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Corradin Giampietro, Group leader



Giampietro Corradin graduated in chemistry at the University of Padua and received his PhD degree in chemistry from the University of California, Santa Barbara, after completion of a thesis on the structure and function of cytochrome c. After a post-doctoral position in biochemistry at Dartmouth Medical School, Hanover, New Hampshire, he continued his training in molecular immunology at the National Jewish Hospital, Denver, Colorado. He joined the Institute of Biochemistry in 1979 where he was an Associate Professor. For the last 15 years the main focus of his laboratory has been the elucidation of the immunological mechanisms of protection in malaria using well-defined animal models. In addition, development of vaccine candidates has been actively pursued by introducing new and faster approaches for the identification, production and development of novel malaria vaccine candidates.


Malaria is a world-wide parasitic disease which affects millions of people especially young children and pregnant women. Among the measures directed toward the prevention of this disease, vaccines represent a cost-effective approach. Identification of molecules important in the elicitation of a protective immune response and their use in experimental animals to be followed by testing in human volunteers has been a constant goal of our laboratory.

Malaria is a parasitic disease transmitted during the blood meal of infected mosquitoes, which inoculate sporozoites into the mammalian host. Within minutes, sporozoites invade hepatocytes and develop into merozoites intracellularly by asexual schizogony. The merozoites then invade red blood cells, producing the various symptoms associated with the disease. The life cycle is completed when gametocytes are ingested during the blood meal of the mosquito vectors. Upon repeated infections, partial antibody-dependent immunity directed against the erythrocytic stage is elicited in humans.

Exo-erythrocytic cycle

Protective immunity against malaria can be obtained by immunizing mice and humans with irradiation-attenuated sporozoites. This immunity is the result of the effect of neutralizing antibodies recognizing free sporozoites in the blood stream and of CD4+ and CD8+ T cells which prevent the development of the parasite hepatic forms. Experiments performed in B cell deficient mice have demonstrated that, despite the absence of anti-sporozoite antibodies, protection is induced by irradiated sporozoite immunization. This suggests that T cells specific for proteins present in the intracellular hepatic stage play a predominant role in protection. Therefore, one of the aims in malaria vaccine research is to mimic the protective immune response induced by injection of irradiated sporozoites.

The impossibility of culturing sporozoites outside the mosquitos renders this vaccination approach impracticable on a large scale. Thus, considerable effort has been devoted to the identification of highly antigenic sporozoite derived antigens, which can substitute for the whole sporozoite in the design of anti-malaria vaccines. A second target of vaccine intervention is represented by the erythrocytic stage of the parasite and its specific antigens.

Our approach to vaccine development involves the use of long polypeptides containing various B, T-helper, and T-cytotoxic epitopes. The use of longer antigen fragments will also provide epitopes capable of binding to the various MHC class I and II molecules, thus overcoming the MHC restriction observed in response to shorter epitopes. This approach has lead to numerous malaria phase I clinical trials in record time.

Erythrocytic cycle

While this work continues in order to optimize the vaccine formulation to be used in further clinical trials, the availability of the P. falciparum genome provides an ideal basis from which to identify new proteins associated with protective immune responses. To this effect, we performed a selection of new antigens using a genome-wide approach complemented with high-throughput peptide synthesis. We first identified potential protein antigens present on the surface of asexual malaria blood stages through bioinformatics and published transcriptome and proteome analysis. Amongst the proteins identified, we selected those that contain protein regions, which are relatively short (30-50 amino acid residues) and structurally stable as isolated fragments or longer unstructured regions ( up to 100 amino acids). All selected antigens were then tested in ELISA assay using a panel of sera from donors living in different malaria endemic areas. Recognition of these synthetic antigens varied from few to 100 %, thus identifying a number of new potential vaccine candidates.

Affinity purified antibodies recognize the infected red blood cells and are immunogenic in mice. Further characterization of these proteins using mouse specific or affinity purified human antibodies is underway. In order to select the most appropriate protective antigens, a series of assays like antibody dependent cytotoxic inhibition (ADCI) and growth inhibition assay (GIA) are being employed to determine the biological properties of purified antibodies. Results obtained to date demonstrate that our bioinformatics/chemical synthesis approach can lead to the identification of new proteins that can be targets of potential vaccines and/or drugs in a very short time frame (2 years, see reference Olugbile et al.). In addition, the antigen selection mechanism is of general application, and can be applied to any other pathogen where protection is mediated by antibodies.

