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Fasel Nicolas, Full Professor



Nicolas Fasel is full professor at the Faculty of Biology and Medicine of the University of Lausanne. After studying biology at the University of Fribourg (Switzerland) and obtaining a doctoral degree at the Swiss Institute for Experimental Cancer Research working on mouse mammary tumor virus, he took up a post-doctoral position at the University of California Los Angeles working on immunoglobulin gene regulation. On his return to Switzerland, he studied post-translational modifications of cell surface antigens. As an independant researcher of the Dr. Max Cloëtta Research Foundation, he had the opportunity to establish his own group investigating the molecular and cellular biology of protozoan parasites. Since September 2006, he is director of the Department. Since August 2015, he is Vice-Dean for Research and Innovation of the Faculty of Biology and Medicine.

Research Interests


The human parasite Leishmania is the causative agent of leishmaniasis. After malaria, leishmaniasis stands as the most important protozoan parasitic disease in the world, with 350 million people at risk on 5 continents in 98 countries and steadfastly listed in the top 10 most debilitating infectious diseases in the world (according to DALY units). Cutaneous leishmaniasis (CL) is, by far, the most prevalent form of the disease with symptoms ranging from a single self-healing lesion to chronic metastatic leishmaniasis (ML). In an increasingly immunocompromised population, complicated CL is becoming a more likely outcome, characterised by an allergic hyper-reactivity and resulting in severely inflamed, destructive lesions that are often refractory to current treatment. Despite its staggering prevalence and morbidity, it has been categorised as a ‘neglected disease’, with little clinical research interest, no vaccine and a vastly inadequate therapeutic arsenal.

In the past years, our research has centered around immunotyping the response to metastatic Leishmania guyanensis.

As veterans of infection, Leishmania guyanensis parasites have been plaguing humankind for centuries, provoking a deleterious hyper-inflammatory immune response, destroying host tissue and forming the ulcerating lesions, which typify most forms of the disease. About 15% of patients develop secondary lesions in the mouth and nose, where parasites metastasise to mucocutaneous tissues creating debilitating and exceptionally disfiguring inflammation.

Our lab has recently shown that a virus within metastatic Leishmania parasites (Leishmania RNA virus: LRV) can act as an independently immunogenic entity, where its RNA-based nucleic acid acted as a potent innate immunogen, triggering a destructive hyper-inflammatory cascade through Toll-Like-Receptor 3 recognition. We dub this process “hyperpathogenism” and have exposed its importance as major clinical consideration in metastatic leishmaniasis.

By appreciating the microbial-virus as a backseat driver of human disease, we may be able to better formulate appropriate clinical intervention or even exploit its presence for clinical benefit. Further, its presence could act as a biomarker, guiding diagnostics, treatment and phylogenetics as well as a having potential as a novel molecular target for therapeutic and prophylactic intervention.

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Bourreau E., Ginouves M., Prévot G., Hartley M.A., Gangneux J.P., Robert-Gangneux F., Dufour J., Sainte-Marie D., Bertolotti A., Pratlong F. et al., 2016. Presence of Leishmania RNA Virus 1 in Leishmania guyanensis Increases the Risk of First-Line Treatment Failure and Symptomatic Relapse. Journal of Infectious Diseases 213(1) pp. 105-111. [DOI] [Web of Science] [Pubmed]
