Go to: content | top | bottom | search
You are hereUNIL > Department of Biochemistry > Research > Thome Miazza Margot

Thome Miazza Margot, Associate Professor



Margot Thome studied Biochemistry at the University of Tübingen and the University of Arizona, and carried out her PhD work in the laboratory of Oreste Acuto at the Pasteur Institute in Paris. As a postdoctoral fellow she worked with Jürg Tschopp at the University of Lausanne, where she identified human and viral FLIP proteins as key apoptosis regulators. She became Assistant Professor of the Swiss National Science Foundation at the Department of Biochemistry of the University of Lausanne in 2004, and was appointed Associate Professor in 2009. Since 2015 she is the Deputy Director of the Department

Research Interests

Present work of the Thome laboratory focuses on the study of signaling pathways that control lymphocyte activation and survival and the development of lymphomas.
Lymphocytes play a crucial role in the defense against pathogens and tumor cells. One focus of our research is to understand the molecular mechanisms that control the activation of T-lymphocytes, initiated upon triggering of the T-cell antigen receptor by MHC-bound antigen. This leads to the initiation of multiple signaling pathways that regulate changes in cell shape and gene expression that are critical for efficient T-cell activation, proliferation and survival. Another focus of our research is to understand the molecular mechanisms underlying aberrant lymphocyte proliferation and survival that occurs in certain lymphoid tumors (lymphomas). 
By uncovering new molecular players and enzymatic activities relevant to these pathways, we aim at identifying possible targets for therapeutic immuno-modulation or treatment of lymphomas.

Key words: Antigen receptor, Signaling, NF-κB, Lymphocytes, Lymphoma

Representative Publications

Hailfinger, S., Nogai, H., Pelzer, C., Jaworski, M., Cabalzar, K., Charton, J.E., Guzzardi, M., Décaillet, C., Grau, M., Dörken, B., Lenz, P., Lenz, G. and Thome, M.  Malt1-dependent RelB cleavage promotes canonical NF-B activation in lymphocytes and lymphoma cell lines.  Proc. Natl. Acad. Sci. USA. 108, 14596-14601 (2011).

Pelzer, C., Cabalzar, K., Wolf, A., Gonzalez, M., Lenz, G. and Thome, M.  Malt1 activity is controlled by monoubiquitination.  Nature Immunol. 14, 337-347 (2013).

Jaworski, M., Marsland, B.J., Gehrig, J., Held, W., Favre, S., Luther, S.A., Perroud, M., Golshayan, D., Gaide, O. and Thome, M.  Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity. EMBO J. 33, 2765-2781 (2014).

Juilland, M., Gonzalez, M., Erdmann, T., Banz, Y., Jevnikar, Z., Hailfinger, S., Tzankov, A., Grau, M., Lenz, G., Novak, U. and Thome, M.  CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas. Blood. 127, 1780-1789 (2016).

Juilland, M. and Thome, M.  The role of the CBM complex in lymphoid malignancies.  Curr. Opin. Hematol. 23, 402-409 (2016).

Bonsignore, L., Passelli, K., Pelzer, C., Perroud, M., Konrad, A., Thurau, M., Stürzl, M., Dai, L., Trillo-Trinoco, J., Del Valle, L., Qin, Z. and Thome, M.  A role for MALT1 activity in Kaposi’s sarcoma-associated herpesvirus latency and growth of primary effusion lymphoma.  Leukemia doi: 10.1038/leu.2016.239 [Epub ahead of print] (2016).

