. Rapid resolution of massive lung abcesses complicating tricuspid valve endocarditis. Circulation, 114(14):e523-4, 2006

  • Heying R., van de Gevel J., Que Y-A., Moreillon P., Beekhuizen H. Fibronectin-binding proteins and clumping factor A in Staphylococcus aureus experimental endocarditis : FnBPA is sufficient to elicit procoagulant and inflammatory responses in human endothelial cells. Thrombosis and Haemostasis, 97(4):617-26, 2007

  • Piroth L, Que YA, Widmer E, Panchaud A, Piu S, Entenza JM, Moreillon P. The fibrinogen- and fibronectin-binding domains of Staphylococcus aureus fibronectin-binding protein A synergistically promote endothelial invasion and experimental endocarditis. Infect Immun. 76(8):3824-31, 2008.

Books and Monographs

  • Moreillon P, Que Y-A., Glauser M-P. Staphylococcus aureus (including toxic shock syndrome).
    In : Principles and practice of infectious diseases. Mandell GL, Bennett JE, Dolin R. 6th edition. 2004.

  • Moreillon P, Bizzini A, Que Y-A. Infective endocarditis in the elderly. In : Principles and practice of geriatric medicine. Pathy John, Sinclair AJ, Morley JE. 4th edition.2006

  • Que Y-A., Bracco D., Chioléro R. Aspects métaboliques et nutritionnels des catécholamines et des glucocorticoïdes. In : Traité de nutrition artificielle de l'adulte. 3rd Edtition. Cano N., Barnoud D., Schneider SM., Vasson M-P, Hasselmann M., Leverve X. 3rd Edition. 2007

Review Articles

  • Moreillon P, Que Y-A., Bayer AS. Pathogenesis of streptococcal and staphylococcal endocarditis. Infectious Disease Clinics of North America. 16(2) :297-318, 2002. Review.

  • Moreillon P, Que Y-A. Infective endocarditis. Lancet 363(9403) :139-49. 2004. Review.

  • Que Y-A., Oddo M., Liaudet L., Moreillon P. Endocardite infectieuse : mise au point. Revue Medicale de la  Suisse Romande. 124(6) :341-6. 2004. Review.

  • Que Y-A., Moreillon P., Francioli P. L'endocardite en pratique ambulatoire. Revue Médicale Suisse. 2(60) :903-6, 2006. Review.

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