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  1. Arlehamn C.S., Pétrilli V., Gross O., Tschopp J., Evans T.J., 2010. The role of potassium in inflammasome activation by bacteria. Journal of Biological Chemistry 285(14) p. 10508-10518.
  2. Bauer C., Duewell P., Mayer C., Lehr H.A., Fitzgerald K.A., Dauer M., Tschopp J., Endres S., Latz E., Schnurr M., 2010. Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut 59(9) p. 1192-1199.
  3. Beleut M., Rajaram R.D., Caikovski M., Ayyanan A., Germano D., Choi Y., Schneider P., Brisken C., 2010. Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland. Proceedings of the National Academy of Sciences of the United States of America 107(7) p. 2989-2994.
  4. Bellecave P., Sarasin-Filipowicz M., Donze O., Kennel A., Gouttenoire J., Meylan E., Terracciano L., Tschopp J., Sarrazin C., Berg T., Moradpour D., Heim M.H., 2010. Cleavage of mitochondrial antiviral signaling protein in the liver of patients with chronic hepatitis C correlates with a reduced activation of the endogenous interferon system. Hepatology 51(4) p. 1127-1136.
  5. Borrelli S., Candi E., Hu B., Dolfini D., Ravo M., Grober O.M., Weisz A., Dotto G.P., Melino G., Viganò M.A., Mantovani R., 2010. The p63 target HBP1 is required for skin differentiation and stratification. Cell Death and Differentiation 17(12) p. 1896-1907.
  6. Britschgi M.R., Favre S., Luther S.A., 2010. CCL21 is sufficient to mediate DC migration, maturation and function in the absence of CCL19. European Journal of Immunology 40(5) p. 1266-1271.
  7. Charmoy M., Auderset F., Allenbach C., Tacchini-Cottier F., 2010. The prominent role of neutrophils during the initial phase of infection by Leishmania parasites. Journal of Biomedicine and Biotechnology 2010 p. 719361.
  8. Charmoy M., Brunner-Agten S., Aebischer D., Auderset F., Launois P., Milon G., Proudfoot A.E., Tacchini-Cottier F., 2010. Neutrophil-derived CCL3 is essential for the rapid recruitment of dendritic cells to the site of Leishmania major inoculation in resistant mice. PLoS Pathogens 6(2) p. e1000755.
  9. Corradin G., Kajava A.V., 2010. Malaria vaccine: why is it taking so long? Expert Review of Vaccines 9(2) p. 111-114.
  10. Corradin G., Kajava A.V., Verdini A., 2010. Long synthetic peptides for the production of vaccines and drugs: a technological platform coming of age. Science Translational Medicine 2(50) p. 50rv3.
  11. Dunne A., Ross P.J., Pospisilova E., Masin J., Meaney A., Sutton C.E., Iwakura Y., Tschopp J., Sebo P., Mills K.H., 2010. Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis. Journal of Immunology 185(3) p. 1711-1719.
  12. El-Fadili A. K., Zangger H., Desponds C., Gonzalez I.J., Zalila H., Schaff C., Ives A., Masina S., Mottram J.C., Fasel N., 2010. Cathepsin B-like and cell death in the unicellular human pathogen Leishmania. Cell Death and Disease 1 p. e71.
  13. Feltham R., Moulin M., Vince J.E., Mace P.D., Wong W.W., Anderton H., Day C.L. ,Vaux D.L., Silke J., 2010. Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding. Journal of Biological Chemistry 285(23) p. 17525-17536.
  14. Golay J., Bologna L., André P.A., Buchegger F., Mach J.P., Boumsell L., Introna M., 2010. Possible misinterpretation of the mode of action of therapeutic antibodies in vitro: homotypic adhesion and flow cytometry result in artefactual direct cell death. Blood 116(17) p. 3372-3373.
  15. Guarda G., So A., 2010. Regulation of inflammasome activity. Immunology 130(3) p. 329-336.
  16. Halili M.A., Andrews M.R., Labzin L.I., Schroder K., Matthias G., Cao C., Lovelace E., Reid R.C., Le G.T., Hume D.A., Irvine K.M., Matthias P., Fairlie D.P., Sweet M.J., 2010. Differential effects of selective HDAC inhibitors on macrophage inflammatory responses to the Toll-like receptor 4 agonist LPS. Journal of Leukocyte Biology 87(6) p. 1103-1114.