2016 |  2014 |  2013 |  2012 |  2011 |  2010 |  2009 |  2008 |  2007 |  2006 |  2005 |  2004 |  2003 |  2002 |  2001 |  2000 |  1999 |  1998 |  1997 |  1996 |  1995 |  1994 |  1993 |  Thèses (doctorat) | 

Jaworski M., Thome M., 2016. The paracaspase MALT1: biological function and potential for therapeutic inhibition. Cellular and Molecular Life Sciences : Cmls 73(3) pp. 459-473. [DOI] [Web of Science] [Pubmed]
Juilland M., Gonzalez M., Erdmann T., Banz Y., Jevnikar Z., Hailfinger S., Tzankov A., Grau M., Lenz G., Novak U. et al., 2016. CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas. Blood 127(14) pp. 1780-1789. [DOI] [Web of Science] [Pubmed]
Juilland M., Thome M., 2016. Role of the CARMA1/BCL10/MALT1 complex in lymphoid malignancies. Current Opinion in Hematology 23(4) pp. 402-409. [DOI] [Web of Science] [Pubmed]
Martin R, Desponds C, Eren R O, Quadroni M, Thome M, Fasel N, 2016. Caspase-mediated cleavage of raptor participates in the inactivation of mTORC1 during cell death. Cell Death Discovery 2 p. 16024. [Document] [url editor site] [DOI]
Martin R., Thome M., Martinon F., Fasel N., 2016. Raptor hunted by caspases. Cell Death and Disease 7(6) pp. e2242. [Document] [DOI] [Web of Science] [Pubmed]
Baens M., Bonsignore L., Somers R., Vanderheydt C., Weeks S.D., Gunnarsson J., Nilsson E., Roth R.G., Thome M., Marynen P., 2014. MALT1 auto-proteolysis is essential for NF-κB-dependent gene transcription in activated lymphocytes. PLoS One 9(8) pp. e103774. [Document] [DOI] [Web of Science] [Pubmed]
Hailfinger S., Lenz G., Thome M., 2014. Targeting B-cell lymphomas with inhibitors of the MALT1 paracaspase. Current Opinion in Chemical Biology 23C pp. 47-55. [DOI] [Web of Science] [Pubmed]
Hailfinger S., Pelzer C., Thome M., 2014. Detection and measurement of paracaspase MALT1 activity. Methods in Molecular Biology 1133 pp. 177-188. [DOI] [Web of Science] [Pubmed]
Jaworski M., Marsland B.J., Gehrig J., Held W., Favre S., Luther S.A., Perroud M., Golshayan D., Gaide O., Thome M., 2014. Malt1 protease inactivation efficiently dampens immune responses but causes spontaneous autoimmunity. EMBO Journal 33(23) pp. 2765-2781. [DOI] [Web of Science] [Pubmed]
Shin H.M., Tilahun M.E., Cho O.H., Chandiran K., Kuksin C.A., Keerthivasan S., Fauq A.H., Golde T.E., Miele L., Thome M. et al., 2014. NOTCH1 can initiate NF-κB activation via cytosolic interactions with components of the T cell Signalosome. Frontiers in Immunology 5 p. 249. [Document] [DOI] [Web of Science] [Pubmed]
Cabalzar K., Pelzer C., Wolf A., Lenz G., Iwaszkiewicz J., Zoete V., Hailfinger S., Thome M., 2013. Monoubiquitination and Activity of the Paracaspase MALT1 Requires Glutamate 549 in the Dimerization Interface. PLoS One 8(8) pp. e72051. [Document] [DOI] [Web of Science] [Pubmed]
Hailfinger S., Thome M, 2013. Paracaspase. pp. 2295-2300 in Rawlings N.D., Salvesen G.S. (eds.) Handbook of proteolytic enzymes. 3rd, Academic Press, London. [DOI] [Web of Science]
Nogai H., Wenzel S.S., Hailfinger S., Grau M., Kaergel E., Seitz V., Wollert-Wulf B., Pfeifer M., Wolf A., Frick M. et al., 2013. IκB-ζ controls the constitutive NF-κB target gene network and survival of ABC DLBCL. Blood 122(13) pp. 2242-2250. [DOI] [Web of Science] [Pubmed]
Pelzer C., Cabalzar K., Wolf A., Gonzalez M., Lenz G., Thome M., 2013. The protease activity of the paracaspase MALT1 is controlled by monoubiquitination. Nature Immunology 14(4) pp. 337-345. [DOI] [Web of Science] [Pubmed]
