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  1. Allam R., Darisipudi M.N., Rupanagudi K.V., Lichtnekert J., Tschopp J., Anders H.J., 2011. Cutting edge: cyclic polypeptide and aminoglycoside antibiotics trigger IL-1β secretion by activating the NLRP3 inflammasome. Journal of Immunology 186(5) p. 2714-2718.
  2. Arévalo-Herrera M., Soto L., Perlaza B.L., Céspedes N., Vera O., Lenis A.M., Bonelo A., Corradin G., Herrera S., 2011. Antibody-mediated and cellular immune responses induced in naive volunteers by vaccination with long synthetic peptides derived from the Plasmodium vivax circumsporozoite protein. American Journal of Tropical Medicine and Hygiene 84(2 Suppl) p. 35-42.
  3. Arévalo-Herrera M., Vera O., Castellanos A., Céspedes N., Soto L., Corradin G., Herrera S., 2011. Preclinical vaccine study of Plasmodium vivax circumsporozoite protein derived-synthetic polypeptides formulated in montanide ISA 720 and montanide ISA 51 adjuvants. American Journal of Tropical Medicine and Hygiene 84(2 Suppl) p. 21-27.
  4. Bacchelli C., Buckland K.F., Buckridge S., Salzer U., Schneider P., Thrasher A.J., Gaspar H.B., 2011. The C76R transmembrane activator and calcium modulator cyclophilin ligand interactor mutation disrupts antibody production and B-cell homeostasis in heterozygous and homozygous mice. Journal of Allergy and Clinical Immunology 127(5) p. 1253-9.e13.
  5. Besnard A.G., Guillou N., Tschopp J., Erard F., Couillin I., Iwakura Y., Quesniaux V., Ryffel B., Togbe D., 2011. NLRP3 inflammasome is required in murine asthma in the absence of aluminum adjuvant. Allergy 66(8) p. 1047-1057.
  6. Boeglin E., Smulski C.R., Brun S., Milosevic S., Schneider P., Fournel S., 2011. Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells. PLoS One 6(10) p. e25542.
  7. Bossen C., Tardivel A., Willen L., Fletcher C.A., Perroud M., Beermann F., Rolink A.G., Scott M.L., Mackay F., Schneider P., 2011. Mutation of the BAFF furin cleavage site impairs B-cell homeostasis and antibody responses. European Journal of Immunology 41(3) p. 787-797.
  8. Cheng J.M., Chee S.H., Knight D.A., Acha-Orbea H., Hermans I.F., Timmer M.S., Stocker B.L., 2011. An improved synthesis of dansylated α-galactosylceramide and its use as a fluorescent probe for the monitoring of glycolipid uptake by cells. Carbohydrate Research 346(7) p. 914-926.
  9. Collin N., Dubois P.M., 2011. The Vaccine Formulation Laboratory: a platform for access to adjuvants. Vaccine 29(Suppl 1) p. A37-A39.
  10. Coppi A., Natarajan R., Pradel G., Bennett B.L., James E.R., Roggero M.A., Corradin G., Persson C., Tewari R., Sinnis P., 2011. The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host. Journal of Experimental Medicine 208(2) p. 341-356.
  11. Darisipudi M.N., Allam R., Rupanagudi K.V., Anders H.J., 2011. Polyene macrolide antifungal drugs trigger interleukin-1β secretion by activating the NLRP3 inflammasome. PLoS One 6(5) p. e19588.
  12. Dotto G.P., 2011. Calcineurin signaling as a negative determinant of keratinocyte cancer stem cell potential and carcinogenesis. Cancer Research 71(6) p. 2029-2033.
  13. Dunand-Sauthier I., Santiago-Raber M.L., Capponi L., Vejnar C.E., Schaad O., Irla M., Seguín-Estévez Q., Descombes P., Zdobnov E.M., Acha-Orbea H., Reith W., 2011. Silencing of c-Fos expression by microRNA-155 is critical for dendritic cell maturation and function. Blood 117(17) p. 4490-4500.
  14. Flach T.L., Ng G., Hari A., Desrosiers M.D., Zhang P., Ward S.M., Seamone M.E., Vilaysane A., Mucsi A.D., Fong Y., Prenner E., Ling C.C., Tschopp J., Muruve D.A., Amrein M.W., Shi Y., 2011. Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity. Nature Medicine 17(4) p. 479-487.