Malaria cycle


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Balam S., Olugbile S., Servis C., Diakité M., D'Alessandro A., Frank G., Moret R., Nebie I., Tanner M., Felger I. et al., 2014. Plasmodium falciparum merozoite surface protein 2: epitope mapping and fine specificity of human antibody response against non-polymorphic domains. Malaria Journal 13 p. 510. [DOI] [Web of Science] [Pubmed]
Céspedes N., Habel C., Lopez-Perez M., Castellanos A., Kajava A.V., Servis C., Felger I., Moret R., Arévalo-Herrera M., Corradin G. et al., 2014. Plasmodium vivax antigen discovery based on alpha-helical coiled coil protein motif. PLoS One 9(6) pp. e100440. [DOI] [Web of Science] [Pubmed]
Céspedes N., Jiménez E., Lopez-Perez M., Rubiano K., Felger I., Alonso P., Arévalo-Herrera M., Corradin G., Herrera S., 2014. Antigenicity and immunogenicity of a novel Plasmodium vivax circumsporozoite derived synthetic vaccine construct. Vaccine 32(26) pp. 3179-3186. [DOI] [Web of Science] [Pubmed]
Corradin G., Levitskaya J., 2014. Priming of CD8(+) T Cell Responses to Liver Stage Malaria Parasite Antigens. Frontiers in Immunology 5 p. 527. [DOI] [Web of Science] [Pubmed]
Céspedes N., Arévalo-Herrera M., Felger I., Reed S., Kajava A.V., Corradin G., Herrera S., 2013. Antigenicity and immunogenicity of a novel chimeric peptide antigen based on the P. vivax circumsporozoite protein. Vaccine 31(42) pp. 4923-4930. [DOI] [Web of Science] [Pubmed]
Pellaton C., Perrin Y., Boudousquié C., Barbier N., Wassenberg J., Corradin G., Thierry A.C., Audran R., Reymond C., Spertini F., 2013. Novel birch pollen specific immunotherapy formulation based on contiguous overlapping peptides. Clinical and Translational Allergy 3(1) p. 17. [DOI] [Pubmed]
Wetter M., Kowarik M., Steffen M., Carranza P., Corradin G., Wacker M., 2013. Engineering, conjugation, and immunogenicity assessment of Escherichia coli O121 O antigen for its potential use as a typhoid vaccine component. Glycoconjugate Journal 30(5) pp. 511-522. [DOI] [Web of Science] [Pubmed]
Balam S., Romero J.F., Bongfen S.E., Guillaume P., Corradin G., 2012. CSP-A Model for In Vivo Presentation of Plasmodium berghei Sporozoite Antigens by Hepatocytes. PLoS One 7(12) pp. e51875. [DOI] [Web of Science] [Pubmed]
Bernabeu M., Lopez F.J., Ferrer M., Martin-Jaular L., Razaname A., Corradin G., Maier A.G., Del Portillo H.A., Fernandez-Becerra C., 2012. Functional analysis of Plasmodium vivax VIR proteins reveals different subcellular localizations and cytoadherence to the ICAM-1 endothelial receptor. Cellular Microbiology 14(3) pp. 386-400. [DOI] [Web of Science] [Pubmed]
Corradin G., Céspedes N., Verdini A., Kajava A.V., Arévalo-Herrera M., Herrera S., 2012. Malaria vaccine development using synthetic peptides as a technical platform. Advances in Immunology 114 pp. 107-149. [DOI] [Pubmed]
Kulangara C., Luedin S., Dietz O., Rusch S., Frank G., Mueller D., Moser M., Kajava A.V., Corradin G., Beck H.P. et al., 2012. Cell biological characterization of the malaria vaccine candidate trophozoite exported protein 1. PLoS One 7(10) pp. e46112. [DOI] [Web of Science] [Pubmed]
Arévalo-Herrera M., Soto L., Perlaza B.L., Céspedes N., Vera O., Lenis A.M., Bonelo A., Corradin G., Herrera S., 2011. Antibody-mediated and cellular immune responses induced in naive volunteers by vaccination with long synthetic peptides derived from the Plasmodium vivax circumsporozoite protein. American Journal of Tropical Medicine and Hygiene 84(2 Suppl) pp. 35-42. [DOI] [Web of Science] [Pubmed]
Arévalo-Herrera M., Vera O., Castellanos A., Céspedes N., Soto L., Corradin G., Herrera S., 2011. Preclinical vaccine study of Plasmodium vivax circumsporozoite protein derived-synthetic polypeptides formulated in montanide ISA 720 and montanide ISA 51 adjuvants. American Journal of Tropical Medicine and Hygiene 84(2 Suppl) pp. 21-27. [DOI] [Web of Science] [Pubmed]
Balam S., Frank G., Diakite M., Moret R., Corradin G., Spertini F., 2011. Plasmodium falciparum merozoite surface protein 2: epitope mapping and biological activity analysis of specific antibodies. p. 103 in Annual Congress SGAI-SSAI, Advances in immunology and allergology: from research to diagnosis and therapy. Allergologie 34(2). [Web of Science]
Coppi A., Natarajan R., Pradel G., Bennett B.L., James E.R., Roggero M.A., Corradin G., Persson C., Tewari R., Sinnis P., 2011. The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host. Journal of Experimental Medicine 208(2) pp. 341-356. [DOI] [Web of Science] [Pubmed]
Herrera S., Fernández O.L., Vera O., Cárdenas W., Ramírez O., Palacios R., Chen-Mok M., Corradin G., Arévalo-Herrera M., 2011. Phase I safety and immunogenicity trial of Plasmodium vivax CS derived long synthetic peptides adjuvanted with montanide ISA 720 or montanide ISA 51. American Journal of Tropical Medicine and Hygiene 84(2 Suppl) pp. 12-20. [DOI] [Web of Science] [Pubmed]
malERA Consultative Group on Vaccines, 2011. A research agenda for malaria eradication: vaccines. Plos Medicine 8(1) pp. e1000398. [DOI] [Web of Science] [Pubmed]
Olugbile S., Villard V., Bertholet S., Jafarshad A., Kulangara C., Roussilhon C., Frank G., Agak G.W., Felger I., Nebie I. et al., 2011. Malaria vaccine candidate: design of a multivalent subunit α-helical coiled coil poly-epitope. Vaccine 29(40) pp. 7090-7099. [DOI] [Web of Science] [Pubmed]
Stubbs J., Olugbile S., Saidou B., Simpore J., Corradin G., Lanzavecchia A., 2011. Strain-transcending Fc-dependent killing of Plasmodium falciparum by merozoite surface protein 2 allele-specific human antibodies. Infection and Immunity 79(3) pp. 1143-1152. [DOI] [Web of Science] [Pubmed]
Corradin G., Kajava A.V., 2010. Malaria vaccine: why is it taking so long? Expert Review of Vaccines 9(2) pp. 111-114. [DOI] [Web of Science] [Pubmed]
Corradin G., Kajava A.V., Verdini A., 2010. Long synthetic peptides for the production of vaccines and drugs: a technological platform coming of age. Science Translational Medicine 2(50) pp. 50rv3. [DOI] [Web of Science] [Pubmed]
Maestre A., Muskus C., Duque V., Agudelo O., Liu P., Takagi A., Ntumngia F.B., Adams J.H., Sim K.L., Hoffman S.L. et al., 2010. Acquired antibody responses against Plasmodium vivax infection vary with host genotype for duffy antigen receptor for chemokines (DARC). PLoS One 5(7) pp. e11437. [DOI] [Web of Science] [Pubmed]
Olugbile S., Habel C., Servis C., Spertini F., Verdini A., Corradin G., 2010. Malaria vaccines - The long synthetic peptide approach: Technical and conceptual advancements. Current Opinion in Molecular Therapeutics 12(1) pp. 64-76. [Web of Science] [Pubmed]
Verdini A., Olugbile S., Corradin G., Pink R., 2010. Malaria vaccine development: 20 years of hopes, hypes and limited achievements. pp. 21-42 in Jirillo E., Brandonisio O. (eds.) Protozoa. Immune Response to Parasitic Infections 1. Bentham eBook. [url editor site]
Audran Regine, Lurati-Ruiz Floriana, Genton Blaise, Blythman Hildur E., Ofori-Anyinam Opokua, Reymond Christophe, Corradin Giampietro, Spertini Francois, 2009. The synthetic Plasmodium falciparum circumsporozoite peptide PfCS102 as a malaria vaccine candidate: a randomized controlled phase I trial. PloS One 4(10) p. 7304. [Document] [DOI] [Web of Science] [Pubmed]
Bongfen S.E., Ntsama P.M., Offner S., Smith T., Felger I., Tanner M., Alonso P., Nebie I., Romero J.F., Silvie O. et al., 2009. The N-terminal domain of Plasmodium falciparum circumsporozoite protein represents a target of protective immunity. Vaccine 27(2) pp. 328-335. [DOI] [Pubmed]
Dostert C., Guarda G., Romero J.F., Menu P., Gross O., Tardivel A., Suva M.L., Stehle J.C., Kopf M., Stamenkovic I. et al., 2009. Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PloS one 4(8) pp. e6510. [Document] [DOI] [Web of Science] [Pubmed]
