Summer School- Cancer

Summer School- Cancer

Department of Biochemistry

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Summer School- Immunology
The summer school in immunology , hosted by the PhD programme in Immunology and Cancer took place on the Epalinges campus between August 26th-29th. Organisers: Prof. Fabienne Tacchini Cottier and Prof. Werner Held.
CSL controls telomere homeostasis in human dermal fibroblasts
In the new paper published in Nature Communications, the group of Gian Paolo Dotto describes the central role of CSL in telomere homeostasis of dermal fibroblasts with important implications for genomic instability of cancer stromal cells
FGF and TGF-β signaling exert opposite roles in the control of cancer-associated...
In the new paper published in Cell Reports, the group of Gian Paolo Dotto describes the dual functions of FGF and TGF-β signaling in the modulation of heterogenous CAF populations promoting cancer development
Lymph node fibroblasts suppress chronic T cell responses via prostanoid release
Dr. Karin Schäuble from Prof. Sanjiv Luther’s lab published an article in PLoS Biology describing how lymph node fibroblasts ( FRC) which act as organizers of the T cell rich zone, constitutively express high levels of the COX2 enzyme responsible for prostaglandin E2 (PGE2) synthesis. This PGE2 inhibits T cell expansion in contrast to its proinflammatory role on innate immune cells. In vivo, fibroblast-expressed COX2 is responsible for suppressing chronic T cell responses. COX inhibitors, such as Aspirin and Ibuprofen, belong to the most used drugs for dampening inflammatory reactions, in part by blocking PGE2 synthesis. These results represent the first direct in vivo evidence for a suppressive role of lymph node fibroblasts on the T cell response
Summer School- Cancer
The summer school in cancer , hosted by the PhD programme in Immunology and Cancer took place on the Epalinges campus between September 3rd to 6th. Organisers: Prof. Monika Hegi, Prof. Tatiana Petrova, Prof. Johanna Joyce
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Switzerland
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