Unités de recherche
Collaborators are studying:
- Environmental and evolutionary microbiology (van der Meer)
Bacterial evolution and adaptation related to degradation of toxic compounds. Biochemical mechanisms leading to modification of DNA: small (mutations) and large genetic changes (transpositions, horizontal gene exchange). Study of specificities and modes of action of self-transmissible genomic islands. Genetic characterization of pathways for degradation of hexachlorocyclohexane and mecoprop.
Development of bacterial biosensors: study of regulatory proteins specialized in the perception of the environment, in order to achieve new recognition capabilities of toxic compounds. Development of a biosensor for the detection of arsenic, easily usable in the field in developing countries.
- Microbial pathogenesis (Moreillon)
- Antimicrobial agents and experimental infection (Entenza)
Structure, function and regulation of bacterial molecules interfering with the eucaryotic environment (factors of virulence). Strategies of colonization and invasion of the host in vitro and in vivo. Adaptation to medium change (fever, inflammation). Mechanisms of survival (antibiotic tolerance and resistance). Genomic analysis of virulence genes.
- Molecular mechanisms underlying eukaryotic cell polarization (Martin)
We aim to dissect the fundamental mechanisms by which cells spatially self-organize. The ability to define a polarity axis is a fundamental property that underlies many cellular functions. In particular, we study how cells polarize during their proliferative cycle, how this cellular spatial organization modulates cell cycle progression and how the cell re-organizes during sexual differentiation for formation of a diploid zygote. For this we use fission yeasts, which are amongst the simplest eukaryotic cells.
- Plant disease and pest insect control by beneficial bacteria (Keel)
Molecular interactions between root-colonizing plant-beneficial pseudomonads, phytopathogenic fungi, pest insects and crop plants: traits involved in pant beneficial-activity of the bacteria and regulation of their expression in response to the host.
- Pseudomonas adaptation to its environment and small regulatory RNAs (Lapouge)
- Secondary metabolites of fluorescent pseudomonas (Reimmann)
The adaptation of Pseudomonas aeruginosa, an opportunistic human pathogen to stress conditions. Importance of Pseudmonas aeruginosa virulence factors and their impact on target organisms.
- Quantitative signal transduction in yeast MAPK pathways (Pelet)
The development of new assays to quantify at the single cell level the activity of these signaling pathways. The aim is to understand the regulation of individual pathways and investigate how signaling specificity is achieved in order to avoid cross-talk in these cascades that share a large number of common components.