  17. Hirota S.A., Ng J., Lueng A., Khajah M., Parhar K., Li Y., Lam V., Potentier M.S., Ng K., Bawa M., McCafferty D.M., Rioux K.P., Ghosh S., Xavier R.J., Colgan S.P., Tschopp J., Muruve D., Macdonald J.A., Beck P.L., 2010. NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflammatory Bowel Diseases Sep 24. Ahead of print
  18. Hu B., Lefort K., Qiu W., Nguyen B.C., Rajaram R.D., Castillo E., He F., Chen Y., Angel P., Brisken C., Dotto G.P., 2010. Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis. Genes and Development 24(14) p. 1519-1532.
  19. Johannsen A., Genolet R., Legler D.F., Luther S.A., Luescher I.F., 2010. Definition of key variables for the induction of optimal NY-ESO-1-specific T cells in HLA transgene mice. Journal of Immunology 185(6) p. 3445-3455.
  20. Kang J., Yoo J., Lee S., Tang W., Aguilar B., Ramu S., Choi I., Otu H.H., Shin J.W., Dotto G.P., Koh C.J., Detmar M., Hong Y.K., 2010. An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells. Blood 116(1) p. 140-150.
  21. Kochs G., Bauer S., Vogt C., Frenz T., Tschopp J., Kalinke U., Waibler Z., 2010. Thogoto virus infection induces sustained type I interferon responses that depend on RIG-I-like helicase signaling of conventional dendritic cells. Journal of Virology 84(23) p. 12344-12350.
  22. Lambertini C., Pantano S., Dotto G.P., 2010. Differential control of Notch1 gene transcription by Klf4 and Sp3 transcription factors in normal versus cancer-derived keratinocytes. PLoS One 5(4) p. e10369.
  23. Larbouret C., Robert B., Bascoul-Mollevi C., Penault-Llorca F., Ho-Pun-Cheung A., Morisseau S., Navarro-Teulon I., Mach J.P., Pèlegrin A., Azria D., 2010. Combined cetuximab and trastuzumab are superior to gemcitabine in the treatment of human pancreatic carcinoma xenografts. Annals of Oncology 21(1) p. 98-103.
  24. Le Renard P.E., Jordan O., Faes A., Petri-Fink A., Hofmann H., Rüfenacht D., Bosman F., Buchegger F., Doelker E., 2010. The in vivo performance of magnetic particle-loaded injectable, in situ gelling, carriers for the delivery of local hyperthermia. Biomaterials 31(4) p. 691-705.
  25. Lluis J.M., Nachbur U., Cook W.D., Gentle I.E., Moujalled D., Moulin M., Wong W.W., Khan N., Chau D., Callus B.A., Vince J.E., Silke J., Vaux D.L., 2010. TAK1 is required for survival of mouse fibroblasts treated with TRAIL, and does so by NF-kappaB dependent induction of cFLIPL. PLoS One 5(1) p. e8620.
  26. Luber C.A., Cox J., Lauterbach H., Fancke B., Selbach M., Tschopp J., Akira S., Wiegand M., Hochrein H., O'Keeffe M., Mann M., 2010. Quantitative proteomics reveals subset-specific viral recognition in dendritic cells. Immunity 32(2) p. 279-289.
  27. Luke-Glaser S., Luke B., Grossi S., Constantinou A., 2010. FANCM regulates DNA chain elongation and is stabilized by S-phase checkpoint signalling. EMBO Journal 29(4) p. 795-805.
  28. Luther S.A., 2010. Plasma cell precursors: long-distance travelers looking for a home. Immunity 33(1) p. 9-11.
  29. Lyubimova A., Garber J.J., Upadhyay G., Sharov A., Anastasoaie F., Yajnik V., Cotsarelis G., Dotto G.P., Botchkarev V., Snapper S.B., 2010. Neural Wiskott-Aldrich syndrome protein modulates Wnt signaling and is required for hair follicle cycling in mice. Journal of Clinical Investigation 120(2) p. 446-456.