  15. Fuertes Marraco S.A., Scott C.L., Bouillet P., Ives A., Masina S., Vremec D., Jansen E.S., O'Reilly L.A., Schneider P., Fasel N., Shortman K., Strasser A., Acha-Orbea H., 2011. Type I interferon drives dendritic cell apoptosis via multiple BH3-only proteins following activation by PolyIC in vivo. PLoS One 6(6) p. e20189.
  16. Ganeff C., Remouchamps C., Boutaffala L., Benezech C., Galopin G., Vandepaer S., Bouillenne F., Ormenese S., Chariot A., Schneider P., Caamaño J., Piette J., Dejardin E., 2011. Induction of the alternative NF-κB pathway by lymphotoxin αβ (LTαβ) relies on internalization of LTβ receptor. Molecular and Cellular Biology 31(21) p. 4319-4334.
  17. Guarda G., Braun M., Staehli F., Tardivel A., Mattmann C., Förster I., Farlik M., Decker T., Du Pasquier R.A., Romero P., Tschopp J., 2011. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity 34(2) p. 213-223.
  18. Guarda G., Zenger M., Yazdi A.S., Schroder K., Ferrero I., Menu P., Tardivel A., Mattmann C., Tschopp J., 2011. Differential expression of NLRP3 among hematopoietic cells. Journal of Immunology 186(4) p. 2529-2534.
  19. Hailfinger S., Nogai H., Pelzer C., Jaworski M., Cabalzar K., Charton J.E., Guzzardi M., Décaillet C., Grau M., Dörken B., Lenz P., Lenz G., Thome M., 2011. Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines. Proceedings of the National Academy of Sciences of the United States of America 108(35) p. 14596-14601.
  20. Harris J., Hartman M., Roche C., Zeng S.G., O'Shea A., Sharp F.A., Lambe E.M., Creagh E.M., Golenbock D.T., Tschopp J., Kornfeld H., Fitzgerald K.A., Lavelle E.C., 2011. Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation. Journal of Biological Chemistry 286(11) p. 9587-9597.
  21. Heinz L.X., Rebsamen M., Rossi D.C., Staehli F., Schroder K., Quadroni M., Gross O., Schneider P., Tschopp J., 2011. The death domain-containing protein Unc5CL is a novel MyD88-independent activator of the pro-inflammatory IRAK signaling cascade. Cell Death and Differentiation.
  22. Henríquez M., Herrera-Molina R., Valdivia A., Alvarez A., Kong M., Muñoz N., Eisner V., Jaimovich E., Schneider P., Quest A.F., Leyton L., 2011. ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation. Journal of Cell Science 124(Pt 9) p. 1581-1588.
  23. Herrera S., Fernández O.L., Vera O., Cárdenas W., Ramírez O., Palacios R., Chen-Mok M., Corradin G., Arévalo-Herrera M., 2011. Phase I safety and immunogenicity trial of Plasmodium vivax CS derived long synthetic peptides adjuvanted with montanide ISA 720 or montanide ISA 51. American Journal of Tropical Medicine and Hygiene 84(2 Suppl) p. 12-20.
  24. Hirota S.A., Ng J., Lueng A., Khajah M., Parhar K., Li Y., Lam V., Potentier M.S., Ng K., Bawa M., McCafferty D.M., Rioux K.P., Ghosh S., Xavier R.J., Colgan S.P., Tschopp J., Muruve D., MacDonald J.A., Beck P.L., 2011. NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflammatory Bowel Diseases 17(6) p. 1359-1372.
  25. Ives A., Ronet C., Prevel F., Ruzzante G., Fuertes-Marraco S., Schutz F., Zangger H., Revaz-Breton M., Lye L.F., Hickerson S.M., Beverley S.M., Acha-Orbea H., Launois P., Fasel N.*, Masina S., 2011. Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis. Science 331(6018) p. 775-778. *Corresponding author
  26. Jevnikar Z., Obermajer N., Doljak B., Turk S., Gobec S., Svajger U., Hailfinger S., Thome M., Kos J., 2011. Cathepsin X cleavage of the beta2 integrin regulates talin-binding and LFA-1 affinity in T cells. Journal of Leukocyte Biology 90(1) p. 99-109.
  27. Kawaji H., Severin J., Lizio M., Forrest A.R., van Nimwegen E., Rehli M., Schroder K., Irvine K., Suzuki H., Carninci P., Hayashizaki Y., Daub C.O., 2011. Update of the FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation. Nucleic Acids Research 39(Database issue) p. D856-D860.
