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Publications 2000/2001

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  • Astori, M., von Garnier, C., Kettner, A., Dufour, N., Corradin, G., and Spertini, F. (2000). Inducing tolerance by intranasal administration of long peptides in naive and primed CBA/J mice. J Immunol 165, 3497-3505.
  • Attinger, A., Acha-Orbea, H., and MacDonald, H. R. (2000). Cutting edge: cell autonomous rather than environmental factors control bacterial superantigen-induced T cell anergy in vivo. J Immunol 165, 1171-1174.
  • Attinger, A., MacDonald, H. R., and Acha-Orbea, H. (2001). Lymphoid environment limits superantigen and antigen-induced T cell proliferation at high precursor frequency. Eur J Immunol 31, 884-893.
  • Bachmann, M. F., Gallimore, A., Jones, E., Ecabert, B., Acha-Orbea, H., and Kopf, M. (2001). Normal pathogen-specific immune responses mounted by CTLA-4-deficient T cells: a paradigm reconsidered. Eur J Immunol 31, 450-458.
  • Baribaud, F., Wirth, S., Maillard, I., Valsesia, S., Acha-Orbea, H., and Diggelmann, H. (2001). Identification of key amino acids of the mouse mammary tumor virus superantigen involved in the specific interaction with T-cell receptor Vb domains. J Virol 75, 7453-7461.
  • Batten, M., Groom, J., Cachero, T. G., Qian, F., Schneider, P., Tschopp, J., Browning, J. L., and Mackay, F. (2000). BAFF mediates survival of peripheral immature B lymphocytes. J Exp Med 192, 1453-1466.
  • Bender, F. C., Reymond, M. A., Bron, C., and Quest, A. F. (2000). Caveolin-1 levels are downregulated in human colon tumors, and ectopic expression of caveolin-1 in colon carcinoma cell lines reduces cell tumorigenicity. Cancer Res 60, 5870-5878.
  • Benedict, C. A., Norris, P. S., Prigozy, T. I., Bodmer, J. L., Mahr, J. A., Garnett, C. T., Martinon, F., Tschopp, J., Gooding, L. R., and Ware, C. F. (2001). Three adenovirus E3 proteins cooperate to evade apoptosis by tumor necrosis factor-related apoptosis-inducing ligand receptor-1 and -2. J Biol Chem 276, 3270-3278.
  • Bertholet, S., and Mauël, J. (2000). Human monocytic U937 cells transfected with human hepatic inducible nitric oxide synthase exhibit leishmanicidal activity. J Leukoc Biol 67, 34-39.
  • Biedermann, T., Zimmermann, S., Himmelrich, H., Gumy, A., Egeter, O., Sakrauski, A. K., Seegmüller, I., Voigt, H., Launois, P., Levine, A. D., Wagner, H., Heeg, K., Louis, J. A., and Röcken, M. (2001). IL-4 instructs Th1 responses and resistance to Leishmania major in susceptible BALB/c mice. Nat Immunol 2, 1054-1060.
  • Bodmer, J. L., Holler, N., Reynard, S., Vinciguerra, P., Schneider, P., Juo, P., Blenis, J., and Tschopp, J. (2000). TRAIL receptor-2 signals apoptosis through FADD and caspase-8. Nat Cell Biol 2, 241-243.
  • Bodmer, J. L., Meier, P., Tschopp, J., and Schneider, P. (2000). Cysteine 230 is essential for the structure and activity of the cytotoxic ligand TRAIL. J Biol Chem 275, 20632-20637.
  • Bonelo, A., Valmori, D., Triponez, F., Tiercy, J. M., Mentha, G., Oberholzer, J., Champagne, P., Romero, J. F., Esposito, F., Nebie, I., Barbey, C., Romero, P., Herrera, S., Corradin, G., and Lopez, J. A. (2000). Generation and characterization of malaria-specific human CD8(+) lymphocyte clones: effect of natural polymorphism on T cell recognition and endogenous cognate antigen presentation by liver cells. Eur J Immunol 30, 3079-3088.
  • Buchegger, F., Allal, A. S., Roth, A., Papazyan, J. P., Dupertuis, Y., Mirimanoff, R. O., Gillet, M., Pèlegrin, A., Mach, J. P., and Slosman, D. O. (2000). Combined radioimmunotherapy and radiotherapy of liver metastases from colorectal cancer: a feasibility study. Anticancer Res 20, 1889-1896.
  • Buchegger, F., Roth, A., Allal, A., Dupertuis, Y. M., Slosman, D. O., Delaloye, A. B., and Mach, J. P. (2000). Radioimmunotherapy of colorectal cancer liver metastases: combination with radiotherapy. Ann N Y Acad Sci 910, 263-269; discussion 269-270.