Dias-Teixeira K.L., Pereira R.M., Silva J.S., Fasel N., Aktas B.H., Lopes U.G., 2016. Unveiling the Role of the Integrated Endoplasmic Reticulum Stress Response in Leishmania Infection - Future Perspectives. Frontiers In Immunology 7 p. 283. [Document] [DOI] [Web of Science] [Pubmed]
Eren R.O., Reverte M., Rossi M., Hartley M.A., Castiglioni P., Prevel F., Martin R., Desponds C., Lye L.F., Drexler S.K. et al., 2016. Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence. Cell Host and Microbe 20(3) pp. 318-328. [embargo 01/09/2017] [DOI] [Web of Science] [Pubmed]
Genes C.M., de Lucio H., González V.M., Sánchez-Murcia P.A., Rico E., Gago F., Fasel N., Jiménez-Ruiz A., 2016. A functional BH3 domain in an aquaporin from Leishmania infantum. Cell Death Discovery 2 p. 16043. [Document] [DOI] [Pubmed]
Hartley M.A., Bourreau E., Rossi M., Castiglioni P., Eren R.O., Prevel F., Couppié P., Hickerson S.M., Launois P., Beverley S.M. et al., 2016. Leishmaniavirus-Dependent Metastatic Leishmaniasis Is Prevented by Blocking IL-17A. Plos Pathogens 12(9) pp. e1005852. [Document] [DOI] [Pubmed]
Martin R, Desponds C, Eren R O, Quadroni M, Thome M, Fasel N, 2016. Caspase-mediated cleavage of raptor participates in the inactivation of mTORC1 during cell death. Cell Death Discovery 2 p. 16024. [Document] [url editor site] [DOI]
Martin R., Thome M., Martinon F., Fasel N., 2016. Raptor hunted by caspases. Cell Death and Disease 7(6) pp. e2242. [Document] [DOI] [Web of Science] [Pubmed]
Parmentier L., Cusini A., Müller N., Zangger H., Hartley M.A., Desponds C., Castiglioni P., Dubach P., Ronet C., Beverley S.M. et al., 2016. Severe Cutaneous Leishmaniasis in a Human Immunodeficiency Virus Patient Coinfected with Leishmania braziliensis and Its Endosymbiotic Virus. American Journal of Tropical Medicine and Hygiene 94(4) pp. 840-843. [Document] [DOI] [Web of Science] [Pubmed]
Casanova M., Gonzalez I.J., Sprissler C., Zalila H., Dacher M., Basmaciyan L., Späth G.F., Azas N., Fasel N., 2015. Implication of different domains of the Leishmania major metacaspase in cell death and autophagy. Cell Death and Disease 6 pp. e1933. [Document] [DOI] [Pubmed]
Ashok D., Schuster S., Ronet C., Rosa M., Mack V., Lavanchy C., Marraco S.F., Fasel N., Murphy K.M., Tacchini-Cottier F. et al., 2014. Cross-presenting dendritic cells are required for control of Leishmania major infection. European Journal of Immunology 44(5) pp. 1422-1432. [DOI] [Web of Science] [Pubmed]
Hartley M.A., Drexler S., Ronet C., Beverley S.M., Fasel N., 2014. The immunological, environmental, and phylogenetic perpetrators of metastatic leishmaniasis. Trends in Parasitology 30(8) pp. 412-422. [Document] [DOI] [Web of Science] [Pubmed]
Ives A., Masina S., Castiglioni P., Prével F., Revaz-Breton M., Hartley M.A., Launois P., Fasel N., Ronet C., 2014. MyD88 and TLR9 dependent immune responses mediate resistance to Leishmania guyanensis infections, irrespective of Leishmania RNA virus burden. PLoS One 9(5) pp. e96766. [Document] [DOI] [Web of Science] [Pubmed]
Martin R., Gonzalez I., Fasel N., 2014. Leishmania metacaspase: an arginine-specific peptidase. Methods in Molecular Biology 1133 pp. 189-202. [Document] [DOI] [Web of Science] [Pubmed]
Zangger H., Hailu A., Desponds C., Lye L.F., Akopyants N.S., Dobson D.E., Ronet C., Ghalib H., Beverley S.M., Fasel N., 2014. Leishmania aethiopica field isolates bearing an endosymbiontic dsRNA virus induce pro-inflammatory cytokine response. PLoS Neglected Tropical Diseases 8(4) pp. e2836. [Document] [DOI] [Web of Science] [Pubmed]
Hartley M.A., Kohl K., Ronet C., Fasel N., 2013. The therapeutic potential of immune cross-talk in leishmaniasis. Clinical Microbiology and Infection 19(2) pp. 119-130. [DOI] [Web of Science] [Pubmed]