Flueck C., Frank G., Smith T., Jafarshad A., Nebie I., Sirima S.B., Olugbile S., Alonso P., Tanner M., Druilhe P. et al., 2009. Evaluation of two long synthetic merozoite surface protein 2 peptides as malaria vaccine candidates. Vaccine 27(20) pp. 2653-2661. [DOI] [Web of Science] [Pubmed]
Gondeau C., Corradin G., Heitz F., Le Peuch C., Balbo A., Schuck P., Kajava A.V., 2009. The C-terminal domain of Plasmodium falciparum merozoite surface protein 3 self-assembles into alpha-helical coiled coil tetramer. Molecular and biochemical parasitology 165(2) pp. 153-161. [DOI] [Web of Science] [Pubmed]
Kulangara C., Kajava A.V., Corradin G., Felger I., 2009. Sequence conservation in Plasmodium falciparum alpha-helical coiled coil domains proposed for vaccine development. PloS one 4(5) pp. e5419. [Document] [DOI] [Pubmed]
Olugbile S., Kulangara C., Bang G., Bertholet S., Suzarte E., Villard V., Frank G., Audran R., Razaname A., Nebie I. et al., 2009. Vaccine potentials of an intrinsically unstructured fragment derived from the blood stage-associated Plasmodium falciparum protein PFF0165c. Infection and immunity 77(12) pp. 5701-5709. [DOI] [Web of Science] [Pubmed]
Toure-Balde A., Perlaza B.L., Sauzet J.P., Ndiaye M., Aribot G., Tall A., Sokhna C., Rogier C., Corradin G., Roussilhon C. et al., 2009. Evidence for multiple B- and T-cell epitopes in Plasmodium falciparum liver-stage antigen 3. Infection and immunity 77(3) pp. 1189-1196. [DOI] [Web of Science] [Pubmed]
Agak G. W., Bejon P., Fegan G., Gicheru N., Villard V., Kajava A. V., Marsh K., Corradin G., 2008. Longitudinal analyses of immune responses to Plasmodium falciparum derived peptides corresponding to novel blood stage antigens in coastal Kenya. Vaccine 26(16) pp. 1963-1971. [DOI] [Web of Science] [Pubmed]
Bongfen S. E., Balam S., Torgler R., Romero J. F., Corradin G., 2008. Processing of the circumsporozoite protein in infected hepatocytes is not dependent on aspartic proteases. Parasite Immunology 30(6-7) pp. 375-378. [DOI] [Web of Science] [Pubmed]
Nebie I., Tiono A.B., Diallo D.A., Samandoulougou S., Diarra A., Konate A.T., Cuzin-Ouattara N., Theisen M., Corradin G., Cousens S. et al., 2008. Do antibody responses to malaria vaccine candidates influenced by the level of malaria transmission protect from malaria? Tropical medicine & international health 13(2) pp. 229-237. [DOI] [Pubmed]
Stirnemann K., Romero J. F., Baldi L., Robert B., Cesson V., Besra G. S., Zauderer M., Wurm F., Corradin G., Mach J. P. et al., 2008. Sustained activation and tumor targeting of NKT cells using a CD1d-anti-HER2-scFv fusion protein induce antitumor effects in mice. Journal of Clinical Investigation 118(3) pp. 994-1005. [DOI] [Web of Science] [Pubmed]
Torgler R., Bongfen S. E., Romero J. C., Tardivel A., Thome M., Corradin G., 2008. Sporozoite-mediated hepatocyte wounding limits Plasmodium parasite development via MyD88-mediated NF-kappa B activation and inducible NO synthase expression. Journal of Immunology 180(6) pp. 3990-3999. [Web of Science] [Pubmed]
Verdini A., Terenzi S., Brossard V., Roggero M., Corradin G., 2008. Oxidative folding of synthetic polypeptides S-protected as tert-butylthio derivatives. Journal of Peptide Science 14(12) pp. 1271-1282. [DOI] [Web of Science] [Pubmed]
Bongfen S. E., Torgler R., Romero J. F., Renia L., Corradin G., 06-2007. Plasmodium berghei-infected primary hepatocytes process and present the circumsporozoite protein to specific CD8+ T cells in vitro. Journal of Immunology 178(11) pp. 7054-63. [Web of Science] [Pubmed]
Castellanos A., Arevalo-Herrera M., Restrepo N., Gulloso L., Corradin G., Herrera S., 06-2007. Plasmodium vivax thrombospondin related adhesion protein: immunogenicity and protective efficacy in rodents and Aotus monkeys. Memorias do Instituto Oswaldo Cruz 102(3) pp. 411-6. [Web of Science] [Pubmed]
Corradin G., 05-2007. Peptide based malaria vaccine development: personal considerations. Microbes and Infection 9(6) pp. 767-71. [DOI] [Web of Science] [Pubmed]
Hermsen C. C., Verhage D. F., Telgt D. S., Teelen K., Bousema J. T., Roestenberg M., Bolad A., Berzins K., Corradin G., Leroy O. et al., 04-2007. Glutamate-rich protein (GLURP) induces antibodies that inhibit in vitro growth of Plasmodium falciparum in a phase 1 malaria vaccine trial. Vaccine 25(15) pp. 2930-40. [DOI] [Web of Science] [Pubmed]
Herrera S., Corradin G., Arevalo-Herrera M., 03-2007. An update on the search for a Plasmodium vivax vaccine. Trends in Parasitology 23(3) pp. 122-8. [DOI] [Web of Science] [Pubmed]
Mata E., Carcaboso A. M., Hernandez R. M., Igartua M., Corradin G., Pedraz J. L., 01-2007. Adjuvant activity of polymer microparticles and Montanide ISA 720 on immune responses to Plasmodium falciparum MSP2 long synthetic peptides in mice. Vaccine 25(5) pp. 877-85. [DOI] [Web of Science] [Pubmed]
Romero J. F., Ibrahim G. H., Renggli J., Himmelrich H., Graber P., Corradin G., 11-2007. IL-12p40-independent induction of protective immunity upon multiple Plasmodium berghei irradiated sporozoite immunizations. Parasite Immunology 29(11) pp. 541-8. [DOI] [Web of Science] [Pubmed]
Villard V., Agak G.W., Frank G., Jafarshad A., Servis C., Nébié I., Sirima S.B., Felger I., Arevalo-Herrera M., Herrera S. et al., 2007. Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif. Plos One 2(7) pp. e645. [Document] [DOI] [Web of Science] [Pubmed]
Cesson V., Stirnemann K., Robert B., Luescher I., Filleron T., Corradin G., Mach J.P., Donda A., 2006. Active antiviral T-lymphocyte response can be redirected against tumor cells by antitumor antibody x MHC/viral peptide conjugates. Clinical cancer research 12(24) pp. 7422-7430. [DOI] [Web of Science] [Pubmed]
Prato S., Fleming J., Schmidt C. W., Corradin G., Lopez J. A., 05-2006. Cross-presentation of a human malaria CTL epitope is conformation dependent. Molecular Immunology 43(13) pp. 2031-6. [DOI] [Web of Science] [Pubmed]
Villard V., Kalyuzhniy O., Riccio O., Potekhin S., Melnik T.N., Kajava A.V., Rüegg C., Corradin G., 2006. Synthetic RGD-containing alpha-helical coiled coil peptides promote integrin-dependent cell adhesion. Journal of Peptide Science 12(3) pp. 206-212. [DOI] [Web of Science] [Pubmed]
Audran R., Cachat M., Lurati F., Soe S., Leroy O., Corradin G., Druilhe P., Spertini F., 12-2005. Phase I malaria vaccine trial with a long synthetic peptide derived from the merozoite surface protein 3 antigen. Infection and Immunity 73(12) pp. 8017-26. [DOI] [Web of Science] [Pubmed]
Druilhe P., Spertini F., Soesoe D., Corradin G., Mejia P., Singh S., Audran R., Bouzidi A., Oeuvray C., Roussilhon C., 2005. A malaria vaccine that elicits in humans antibodies able to kill Plasmodium falciparum. PLoS Medicine 2(11) pp. e344. [Document] [DOI] [Web of Science] [Pubmed]
Herrera S., Bonelo A., Perlaza B. L., Fernandez O. L., Victoria L., Lenis A. M., Soto L., Hurtado H., Acuna L. M., Velez J. D. et al., 11-2005. Safety and elicitation of humoral and cellular responses in colombian malaria-naive volunteers by a Plasmodium vivax circumsporozoite protein-derived synthetic vaccine. American Journal of Tropical Medicine and Hygiène 73(5 Suppl) pp. 3-9. [Web of Science] [Pubmed]
Luzardo-Alvarez A., Blarer N., Peter K., Romero J.F., Reymond C., Corradin G., Gander B., 12-2005. Biodegradable microspheres alone do not stimulate murine macrophages in vitro, but prolong antigen presentation by macrophages in vitro and stimulate a solid immune response in mice. Journal of Controlled Release 109(1-3) pp. 62-76. [DOI] [Web of Science] [Pubmed]
Prato S., Maxwell T., Pinzon-Charry A., Schmidt C. W., Corradin G., Lopez J. A., 03-2005. MHC class I-restricted exogenous presentation of a synthetic 102-mer malaria vaccine polypeptide. European Journal of Immunology 35(3) pp. 681-9. [DOI] [Web of Science] [Pubmed]