  • Bullani, R. R., Huard, B., Viard-Leveugle, I., Byers, H. R., Irmler, M., Saurat, J. H., Tschopp, J., and French, L. E. (2001). Selective expression of FLIP in malignant melanocytic skin lesions. J Invest Dermatol 117, 360-364.
  • Burns, K., Clatworthy, J., Martin, L., Martinon, F., Plumpton, C., Maschera, B., Lewis, A., Ray, K., Tschopp, J., and Volpe, F. (2000). Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat Cell Biol 2, 346-351.
  • Chapuis, A. G., Paolo Rizzardi, G., D'Agostino, C., Attinger, A., Knabenhans, C., Fleury, S., Acha-Orbea, H., and Pantaleo, G. (2000). Effects of mycophenolic acid on human immunodeficiency virus infection in vitro and in vivo. Nat Med 6, 762-768.
  • Cloutier, S. M., Couty, S., Terskikh, A., Marguerat, L., Crivelli, V., Pugnieres, M., Mani, J. C., Leisinger, H. J., Mach, J. P., and Deperthes, D. (2000). Streptabody, a high avidity molecule made by tetramerization of in vivo biotinylated, phage display-selected scFv fragments on streptavidin. Mol Immunol 37, 1067-1077.
  • Coste, A., Cohen, J., Reinhardt, M., Kraehenbuhl, J. P., and Sirard, J. C. (2001). Nasal immunisation with Salmonella typhimurium producing rotavirus VP2 and VP6 antigens stimulates specific antibody response in serum and milk but fails to protect offspring. Vaccine 19, 4167-4174.
  • Coste, A., Sirard, J. C., Johansen, K., Cohen, J., and Kraehenbuhl, J. P. (2000). Nasal immunization of mice with virus-like particles protects offspring against rotavirus diarrhea. J Virol 74, 8966-8971.
  • Cremesti, A., Paris, F., Grassme, H., Holler, N., Tschopp, J., Fuks, Z., Gulbins, E., and Kolesnick, R. (2001). Ceramide enables Fas to cap and kill. J Biol Chem 276, 23954-23961.
  • Debard, N., Sierro, F., Browning, J., and Kraehenbuhl, J. P. (2001). Effect of mature lymphocytes and lymphotoxin on the development of the follicle-associated epithelium and M cells in mouse Peyer's patches. Gastroenterology 120, 1173-1182.
  • Demotz, S., Moulon, C., Roggero, M. A., Fasel, N., and Masina, S. (2001). Native-like, long synthetic peptides as components of sub-unit vaccines: practical and theoretical considerations for their use in humans. Mol Immunol 38, 415-422.
  • Doucey, M. A., Legler, D. F., Boucheron, N., Cerottini, J. C., Bron, C., and Luescher, I. F. (2001). CTL activation is induced by cross-linking of TCR/MHC-peptide-CD8/p56lck adducts in rafts. Eur J Immunol 31, 1561-1570.
  • Dupertuis, Y. M., Vazquez, M., Mach, J. P., De Tribolet, N., Pichard, C., Slosman, D. O., and Buchegger, F. (2001). Fluorodeoxyuridine improves imaging of human glioblastoma xenografts with radiolabeled iododeoxyuridine. Cancer Res 61, 7971-7977.
  • Elzey, B. D., Griffith, T. S., Herndon, J. M., Barreiro, R., Tschopp, J., and Ferguson, T. A. (2001). Regulation of Fas ligand-induced apoptosis by TNF. J Immunol 167, 3049-3056.
  • Favier, B., Burroughs, N. J., Wedderburn, L., and Valitutti, S. (2001). TCR dynamics on the surface of living T cells. Int Immunol 13, 1525-1532.
  • Felley-Bosco, E., Bender, F. C., Courjault-Gautier, F., Bron, C., and Quest, A. F. (2000). Caveolin-1 down-regulates inducible nitric oxide synthase via the proteasome pathway in human colon carcinoma cells. Proc Natl Acad Sci U S A 97, 14334-14339.
  • Finke, D., and Acha-Orbea, H. (2001). Differential migration of in vivo primed B and T lymphocytes to lymphoid and non-lymphoid organs. Eur J Immunol 31, 2603-2611.
  • Finke, D., Baribaud, F., Diggelmann, H., and Acha-Orbea, H. (2001). Extrafollicular plasmablast B cells play a key role in carrying retroviral infection to peripheral organs. J Immunol 166, 6266-6275.
  • Foyouzi-Youssefi, R., Arnaudeau, S., Borner, C., Kelley, W. L., Tschopp, J., Lew, D. P., Demaurex, N., and Krause, K. H. (2000). Bcl-2 decreases the free Ca2 concentration within the endoplasmic reticulum. Proc Natl Acad Sci U S A 97, 5723-5728.