Weinkopff T., Mariotto A., Simon G., Hauyon-La Torre Y., Auderset F., Schuster S., Zangger H., Fasel N., Barral A., Tacchini-Cottier F., 2013. Role of Toll-Like Receptor 9 Signaling in Experimental Leishmania braziliensis Infection. Infection and Immunity 81(5) pp. 1575-1584. [DOI] [Web of Science] [Pubmed]
Zangger H., Ronet C., Desponds C., Kuhlmann F.M., Robinson J., Hartley M.A., Prevel F., Castiglioni P., Pratlong F., Bastien P. et al., 2013. Detection of Leishmania RNA virus in Leishmania parasites. PLoS Neglected Tropical Diseases 7(1) pp. e2006. [Document] [DOI] [Web of Science] [Pubmed]
Hartley M.A., Ronet C., Fasel N., 2012. Backseat drivers: the hidden influence of microbial viruses on disease. Current Opinion in Microbiology 15(4) pp. 538-545. [DOI] [Web of Science] [Pubmed]
Hartley M.A., Ronet C., Zangger H., Beverley S.M., Fasel N., 2012. Leishmania RNA virus: when the host pays the toll. Frontiers in Cellular and Infection Microbiology 2 p. 99. [Document] [DOI] [Web of Science] [Pubmed]
Fuertes Marraco S.A., Scott C.L., Bouillet P., Ives A., Masina S., Vremec D., Jansen E.S., O'Reilly L.A., Schneider P., Fasel N. et al., 2011. Type I interferon drives dendritic cell apoptosis via multiple BH3-only proteins following activation by PolyIC in vivo. PLoS One 6(6) pp. e20189. [Document] [DOI] [Web of Science] [Pubmed]
Ives A., Ronet C., Prevel F., Ruzzante G., Fuertes-Marraco S., Schutz F., Zangger H., Revaz-Breton M., Lye L.F., Hickerson S.M. et al., 2011. Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis. Science 331(6018) pp. 775-778. [Document] [DOI] [Web of Science] [Pubmed]
Meslin B., Zalila H., Fasel N., Picot S., Bienvenu A.L., 2011. Are protozoan metacaspases potential parasite killers? Parasites and Vectors 4 pp. 26-32. [Document] [DOI] [Web of Science] [Pubmed]
Ronet C., Beverley S.M., Fasel N., 2011. Muco-cutaneous leishmaniasis in the New World: The ultimate subversion. Virulence 2(6) pp. 547-552. [DOI] [Web of Science] [Pubmed]
Zalila H., González I.J., El-Fadili A.K., Delgado M.B., Desponds C., Schaff C., Fasel N., 2011. Processing of metacaspase into a cytoplasmic catalytic domain mediating cell death in Leishmania major. Molecular Microbiology 79(1) pp. 222-239. [Document] [DOI] [Web of Science] [Pubmed]
El-Fadili A.K., Zangger H., Desponds C., Gonzalez I.J., Zalila H., Schaff C., Ives A., Masina S., Mottram J.C., Fasel N., 2010. Cathepsin B-like and cell death in the unicellular human pathogen Leishmania. Cell Death and Disease 1(9) pp. e71. [Document] [DOI] [Web of Science] [Pubmed]
Jiménez-Ruiz A., Alzate J.F., Macleod E.T., Lüder C.G., Fasel N., Hurd H., 2010. Apoptotic markers in protozoan parasites. Parasites and Vectors 3 p. 104. [Document] [DOI] [Web of Science] [Pubmed]
Ronet C., Ives A., Bourreau E., Fasel N., Launois P., Masina S., 2010. Immune responses to Leishmania guyanensis infection in humans and animal models. pp. 165-176 in Jirillo E., Brandonisio O. (eds.) Protozoa. Immune Response to Parasitic Infections 1. Bentham eBooks. [url editor site]
Smirlis D., Duszenko M., Ruiz A.J., Scoulica E., Bastien P., Fasel N., Soteriadou K., 2010. Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death. Parasites and Vectors 3 p. 107. [Document] [DOI] [Web of Science] [Pubmed]
Ambit A., Fasel N., Coombs G.H., Mottram J.C., 2008. An essential role for the Leishmania major metacaspase in cell cycle progression. Cell Death and Differentiation 15(1) pp. 113-122. [DOI] [Web of Science] [Pubmed]
Fasel N., Acestor N., El Fadili-Kündig A., Gonzalez I., Masina S., 2008. The Leishmania Proteome. pp. 55-74 in Myler P.J., Fasel N. (eds.) Leishmania : after the genome. Caister Academic Press, Norfolk.
