The Institute of Pharmacology of the University of Lausanne was created in 1962. Actually the research of the Department of Pharmacology and Toxicology (DPT) is related to the identification, the structure, the function, the regulation of receptors, cellular enzymes that represent potential molecules targets of pharmacological and therapeutical interest. This research revolved around the following themes:
- The transepithelial transport and homeostasis of sodium, water, calcium and their implications in renal, cardiovascular, pulmonary, cutaneous pathologies (research groups of O. Bonny, D. Firsov, E. Hummler, B. Rossier, L. Schild and O. Staub).
- G-protein coupled receptors and their mechanisms of intracellular signalization: implications in the phenomena of proliferation development, cellular hypertrophy of the heart or during development (research groups of D. Diviani and V. Katanaev).
- Neurophysiology of pain, of olfaction and taste (research groups of M.-C. Broillet and S. Kellenberger).
The DPT played an active role in the geographical merging of research groups oriented towards human genetic and in the cardiovascular domain. Thus, the Bugnon 27 building has seen the merge of the research groups of the Department of Medical Genetics (DGM) of the UNIL, of the Division of Nephrology of the CHUV, of the Center for Cardiovascular and Metabolic diseases (Cardiomet), and of the group of Thierry Pedrazzini at the Department of Internal Medicine of the CHUV.
In addition, the site of the Bugnon 27 welcomes the platforms for transgenesis (TAF, in charge Edith Hummler, PhD, MER), and for the phenotyping of rodents in the cardiovascular areas (CAF, in charge: Prof, Thierry Pedrazzini (Cardiomet).
The DPT is largely implicated in the teaching of pharmacology to the students of the School of Medicine (Faculty of Biology and Medicine). This teaching, axed on fundamental pharmacology, is given in close collaboration with the Clinical Division of Pharmacology and Toxicology of the CHUV. In the context of the Biomedical Master of the School of Biology, the DPT is responsible for the teaching of pharmacology and toxicology.
Key words: Ionic transport, Ionic channels, Ionic transporters, Receptors coupled to G proteins, Nuclear receptors, Hormones, Arrhythmias, Hypertension, Pain, Olfaction