  • Franke, E. D., Sette, A., Sacci, J., Jr., Southwood, S., Corradin, G., and Hoffman, S. L. (2000). A subdominant CD8(+) cytotoxic T lymphocyte (CTL) epitope from the Plasmodium yoelii circumsporozoite protein induces CTLs that eliminate infected hepatocytes from culture. Infect Immun 68, 3403-3411.
  • Fukazawa, T., Fujiwara, T., Uno, F., Teraishi, F., Kadowaki, Y., Itoshima, T., Takata, Y., Kagawa, S., Roth, J. A., Tschopp, J., and Tanaka, N. (2001). Accelerated degradation of cellular FLIP protein through the ubiquitin-proteasome pathway in p53-mediated apoptosis of human cancer cells. Oncogene 20, 5225-5231.
  • Gaide, O., Martinon, F., Micheau, O., Bonnet, D., Thome, M., and Tschopp, J. (2001). Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation. FEBS Lett 496, 121-127.
  • Gervaz, P., Blanchard, A., Pampallona, S., Mach, J. P., Fontolliet, C., and Gillet, M. (2000). Prognostic value of postoperative carcinoembryonic antigen concentration and extent of invasion of resection margins after hepatic resection for colorectal metastases. Eur J Surg 166, 557-561.
  • Gonzalez, J. M., Peter, K., Esposito, F., Nebie, I., Tiercy, J. M., Bonelo, A., Arevalo-Herrera, M., Valmori, D., Romero, P., Herrera, S., Corradin, G., and Lopez, J. A. (2000). HLA-A*0201 restricted CD8 T-lymphocyte responses to malaria: identification of new plasmodium falciparum epitopes by IFN-gamma ELISPOT. Parasite Immunol 22, 501-514.
  • Gross, N., Balmas, K., Beretta Brognara, C., and Tschopp, J. (2001). Expression of Fas (APO-1/CD95) and Fas ligand (FasL) in human neuroblastoma. Med Pediatr Oncol 36, 111-114.
  • Hathaway, L. J., and Kraehenbuhl, J. P. (2000). The role of M cells in mucosal immunity. Cell Mol Life Sci 57, 323-332.
  • Heppner, F. L., Christ, A. D., Klein, M. A., Prinz, M., Fried, M., Kraehenbuhl, J. P., and Aguzzi, A. (2001). Transepithelial prion transport by M cells. Nat Med 7, 976-977.
  • Himmelrich, H., Launois, P., Maillard, I., Biedermann, T., Tacchini-Cottier, F., Locksley, R. M., Röcken, M., and Louis, J. A. (2000). In BALB/c mice, IL-4 production during the initial phase of infection with Leishmania major is necessary and sufficient to instruct Th2 cell development resulting in progressive disease. J Immunol 164, 4819-4825.
  • Holler, N., Kataoka, T., Bodmer, J. L., Romero, P., Romero, J., Deperthes, D., Engel, J., Tschopp, J., and Schneider, P. (2000). Development of improved soluble inhibitors of FasL and CD40L based on oligomerized receptors. J Immunol Methods 237, 159-173.
  • Holler, N., Zaru, R., Micheau, O., Thome, M., Attinger, A., Valitutti, S., Bodmer, J.-L., Schneider, P., Seed, B., and Tschopp, J. (2000). Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nat Immunol 1, 489-495.
  • Hopkins, S. A., Niedergang, F., Corthésy-Theulaz, I. E., and Kraehenbuhl, J. P. (2000). A recombinant Salmonella typhimurium vaccine strain is taken up and survives within murine Peyer's patch dendritic cells. Cell Microbiol 2, 59-68.
  • Hopkins-Donaldson, S., Bodmer, J. L., Bourloud, K. B., Brognara, C. B., Tschopp, J., and Gross, N. (2000). Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis. Cancer Res 60, 4315-4319.
  • Houimel, M., Corthésy-Theulaz, I., Fisch, I., Wong, C., Corthésy, B., Mach, J., and Finnern, R. (2001). Selection of human single chain Fv antibody fragments binding and inhibiting Helicobacter pylori urease. Tumour Biol 22, 36-44.
  • Houimel, M., Schneider, P., Terskikh, A., and Mach, J. P. (2001). Selection of peptides and synthesis of pentameric peptabody molecules reacting specifically with ErbB-2 receptor. Int J Cancer 92, 748-755.
  • Huard, B., Schneider, P., Mauri, D., Tschopp, J., and French, L. E. (2001). T cell costimulation by the TNF ligand BAFF. J Immunol 167, 6225-6231.
  • Irmler, M., Steiner, V., Ruegg, C., Wajant, H., and Tschopp, J. (2000). Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis. FEBS Lett 468, 129-133.