Rebeaud F., Hailfinger S., Posevitz-Fejfar A., Tapernoux M., Moser R., Rueda D., Gaide O., Guzzardi M., Iancu E. M., Rufer N. et al., 2008. The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nature Immunology 9(3) pp. 272-281. [DOI] [Web of Science] [Pubmed]
González I.J., Desponds C., Schaff C., Mottram J.C., Fasel N., 2007. Leishmania major metacaspase can replace yeast metacaspase in programmed cell death and has arginine-specific cysteine peptidase activity. International Journal for Parasitology 37(2) pp. 161-172. [DOI] [Web of Science] [Pubmed]
Masina S., Zangger H., Rivier D., Fasel N., 2007. Histone H1 regulates chromatin condensation in Leishmania parasites. Experimental Parasitology 116(1) pp. 83-87. [DOI] [Web of Science] [Pubmed]
Moreno J., Nieto J., Masina S., Cañavate C., Cruz I., Chicharro C., Carrillo E., Napp S., Reymond C., Kaye P.M. et al., 2007. Immunization with H1, HASPB1 and MML Leishmania proteins in a vaccine trial against experimental canine leishmaniasis. Vaccine 25(29) pp. 5290-5300. [DOI] [Web of Science] [Pubmed]
Acestor N., Masina S., Ives A., Walker J., Saravia N.G., Fasel N., 2006. Resistance to oxidative stress is associated with metastasis in mucocutaneous leishmaniasis. Journal of Infectious Diseases 194(8) pp. 1160-1167. [DOI] [Web of Science] [Pubmed]
Walker J., Acestor N., Gongora R., Quadroni M., Segura I., Fasel N., Saravia N.G., 2006. Comparative protein profiling identifies elongation factor-1beta and tryparedoxin peroxidase as factors associated with metastasis in Leishmania guyanensis. Molecular and Biochemical Parasitology 145(2) pp. 254-264. [DOI] [Web of Science] [Pubmed]
Monnerat S., Martinez-Calvillo S., Worthey E., Myler P.J., Stuart K.D., Fasel N., 2004. Genomic organization and gene expression in a chromosomal region of Leishmania major. Molecular and Biochemical Parasitology 134(2) pp. 233-243. [DOI] [Web of Science] [Pubmed]
Nakhaee A., Taheri T., Taghikhani M., Mohebali M., Salmanian A.H., Fasel N., Rafati S., 2004. Humoral and cellular immune responses against Type I cysteine proteinase of Leishmania infantum are higher in asymptomatic than symptomatic dogs selected from a naturally infected population. Veterinary Parasitology 119(2-3) pp. 107-123. [DOI] [Web of Science] [Pubmed]
Perrenoud G., Messerli F., Thierry A.C., Beltraminelli N., Cousin P., Fasel N., Vallet V., Demotz S., Duchosal M.A., Moulon C., 2004. A recombinant rubella virus E1 glycoprotein as a rubella vaccine candidate. Vaccine 23(4) pp. 480-488. [DOI] [Web of Science] [Pubmed]
Rafati S., Salmanian A.H., Taheri T., Masina S., Schaff C., Taslimi Y., Fasel N., 2004. Type I signal peptidase from Leishmania is a target of the immune response in human cutaneous and visceral leishmaniasis. Molecular and Biochemical Parasitology 135(1) pp. 13-20. [DOI] [Web of Science] [Pubmed]
Belli S.I., Monnerat S., Schaff C., Masina S., Noll T., Myler P.J., Stuart K., Fasel N., 2003. Sense and antisense transcripts in the histone H1 (HIS-1) locus of Leishmania major. International Journal for Parasitology 33(9) pp. 965-975. [DOI] [Web of Science] [Pubmed]
Fasel N., Masina M.S., 2003. Life after death: are trypanosomatids programmed to die for the survival of their partners? Kinetoplastid Biology and Disease 2(1) p. 4. [Document] [DOI] [Pubmed]
Góngora R., Acestor N., Quadroni M., Fasel N., Saravia N.G., Walker J., 2003. Mapping the proteome of Leishmania Viannia parasites using two-dimensional polyacrylamide gel electrophoresis and associated technologies. Biomédica 23(2) pp. 153-160. [Pubmed]
Masina S., Gicheru M.M., Demotz S.O., Fasel N.J., 2003. Protection against cutaneous leishmaniasis in outbred vervet monkeys using a recombinant histone H1 antigen. Journal of Infectious Diseases 188(8) pp. 1250-1257. [DOI] [Web of Science] [Pubmed]