  30. Maestre A., Muskus C., Duque V., Agudelo O., Liu P., Takagi A., Ntumngia F.B., Adams J.H., Sim K.L., Hoffman S.L., Corradin G., Velez I.D., Wang R., 2010. Acquired antibody responses against Plasmodium vivax infection vary with host genotype for duffy antigen receptor for chemokines (DARC). PLoS One 5(7) p. e11437.
  31. McCoy A.J., Koizumi Y., Toma C., Higa N., Dixit V., Taniguchi S., Tschopp J., Suzuki T., 2010. Cytotoxins of the human pathogen Aeromonas hydrophila trigger, via the NLRP3 inflammasome, caspase-1 activation in macrophages. European Journal of Immunology 40(10) p. 2797-2803.
  32. McNeela E.A., Burke A., Neill D.R., Baxter C., Fernandes V.E., Ferreira D., Smeaton S., El-Rachkidy R., McLoughlin R.M., Mori A., Moran B., Fitzgerald K.A., Tschopp J., Pétrilli V., Andrew P.W., Kadioglu A., Lavelle E.C., 2010. Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4. PLoS Pathogens 6(11) p. e1001191.
  33. Mues G., Tardivel A., Willen L., Kapadia H., Seaman R., Frazier-Bowers S., Schneider P., D'Souza R.N., 2010. Functional analysis of Ectodysplasin-A mutations causing selective tooth agenesis. European Journal of Human Genetics 18(1) p. 19-25.
  34. Ng J., Hirota S.A., Gross O., Li Y., Ulke-Lemee A., Potentier M.S., Schenck L.P., Vilaysane A., Seamone M.E., Feng H., Armstrong G.D., Tschopp J., Macdonald J.A., Muruve D.A., Beck P.L., 2010. Clostridium difficile toxin-induced inflammation and intestinal injury are mediated by the inflammasome. Gastroenterolog Gastroenterolog y 139(2) p. 542-552.
  35. Olugbile S., Habel C., Servis C., Spertini F., Verdini A., Corradin G., 2010. Malaria vaccines - The long synthetic peptide approach: Technical and conceptual advancements. Current Opinion in Molecular Therapeutics 12(1) p. 64-76
  36. Perrot I., Deauvieau F., Massacrier C., Hughes N., Garrone P., Durand I., Demaria O., Viaud N., Gauthier L., Blery M., Bonnefoy-Berard N., Morel Y., Tschopp J., Alexopoulou L., Trinchieri G., Paturel C., Caux C., 2010. TLR3 and Rig-like receptor on myeloid dendritic cells and Rig-like receptor on human NK cells are both mandatory for production of IFN-gamma in response to double-stranded RNA. Journal of Immunology 185(4) p. 2080-2088.
  37. Pieren M., Schmidt A., Mayer A., 2010. The SM protein Vps33 and the t-SNARE H(abc) domain promote fusion pore opening. Nature Structural and Molecular Biology 17(6) p. 710-717.
  38. Poeck H., Bscheider M., Gross O., Finger K., Roth S., Rebsamen M., Hannesschläger N., Schlee M., Rothenfusser S., Barchet W., Kato H., Akira S., Inoue S., Endres S., Peschel C., Hartmann G., Hornung V., Ruland J., 2010. Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Nature Immunology 11(1) p. 63-69.
  39. Qiao G., Li Z., Minto A.W., Shia J., Yang L., Bao L., Tschopp J., Gao J.X., Wang J., Quigg R.J., Zhang J., 2010. Altered thymic selection by overexpressing cellular FLICE inhibitory protein in T cells causes lupus-like syndrome in a BALB/c but not C57BL/6 strain. Cell Death and Differentiation 17(3) p. 522-533.
  40. Ramelli G., Fuertes S., Narayan S., Busso N., Acha-Orbea H., So A., 2010. Protease-activated receptor 2 signalling promotes dendritic cell antigen transport and T-cell activation in vivo. Immunology 129(1) p. 20-27.
  41. Rebsamen M., Tschopp J., 2010. Viruses under the control of RIP kinases. Cell Cycle 9(3) p. 438-439.
  42. Revaz-Breton M., Ronet C., Ives A., Torre Y.H., Masina S., Tacchini-Cottier F., Launois P., 2010. The MyD88 protein 88 pathway is differently involved in immune responses induced by distinct substrains of Leishmania major. European Journal of Immunology 40(6) p. 1697-1707.