Ballou W. R., Arevalo-Herrera M., Carucci D., Richie T. L., Corradin G., Diggs C., Druilhe P., Giersing B. K., Saul A., Heppner D. G. et al., 08-2004. Update on the clinical development of candidate malaria vaccines. American Journal of Tropical Medicine and Hygiène 71(2 Suppl) pp. 239-47. [Web of Science] [Pubmed]
Corradin G., Spertini F., Verdini A., 2004. Medicinal application of long synthetic peptide technology. Expert opinion on biological therapy 4(10) pp. 1629-39. [DOI] [Web of Science] [Pubmed]
Herrera S., Bonelo A., Perlaza B. L., Valencia A. Z., Cifuentes C., Hurtado S., Quintero G., Lopez J. A., Corradin G., Arevalo-Herrera M., 12-2004. Use of long synthetic peptides to study the antigenicity and immunogenicity of the Plasmodium vivax circumsporozoite protein. International Journal for Parasitology 34(13-14) pp. 1535-46. [DOI] [Web of Science] [Pubmed]
Kajava A.V., Potekhin S.A., Corradin G., Leapman R.D., 05-2004. Organization of designed nanofibrils assembled from alpha-helical peptides as determined by electron microscopy. Journal of Peptide Science 10(5) pp. 291-297. [DOI] [Web of Science] [Pubmed]
Meraldi V., Nebie I., Tiono A. B., Diallo D., Sanogo E., Theisen M., Druilhe P., Corradin G., Moret R., Sirima B. S., 07-2004. Natural antibody response to Plasmodium falciparum Exp-1, MSP-3 and GLURP long synthetic peptides and association with protection. Parasite Immunology 26(6-7) pp. 265-72. [DOI] [Web of Science] [Pubmed]
Peyre M., Audran R., Estevez F., Corradin G., Gander B., Sesardic D., Johansen P., 2004. Childhood and malaria vaccines combined in biodegradable microspheres produce immunity with synergistic interactions. Journal of Controlled Release 99(3) pp. 345-355. [DOI] [Web of Science] [Pubmed]
Sedegah M., Charoenvit Y., Aguiar J., Sacci J., Hedstrom R., Kumar S., Belmonte A., Lanar D. E., Jones T. R., Abot E. et al., 11-2004. Effect on antibody and T-cell responses of mixing five GMP-produced DNA plasmids and administration with plasmid expressing GM-CSF. Genes Immun 5(7) pp. 553-61. [DOI] [Web of Science] [Pubmed]
Singh S., Soe S., Mejia J. P., Roussilhon C., Theisen M., Corradin G., Druilhe P., 09-2004. Identification of a conserved region of Plasmodium falciparum MSP3 targeted by biologically active antibodies to improve vaccine design. Journal of Infectious Diseases 190(5) pp. 1010-8. [DOI] [Web of Science] [Pubmed]
Audran R., Peter K., Dannull J., Men Y., Scandella E., Groettrup M., Gander B., Corradin G., 03-2003. Encapsulation of peptides in biodegradable microspheres prolongs their MHC class-I presentation by dendritic cells and macrophages in vitro. Vaccine 21(11-12) pp. 1250-5. [DOI] [Web of Science] [Pubmed]
Fellrath J. M., Kettner A., Dufour N., Frigerio C., Schneeberger D., Leimgruber A., Corradin G., Spertini F., 04-2003. Allergen-specific T-cell tolerance induction with allergen-derived long synthetic peptides: results of a phase I trial. Journal of Allergy and Clinical Immunology 111(4) pp. 854-61. [DOI] [Web of Science] [Pubmed]
Melnik T. N., Villard V., Vasiliev V., Corradin G., Kajava A. V., Potekhin S. A., 12-2003. Shift of fibril-forming ability of the designed alpha-helical coiled-coil peptides into the physiological pH region. Protein Engineering 16(12) pp. 1125-30. [DOI] [Web of Science] [Pubmed]
Nebie I., Cuzin-Ouattara N., Diallo D. A., Cousens S. N., Theisen M., Corradin G., Traore A. S., Esposito F., 09-2003. Humoral responses to defined malaria antigens in children living since birth under insecticide treated curtains in Burkina Faso. Acta Tropica 88(1) pp. 17-25. [DOI] [Web of Science] [Pubmed]
Arevalo-Herrera M., Valencia A. Z., Vergara J., Bonelo A., Fleischhauer K., Gonzalez J. M., Restrepo J. C., Lopez J. A., Valmori D., Corradin G. et al., 03-2002. Identification of HLA-A2 restricted CD8(+) T-lymphocyte responses to Plasmodium vivax circumsporozoite protein in individuals naturally exposed to malaria. Parasite Immunology 24(3) pp. 161-9. [DOI] [Web of Science] [Pubmed]
Corradin S., Ransijn A., Corradin G., Bouvier J., Delgado M. B., Fernandez-Carneado J., Mottram J. C., Vergeres G., Mauel J., 11-2002. Novel peptide inhibitors of Leishmania gp63 based on the cleavage site of MARCKS (myristoylated alanine-rich C kinase substrate)-related protein. Biochemical Journal 367(3) pp. 761-769. [DOI] [Web of Science] [Pubmed]
Genton B., Corradin G., 10-2002. Malaria vaccines: from the laboratory to the field. Current Drug Targets. Immune, Endocrine and Metabolic Disorders 2(3) pp. 255-267. [Pubmed]
Meraldi V., Nebie I., Moret R., Cuzin-Ouattara N., Thiocone A., Doumbo O., Esposito F., Traore A. S., Corradin G., Terenzi S., 03-2002. Recognition of synthetic polypeptides corresponding to the N- and C-terminal fragments of Plasmodium falciparum Exp-1 by T-cells and plasma from human donors from African endemic areas. Parasite Immunology 24(3) pp. 141-50. [DOI] [Web of Science] [Pubmed]
Meraldi V., Romero J. F., Corradin G., 2002. Peptide vaccination. Methods in Molecular Medicine 72 pp. 335-45. [DOI] [Pubmed]
Peter K., Audran R., Bonelo A., Corradin G., Lopez J. A., 2002. Assessment of antigen-specific CTL- and CD8(+)-dependent IFN-gamma responses in mice. Methods in Molecular Medicine 72 pp. 437-44. [DOI] [Pubmed]
Von Garnier C., Astori M., Kettner A., Dufour N., Corradin G., Spertini F., 03-2002. In vivo kinetics of the immunoglobulin E response to allergen: bystander effect of coimmunization and relationship with anaphylaxis. Clinical and Experimental Allergy 32(3) pp. 401-10. [DOI] [Web of Science] [Pubmed]
Kettner A., Hughes G. J., Frutiger S., Astori M., Roggero M., Spertini F., Corradin G., 05-2001. Api m 6: a new bee venom allergen. Journal of Allergy and Clinical Immunology 107(5) pp. 914-20. [DOI] [Web of Science] [Pubmed]
Lopez J. A., Weilenman C., Audran R., Roggero M. A., Bonelo A., Tiercy J. M., Spertini F., Corradin G., 07-2001. A synthetic malaria vaccine elicits a potent CD8(+) and CD4(+) T lymphocyte immune response in humans. Implications for vaccination strategies. European Journal of Immunology 31(7) pp. 1989-98. [Web of Science] [Pubmed]
Perlaza B. L., Sauzet J. P., Balde A. T., Brahimi K., Tall A., Corradin G., Druilhe P., 07-2001. Long synthetic peptides encompassing the Plasmodium falciparum LSA3 are the target of human B and T cells and are potent inducers of B helper, T helper and cytolytic T cell responses in mice. European Journal of Immunology 31(7) pp. 2200-9. [DOI] [Web of Science] [Pubmed]
Peter K., Men Y., Pantaleo G., Gander B., Corradin G., 07-2001. Induction of a cytotoxic T-cell response to HIV-1 proteins with short synthetic peptides and human compatible adjuvants. Vaccine 19(30) pp. 4121-9. [DOI] [Web of Science] [Pubmed]
Potekhin S. A., Melnik T. N., Popov V., Lanina N. F., Vazina A. A., Rigler P., Verdini A. S., Corradin G., Kajava A. V., 11-2001. De novo design of fibrils made of short alpha-helical coiled coil peptides. Chemistry and Biology 8(11) pp. 1025-32. [DOI] [Web of Science] [Pubmed]
Theisen M., Dodoo D., Toure-Balde A., Soe S., Corradin G., Koram K. K., Kurtzhals J. A., Hviid L., Theander T., Akanmori B. et al., 09-2001. Selection of glutamate-rich protein long synthetic peptides for vaccine development: antigenicity and relationship with clinical protection and immunogenicity. Infection and Immunity 69(9) pp. 5223-9. [DOI] [Web of Science] [Pubmed]
Astori M., von Garnier C., Kettner A., Dufour N., Corradin G., Spertini F., 09-2000. Inducing tolerance by intranasal administration of long peptides in naive and primed CBA/J mice. Journal of Immunology 165(6) pp. 3497-505. [Web of Science] [Pubmed]