Rafati S., Fasel N., Masina S., 2003. Leishmania cysteine proteinases: from gene to subunit vaccine. Current Genomics 4(3) pp. 253-261. [DOI]
Rafati S., Nakhaee A., Taheri T., Ghashghaii A., Salmanian A.H., Jimenez M., Mohebali M., Masina S., Fasel N., 2003. Expression of cysteine proteinase type I and II of Leishmania infantum and their recognition by sera during canine and human visceral leishmaniasis. Experimental Parasitology 103(3-4) pp. 143-151. [DOI] [Web of Science] [Pubmed]
Volle J.N., Chambon G., Sayah A., Reymond C., Fasel N., Gijs M.A., 2003. Enhanced sensitivity detection of protein immobilization by fluorescent interference on oxidized silicon. Biosensors and Bioelectronics 19(5) pp. 457-464. [DOI] [Web of Science] [Pubmed]
Acestor N., Masina S., Walker J., Saravia N.G., Fasel N., Quadroni M., 2002. Establishing two-dimensional gels for the analysis of Leishmania proteomes. Proteomics 2(7) pp. 877-879. [DOI] [Web of Science] [Pubmed]
Johnson-Léger C.A., Aurrand-Lions M., Beltraminelli N., Fasel N., Imhof B.A., 2002. Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration. Blood 100(7) pp. 2479-2486. [DOI] [Web of Science] [Pubmed]
Zangger H., Mottram J.C., Fasel N., 2002. Cell death in Leishmania induced by stress and differentiation: programmed cell death or necrosis? Cell Death and Differentiation 9(10) pp. 1126-1139. [DOI] [Web of Science] [Pubmed]
Demotz S., Moulon C., Roggero M.A., Fasel N., Masina S., 2001. Native-like, long synthetic peptides as components of sub-unit vaccines: practical and theoretical considerations for their use in humans. Molecular Immunology 38(6) pp. 415-422. [DOI] [Web of Science] [Pubmed]
Rafati S., Salmanian A.H., Hashemi K., Schaff C., Belli S., Fasel N., 2001. Identification of Leishmania major cysteine proteinases as targets of the immune response in humans. Molecular and Biochemical Parasitology 113(1) pp. 35-43. [DOI] [Web of Science] [Pubmed]
Rafati S., Salmanian A.H., Taheri T., Vafa M., Fasel N., 2001. A protective cocktail vaccine against murine cutaneous leishmaniasis with DNA encoding cysteine proteinases of Leishmania major. Vaccine 19(25-26) pp. 3369-3375. [DOI] [Web of Science] [Pubmed]
Thierry A.C., Pinaud S., Bigler N., Perrenoud G., Denis B., Roggero M.A., Fasel N., Moulon C., Demotz S., 2001. Long synthetic peptides as biologically active proteins: the example of the chemokines. Biologicals : Journal of the International Association of Biological Standardization 29(3-4) pp. 259-263. [DOI] [Web of Science] [Pubmed]
van Bemmelen M.X., Beghdadi-Rais C., Desponds C., Vargas E., Herrera S., Reymond C.D., Fasel N., 2000. Expression and one-step purification of Plasmodium proteins in dictyostelium. Molecular and Biochemical Parasitology 111(2) pp. 377-390. [DOI] [Web of Science] [Pubmed]
Belli S., Formenton A., Noll T., Ivens A., Jacquet R., Desponds C., Hofer D., Fasel N., 1999. Leishmania major: histone H1 gene expression from the sw3 locus. Experimental Parasitology 91(2) pp. 151-160. [DOI] [Web of Science] [Pubmed]
Solioz N., Blum-Tirouvanziam U., Jacquet R., Rafati S., Corradin G., Mauël J., Fasel N., 1999. The protective capacities of histone H1 against experimental murine cutaneous leishmaniasis. Vaccine 18(9-10) pp. 850-859. [DOI] [Web of Science] [Pubmed]
Rais-Beghdadi C., Roggero M.A., Fasel N., Reymond C.D., 1998. Purification of recombinant proteins by chemical removal of the affinity tag. Applied Biochemistry and Biotechnology 74(2) pp. 95-103. [DOI] [Web of Science] [Pubmed]