  • Johansen, P., Estevez, F., Zurbriggen, R., Merkle, H. P., Glück, R., Corradin, G., and Gander, B. (2000). Towards clinical testing of a single-administration tetanus vaccine based on PLA/PLGA microspheres. Vaccine 19, 1047-1054.
  • Kaptein, A., Jansen, M., Dilaver, G., Kitson, J., Dash, L., Wang, E., Owen, M. J., Bodmer, J., Tschopp, J., and Farrow, S. N. (2000). Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3). FEBS Lett 485, 135-141.
  • Kataoka, T., Budd, R. C., Holler, N., Thome, M., Martinon, F., Irmler, M., Burns, K., Hahne, M., Kennedy, N., Kovacsovics, M., and Tschopp, J. (2000). The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways. Curr Biol 10, 640-648.
  • Kataoka, T., Holler, N., Micheau, O., Martinon, F., Tinel, A., Hofmann, K., and Tschopp, J. (2001). Bcl-rambo, a novel Bcl-2 homologue that induces apoptosis via its unique C-terminal extension. J Biol Chem 276, 19548-19554.
  • Kausalya, P. J., Reichert, M., and Hunziker, W. (2001). Connexin45 directly binds to ZO-1 and localizes to the tight junction region in epithelial MDCK cells. FEBS Lett 505, 92-96.
  • Kerneis, S., Caliot, E., Stubbe, H., Bogdanova, A., Kraehenbuhl, J. P., and Pringault, E. (2000). Molecular studies of the intestinal mucosal barrier physiopathology using co-cultures of epithelial and immune cells: a technical update. Microbes Infect 2, 1119-1124.
  • Kettner, A., Hughes, G. J., Frutiger, S., Astori, M., Roggero, M., Spertini, F., and Corradin, G. (2001). Api m 6: a new bee venom allergen. J Allergy Clin Immunol 107, 914-920.
  • Klein, M. A., Kaeser, P. S., Schwarz, P., Weyd, H., Xenarios, I., Zinkernagel, R. M., Carroll, M. C., Verbeek, J. S., Botto, M., Walport, M. J., Molina, H., Kalinke, U., Acha-Orbea, H., and Aguzzi, A. (2001). Complement facilitates early prion pathogenesis. Nat Med 7, 488-492.
  • Legler, D. F., Doucey, M. A., Cerottini, J. C., Bron, C., and Luescher, I. F. (2001). Selective inhibition of CTL activation by a dipalmitoyl-phospholipid that prevents the recruitment of signaling molecules to lipid rafts. FASEB J 15, 1601-1603.
  • Legler, D. F., Wiedle, G., Ross, F. P., and Imhof, B. A. (2001). Superactivation of integrin avb3 by low antagonist concentrations. J Cell Sci 114, 1545-1553.
  • Leupin, O., Zaru, R., Laroche, T., Müller, S., and Valitutti, S. (2000). Exclusion of CD45 from the T-cell receptor signaling area in antigen-stimulated T lymphocytes. Curr Biol 10, 277-280.
  • Leyton, L., Schneider, P., Labra, C. V., Ruegg, C., Hetz, C. A., Quest, A. F., and Bron, C. (2001). Thy-1 binds to integrin beta(3) on astrocytes and triggers formation of focal contact sites. Curr Biol 11, 1028-1038.
  • Lopez, J. A., Weilenman, C., Audran, R., Roggero, M. A., Bonelo, A., Tiercy, J. M., Spertini, F., and Corradin, G. (2001). A synthetic malaria vaccine elicits a potent CD8(+) and CD4(+) T lymphocyte immune response in humans. Implications for vaccination strategies. Eur J Immunol 31, 1989-1998.
  • Maillard, I., Launois, P., Himmelrich, H., Acha-Orbea, H., Diggelmann, H., Locksley, R. M., and Louis, J. A. (2001). Functional plasticity of the LACK-reactive Vb4-Va8 CD4(+) T cells normally producing the early IL-4 instructing Th2 cell development and susceptibility to Leishmania major in BALB / c mice. Eur J Immunol 31, 1288-1296.
  • Martinon, F., Hofmann, K., and Tschopp, J. (2001). The pyrin domain: a possible member of the death domain-fold family implicated in apoptosis and inflammation. Curr Biol 11, R118-120.
  • Martinon, F., Holler, N., Richard, C., and Tschopp, J. (2000). Activation of a pro-apoptotic amplification loop through inhibition of NF-kB-dependent survival signals by caspase-mediated inactivation of RIP. FEBS Lett 468, 134-136.
  • Medana, I., Li, Z., Flugel, A., Tschopp, J., Wekerle, H., and Neumann, H. (2001). Fas ligand (CD95L) protects neurons against perforin-mediated T lymphocyte cytotoxicity. J Immunol 167, 674-681.
  • Micheau, O., Lens, S., Gaide, O., Alevizopoulos, K., and Tschopp, J. (2001). NF-kB signals induce the expression of c-FLIP. Mol Cell Biol 21, 5299-5305.