Bonelo A., Valmori D., Triponez F., Tiercy J. M., Mentha G., Oberholzer J., Champagne P., Romero J. F., Esposito F., Nebie I. et al., 11-2000. Generation and characterization of malaria-specific human CD8(+) lymphocyte clones: effect of natural polymorphism on T cell recognition and endogenous cognate antigen presentationby liver cells. European Journal of Immunology 30(11) pp. 3079-88. [DOI] [Web of Science] [Pubmed]
Franke E. D., Sette A., Sacci J. Jr., Southwood S., Corradin G., Hoffman S. L., 06-2000. A subdominant CD8(+) cytotoxic T lymphocyte (CTL) epitope from the Plasmodium yoelii circumsporozoite protein induces CTLs that eliminate infected hepatocytes from culture. Infection and Immunity 68(6) pp. 3403-11. [DOI] [Web of Science] [Pubmed]
Gonzalez J. M., Peter K., Esposito F., Nebie I., Tiercy J. M., Bonelo A., Arevalo-Herrera M., Valmori D., Romero P., Herrera S. et al., 10-2000. HLA-A*0201 restricted CD8+ T-lymphocyte responses to malaria: identification of new Plasmodium falciparum epitopes by IFN-gamma ELISPOT. Parasite Immunology 22(10) pp. 501-14. [DOI] [Web of Science] [Pubmed]
Johansen P., Estevez F., Zurbriggen R., Merkle H. P., Gluck R., Corradin G., Gander B., 12-2000. Towards clinical testing of a single-administration tetanus vaccine based on PLA/PLGA microspheres. Vaccine 19(9-10) pp. 1047-54. [DOI] [Web of Science] [Pubmed]
Roggero M. A., Meraldi V., Lopez J. A., Eberl G., Romero J. C., Matile H., Betschart B., Corradin G., Renggli J., 09-2000. The synthetic, oxidized C-terminal fragment of the Plasmodium berghei circumsporozoite protein elicits a high protective response. European Journal of Immunology 30(9) pp. 2679-85. [DOI] [Web of Science] [Pubmed]
Tosi G., Meazza R., De Lerma Barbaro A., D'Agostino A., Mazza S., Corradin G., Albini A., Noonan D. M., Ferrini S., Accolla R. S., 04-2000. Highly stable oligomerization forms of HIV-1 Tat detected by monoclonal antibodies and requirement of monomeric forms for the transactivating function on the HIV-1 LTR. European Journal of Immunology 30(4) pp. 1120-6. [DOI] [Web of Science] [Pubmed]
von Garnier C., Astori M., Kettner A., Dufour N., Heusser C., Corradin G., Spertini F., 06-2000. Allergen-derived long peptide immunotherapy down-regulates specific IgE response and protects from anaphylaxis. European Journal of Immunology 30(6) pp. 1638-45. [DOI] [Web of Science] [Pubmed]
Charoenvit Y., Majam V. F., Corradin G., Sacci J. B. Jr., Wang R., Doolan D. L., Jones T. R., Abot E., Patarroyo M. E., Guzman F. et al., 11-1999. CD4(+) T-cell- and gamma interferon-dependent protection against murine malaria by immunization with linear synthetic peptides from a Plasmodium yoelii 17-kilodalton hepatocyte erythrocyte protein. Infection and Immunity 67(11) pp. 5604-14. [Web of Science] [Pubmed]
Corradin S., Ransijn A., Corradin G., Roggero M.A., Schmitz A.A., Schneider P., Mauël J., Vergères G., 1999. MARCKS-related protein (MRP) is a substrate for the Leishmania major surface protease leishmanolysin (gp63). Journal of Biological Chemistry 274(36) pp. 25411-25418. [DOI] [Web of Science] [Pubmed]
Eberl G., Renggli J., Men Y., Roggero M. A., Lopez J. A., Corradin G., 02-1999. Extracellular processing and presentation of a 69-mer synthetic polypetide to MHC class I-restricted T cells. Molecular Immunology 36(2) pp. 103-12. [DOI] [Web of Science] [Pubmed]
Escobar P., Yu Z., Terskikh A., Holmes N., Corradin G., Mach J.P., Healy F., 1999. Induction in transgenic mice of HLA-A2.1-restricted cytotoxic T cells specific for a peptide sequence from a mutated p21ras protein. Clinical and Experimental Immunology 116(2) pp. 214-219. [Web of Science] [Pubmed]
Fryauff D. J., Mouzin E., Church L. W., Ratiwayanto S., Hadiputranto H., Sutamihardja M. A., Widjaja H., Corradin G., Subianto B., Hoffman S. L., 01-1999. Lymphocyte response to tetanus toxin T-cell epitopes: effects of tetanus vaccination and concurrent malaria prophylaxis. Vaccine 17(1) pp. 59-63. [DOI] [Web of Science] [Pubmed]
Kettner A., Henry H., Hughes G. J., Corradin G., Spertini F., 03-1999. IgE and T-cell responses to high-molecular weight allergens from bee venom. Clinical and Experimental Allergy 29(3) pp. 394-401. [Web of Science] [Pubmed]
Men Y., Audran R., Thomasin C., Eberl G., Demotz S., Merkle H. P., Gander B., Corradin G., 03-1999. MHC class I- and class II-restricted processing and presentation of microencapsulated antigens. Vaccine 17(9-10) pp. 1047-56. [DOI] [Web of Science] [Pubmed]
Modiano D., Chiucchiuini A., Petrarca V., Sirima B. S., Luoni G., Roggero M. A., Corradin G., Coluzzi M., Esposito F., 10-1999. Interethnic differences in the humoral response to non-repetitive regions of the Plasmodium falciparum circumsporozoite protein. American Journal of Tropical Medicine and Hygiène 61(4) pp. 663-7. [Web of Science] [Pubmed]
Roggero M. A., Weilenmann C., Bonelo A., Audran R., Renggli J., Spertini F., Corradin G., Lopez J. A., 09-1999. Plasmodium falciparum CS C-terminal fragment: preclinical evaluation and phase I clinical studies. Parassitologia 41(1-3) pp. 421-4. [Pubmed]
Solioz N., Blum-Tirouvanziam U., Jacquet R., Rafati S., Corradin G., Mauël J., Fasel N., 1999. The protective capacities of histone H1 against experimental murine cutaneous leishmaniasis. Vaccine 18(9-10) pp. 850-859. [DOI] [Web of Science] [Pubmed]
Arevalo-Herrera M., Roggero M. A., Gonzalez J. M., Vergara J., Corradin G., Lopez J. A., Herrera S., 07-1998. Mapping and comparison of the B-cell epitopes recognized on the Plasmodium vivax circumsporozoite protein by immune Colombians and immunized Aotus monkeys. Annals of Tropical Medicine and Parasitology 92(5) pp. 539-51. [DOI] [Web of Science] [Pubmed]
Audran R., Men Y., Johansen P., Gander B., Corradin G., 07-1998. Enhanced immunogenicity of microencapsulated tetanus toxoid with stabilizing agents. Pharmaceutical Research 15(7) pp. 1111-6. [DOI] [Web of Science] [Pubmed]
Eberl G., Jiang S., Yu Z., Schneider P., Corradin G., Mach J.P., 1998. An anti-CD19 antibody coupled to a tetanus toxin peptide induces efficient Fas ligand (FasL)-mediated cytotoxicity of a transformed human B cell line by specific CD4+ T cells. Clinical and Experimental Immunology 114(2) pp. 173-178. [DOI] [Web of Science] [Pubmed]
Johansen P., Corradin G., Merkle H.P., Gander B., 12-1998. Release of tetanus toxoid from adjuvants and PLGA microspheres: how experimental set-up and surface adsorption fool the pattern. Journal of Controlled Release : Official Journal of the Controlled Release Society 56(1-3) pp. 209-217. [DOI] [Web of Science] [Pubmed]
Johansen P., Men Y., Audran R., Corradin G., Merkle H. P., Gander B., 07-1998. Improving stability and release kinetics of microencapsulated tetanus toxoid by co-encapsulation of additives. Pharmaceutical Research 15(7) pp. 1103-10. [DOI] [Web of Science] [Pubmed]
Le T. P., Church L. W., Corradin G., Hunter R. L., Charoenvit Y., Wang R., de la Vega P., Sacci J., Ballou W. R., Kolodny N. et al., 02-1998. Immunogenicity of Plasmodium falciparum circumsporozoite protein multiple antigen peptide vaccine formulated with different adjuvants. Vaccine 16(2-3) pp. 305-12. [DOI] [Web of Science] [Pubmed]
Bertholet S., Iggo R., Corradin G., 03-1997. Cytotoxic T lymphocyte responses to wild-type and mutant mouse p53 peptides. European Journal of Immunology 27(3) pp. 798-801. [DOI] [Web of Science] [Pubmed]
Charoenvit Y., Fallarme V., Rogers W. O., Sacci J. B. Jr., Kaur M., Aguiar J. C., Yuan L. F., Corradin G., Andersen E., Wizel B. et al., 08-1997. Development of two monoclonal antibodies against Plasmodium falciparum sporozoite surface protein 2 and mapping of B-cell epitopes. Infection and Immunity 65(8) pp. 3430-7. [Web of Science] [Pubmed]
Franke E. D., Corradin G., Hoffman S. L., 10-1997. Induction of protective CTL responses against the Plasmodium yoelii circumsporozoite protein by immunization with peptides. Journal of Immunology 159(7) pp. 3424-33. [Web of Science] [Pubmed]