Ravel C., Dubessay P., Bastien P., Blackwell J.M., Ivens A.C., The Leishmania Genome Network, 1998. The Complete Chromosomal Organization of the Reference Strain of the Leishmania Genome Project, L. major ;Friedlin'. Parasitology Today 14(8) pp. 301-303. [DOI] [Web of Science] [Pubmed]
Noll T.M., Desponds C., Belli S.I., Glaser T.A., Fasel N.J., 1997. Histone H1 expression varies during the Leishmania major life cycle. Molecular and Biochemical Parasitology 84(2) pp. 215-227. [DOI] [Web of Science] [Pubmed]
Bernasconi E., Fasel N., Wittek R., 06-1996. Cell surface expression of a functional rubella virus E1 glycoprotein by addition of a GPI anchor. Journal of Cell Science 109(6) pp. 1195-1201. [Web of Science] [Pubmed]
Blum-Tirouvanziam U., Servis C., Habluetzel A., Valmori D., Men Y., Esposito F., Del Nero L., Holmes N., Fasel N., Corradin G., 1995. Localization of HLA-A2.1-restricted T cell epitopes in the circumsporozoite protein of Plasmodium falciparum. Journal of Immunology 154(8) pp. 3922-3931. [Web of Science] [Pubmed]
Déglon N., Wilson A., Desponds C., Laurent P., Bron C., Fasel N., 1995. Fatty acids regulate Thy-1 antigen mRNA stability in T lymphocyte precursors. European Journal of Biochemistry 231(3) pp. 687-696. [DOI] [Web of Science] [Pubmed]
Poulain-Godefroy O., Hirt R.P., Fasel N., Kraehenbühl J.P., 1995. The polymeric immunoglobulin receptor: signals for polarized expression. Advances in Experimental Medicine and Biology 371A pp. 217-220. [Web of Science] [Pubmed]
Reymond C.D., Beghdadi-Rais C., Roggero M., Duarte E.A., Desponds C., Bernard M., Groux D., Matile H., Bron C., Corradin G. et al., 1995. Anchoring of an immunogenic Plasmodium falciparum circumsporozoite protein on the surface of Dictyostelium discoideum. Journal of Biological Chemistry 270(21) pp. 12941-12947. [DOI] [Web of Science] [Pubmed]
Roggero M.A., Filippi B., Church P., Hoffman S.L., Blum-Tirouvanziam U., Lopez J.A., Esposito F., Matile H., Reymond C.D., Fasel N. et al., 1995. Synthesis and immunological characterization of 104-mer and 102-mer peptides corresponding to the N- and C-terminal regions of the Plasmodium falciparum CS protein. Molecular Immunology 32(17-18) pp. 1301-1309. [DOI] [Web of Science] [Pubmed]
Blum-Tirouvanziam U., Beghdadi-Rais C., Roggero M.A., Valmori D., Bertholet S., Bron C., Fasel N., Corradin G., 1994. Elicitation of specific cytotoxic T cells by immunization with malaria soluble synthetic polypeptides. Journal of Immunology 153(9) pp. 4134-4141. [Web of Science] [Pubmed]
Fasel N., Stark H., Bron C., Beghdadi-Rais C., 1994. A trap system for the isolation of amino acid sequences inducing GPI anchor addition. Brazilian Journal of Medical and Biological Research 27(2) pp. 189-193. [Web of Science] [Pubmed]
Fasel N.J., Deglon N., Beghdadi-Rais C., Law R., Bron C., Wall R., 1994. Minimal membrane and secreted mu poly(A) signals specify developmentally-regulated immunoglobulin heavy chain mRNA ratios without RNA splicing. Molecular Immunology 31(7) pp. 563-566. [Web of Science] [Pubmed]
Hirt R.P., Fasel N., Kraehenbuhl J.P., 1994. Inducible protein expression using a glucocorticoid-sensitive vector. Methods in Cell Biology 43 Pt A pp. 247-262. [Web of Science] [Pubmed]
Beghdadi-Rais C., Schreyer M., Rousseaux M., Borel P., Eisenberg R.J., Cohen G.H., Bron C., Fasel N., 1993. Carboxyl terminus structural requirements for glycosyl-phosphatidylinositol anchor addition to cell surface proteins. Journal of Cell Science 105(3) pp. 831-840. [Web of Science] [Pubmed]
Corradin S.B., Fasel N., Buchmüller-Rouiller Y., Ransijn A., Smith J., Mauël J., 1993. Induction of macrophage nitric oxide production by interferon-gamma and tumor necrosis factor-alpha is enhanced by interleukin-10. European Journal of Immunology 23(8) pp. 2045-2048. [DOI] [Web of Science] [Pubmed]