  • Michetti, M., Kelly, C. P., Kraehenbuhl, J. P., Bouzourene, H., and Michetti, P. (2000). Gastric mucosal a4b7-integrin-positive CD4 T lymphocytes and immune protection against helicobacter infection in mice. Gastroenterology 119, 109-118.
  • Miconnet, I., Servis, C., Cerottini, J. C., Romero, P., and Lévy, F. (2000). Amino acid identity and/or position determines the proteasomal cleavage of the HLA-A*0201-restricted peptide tumor antigen MAGE-3271-279. J Biol Chem 275, 26892-26897.
  • Mühlenbeck, F., Schneider, P., Bodmer, J. L., Schwenzer, R., Hauser, A., Schubert, G., Scheurich, P., Moosmayer, D., Tschopp, J., and Wajant, H. (2000). The tumor necrosis factor-related apoptosis-inducing ligand receptors TRAIL-R1 and TRAIL-R2 have distinct cross-linking requirements for initiation of apoptosis and are non-redundant in JNK activation. J Biol Chem 275, 32208-32213.
  • Nardelli-Haefliger, D., Benyacoub, J., Lemoine, R., Hopkins-Donaldson, S., Potts, A., Hartman, F., Kraehenbuhl, J. P., and De Grandi, P. (2001). Nasal vaccination with attenuated Salmonella typhimurium strains expressing the Hepatitis B nucleocapsid: dose response analysis. Vaccine 19, 2854-2861.
  • Neutra, M. R., Mantis, N. J., and Kraehenbuhl, J. P. (2001). Collaboration of epithelial cells with organized mucosal lymphoid tissues. Nat Immunol 2, 1004-1009.
  • Niedergang, F., Sirard, J. C., Tallichet-Blanc, C., and Kraehenbuhl, J. P. (2000). Entry and survival of salmonella typhimurium in dendritic cells and presentation of recombinant antigens do not require macrophage-specific virulence factors. Proc Natl Acad Sci U S A 97, 14650-14655.
  • Perlaza, B. L., Sauzet, J. P., Balde, A. T., Brahimi, K., Tall, A., Corradin, G., and Druilhe, P. (2001). Long synthetic peptides encompassing the Plasmodium falciparum LSA3 are the target of human B and T cells and are potent inducers of B helper, T helper and cytolytic T cell responses in mice. Eur J Immunol 31, 2200-2209.
  • Peter, K., Men, Y., Pantaleo, G., Gander, B., and Corradin, G. (2001). Induction of a cytotoxic Tcell response to HIV-1 proteins with short synthetic peptides and human compatible adjuvants. Vaccine 19, 4121-4129.
  • Piguet, P. F., Da Laperrousaz, C., Vesin, C., Tacchini-Cottier, F., Senaldi, G., and Grau, G. E. (2000). Delayed mortality and attenuated thrombocytopenia associated with severe malaria in urokinase- and urokinase receptor-deficient mice. Infect Immun 68, 3822-3829.
  • Potekhin, S. A., Melnik, T. N., Popov, V., Lanina, N. F., Vazina, A. A., Rigler, P., Verdini, A. S., Corradin, G., and Kajava, A. V. (2001). De novo design of fibrils made of short alpha-helical coiled coil peptides. Chem Biol 8, 1025-1032.
  • Rafati, S., Salmanian, A. H., Hashemi, K., Schaff, C., Belli, S., and Fasel, N. (2001). Identification of Leishmania major cysteine proteinases as targets of the immune response in humans. Mol Biochem Parasitol 113, 35-43.
  • Rafati, S., Salmanian, A. H., Taheri, T., Vafa, M., and Fasel, N. (2001). A protective cocktail vaccine against murine cutaneous leishmaniasis with DNA encoding cysteine proteinases of Leishmania major. Vaccine 19, 3369-3375.
  • Rescigno, M., Piguet, V., Valzasina, B., Lens, S., Zubler, R., French, L., Kindler, V., Tschopp, J., and Ricciardi-Castagnoli, P. (2000). Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction. A new role for Fas ligand in inflammatory responses. J Exp Med 192, 1661-1668.
  • Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J. P., and Ricciardi-Castagnoli, P. (2001). Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria. Nat Immunol 2, 361-367.
  • Rimoldi, D., Rubio-Godoy, V., Dutoit, V., Lienard, D., Salvi, S., Guillaume, P., Speiser, D., Stockert, E., Spagnoli, G., Servis, C., Cerottini, J. C., Lejeune, F., Romero, P., and Valmori, D. (2000). Efficient simultaneous presentation of NY-ESO-1/LAGE-1 primary and nonprimary open reading frame-derived CTL epitopes in melanoma. J Immunol 165, 7253-7261.