Herrera S., De Plata C., Gonzalez M., Perlaza B. L., Bettens F., Corradin G., Arevalo-Herrera M., 04-1997. Antigenicity and immunogenicity of multiple antigen peptides (MAP) containing P. vivax CS epitopes in Aotus monkeys. Parasite Immunology 19(4) pp. 161-70. [DOI] [Web of Science] [Pubmed]
Kammerer R., Chvatchko Y., Kettner A., Dufour N., Corradin G., Spertini F., 07-1997. Modulation of T-cell response to phospholipase A2 and phospholipase A2-derived peptides by conventional bee venom immunotherapy. Journal of Allergy and Clinical Immunology 100(1) pp. 96-103. [Web of Science] [Pubmed]
Kammerer R., Kettner A., Chvatchko Y., Dufour N., Tiercy J. M., Corradin G., Spertini F., 09-1997. Delineation of PLA2 epitopes using short or long overlapping synthetic peptides: interest for specific immunotherapy. Clinical and Experimental Allergy 27(9) pp. 1016-26. [DOI] [Web of Science] [Pubmed]
Lopez J. A., Gonzalez J. M., Kettner A., Arevalo-Herrera M., Herrera S., Corradin G., Roggero M. A., 04-1997. Synthetic polypeptides corresponding to the non-repeat regions from the circumsporozoite protein of Plasmodium falciparum: recognition by human T-cells and immunogenicity in owl monkeys. Annals of Tropical Medicine and Parasitology 91(3) pp. 253-65. [Web of Science] [Pubmed]
Marussig M., Renia L., Motard A., Miltgen F., Petour P., Chauhan V., Corradin G., Mazier D., 12-1997. Linear and multiple antigen peptides containing defined T and B epitopes of the Plasmodium yoelii circumsporozoite protein: antibody-mediated protection and boosting by sporozoite infection. International Immunology 9(12) pp. 1817-24. [DOI] [Web of Science] [Pubmed]
Renggli J., Hahne M., Matile H., Betschart B., Tschopp J., Corradin G., 03-1997. Elimination of P. berghei liver stages is independent of Fas (CD95/Apo-I) or perforin-mediated cytotoxicity. Parasite Immunology 19(3) pp. 145-8. [DOI] [Web of Science] [Pubmed]
Toujas L., Delcros J. G., Diez E., Gervois N., Semana G., Corradin G., Jotereau F., 08-1997. Human monocyte-derived macrophages and dendritic cells are comparably effective in vitro in presenting HLA class I-restricted exogenous peptides. Immunology 91(4) pp. 635-42. [DOI] [Web of Science] [Pubmed]
Duarte E. A., Eberl G., Corradin G., 04-1996. Specific tolerization of active cytolytic T lymphocyte responses in vivo with soluble peptides. Cellular Immunology 169(1) pp. 16-23. [DOI] [Web of Science] [Pubmed]
Eberl G., Kessler B., Eberl L. P., Brunda M. J., Valmori D., Corradin G., 11-1996. Immunodominance of cytotoxic T lymphocyte epitopes co-injected in vivo and modulation by interleukin-12. European Journal of Immunology 26(11) pp. 2709-16. [DOI] [Web of Science] [Pubmed]
Eberl G., Widmann C., Corradin G., 09-1996. The functional half-life of H-2Kd-restricted T cell epitopes on living cells. European Journal of Immunology 26(9) pp. 1993-9. [DOI] [Web of Science] [Pubmed]
Lopez J. A., Roggero M. A., Duombo O., Gonzalez J. M., Tolle R., Koita O., Arevalo-Herrera M., Herrera S., Corradin G., 10-1996. Recognition of synthetic 104-mer and 102-mer peptides corresponding to N- and C-terminal nonrepeat regions of the Plasmodium falciparum circumsporozoite protein by sera from human donors. American Journal of Tropical Medicine and Hygiène 55(4) pp. 424-9. [Web of Science] [Pubmed]
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Wang R., Charoenvit Y., Daly T. M., Long C. A., Corradin G., Hoffman S. L., 11-1996. Protective efficacy against malaria of a combination sporozoite and erythrocytic stage vaccine. Immunology Letters 53(2-3) pp. 83-93. [DOI] [Web of Science] [Pubmed]
Barbey C., Watts C., Corradin G., 01-1995. Antigen-processing organelles from DRB1*1101 and DRB1*1104 B cell lines display a differential degradation activity. European Journal of Immunology 25(1) pp. 30-6. [DOI] [Web of Science] [Pubmed]
Blum-Tirouvanziam U., Servis C., Habluetzel A., Valmori D., Men Y., Esposito F., Del Nero L., Holmes N., Fasel N., Corradin G., 1995. Localization of HLA-A2.1-restricted T cell epitopes in the circumsporozoite protein of Plasmodium falciparum. Journal of Immunology 154(8) pp. 3922-3931. [Web of Science] [Pubmed]
Boitel B., Blank U., Mege D., Corradin G., Sidney J., Sette A., Acuto O., 04-1995. Strong similarities in antigen fine specificity among DRB1* 1302-restricted tetanus toxin tt830-843-specific TCRs in spite of highly heterogeneous CDR3. Journal of Immunology 154(7) pp. 3245-55. [Web of Science] [Pubmed]
Brander C., Pichler W. J., Corradin G., 07-1995. Identification of HIV protein-derived cytotoxic T lymphocyte (CTL) epitopes for their possible use as synthetic vaccine. Clinical and Experimental Immunology 101(1) pp. 107-13. [Web of Science] [Pubmed]
Corradin G., Watts C., 1995. Cellular immunology of tetanus toxoid. Current Topics in Microbiology and Immunology 195 pp. 77-87. [Web of Science] [Pubmed]
Eberl G., Roggero M. A., Corradin G., 01-1995. A simple mathematical model for the functional peptide/MHC/TCR interactions. Journal of Immunology 154(1) pp. 219-25. [Web of Science] [Pubmed]
Malik A., Houghten R., Corradin G., Buus S., Berzofsky J. A., Hoffman S. L., 05-1995. Identification of a nonameric H-2Kk-restricted CD8+ cytotoxic T lymphocyte epitope on the Plasmodium falciparum circumsporozoite protein. Infection and Immunity 63(5) pp. 1955-9. [Web of Science] [Pubmed]
Reymond C.D., Beghdadi-Rais C., Roggero M., Duarte E.A., Desponds C., Bernard M., Groux D., Matile H., Bron C., Corradin G. et al., 1995. Anchoring of an immunogenic Plasmodium falciparum circumsporozoite protein on the surface of Dictyostelium discoideum. Journal of Biological Chemistry 270(21) pp. 12941-12947. [DOI] [Web of Science] [Pubmed]
Roggero M.A., Filippi B., Church P., Hoffman S.L., Blum-Tirouvanziam U., Lopez J.A., Esposito F., Matile H., Reymond C.D., Fasel N. et al., 1995. Synthesis and immunological characterization of 104-mer and 102-mer peptides corresponding to the N- and C-terminal regions of the Plasmodium falciparum CS protein. Molecular Immunology 32(17-18) pp. 1301-1309. [DOI] [Web of Science] [Pubmed]
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Barbey C., Tiercy J. M., Fairweather N., Niemann H., Seger R., Corradin G., 02-1994. Processing and presentation of tetanus toxin by antigen-presenting cells from patients with chronic granulomatous disease (CGD) to human specific T cell clones are not impaired. Clinical and Experimental Immunology 95(2) pp. 227-31. [Web of Science] [Pubmed]
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Duschl C., Liley M., Corradin G., Vogel H., 09-1994. Biologically addressable monolayer structures formed by templates of sulfur-bearing molecules. Biophysical Journal 67(3) pp. 1229-37. [DOI] [Web of Science] [Pubmed]
Herrera M. A., de Plata C., Gonzalez J. M., Corradin G., Herrera S., 1994. Immunogenicity of multiple antigen peptides containing Plasmodium vivax CS epitopes in BALB/c mice. Memorias do Instituto Oswaldo Cruz 89 Suppl 2 pp. 71-6. [Web of Science] [Pubmed]
Valmori D., Sabbatini A., Lanzavecchia A., Corradin G., Matricardi P. M., 03-1994. Functional analysis of two tetanus toxin universal T cell epitopes in their interaction with DR1101 and DR1104 alleles. Journal of Immunology 152(6) pp. 2921-9. [Web of Science] [Pubmed]
Demotz S., Barbey C., Corradin G., Amoroso A., Lanzavecchia A., 02-1993. The set of naturally processed peptides displayed by DR molecules is tuned by polymorphism of residue 86. European Journal of Immunology 23(2) pp. 425-32. [DOI] [Web of Science] [Pubmed]
Eberl G., Sabbatini A., Servis C., Romero P., Maryanski J. L., Corradin G., 11-1993. MHC class I H-2Kd-restricted antigenic peptides: additional constraints for the binding motif. International Immunology 5(11) pp. 1489-92. [DOI] [Web of Science] [Pubmed]
