You are hereUNIL > Department of Biochemistry > Research > Research groups > Martinon Fabio

Martinon Fabio, Assistant Professor

| Research interests | Publications | Group members
 




 

Fabio Martinon received his PhD in 2003 from the University of Lausanne for his work on the characterization of the Inflammasome in the laboratory of Jürg Tschopp. After a short post-doctoral fellowship in Jürg Tschopp’s laboratory, he moved in 2006 to the laboratory of Laurie Glimcher at the Harvard School of Public Health, where he investigated the link between inflammatory programs and the endoplasmic reticulum stress response. In August 2010 he joined the Department of Biochemistry as Assistant Professor. His current research focuses on the characterization of signaling pathways emerging from the endoplasmic reticulum.

Fabio.Martinon@unil.ch

Research interests

The endoplasmic reticulum (ER) serves many general functions, including the facilitation of protein folding and the transport of synthesized proteins, but it also has an important role in sensing cellular stress. ER-stress identifies a group of signals that induce a transcriptional program enabling cells to survive protein overload and injury in the ER. This highly coordinated response involves three parallel signaling branches localized at the ER, namely IRE1, ATF6 and PERK.

New findings suggest that these signaling pathways can initiate inflammation and, in specialized cells and tissues, may be involved in the pathogenesis of inflammatory and infectious diseases. However, this is an emerging field of research and little is known on the specific nature of these signaling pathways and their function in regulating immunity. We recently found that TLR4 and TLR2 specifically activate the ER-stress sensor kinase IRE1 and its downstream target, the transcription factor XBP1. Previously described XBP1 ER stress target genes are not induced by TLR signaling. Instead, TLR-activated XBP1 is required for optimal and sustained production of proinflammatory cytokines in macrophages. Consistent with this finding, IRE1 activation by ER-stress synergizes with TLR activation for cytokine production. Moreover, XBP1 deficiency markedly increases bacterial burden in animals infected with the TLR2-activating human pathogen Francisella tularensis.

These findings uncovered an unsuspected critical new function for the XBP1 transcription factor in mammalian host defenses. The knowledge gained from these studies will provide a better understanding of regulatory pathways controlling immune responses and will aid in the development of therapies aimed at improving the outcome of diseases characterized by inflammation and ER-stress.
 

TOP ^

Publications

 Recent Publications

 Full list of Publications: ResearcherID;  Google Scholar

TOP ^

Group members

Bojan Bujisic Ph.D student
Aude de Gassart Postdoctoral fellow
Antonia Di Micco  Ph.D student
Gianluca Frera Ph.D student
Rémy Tallant Ph.D student
Yvan Jamilloux Visiting Ph.D student
Rébecca Panes Premaster student 2013
Léa Zaffalon Technician

 

Alumni

Emma Proïcs Erasmus student  
Marianne Ethenoz Technician  
Einar Castillo Technician  
Zaiyue Shu Student SUR Programme 2013 Shanghai Jiao Tong University
Patricia Renck Nunes Premaster student 2012 UNIL
Nicoletta Corti Premaster student 2012 UNIL
Malak Benslimane Student SUR Programme 2012 Univ. of Wisconsin at Madison
Basiglio Giangreco Premaster student 2011 UNIL
     

 

TOP ^

Search:
 inside this site:
   
   
 Go
 
rss/atom
Chemin des Boveresses 155 - CH-1066 Epalinges  - Switzerland  -  Tel. +41 21 692 5700  -  Fax +41 21 692 5705
Swiss University