  28. Kowalczyk C., Dunkel N., Willen L., Casal M.L., Mauldin E.A., Gaide O., Tardivel A., Badic G., Etter A.L., Favre M., Jefferson D.M., Headon D.J., Demotz S., Schneider P., 2011. Molecular and therapeutic characterization of anti-ectodysplasin A receptor (EDAR) agonist monoclonal antibodies. Journal of Biological Chemistry 286(35) p. 30769-30779.
  29. Launois P., Drowart A., Bourreau E., Couppie P., Farber C.M., Van Vooren J.P., Huygen K., 2011. T cell reactivity against mycolyl transferase antigen 85 of M. tuberculosis in HIV-TB coinfected subjects and in AIDS patients suffering from tuberculosis and nontuberculous mycobacterial infections. Clinical and Developmental Immunology 2011 p. 1-10.
  30. Link A., Hardie D.L., Favre S., Britschgi M.R., Adams D.H., Sixt M., Cyster J.G., Buckley C.D., Luther S.A., 2011. Association of T-zone reticular networks and conduits with ectopic lymphoid tissues in mice and humans. American Journal of Pathology 178(4) p. 1662-1675.
  31. Logette E., Schuepbach-Mallepell S., Eckert M.J., Leo X.H., Jaccard B., Manzl C., Tardivel A., Villunger A., Quadroni M., Gaide O., Tschopp J., 2011. PIDD orchestrates translesion DNA synthesis in response to UV irradiation. Cell Death and Differentiation 18(6) p. 1036-1045.
  32. Loisel S., André P.A., Golay J., Buchegger F., Kadouche J., Cérutti M., Bologna L., Kosinski M., Viertl D., Delaloye A.B., Berthou C., Mach J.P., Boumsell L., 2011. Antitumour effects of single or combined monoclonal antibodies directed against membrane antigens expressed by human B cells leukaemia. Molecular Cancer 10 p. 42.
  33. Manca S., Magrelli A., Cialfi S., Lefort K., Ambra R., Alimandi M., Biolcati G., Uccelletti D., Palleschi C., Screpanti I., Candi E., Melino G., Salvatore M., Taruscio D., Talora C., 2011. Oxidative stress activation of miR-125b is part of the molecular switch for Hailey-Hailey disease manifestation. Experimental Dermatology 20(11) p. 932-937.
  34. Mankan A.K., Canli O., Schwitalla S., Ziegler P., Tschopp J., Korn T., Greten F.R., 2011. TNF-alpha-dependent loss of IKKbeta-deficient myeloid progenitors triggers a cytokine loop culminating in granulocytosis. Proceedings of the National Academy of Sciences of the United States of America 108(16) p. 6567-6572.
  35. Matter M.S., Hilmenyuk T., Claus C., Marone R., Schürch C., Tinguely M., Terracciano L., Luther S.A., Ochsenbein A.F., 2011. Destruction of lymphoid organ architecture and hepatitis caused by CD4 T cells. PLoS One 6(9) p. e24772.
  36. Menu P., Pellegrin M., Aubert J.F., Bouzourene K., Tardivel A., Mazzolai L., Tschopp J., 2011. Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome. Cell Death and Disease 2 p. e137.
  37. Meslin B., Beavogui A.H., Fasel N.*, Picot S., 2011. Plasmodium falciparum metacaspase PfMCA-1 triggers a z-VAD-fmk inhibitable protease to promote cell death. PLoS One 6(8) p. e23867. *Corresponding author
  38. Michaelson J.S., Amatucci A., Kelly R., Su L., Garber E., Day E.S., Berquist L., Cho S., Li Y., Parr M., Wille L., Schneider P., Wortham K., Burkly L.C., Hsu Y.M., Joseph I.B., 2011. Development of an Fn14 agonistic antibody as an anti-tumor agent. mAbs 3(4) p. 362-375.
  39. Olugbile S., Villard V., Bertholet S., Jafarshad A., Kulangara C., Roussilhon C., Frank G., Agak G.W., Felger I., Nebie I., Konate K., Kajava A.V., Schuck P., Druilhe P., Spertini F., Corradin G., 2011. Malaria vaccine candidate: design of a multivalent subunit α-helical coiled coil poly-epitope. Vaccine 29(40) p. 7090-7099.