  • Robert, B., Guillaume, P., Luescher, I., Doucey, M.-A., Cerottini, J.-C., Romero, P., and Mach, J.-P. (2001). Redirecting anti-viral CTL against cancer cells by surface targeting of monomeric MHC class-1 viral peptide conjugated to antibody fragments. Cancer Immun 1, 2.
  • Robert, B., Guillaume, P., Luescher, I., Romero, P., and Mach, J. P. (2000). Antibody-conjugated MHC class I tetramers can target tumor cells for specific lysis by T lymphocytes. Eur J Immunol 30, 3165-3170.
  • Rochat-Steiner, V., Becker, K., Micheau, O., Schneider, P., Burns, K., and Tschopp, J. (2000). FIST/HIPK3. A Fas/fadd-interacting serine/threonine kinase that induces fadd phosphorylation and inhibits fas-mediated jun nh(2)-terminal kinase activation. J Exp Med 192, 1165-1174.
  • Roggero, M. A., Meraldi, V., Lopez, J. A., Eberl, G., Romero, J. C., Matile, H., Betschart, B., Corradin, G., and Renggli, J. (2000). The synthetic, oxidized C-terminal fragment of the Plasmodium berghei circumsporozoite protein elicits a high protective response. Eur J Immunol 30, 2679-2685.
  • Romero, J. F., Eberl, G., MacDonald, H. R., and Corradin, G. (2001). CD1d-restricted NK T cells are dispensable for specific antibody responses and protective immunity against liver stage malaria infection in mice. Parasite Immunol 23, 267-269.
  • Romero, P., Dutoit, V., Rubio-Godoy, V., Lienard, D., Speiser, D., Guillaume, P., Servis, K., Rimoldi, D., Cerottini, J. C., and Valmori, D. (2001). CD8 T-cell response to NY-ESO-1: relative antigenicity and in vitro immunogenicity of natural and analogue sequences. Clin Cancer Res 7, 766s-772s.
  • Roth, W., Wagenknecht, B., Klumpp, A., Naumann, U., Hahne, M., Tschopp, J., and Weller, M. (2001). APRIL, a new member of the tumor necrosis factor family, modulates death ligand-induced apoptosis. Cell Death Differ 8, 403-410.
  • Schneider, P. (2000). Production of recombinant TRAIL and TRAIL receptor: Fc chimeric proteins. Methods Enzymol 322, 325-345.
  • Schneider, P., Rennert, P., Cachero, T. G., Thompson, J. S., Trabach, L., Hertig, S., Holler, N., Qian, F., Mullen, C., Strauch, K., Browning, J. L., Ambrose, C., and Tschopp, J. (2000). A soluble form of BCMA, a receptor for the TNF family member APRIL, inhibits tumor cell growth. J Exp Med 192, 1677-1683.
  • Schneider, P., Street, S. L., Gaide, O., Hertig, S., Tardivel, A., Tschopp, J., Runkel, L., Alevizopoulos, K., Ferguson, B. M., and Zonana, J. (2001). Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A. J Biol Chem 276, 18819-18827.
  • Schneider, P., Takatsuka, H., Wilson, A., Mackay, F., Tardivel, A., Lens, S., Cachero, T. G., Finke, D., Beermann, F., and Tschopp, J. (2001). Maturation of marginal zone and follicular B cells requires B cell activating factor of the tumor necrosis factor family and is independent of B cell maturation antigen. J Exp Med 194, 1691-1697.
  • Schneider, P., Thompson, J. S., Kalled, S. L., Wang, L., Lefevre, E., Cachero, T. G., MacKay, F., Bixler, S. A., Zafari, M., Liu, Z.-Y., Woodcock, S. A., Qian, F., Batten, M., Madry, C., Richard, Y., Benjamin, C. D., Browning, J. L., Tsapis, A., Tschopp, J., and Ambrose, C. (2000). BAFF binds to the TNF receptor-like molecule BCMA and is important for maintaining the peripheral B cell population. J Exp Med 192, 129-135.
  • Schröter, M., Peli, J., Hahne, M., Tschopp, J., and Reichmann, E. (2000). Fas-dependent tissue turnover is implicated in tumor cell clearance. Oncogene 19, 1794-1800.
  • Schulte, R., Kerneis, S., Klinke, S., Bartels, H., Preger, S., Kraehenbuhl, J. P., Pringault, E., and Autenrieth, I. B. (2000). Translocation of Yersinia enterocolitica across reconstituted intestinal epithelial monolyers is triggered by Yersinia invasin binding to beta 1 integrins apically expressed on M-like cells. Cell Microbiol 2, 173-185.
  • Siegmund, D., Mauri, D., Peters, N., Juo, P., Thome, M., Reichwein, M., Blenis, J., Scheurich, P., Tschopp, J., and Wajant, H. (2001). Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway. J Biol Chem 276, 32585-32590.