Grillot D., Valmori D., Lambert P. H., Corradin G., Del Giudice G., 07-1993. Presentation of T-cell epitopes assembled as multiple-antigen peptides to murine and human T lymphocytes. Infection and Immunity 61(7) pp. 3064-7. [Web of Science] [Pubmed]
Maryanski J. L., Luthy R., Romero P., Healy F., Drouet C., Casanova J. L., Jaulin C., Kourilsky P., Corradin G., 04-1993. The interaction of antigenic peptides with the H-2Kd MHC class I molecule. Seminars in Immunology 5(2) pp. 95-104. [DOI] [Pubmed]
Migliorini P., Betschart B., Corradin G., 02-1993. Malaria vaccine: immunization of mice with a synthetic T cell helper epitope alone leads to protective immunity. European Journal of Immunology 23(2) pp. 582-5. [DOI] [Web of Science] [Pubmed]
Renia L., Grillot D., Marussig M., Corradin G., Miltgen F., Lambert P. H., Mazier D., Del Giudice G., 02-1993. Effector functions of circumsporozoite peptide-primed CD4+ T cell clones against Plasmodium yoelii liver stages. Journal of Immunology 150(4) pp. 1471-8. [Web of Science] [Pubmed]
Esposito F., Lombardi S., Modiano D., Habluetzel A., Del Nero L., Lamizana L., Pietra V., Rotigliano G., Corradin G., Ravot E. et al., 07-1992. In vitro immune recognition of synthetic peptides from the Plasmodium falciparum CS protein by individuals naturally exposed to different sporozoite challenge. Immunology Letters 33(2) pp. 187-99. [DOI] [Web of Science] [Pubmed]
Fasel N., Begdadi-Rais C., Bernard M., Bron C., Corradin G., Reymond C.D., 1992. Dictyostelium discoideum as an expression host for the circumsporozoite protein of Plasmodium falciparum. Gene 111(2) pp. 157-163. [DOI] [Web of Science] [Pubmed]
Herrera S., Escobar P., de Plata C., Avila G. I., Corradin G., Herrera M. A., 06-1992. Human recognition of T cell epitopes on the Plasmodium vivax circumsporozoite protein. Journal of Immunology 148(12) pp. 3986-90. [Web of Science] [Pubmed]
Lethe B., van den Eynde B., van Pel A., Corradin G., Boon T., 09-1992. Mouse tumor rejection antigens P815A and P815B: two epitopes carried by a single peptide. European Journal of Immunology 22(9) pp. 2283-8. [DOI] [Web of Science] [Pubmed]
Romero P., Eberl G., Casanova J.L., Cordey A.S., Widmann C., Luescher I.F., Corradin G., Maryanski J.L., 1992. Immunization with synthetic peptides containing a defined malaria epitope induces a highly diverse cytotoxic T lymphocyte response. Evidence that two peptide residues are buried in the MHC molecule. Journal of immunology 148(6) pp. 1871-1878. [Web of Science] [Pubmed]
Tuchscherer G., Servis C., Corradin G., Blum U., Rivier J., Mutter M., 10-1992. Total chemical synthesis, characterization, and immunological properties of an MHC class I model using the TASP concept for protein de novo design. Protein Science 1(10) pp. 1377-86. [DOI] [Web of Science] [Pubmed]
Valmori D., Pessi A., Bianchi E., Corradin G., 07-1992. Use of human universally antigenic tetanus toxin T cell epitopes as carriers for human vaccination. Journal of Immunology 149(2) pp. 717-21. [Web of Science] [Pubmed]
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Boulat B., Emsley L., Muller N., Corradin G., Maryanski J. L., Bodenhausen G., 10-1991. NMR studies of an oligoproline-containing peptide analogue that binds specifically to the H-2Kd histocompatibility molecule. Biochemistry 30(39) pp. 9429-34. [DOI] [Web of Science] [Pubmed]
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Corradin G., 08-1990. Antigen processing and presentation. Immunology Letters 25(1-3) pp. 11-3. [DOI] [Web of Science] [Pubmed]
Del Giudice G., Grillot D., Renia L., Muller I., Corradin G., Louis J. A., Mazier D., Lambert P. H., 08-1990. Peptide-primed CD4+ cells and malaria sporozoites. Immunology Letters 25(1-3) pp. 59-63. [DOI] [Web of Science] [Pubmed]
Grillot D., Michel M., Muller I., Tougne C., Renia L., Mazier D., Corradin G., Lambert P. H., Louis J. A., Del Guidice G., 06-1990. Immune responses to defined epitopes of the circumsporozoite protein of the murine malaria parasite, Plasmodium yoelii. European Journal of Immunology 20(6) pp. 1215-22. [DOI] [Web of Science] [Pubmed]
Maryanski J. L., Verdini A. S., Weber P. C., Salemme F. R., Corradin G., 01-1990. Competitor analogs for defined T cell antigens: peptides incorporating a putative binding motif and polyproline or polyglycine spacers. Cell 60(1) pp. 63-72. [DOI] [Web of Science] [Pubmed]
Mazier D., Renia L., Nussler A., Pied S., Marussig M., Goma J., Grillot D., Miltgen F., Drapier J. C., Corradin G. et al., 08-1990. Hepatic phase of malaria is the target of cellular mechanisms induced by the previous and the subsequent stages. A crucial role for liver nonparenchymal cells. Immunology Letters 25(1-3) pp. 65-70. [DOI] [Web of Science] [Pubmed]
Migliorini P., Boulanger N., Betschart B., Corradin G., 02-1990. Plasmodium berghei subunit vaccine: repeat synthetic peptide of circumsporozoite protein comprising T- and B-cell epitopes fails to confer immunity. Scandinavian Journal of Immunology 31(2) pp. 237-42. [DOI] [Web of Science] [Pubmed]
Romero P., Maryanski J. L., Cordey A. S., Corradin G., Nussenzweig R. S., Zavala F., 08-1990. Isolation and characterization of protective cytolytic T cells in a rodent malaria model system. Immunology Letters 25(1-3) pp. 27-31. [DOI] [Web of Science] [Pubmed]
Del Giudice G., Cheng Q., Mazier D., Meuwissen J. H., Grau G. E., Corradin G., Pessi A., Verdini A. S., Lambert P. H., 05-1989. Primary and secondary responses to (NANP) peptides by Plasmodium falciparum sporozoites in various strains of mice. Scandinavian Journal of Immunology 29(5) pp. 555-62. [Web of Science] [Pubmed]
Demotz S., Lanzavecchia A., Eisel U., Niemann H., Widmann C., Corradin G., 01-1989. Delineation of several DR-restricted tetanus toxin T cell epitopes. Journal of Immunology 142(2) pp. 394-402. [Web of Science] [Pubmed]
Demotz S., Matricardi P., Lanzavecchia A., Corradin G., 08-1989. A novel and simple procedure for determining T cell epitopes in protein antigens. Journal of Immunological Methods 122(1) pp. 67-72. [DOI] [Web of Science] [Pubmed]
Demotz S., Matricardi P. M., Irle C., Panina P., Lanzavecchia A., Corradin G., 12-1989. Processing of tetanus toxin by human antigen-presenting cells. Evidence for donor and epitope-specific processing pathways. Journal of Immunology 143(12) pp. 3881-6. [Web of Science] [Pubmed]
Maryanski J. L., Abastado J. P., Corradin G., Cerottini J. C., 1989. Structural features of peptides recognized by H-2Kd-restricted T cells. Cold Spring Harbor Symposia on Quantitative Biology 54 Pt 1 pp. 545-50. [Pubmed]
Panina-Bordignon P., Demotz S., Corradin G., Lanzavecchia A., 1989. Study on the immunogenicity of human class-II-restricted T-cell epitopes: processing constraints, degenerate binding, and promiscuous recognition. Cold Spring Harbor Symposia on Quantitative Biology 54 Pt 1 pp. 445-51. [Pubmed]
Panina-Bordignon P., Tan A., Termijtelen A., Demotz S., Corradin G., Lanzavecchia A., 12-1989. Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells. European Journal of Immunology 19(12) pp. 2237-42. [DOI] [Web of Science] [Pubmed]
Romero P., Maryanski J. L., Corradin G., Nussenzweig R. S., Nussenzweig V., Zavala F., 09-1989. Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria. Nature 341(6240) pp. 323-6. [DOI] [Web of Science] [Pubmed]
Cooper H. M., Corradin G., Paterson Y., 09-1988. The heme moiety of cytochrome c is an autoreactive Ir gene-restricted T cell epitope. Journal of Experimental Medicine 168(3) pp. 1127-43. [DOI] [Web of Science] [Pubmed]
Maryanski J. L., Pala P., Cerottini J. C., Corradin G., 04-1988. Synthetic peptides as antigens and competitors in recognition by H-2-restricted cytolytic T cells specific for HLA. Journal of Experimental Medicine 167(4) pp. 1391-405. [DOI] [Web of Science] [Pubmed]