  43. Ristorcelli E., Lombardo D., 2010. Targeting Notch signaling in pancreatic cancer. Expert Opinion on Therapeutic Targets 14(5) p. 541-552.
  44. Ritter M., Gross O., Kays S., Ruland J., Nimmerjahn F., Saijo S., Tschopp J., Layland L.E., Prazeres da Costa C., 2010. Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses. Proceedings of the National Academy of Sciences of the United States of America 107(47) p. 20459-20464.
  45. Ronet C., Hauyon-La Torre Y., Revaz-Breton M., Mastelic B., Tacchini-Cottier F., Louis J., Launois P., 2010. Regulatory B cells shape the development of Th2 immune responses in BALB/c mice infected with Leishmania major through IL-10 production. Journal of Immunology 184(2) p. 886-894.
  46. Schilte C., Couderc T., Chretien F., Sourisseau M., Gangneux N., Guivel-Benhassine F., Kraxner A., Tschopp J., Higgs S., Michault A., Arenzana-Seisdedos F., Colonna M., Peduto L., Schwartz O., Lecuit M., Albert M.L., 2010. Type I IFN controls chikungunya virus via its action on nonhematopoietic cells. Journal of Experimental Medicine 207(2) p. 429-442.
  47. Schmid D.A., Irving M.B., Posevitz V., Hebeisen M., Posevitz-Fejfar A., Sarria J.C., Gomez-Eerland R., Thome M., Schumacher T.N., Romero P., Speiser D.E., Zoete V., Michielin O., Rufer N., 2010. Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function. Journal of Immunology 184(9) p. 4936-4946.
  48. Schneider P., Huard B., 2010. Buffy's, B-cells, and membrane BAFF. Arthritis & Rheumatism 62(5) p. 1557-1558.
  49. Smirlis D., Duszenko M., Ruiz A.J., Scoulica E., Bastien P., Fasel N., Soteriadou K., 2010. Targeting essential pathways in trypanosomatids gives insights into protozoan mechanisms of cell death. Parasites and Vectors 3 p. 107.
  50. Stubbs J., Olugbile S., Saidou B., Simpore J., Corradin G., Lanzavecchia A., 2010. Strain-transcending Fc-dependent killing of P.falciparum by MSP2 allele-specific human antibodies. Infection and Immunity.
  51. Swee L.K., Tardivel A., Schneider P., Rolink A., 2010. Rescue of the mature B cell compartment in BAFF-deficient mice by treatment with recombinant Fc-BAFF. Immunology Letters 131(1) p. 40-48.
  52. Thomason H.A., Zhou H., Kouwenhoven E.N., Dotto G.P., Restivo G., Nguyen B.C., Little H., Dixon M.J., van Bokhoven H., Dixon J., 2010. Cooperation between the transcription factors p63 and IRF6 is essential to prevent cleft palate in mice. Journal of Clinical Investigation 120(5) p. 1561-1569.
  53. Tinel A., Eckert M.J., Logette E., Lippens S., Janssens S., Jaccard B., Quadroni M., Tschopp J., 2010. Regulation of PIDD auto-proteolysis and activity by the molecular chaperone Hsp90. Cell Death and Differentiation 18(3) p. 506-515.
  54. Toma C., Higa N., Koizumi Y., Nakasone N., Ogura Y., McCoy A.J., Franchi L., Uematsu S., Sagara J., Taniguchi S., Tsutsui H., Akira S., Tschopp J., Núñez G., Suzuki T., 2010. Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling. Journal of Immunology 184(9) p. 5287-5297.
  55. Tschopp J., Schroder K., 2010. NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production? Nature Reviews. Immunology 10(3) p. 210-215.
  56. Viertl D., Bischof Delaloye A., Lanz B., Poitry-Yamate C., Gruetter R., Mlynarik V., Ametamey S.M., Ross T.L., Lehr H.A., André P.A., Perillo-Adamer F., Kosinski M., Dupertuis Y.M., Buchegger F., 2010. Increase of [(18)F]FLT Tumor Uptake In Vivo Mediated by FdUrd: Toward Improving Cell Proliferation Positron Emission Tomography. Molecular Imaging and p. 11 p..