  • Sierro, F., Dubois, B., Coste, A., Kaiserlian, D., Kraehenbuhl, J. P., and Sirard, J. C. (2001). Flagellin stimulation of intestinal epithelial cells triggers CCL20-mediated migration of dendritic cells. Proc Natl Acad Sci U S A 98, 13722-13727.
  • Sierro, F., Pringault, E., Simon-Assman, P., Kraehenbuhl, J. P., and Debard, N. (2000). Transient expression of M-cell phenotype by enterocyte-like cells of the follicle-associated epithelium of mouse Peyer's patches. Gastroenterology 119, 734-743.
  • Stubbe, H., Berdoz, J., Kraehenbuhl, J. P., and Corthésy, B. (2000). Polymeric IgA is superior to monomeric IgA and IgG carrying the same variable domain in preventing Clostridium difficile toxin A damaging of T84 monolayers. J Immunol 164, 1952-1960.
  • Tacchini-Cottier, F., Zweifel, C., Belkaid, Y., Mukankundiye, C., Vasei, M., Launois, P., Milon, G., and Louis, J. A. (2000). An immunomodulatory function for neutrophils during the induction of a CD4 Th2 response in BALB/c mice infected with Leishmania major. J Immunol 165, 2628-2636.
  • Theisen, M., Dodoo, D., Toure-Balde, A., Soe, S., Corradin, G., Koram, K. K., Kurtzhals, J. A., Hviid, L., Theander, T., Akanmori, B., Ndiaye, M., and Druilhe, P. (2001). Selection of glutamaterich protein long synthetic peptides for vaccine development: antigenicity and relationship with clinical protection and immunogenicity. Infect Immun 69, 5223-5229.
  • Thome, M., Gaide, O., Micheau, O., Martinon, F., Bonnet, D., Gonzalez, M., and Tschopp, J. (2001). Equine herpesvirus protein E10 induces membrane recruitment and phosphorylation of its cellular homologue, bcl-10. J Cell Biol 152, 1115-1122.
  • Thompson, J. S., Bixler, S. A., Qian, F., Vora, K., Scott, M. L., Cachero, T. G., Hession, C., Schneider, P., Sizing, I. D., Mullen, C., Strauch, K., Zafari, M., Benjamin, C. D., Tschopp, J., Browning, J. L., and Ambrose, C. (2001). BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293, 2108-2111.
  • Tosi, G., Meazza, R., De Lerma Barbaro, A., D'Agostino, A., Mazza, S., Corradin, G., Albini, A., Noonan, D. M., Ferrini, S., and Accolla, R. S. (2000). Highly stable oligomerization forms of HIV-1 Tat detected by monoclonal antibodies and requirement of monomeric forms for the transactivating function on the HIV-1 LTR. Eur J Immunol 30, 1120-1126.
  • Tucker, A. S., Headon, D. J., Schneider, P., Ferguson, B. M., Overbeek, P., Tschopp, J., and Sharpe, P. T. (2000). Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis. Development 127, 4691-4700.
  • van Bemmelen, M., Rais-Beghdadi, C., Desponds, C., Reymond, C. D., and Fasel, N. (2000). Expression and one step purification of Plasmodium proteins in Dictyostelium. Mol Biochem Parasitol 111, 377-390.
  • Villunger, A., Huang, D. C., Holler, N., Tschopp, J., and Strasser, A. (2000). Fas ligand-induced c-Jun kinase activation in lymphoid cells requires extensive receptor aggregation but is independent of DAXX, and Fas-mediated cell death does not involve DAXX, RIP, or RAIDD. J Immunol 165, 1337-1343.
  • von Garnier, C., Astori, M., Kettner, A., Dufour, N., Heusser, C., Corradin, G., and Spertini, F. (2000). Allergen-derived long peptide immunotherapy down-regulates specific IgE response and protects from anaphylaxis. Eur J Immunol 30, 1638-1645.
  • Vuagnat, B. B., Mach, J. P., and Le Doussal, J. (2000). Activation of the alternative pathway of human complement by autologous cells expressing transmembrane recombinant properdin. Mol Immunol 37, 467-478.
  • Waldburger, J. M., Suter, T., Fontana, A., Acha-Orbea, H., and Reith, W. (2001). Selective abrogation of major histocompatibility complex class II expression on extrahematopoietic cells in mice lacking promoter IV of the class II transactivator gene. J Exp Med 194, 393-406.
  • Wang, E., Pennington, J. G., Goldenring, J. R., Hunziker, W., and Dunn, K. W. (2001). Brefeldin A rapidly disrupts plasma membrane polarity by blocking polar sorting in common endosomes of MDCK cells. J Cell Sci 114, 3309-3321.