Fasel N.J., Robyr D.C., Mauel J., Glaser T.A., 1993. Identification of a histone H1-like gene expressed in Leishmania major. Molecular and Biochemical Parasitology 62(2) pp. 321-323. [DOI] [Web of Science] [Pubmed]
Fasel N., Begdadi-Rais C., Bernard M., Bron C., Corradin G., Reymond C.D., 1992. Dictyostelium discoideum as an expression host for the circumsporozoite protein of Plasmodium falciparum. Gene 111(2) pp. 157-163. [DOI] [Web of Science] [Pubmed]
Fasel N.J., Déglon N., 1992. Multi-level regulation of Thy-1 antigen expression in mouse T lymphomas. Immunogenetics 35(2) pp. 126-130. [DOI] [Web of Science] [Pubmed]
Fasel N.J., Rousseaux M., Déglon N., Govan H.L., Law R., Bron C., Wall R., 1992. Membrane mu poly(A) signal and 3' flanking sequences function as a transcription terminator for immunoglobulin-encoding genes. Gene 122(2) pp. 297-304. [DOI] [Web of Science] [Pubmed]
Hirt R.P., Poulain-Godefroy O., Billotte J., Kraehenbuhl J.P., Fasel N., 1992. Highly inducible synthesis of heterologous proteins in epithelial cells carrying a glucocorticoid-responsive vector. Gene 111(2) pp. 199-206. [DOI] [Web of Science] [Pubmed]
Bron C., Fasel N., 1991. Glycolipid-anchored membrane proteins. Bulletin de l'Institut Pasteur 89(1) pp. 59-69. [Web of Science]
Déglon N., Krapp A., Bron C., Fasel N., 1991. Translocation of the yeast dolichol-phosphate-mannose synthase into microsomal membranes. Biochemical and Biophysical Research Communications 174(3) pp. 1337-1342. [DOI] [Web of Science] [Pubmed]
Fasel N., Déglon N., Rousseaux M., Beghdadi-Rais C., Bernard M., Bron C., 1991. Evaluation of somatic cell variants deficient in glycosylphosphatidyl-inositol anchoring as candidates for genetic correction. Cell Biology International Reports 15(11) pp. 1051-1064. [Web of Science] [Pubmed]
Fasel N.J., Bernard M., Déglon N., Rousseaux M., Eisenberg R.J., Bron C., Cohen G.H., 1991. Isolation from mouse fibroblasts of a cDNA encoding a new form of the fibroblast growth factor receptor (flg). Biochemical and Biophysical Research Communications 178(1) pp. 8-15. [DOI] [Web of Science] [Pubmed]
Michetti P., Hirt R., Weltzin R., Fasel N., Schaerer E., Neutra M.R., Kraehenbühl J.P., 1991. Production and use of monoclonal IgA antibodies complexed with recombinant secretory component for passive mucosal protection. Advances in Experimental Medicine and Biology 310 pp. 183-185. [Pubmed]
Wilson J.M., Fasel N., Kraehenbuhl J.P., 1990. Polarity of endogenous and exogenous glycosyl-phosphatidylinositol-anchored membrane proteins in Madin-Darby canine kidney cells. Journal of Cell Science 96(Pt 1) pp. 143-149. [Web of Science] [Pubmed]
Fasel N., Rousseaux M., Schaerer E., Medof M.E., Tykocinski M.L., Bron C., 1989. In vitro attachment of glycosyl-inositolphospholipid anchor structures to mouse Thy-1 antigen and human decay-accelerating factor. Proceedings of the National Academy of Sciences of the United States of America 86(18) pp. 6858-6862. [DOI] [Web of Science] [Pubmed]
Baumhüter S., Fasel N., Corradin G., Guardiola J., 1987. T cell receptor beta chain gene rearrangements and V beta gene usage in horse cytochrome c-specific T cell hybridomas. European Journal of Immunology 17(5) pp. 657-661. [DOI] [Web of Science] [Pubmed]
Fasel N., Briskin M., Carter C., Govan H., Hermanson G., Law R., Wall R., 1987. Control of μ + ∂ gene expression in B lymphocyte development. pp. 35-46 in Szentivanyi A., Maurer P.H., Janicki B.W. (eds.) Antibodies: structure, synthesis, function, and immunologic intervention in disease. University of South Florida international biomedical symposia series . Plenum Press, New York.
