Yok-Ai Que
MER, Chef de projet

Research theme: Microbial pathogenesis

• Endocarditis & Endovascular infections
• Pathogenesis of Gram-positive Infections
• Staphylococcal Diseases
• Sepsis & Critical Care

Present Position

Education

Internships and Residencies

Attending Physician

Resident

Clinical Fellow

Licensure and Certification

Academic Appointments

Hospital Appointments

Honors and Distinctions

Peer-reviewed publications

• Que Y-A., Entenza J-M., Francioli P., Moreillon P., The impact of penicillinase on cefamandole treatment and prophylaxis of experimental endocarditis due to methicillin-resistant Staphylococcus aureus, Journal of Infectious Diseases, 1998 ;77 :146-154.

• Que Y-A., Haefliger J-A., Francioli P., Moreillon P., Expression of Staphylococcus aureus Clumping-factor A in Lactococcus lactis subsp. cremoris using a new shuttle vector. Infection and Immunity, 2000 ;68 :3516-3522.

• Sinha B., Francois P.,. Que Y-A, Hussain M., Heilmann C., Moreillon P., Lew D.P., Krause K-H., Peters G., Herrmann M. Heterologously expressed Staphylococcus aureus fibronectin-binding proteins are sufficient for invasion of host cells. Infection and Immunity, 2000 ; 68:6871-8.

• Que Y-A., Francois P., Haefliger J-A., Entenza J-M., Vaudaux P., Moreillon P. Reassessing the role of Staphylococcus aureus clumping-factor and fibronectin-binding protein by expression in Lactococcus lactis. Infection and Immunity ; 69:6296-302, 2001.

• Cottagnoud P., Entenza J-M., Cottagnoud M., Que Y-A., Moreillon P., Tauber MG. Sub-inhibitory concentrations of vancomycin prevent quinolone-resistance in a penicillin-resistant isolate of Streptococcus pneumoniae. BMC Microbiology 1(1):9, 2001.

• Entenza J-M., Que Y-A., Vouillamoz J., Glauser M-P., Moreillon P. Efficacies of moxifloxacin, ciprofloxacin, and vancomycin against experimental endocarditis due to methicillin-resistant Staphylococcus aureus expressing various degrees of ciprofloxacin resistance. Antimicrobial Agents Chemotherapy. 45(11):3076-83, 2001.

• Que Y-A., Haefliger J-A., Francois P., Entenza J-M., Shina B., Hermann M., Vaudaux P., Francioli P., Moreillon P. The Staphylococcus aureus Fibronectin-binding protein A - but not Clumping-factor - is sufficient for endothelium invasion in experimental endocarditis. Journal of experimental medicine. 201(10) :1627-35, 2005.

• Aellen S., Que Y-A., Guignard B., Haenni M., Moreillon P. Detection of Live and Antibiotic-Killed Bacteria by Quantitative Real-Time PCR of Specific Fragments of Ribosomal RNA. Antimicrobial Agents Chemotherapy. 50(6) :1913-20, 2006.

• Widmer E, Que, Y-A., Entenza JM, Moreillon P. New concepts in the pathophysiology of infective endocarditis. Current Infectious Disease Report. 8(4) :271-9, 2006.

• Que Y-A., Muller O., Liaudet L. Rapid resolution of massive lung abcesses complicating tricuspid valve endocarditis. Circulation, 114(14):e523-4, 2006

• Heying R., van de Gevel J., Que Y-A., Moreillon P., Beekhuizen H. Fibronectin-binding proteins and clumping factor A in Staphylococcus aureus experimental endocarditis : FnBPA is sufficient to elicit procoagulant and inflammatory responses in human endothelial cells. Thrombosis and Haemostasis, 97(4):617-26, 2007

• Piroth L, Que YA, Widmer E, Panchaud A, Piu S, Entenza JM, Moreillon P. The fibrinogen- and fibronectin-binding domains of Staphylococcus aureus fibronectin-binding protein A synergistically promote endothelial invasion and experimental endocarditis. Infect Immun. 76(8):3824-31, 2008.

Books and Monographs

• Moreillon P, Que Y-A., Glauser M-P. Staphylococcus aureus (including toxic shock syndrome).
  In : Principles and practice of infectious diseases. Mandell GL, Bennett JE, Dolin R. 6th edition. 2004.

• Moreillon P, Bizzini A, Que Y-A. Infective endocarditis in the elderly. In : Principles and practice of geriatric medicine. Pathy John, Sinclair AJ, Morley JE. 4th edition.2006

• Que Y-A., Bracco D., Chioléro R. Aspects métaboliques et nutritionnels des catécholamines et des glucocorticoïdes. In : Traité de nutrition artificielle de l'adulte. 3rd Edtition. Cano N., Barnoud D., Schneider SM., Vasson M-P, Hasselmann M., Leverve X. 3rd Edition. 2007

Review Articles

• Moreillon P, Que Y-A., Bayer AS. Pathogenesis of streptococcal and staphylococcal endocarditis. Infectious Disease Clinics of North America. 16(2) :297-318, 2002. Review.

• Moreillon P, Que Y-A. Infective endocarditis. Lancet 363(9403) :139-49. 2004. Review.

• Que Y-A., Oddo M., Liaudet L., Moreillon P. Endocardite infectieuse : mise au point. Revue Medicale de la  Suisse Romande. 124(6) :341-6. 2004. Review.

• Que Y-A., Moreillon P., Francioli P. L'endocardite en pratique ambulatoire. Revue Médicale Suisse. 2(60) :903-6, 2006. Review.