  • Wehrli, N., Legler, D. F., Finke, D., Toellner, K. M., Loetscher, P., Baggiolini, M., MacLennan, I. C., and Acha-Orbea, H. (2001). Changing responsiveness to chemokines allows medullary plasmablasts to leave lymph nodes. Eur J Immunol 31, 609-616.
  • Wehrli, P., Charnay, Y., Vallet, P., Zhu, G., Harmony, J., Aronow, B., Tschopp, J., Bouras, C., Viard-Leveugle, I., French, L. E., and Giannakopoulos, P. (2001). Inhibition of post-ischemic brain injury by clusterin overexpression. Nat Med 7, 977-979.
  • Werner-Favre, C., Bovia, F., Schneider, P., Holler, N., Barnet, M., Kindler, V., Tschopp, J., and Zubler, R. H. (2001). IgG subclass switch capacity is low in switched and in IgM-only, but high in IgD IgM , post-germinal center (CD27+) human B cells. Eur J Immunol 31, 243-249.
  • Wittelsberger, A., Keler, M., Scarpellino, L., Patiny, L., Acha-Orbea, H., and Mutter, M. (2000). Pseudoprolines: targeting a cis conformation in a mimetic of the gp120 V3 loop of HIV-1. Angew Chem In. ed 39, 1111-1115.
  • Wong, C., Waibel, R., Sheets, M., Mach, J. P., and Finnern, R. (2001). Human scFv antibody fragments specific for the epithelial tumour marker MUC-1, selected by phage display on living cells. Cancer Immunol Immunother 50, 93-101.
  • Zaru, R., Berrie, C. P., Iurisci, C., Corda, D., and Valitutti, S. (2001). CD28 co-stimulates TCR/CD3-induced phosphoinositide turnover in human T lymphocytes. Eur J Immunol 31, 2438-2447.



  • Corradin, G., and Druilhe, P. (2001). Foreword. Mol Immunol 38, 413-414.
  • Finke, D., and Kraehenbuhl, J. P. (2001). Formation of Peyer's patches. Curr Opin Genet Dev 11, 561-567.
  • French, L. E., and Tschopp, J. (2000). Fas-mediated cell death in toxic epidermal necrolysis and graftversus- host disease: potential for therapeutic inhibition. Schweiz Med Wochenschr 130, 1656-1661.
  • Kraehenbuhl, J. P. (2001). Mucosa-targeted DNA vaccination. Trends Immunol 22, 646-648.
  • Kraehenbuhl, J. P., and Neutra, M. R. (2000). Epithelial M Cells: differentiation and function. Annu Rev Cell Dev Biol 16, 301-332.
  • Niedergang, F., and Kraehenbuhl, J. P. (2000). Much ado about M cells. Trends Cell Biol 10, 137-141 (correction p. 196).
  • Peters, P. J., and Hunziker, W. (2001). Subcellular localization of Rab17 by cryo-immunogold electron microscopy in epithelial cells grown on polycarbonate filters. Methods Enzymol 329, 210-225.
  • Schneider, P., and Tschopp, J. (2000). Apoptosis induced by death receptors. Pharm Acta Helv 74, 281-286.
  • Thome, M., and Tschopp, J. (2001). Regulation of lymphocyte proliferation and death by FLIP. Nat Rev Immunol 1, 50-58.
  • Velin, D., and Kraehenbuhl, J. P. (2000). Delivery systems and adjuvants for vaccination against HIV. EXS 89, 227-237.
  • Wehrli, P., Viard, I., Bullani, R., Tschopp, J., and French, L. E. (2000). Death receptors in cutaneous biology and disease. J Invest Dermatol 115, 141-148.

Book sections

  • Finke, D., and Acha-Orbea, H. (2001). Immune response to murine and feline retroviruses. In Retroviral immunology: immune response and restoration, G. Pantaleo and B. D. Walker, eds Totowa, NJ: Humana Press, pp. 125-157.
  • Kraehenbuhl, J. P. (2001). Development of plant vaccines: the point of view of the mucosal immunologist. In 25th International seminar on nuclear war and planetary emergencies, R. Ragaini, ed. (Nuclear strategy and peace technology). Erice (Italy): World scientific, pp. 112-123.
  • Kraehenbuhl, J. P., and Velin, D. (2000). The airways: a site for vaccination and pathogen entry. In Mucosal immunology and ocular disease, M. Zierhut and J. V. Forrester, eds. The Netherlands: Aeolus Press, pp. 231-233.
  • Schneider, P., and Tschopp, J. (2000). Modulation of death receptor signalling" in "Programmed cell death in animals and plants. In Programmed cell death in animals and plants, J. A. Bryant, S. G. Hughes and J. M. Garland, eds. Oxford, UK: BIOS Scientific Publishers Ltd, pp. 31-42.


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