  40. Ostera G., Tokumasu F., Teixeira C., Collin N., Sa J., Hume J., Kumar S., Ribeiro J., Lukat-Rodgers G.S., Rodgers K.R., 2011. Plasmodium falciparum: nitric oxide modulates heme speciation in isolated food vacuoles. Experimental Parasitology 127(1) p. 1-8.
  41. Pelzer C., Thome M., 2011. IKKα takes control of canonical NF-κB activation. Nature Immunology 12(9) p. 815-816.
  42. Restivo G., Nguyen B.C., Dziunycz P., Ristorcelli E., Ryan R.J., Özuysal Ö.Y., Di Piazza M., Radtke F., Dixon M.J., Hofbauer G.F., Lefort K., Dotto G.P., 2011. IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes. EMBO Journal 30(22) p. 4571-4585.
  43. Ronet C., Beverley S.M., Fasel N., 2011. Muco-cutaneous leishmaniasis in the New World: The ultimate subversion. Virulence 2(6) p. 547-552.
  44. Ronet C., Beverley S.M., Fasel N., 2011. Un virus, hôte indésirable de L. guyanensis, détermine la gravité de la forme mucocutanée de la leishmaniose [Mucocutaneous leishmaniasis and an undesired passenger]. Médecine Sciences : M/S 27(11) p. 924-926.
  45. Siegert S., Huang H.Y., Yang C.Y., Scarpellino L., Carrie L., Essex S., Nelson P.J., Heikenwalder M., Acha-Orbea H., Buckley C.D., Marsland B.J., Zehn D., Luther S.A., 2011. Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide. PLoS One 6(11) p. e27618.
  46. Sierro S.R., Donda A., Perret R., Guillaume P., Yagita H., Levy F., Romero P., 2011. Combination of lentivector immunization and low-dose chemotherapy or PD-1/PD-L1 blocking primes self-reactive T cells and induces anti-tumor immunity. European Journal of Immunology 41(8) p. 2217-2228.
  47. Strasser B., Iwaszkiewicz J., Michielin O., Mayer A., 2011. The V-ATPase proteolipid cylinder promotes the lipid-mixing stage of SNARE-dependent fusion of yeast vacuoles. EMBO Journal 30(20) p. 4126-4141.
  48. Stubbs J., Olugbile S., Saidou B., Simpore J., Corradin G., Lanzavecchia A., 2011. Strain-transcending Fc-dependent killing of Plasmodium falciparum by merozoite surface protein 2 allele-specific human antibodies. Infection and Immunity 79(3) p. 1143-1152.
  49. Tinel A., Eckert M.J., Logette E., Lippens S., Janssens S., Jaccard B., Quadroni M., Tschopp J., 2011. Regulation of PIDD auto-proteolysis and activity by the molecular chaperone Hsp90. Cell Death and Differentiation 18(3) p. 506-515.
  50. Turchinovich G., Vu T.T., Frommer F., Kranich J., Schmid S., Alles M., Loubert J.B., Goulet J.P., Zimber-Strobl U., Schneider P., Bachl J., Pearson R., Crossley M., Agenès F., Kirberg J., 2011. Programming of marginal zone B-cell fate by basic Kruppel-like factor (BKLF/KLF3). Blood 117(14) p. 3780-3792.
  51. Uyttenhove C., Marillier R.G., Tacchini-Cottier F., Charmoy M., Caspi R.R., Damsker J.M., Goriely S., Su D., Van Damme J., Struyf S., Opdenakker G., Van Snick J., 2011. Amine-reactive OVA multimers for auto-vaccination against cytokines and other mediators: perspectives illustrated for GCP-2 in L. major infection. Journal of Leukocyte Biology 89(6) p. 1001-1007.
  52. Witzenrath M., Pache F., Lorenz D., Koppe U., Gutbier B., Tabeling C., Reppe K., Meixenberger K., Dorhoi A., Ma J., Holmes A., Trendelenburg G., Heimesaat M.M., Bereswill S., van der Linden M., Tschopp J., Mitchell T.J., Suttorp N., Opitz B., 2011. The NLRP3 inflammasome is differentially activated by pneumolysin variants and contributes to host defense in pneumococcal pneumonia. Journal of Immunology 187(1) p. 434-440.
  53. Xu X., Oliveira F., Chang B.W., Collin N., Gomes R., Teixeira C., Reynoso D., My Pham V., Elnaiem D.E., Kamhawi S., Ribeiro J.M., Valenzuela J.G., Andersen J.F., 2011. Structure and function of a "yellow" protein from saliva of the sand fly Lutzomyia longipalpis that confers protective immunity against Leishmania major infection. Journal of Biological Chemistry 286(37) p. 32383-32393.