Pala P., Corradin G., Strachan T., Sodoyer R., Jordan B. R., Cerottini J. C., Maryanski J. L., 02-1988. Mapping of HLA epitopes recognized by H-2-restricted cytotoxic T lymphocytes specific for HLA using recombinant genes and synthetic peptides. Journal of Immunology 140(3) pp. 871-7. [Web of Science] [Pubmed]
Roosnek E., Demotz S., Corradin G., Lanzavecchia A., 06-1988. Kinetics of MHC-antigen complex formation on antigen-presenting cells. Journal of Immunology 140(12) pp. 4079-82. [Web of Science] [Pubmed]
Saad B., Corradin G., Bosshard H. R., 12-1988. Monoclonal antibody recognizes a conformational epitope in a random coil protein. European Journal of Biochemistry 178(1) pp. 219-24. [DOI] [Web of Science] [Pubmed]
Baumhüter S., Fasel N., Corradin G., Guardiola J., 1987. T cell receptor beta chain gene rearrangements and V beta gene usage in horse cytochrome c-specific T cell hybridomas. European Journal of Immunology 17(5) pp. 657-661. [DOI] [Web of Science] [Pubmed]
Baumhuter S., Wallace C. J., Proudfoot A. E., Bron C., Corradin G., 05-1987. Multiple T cell antigenic determinants identified within a limited region of the horse cytochrome c molecule. European Journal of Immunology 17(5) pp. 651-6. [DOI] [Web of Science] [Pubmed]
Brunati S., Corradin G., Bron C., 01-1987. Production and characterization of a rabbit antiserum to the mouse CD8 antigenic complex by immunization with a synthetic peptide. Journal of Immunological Methods 96(1) pp. 97-105. [DOI] [Web of Science] [Pubmed]
Burnens A., Demotz S., Corradin G., Binz H., Bosshard H. R., 02-1987. Epitope mapping by chemical modification of free and antibody-bound protein antigen. Science 235(4790) pp. 780-3. [DOI] [Web of Science] [Pubmed]
Le Corre R., Gerlier D., Martin A., Le Garrec Y., Corradin G., Bron C., Toujas L., 03-1987. A new epitope of the T200 molecule family defined by the 3A35 monoclonal antibody and expressed by macrophages and activated T lymphocytes. European Journal of Immunology 17(3) pp. 327-33. [DOI] [Web of Science] [Pubmed]
le Corre R., le Garrec Y., Gerlier D., Corradin G., Toujas L., 04-1987. Regulation of the expression on mouse T lymphocytes of the epitope identified by monoclonal antibody 3A35. Cellular Immunology 106(1) pp. 122-31. [Web of Science] [Pubmed]
Maryanski J. L., Kuhn L. C., Corradin G., 03-1987. Mouse fibroblasts that express a cloned gene for the human transferrin receptor induce a specific cytolytic T cell response. European Journal of Immunology 17(3) pp. 441-3. [DOI] [Web of Science] [Pubmed]
Spiazzi A., Corradin G., Nagasawa R., Tridente G., MacDonald H. R., Bron C., 07-1987. Biochemical characterization of a T-lymphoma-specific 90,000 molecular weight disulfide linked dimeric glycoprotein. Molecular Immunology 24(7) pp. 719-27. [DOI] [Web of Science] [Pubmed]
Borin G., Marchiori F., Calderan A., Corradin G., Wallace C. J., 12-1986. Synthesis of fragments by classical solution methods for use in cytochrome c semisynthesis. Biopolymers 25(12) pp. 2271-9. [DOI] [Web of Science] [Pubmed]
Del Giudice G., Cooper J.A., Merino J., Verdini A.S., Pessi A., Togna A.R., Engers H.D., Corradin G., Lambert P.H., 1986. The antibody response in mice to carrier-free synthetic polymers of Plasmodium falciparum circumsporozoite repetitive epitope is I-Ab-restricted: possible implications for malaria vaccines. Journal of Immunology 137(9) pp. 2952-2955. [Web of Science] [Pubmed]
Maryanski J. L., Pala P., Corradin G., Jordan B. R., Cerottini J. C., 12-1986. H-2-restricted cytolytic T cells specific for HLA can recognize a synthetic HLA peptide. Nature 324(6097) pp. 578-9. [DOI] [Web of Science] [Pubmed]
Togna A.R., Del Giudice G., Verdini A.S., Bonelli F., Pessi A., Engers H.D., Corradin G., 1986. Synthetic Plasmodium falciparum circumsporozoite peptides elicit heterogenous L3T4+ T cell proliferative responses in H-2b mice. Journal of Immunology 137(9) pp. 2956-2960. [Web of Science] [Pubmed]
Wallace C.J., Corradin G., Marchiori F., Borin G., 1986. Cytochrome c chimerae from natural and synthetic fragments: significance of the biological properties. Biopolymers 25(11) pp. 2121-2132. [DOI] [Web of Science] [Pubmed]
Naim H.Y., Luescher B., Corradin G., Bron C., 1984. The mouse Lyt-2/3 antigen complex--II. Structural analysis of the subunits. Molecular Immunology 21(4) pp. 337-341. [Web of Science] [Pubmed]
Carel S., Bron C., Corradin G., 1983. T-cell hybridoma specific for a cytochrome c peptide: specific antigen binding and interleukin 2 production. Proceedings of the National Academy of Sciences of the United States of America 80(15) pp. 4832-4836. [DOI] [Web of Science] [Pubmed]
Corradin G., Juillerat M.A., Vita C., Engers H.D., 1983. Fine specificity of a BALB/c T cell clone directed against beef apo cytochrome c. Molecular Immunology 20(7) pp. 763-768. [DOI] [Web of Science] [Pubmed]
Etlinger H.M., Corradin G., Chiller J.M., 1983. Maturation of the lymphoid system. III. Induction of selective unresponsiveness by injection of a haptenated carbohydrate into neonatal mice. Developmental and Comparative Immunology 7(1) pp. 159-168. [DOI] [Web of Science] [Pubmed]
Buchmüller Y., Mauël J., Corradin G., 1982. Antigen presentation in vitro by a murine macrophage cell line. Advances in Experimental Medicine and Biology 155 pp. 557-561. [Web of Science] [Pubmed]
Carel S., Bron C., Corradin G., 1982. Cytochrome c specific T cell hybrid. Current Topics in Microbiology and Immunology 100 pp. 111-116. [Web of Science] [Pubmed]
Corradin G., Zubler R.H., Engers H.D., 1981. Clonal analysis of the BALB/c T cell proliferative response to apo beef cytochrome c. Journal of Immunology 127(6) pp. 2442-2446. [Web of Science] [Pubmed]
Corradin G., Chesnut R.W., Grey H.M., 1979. Antigen degradation by macrophages as an obligatory step in the presentation of antigen to T lymphocytes. La Ricerca in Clinica e in Laboratorio 9(4) pp. 311-318. [Pubmed]
Corradin G., Harbury H.A., 1974. Reconstitution of horse heart cytochrome c: reformation of the peptide bond linking residues 65 and 66. Biochemical and Biophysical Research Communications 61(4) pp. 1400-1406. [DOI] [Web of Science] [Pubmed]
Corradin G., Harbury H.A., 1971. Reconstitution of horse heart cytochrome c: interaction of the components obtained upon cleavage of the peptide bond following methionine residue 65. Proceedings of the National Academy of Sciences of the United States of America 68(12) pp. 3036-3039. [DOI] [Web of Science] [Pubmed]
Corradin G., Harbury H.A., 1970. Cleavage of cytochrome c with cyanogen bromide. Biochimica et Biophysica Acta. Protein Structure 221(3) pp. 489-496. [DOI] [Web of Science] [Pubmed]
Phd thesis
Balam S., 2012. Immune response mechanisms and protection against "Plasmodium falciparum" and "Plasmodium berghei". 158 p., Université de Lausanne, Faculté de biologie et médecine, Spertini, F. (dir.).
Stirnemann K., 2008. Development of a bifunctional CD1d-anti-HER2 scFv fusion molecule to redirect the iNKT cell-mediated immune response to the tumor site. 172 p., Université de Lausanne, Faculté de biologie et médecine, Corradin G. (dir.).
Agak G.W., 10-2007. Immunological and protective properties of novel malaria blood stage peptide antigens. 150 p., Université de Lausanne, Faculté de biologie et médecine, Corradin G. (dir.).
Torgler R., 2007. Role of hepatocyte wounding on " Plasmodium " liver-stage development and survival. 83 p., Université de Lausanne, Faculté de biologie et médecine, Corradin G. (dir.).
Cesson V., 2006. Development and evaluation of antibody-MHC/peptide conjugates as a new form of cancer immunotherapy. 172 p., Université de Lausanne, Faculté de biologie et médecine, Corradin G. (dir.).
Person Function Contact
Victor de Gautard Trainee
Daniel Guignard Trainee



Giampietro Corradin


Tel: + 41 21 314 28 36

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