Dr Liliane Michalik, MER
Transcriptional control of tissue repair, carcinogenesis and angiogenesis
|
Center for Integrative Genomics UNIL Tel: +41 21 692 41 47 |
 |
Research activities :
- Transcriptional control of tissue repair, carcinogenesis and angiogenesis
Research key words :
- skin repair, UV induced skin cancer, angiogenesis, peroxisome proliferator-activated receptors
Link to our web site
Transcriptional control of tissue repair, carcinogenesis and angiogenesis
Due to its peripheral localization, the skin is prone to be damaged, for instance by mechanical injury or UV radiations. In response to an injury, a cascade of events is initiated, which is aimed at repairing the damage in a life saving process, but which does not lead to complete regeneration. Damage provoked by UVB exposure initiates an inflammatory and DNA repair response, and leads to tumour development after long-term chronic exposure. The murine skin is a valuable model that is widely used to study organ repair and tumour development, two situations that share many cellular and molecular similarities.
We are interested in the transcriptional control of skin wound healing and UVB-induced carcinogenesis by the nuclear hormone receptor PPARs. Using genetically modified mice, various organ and cell culture models, as well as genomic approaches, we study PPAR functions in inflammation, epithelial homeostasis, epithelium-mesenchyme interactions, and angiogenesis.
Representative publications :
-
Chong HC, Tan MJ, Philippe V, Tan SH, Tan CK, Ku CW, Goh YY, Wahli W, Michalik L, Tan NS. 2009. Regulation of epithelial-mesenchymal IL-1 signaling by PPARbeta/delta is essential for skin homeostasis and wound healing. J Cell Biol. Mar 23;184(6):817-31
-
Tan, N.S., G. Icre, A. Montagner, B. Bordier-ten-Heggeler, W. Wahli, and L. Michalik, 2007. The nuclear hormone receptor peroxisome proliferator-activated receptor beta/delta potentiates cell chemotactism, polarization, and migration.Mol Cell Biol. 27:7161-75
-
Michalik. L., B. Desvergne, and W. Wahli. 2004. Peroxisome-proliferator-activated receptors and cancers: complex stories.Nat Rev Cancer. 4:61-70