  57. Vilaysane A., Chun J., Seamone M.E., Wang W., Chin R., Hirota S., Li Y., Clark S.A., Tschopp J., Trpkov K., Hemmelgarn B.R., Beck P.L., Muruve D.A., 2010. The NLRP3 inflammasome promotes renal inflammation and contributes to CKD. Journal of the American Society of Nephrology 21(10) p. 1732-1744.
  58. Vince J.E., Tschopp J., 2010. IRF-3 partners Bax in a viral-induced dance macabre. EMBO Journal 29(10) p. 1627-1628.
  59. Walter K., Hölscher C., Tschopp J., Ehlers S., 2010. NALP3 is not necessary for early protection against experimental tuberculosis. Immunobiology 215(9-10) p. 804-811.
  60. Wu X., Nguyen B.C., Dziunycz P., Chang S., Brooks Y., Lefort K., Hofbauer G.F., Dotto G.P., 2010. Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature 465(7296) p. 368-372.
  61. Yan Z., Delannoy M., Ling C., Daee D., Osman F., Muniandy P.A., Shen X., Oostra A.B., Du H., Steltenpool J., Lin T., Schuster B., Décaillet C., Stasiak A., Stasiak A.Z., Stone S., Hoatlin M.E., Schindler D., Woodcock C.L., Joenje H., Sen R., de Winter J.P., Li L., Seidman M.M., Whitby M.C., Myung K., Constantinou A., Wang W., 2010. A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability. Molecular Cell 37(6) p. 865-878.
  62. Yazdi A.S., Drexler S.K., Tschopp J., 2010. The role of the inflammasome in nonmyeloid cells. Journal of Clinical Immunology 30(5) p. 623-627.
  63. Yazdi A.S., Guarda G., D'Ombrain M.C., Drexler S.K., 2010. Inflammatory caspases in innate immunity and inflammation. Journal of Innate Immunity 2(3) p. 228-237.
  64. Yazdi A.S., Guarda G., Riteau N., Drexler S.K., Tardivel A., Couillin I., Tschopp J., 2010. Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β. Proceedings of the National Academy of Sciences of the United States of America 107(45) p. 19449-19454.
  65. Zhou R., Tardivel A., Thorens B., Choi I., Tschopp J., 2010. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nature Immunology 11(2) p. 136-140.



  1. Schroder K., Tschopp J., 2010. The inflammasomes. Cell 140(6) p. 821-832.
  2. Thome M., Charton J.E., Pelzer C., Hailfinger S., 2010. Antigen Receptor Signaling to NF-kappa B via CARMA1, BCL10, and MALT1. Cold Spring Harbor Perspectives in Biology 2(9) p. a003004.


Books and book chapters

  1. Jiménez-Ruiz A., Alzate J.F., Macleod E.T., Lüder C.G., Fasel N., Hurd H., 2010. Apoptotic markers in protozoan parasites. Parasites and Vectors 3 p. 104.
  2. Ronet C., Ives A., Bourreau E., Fasel N., Launois P., Masina S., 2010. Immune responses to Leishmania guyanensis infection in humans and animal models. pp.165-176 in Jirillo E. (eds.), Brandonisio O. (eds.), Protozoa. Immune Response to Parasitic Infections 1. chap. 11 Bentham eBooks.
  3. Schneider P., 2010. The beautiful structures of BAFF, APRIL and their receptors. pp.1-18 in Cancro M.P. (eds.), BLyS ligands and receptors. Contemporary Immunology . chap. 1 Humana Press.
  4. Verdini A., Olugbile S., Corradin G., Pink R., 2010. Malaria vaccine development: 20 years of hopes, hypes and limited achievements. pp.21-42 in Jirillo E. (eds.), Brandonisio O. (eds.), Protozoa. Immune Response to Parasitic Infections 1. chap. 3 Bentham eBook.



  1. Artis D., Tschopp J., 2010. Innate immunity. Current Opinion in Immunology 22(1) p. 1-3.
  2. Schroder K., Zhou R., Tschopp J., 2010. The NLRP3 inflammasome: a sensor for metabolic danger? Science 327(5963) p. 296-300.


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