Law R., Kuwabara M.D., Briskin M., Fasel N., Hermanson G., Sigman D.S., Wall R., 1987. Protein-binding site at the immunoglobulin mu membrane polyadenylylation signal: possible role in transcription termination. Proceedings of the National Academy of Sciences of the United States of America 84(24) pp. 9160-9164. [DOI] [Web of Science] [Pubmed]
Rogers J., Fasel N., Wall R., 1986. A novel RNA in which the 5' end is generated by cleavage at the poly(A) site of immunoglobulin heavy-chain secreted mRNA. Molecular and cellular biology 6(12) pp. 4749-4752. [Web of Science] [Pubmed]
Diggelmann H, Buetti E., Owen D., Fasel N., Firzlaff J., Vessaz A.L., Pearson K., 1985. A short segment of viral DNA is required for stimulation of transcription of mouse mammary tumor virus genes by glucocorticoid hormones. pp. 339-353 in Becker Y. (eds.) Viral messenger RNA : transcription, processing, splicing and molecular structure. Developments in molecular virology 7. Martinus Nijhoff, Boston.
Diggelmann H, Buetti E., Fasel N., Owen D., Vessaz A.L., 1983. The expression of cloned MMTV DNA in transfected cells. pp. 303-315 in Rich M.A., Hager J.C., Furmanski P. (eds.) Understanding breast cancer. Dekker, New York.
Diggelmann H., Buetti E., Fasel N, Owen D., Vessaz A., Pearson K., 1982. Mouse mammary tumor virus : a model system for regulation of gene expression. Jahrbuch der Schweizerischen Naturforschenden Gesellschaft Wissenschaftlicher Teil = Annuaire de la Société Helvétique des Sciences Naturelles. Partie scientifique 162 pp. 31-34. [DOI]
Phd thesis
Castiglioni P., 2016. Leishmaniavirus : a possible target against metastatic leishmaniasis. Université de Lausanne, Faculté de biologie et médecine, Fasel N. (dir.).
Eren R. O., 2016. The innate recognition of the endosymbiotic virus of leishmania guyanensis and its impact on the parasite infection and the immune response. 225 p., Université de Lausanne, Faculté de biologie et médecine, Fasel N. (dir.).
HARTLEY M.-A., 2014. Metastatic leishmaniasis. A chronic inflammatory response to Leishmania's viral endosymbiont. Université de Lausanne, Faculté de biologie et médecine, Fasel N. (dir.).
Hailfinger S., 2009. The role of Malt1 proteolytic activity in T cell activation and lymphoma development. 132 p., Université de Lausanne, Faculté de biologie et médecine, Margot T. (dir.).
Ives A., 2009. Evaluation of the immune response to infection with metastatic and non-metastatic "Leishmania guyanensis" parasites. 104 p., Université de Lausanne, Faculté de biologie et médecine, Masina S. (dir.).
Gari K., 2007. Fanconi anemia and genome stability : the role of FANCM. 101 p., Université de Lausanne, Faculté de biologie et médecine, Constantinou A. (dir.).
González Jiménez I.J., 2007. " Leishmania major " metacaspase in programmed cell death. 99 p., Université de Lausanne, Faculté de biologie et médecine, Fasel N. (dir.).
Acestor N., 2005. The use of proteomics to identify markers associated with metastasis in "Leishmania Viannia" species the role of tryparedoxin peroxidase. 91 p., Université de Lausanne, Faculté de biologie et médecine, Fasel N. (dir.).
Monnerat S., 2004. Genomic organisation, gene expression and antisense transcription in a chromosomal region of Leishmania major. 77 p., Université de Lausanne, Faculté de biologie et médecine, Fasel N. (dir.).
Person Position Contact
Patrik Castiglioni Postdoctoral fellow Unisciences
Chantal Desponds Technician Unisciences
Remzi Onur Eren Postdoctoral fellow Unisciences
Nathalie Isorce Postdoctoral fellow Unisciences
Baijayanti Jha Ph.D student Unisciences
Dmitry Kopelyanskiy Ph.D student Unisciences
Florence Prevel Technician Unisciences
Marta Reverté Royo Ph.D student Unisciences
Matteo Rossi Ph.D student Unisciences



Nicolas Fasel


Tel: + 41 21 692 5732

Chemin des Boveresses 155 - CH-1066 Epalinges  - Switzerland  -  Tel. +41 21 692 5700  -  Fax +41 21 692 5705
Swiss University