Publications 2002-2003

Highlighted Topics Selected Contribution in the November 2002 issue of the Journal of Applied Physiology (93:2002), in the special area "Lung Edema Clearance: 20 Years of Progress".
"Limiting Na+ transport rate in airway epithelia from a-ENaC transgenic mice: a model for pulmonary edema"
Reynald Olivier1, Urs Scherrer2, Jean-Daniel Horisberger1, Bernard Rossier1, Edith Hummler1
1 Institut de pharmacologie et de toxicologie, Université de Lausanne, CH-1005 Lausanne
2 Département de médecine interne, Centre hospitalier universitaire vaudois, CH-1005 Lausanne
Contact:
Edith Hummler, PhD, Assistant Professor
Institut de pharmacologie et de toxicologie, Rue du Bugnon 27, CH-1005 Lausanne
Tel. +41 21 692 5357 - Fax. +41 21 692 5355

Nature 420, 788 - 794 (2002):
"Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex"
JOSHUA T. TRACHTENBERG1*, BRIAN E. CHEN*, GRAHAM W. KNOTT2, GUOPING FENG3, JOSHUA R. SANES3, EGBERT WELKER2 & KAREL SVOBODA1
1 Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
2 Institut de Biologie Cellulaire et de Morphologie, Université de Lausanne, Rue du Bugnon 9, CH 1005, Lausanne, Switzerland
3 Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
* These authors contributed equally to this work
This paper is the result of our collaboration with the group of Karel Svoboda at Cold Spring Harbor (CSH) and forms a demonstration of the power of the application of current state-of-the-art imaging techniques: dual-photon microscopy performed at CSH and Graham Knott's skill in 3D reconstruction of serial electron-microscopy at the IBCM. Here it was used to visualize the turn-over of spines and their synapses in the adult mammalian cerebral cortex. Neurons keep actively looking for new connections even in the adult brain. This novel concept will have important implications in research on the molecular mechanisms involved in synapse formation as well as the basis for neuro-degenerative diseases: two research lines that are major goals of research at the IBCM.
In the hope that this will generate inspiration for future collaborations,
Egbert Welker
Contact:
Egbert Welker, PhD, Associate Professor
Institut de biologie cellulaire et de morphologie (IBCM) - Rue du Bugnon 9 - CH-1005 Lausanne
Tel.: +41 21 692 5193/25 - Fax: +41 21 692 5105