  54. Xu Y., Schnorrer P., Proietto A., Kowalski G., Febbraio M.A., Acha-Orbea H., Dickins R.A., Villadangos J.A., 2011. IL-10 controls cystatin C synthesis and blood concentration in response to inflammation through regulation of IFN regulatory factor 8 expression. Journal of Immunology 186(6) p. 3666-3673.
  55. Zalila H., González I.J., El-Fadili A.K., Delgado M.B., Desponds C., Schaff C., Fasel N., 2011. Processing of metacaspase into a cytoplasmic catalytic domain mediating cell death in Leishmania major. Molecular Microbiology 79(1) p. 222-239.
  56. Zhou R., Yazdi A.S., Menu P., Tschopp J., 2011. A role for mitochondria in NLRP3 inflammasome activation. Nature 469(7329) p. 221-225.



  1. Gross O., Thomas C.J., Guarda G., Tschopp J., 2011. The inflammasome: an integrated view. Immunological Reviews 243(1) p. 136-151.
  2. Hetz C., Martinon F., Rodriguez D., Glimcher L.H., 2011. The unfolded protein response: integrating stress signals through the stress sensor IRE1α. Physiological Reviews 91(4) p. 1219-1243.
  3. Luther S.A., Vogt T.K., Siegert S., 2011. Guiding blind T cells and dendritic cells: A closer look at fibroblastic reticular cells found within lymph node T zones. Immunology Letters 138(1) p. 9-11.
  4. malERA Consultative Group on Vaccines, 2011. A research agenda for malaria eradication: vaccines. PLoS Medicine 8(1) p. e1000398.
  5. Martinon F., Glimcher L.H., 2011. Regulation of innate immunity by signaling pathways emerging from the endoplasmic reticulum. Current Opinion in Immunology 23(1) p. 35-40.
  6. Menu P., Vince J.E., 2011. The NLRP3 inflammasome in health and disease: the good, the bad and the ugly. Clinical and Experimental Immunology 166(1) p. 1-15.
  7. Meslin B., Zalila H., Fasel N., Picot S., Bienvenu A.L., 2011. Are protozoan metacaspases potential parasite killers? Parasites and Vectors 4 p. 26-32
  8. Tschopp J., 2011. Mitochondria: Sovereign of inflammation? European Journal of Immunology 41(5) p. 1196-1202.



  1. Couillin I. (eds.), Pétrilli V. (eds.), Martinon F. (eds.), 2011. The inflammasomes. Progress in Inflammation Research. 224 p. Springer.
  2. Tacchini-Cottier F. (eds.), van Zandbergen G. (eds.), 2011. Neutrophils in infectious diseases. 79 p. Bentham e Books.


Book chapter

  1. Charmoy M., Milon G., Tacchini-Cottier F., 2011. Role of neutrophils in the early shaping of the Leishmania major specific immune response in experimental murine cutaneous Leishmaniasis. pp.49-58 in Tacchini-Cottier F. (eds.), van Zandbergen G. (eds.), Neutrophils in infectious diseases. Bentham e Books.
  2. Gross O., Thomas C.J., Layland L.E., 2011. Inflammasome Activation in Response to Eukaryotic Pathogens. pp.65-84 in Couillin I. (eds.), Pétrilli V. (eds.), Martinon F. (eds.), The inflammasomes. Springer.
  3. Pétrilli V., Martinon F., 2011. Molecular definition of inflammasomes. pp.1-16 in Couillin I. (eds.), Pétrilli V. (eds.), Martinon F. (eds.), The inflammasomes. Progress in Inflammation Research. Springer.



  1. Glimcher L.H. , Martinon F. , Modlin R.L., 2011. Innate immunity. Current Opinion in Immunology 23(1) p. 1-2.
  2. Lefort K. , Dotto G.P., 2011. p63 and epithelial metaplasia: a gutsy choice. Cell 145(7) p. 1003-1005.
  3. Pelzer C. , Thome M., 2011. IKKα takes control of canonical NF-κB activation. Nature Immunology 12(9) p. 815-816.



  1. Rebsamen M., Vazquez J., Tardivel A., Guarda G., Curran J., Tschopp J., 2011. NLRX1/NOD5 deficiency does not affect MAVS signalling. Cell Death and Differentiation 18(8) p. 1387.


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