Thuille N., Wachowicz K., Hermann-Kleiter N., Kaminski S., Fresser F., Lutz-Nicoladoni C., Leitges M., Thome M., Massoumi R., Baier G., 2013. PKCθ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes. PLoS One 8(1) pp. e53709. [Document] [DOI] [Web of Science] [Pubmed]
Wenzel S.S., Grau M., Mavis C., Hailfinger S., Wolf A., Madle H., Deeb G., Dörken B., Thome M., Lenz P. et al., 2013. MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma. Leukemia 27(6) pp. 1381-1390. [DOI] [Web of Science] [Pubmed]
Marion S., Mazzolini J., Herit F., Bourdoncle P., Kambou-Pene N., Hailfinger S., Sachse M., Ruland J., Benmerah A., Echard A. et al., 2012. The NF-κB signaling protein Bcl10 regulates actin dynamics by controlling AP1 and OCRL-bearing vesicles. Developmental Cell 23(5) pp. 954-967. [DOI] [Web of Science] [Pubmed]
Hailfinger S., Nogai H., Pelzer C., Jaworski M., Cabalzar K., Charton J.E., Guzzardi M., Décaillet C., Grau M., Dörken B. et al., 2011. Malt1-dependent RelB cleavage promotes canonical NF-kappaB activation in lymphocytes and lymphoma cell lines. Proceedings of the National Academy of Sciences of the United States of America 108(35) pp. 14596-14601. [DOI] [Web of Science] [Pubmed]
Jevnikar Z., Obermajer N., Doljak B., Turk S., Gobec S., Svajger U., Hailfinger S., Thome M., Kos J., 2011. Cathepsin X cleavage of the beta2 integrin regulates talin-binding and LFA-1 affinity in T cells. Journal of Leukocyte Biology 90(1) pp. 99-109. [DOI] [Web of Science] [Pubmed]
Pelzer C., Thome M., 2011. IKKα takes control of canonical NF-κB activation. Nature Immunology 12(9) pp. 815-816. [DOI] [Web of Science] [Pubmed]
Schmid D.A., Irving M.B., Posevitz V., Hebeisen M., Posevitz-Fejfar A., Sarria J.C., Gomez-Eerland R., Thome M., Schumacher T.N., Romero P. et al., 2010. Evidence for a TCR affinity threshold delimiting maximal CD8 T cell function. Journal of Immunology 184(9) pp. 4936-4946. [Document] [DOI] [Web of Science] [Pubmed]
Thome M., Charton J. E., Pelzer C., Hailfinger S., 2010. Antigen Receptor Signaling to NF-kappa B via CARMA1, BCL10, and MALT1. Cold Spring Harbor Perspectives in Biology 2(9) pp. a003004. [DOI] [Web of Science]
Brenner D., Brechmann M., Röhling S., Tapernoux M., Mock T., Winter D., Lehmann W.D., Kiefer F., Thome M., Krammer P.H. et al., 2009. Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells. Proceedings of the National Academy of Sciences of the United States of America 106(34) pp. 14508-14513. [DOI] [Web of Science] [Pubmed]
Hailfinger S., Lenz G., Ngo V., Posvitz-Fejfar A., Rebeaud F., Guzzardi M., Penas E.M., Dierlamm J., Chan W.C., Staudt L.M. et al., 2009. Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America 106(47) pp. 19946-19951. [DOI] [Web of Science] [Pubmed]
Hailfinger S., Rebeaud F., Thome M., 2009. Adapter and enzymatic functions of proteases in T-cell activation. Immunological reviews 232(1) pp. 334-347. [DOI] [Web of Science] [Pubmed]
Thurau M., Marquardt G., Gonin-Laurent N., Weinländer K., Naschberger E., Jochmann R., Alkharsah K.R., Schulz T.F., Thome M., Neipel F. et al., 2009. Viral inhibitor of apoptosis vFLIP/K13 protects endothelial cells against superoxide-induced cell death. Journal of virology 83(2) pp. 598-611. [DOI] [Web of Science] [Pubmed]
Rebeaud F., Hailfinger S., Posevitz-Fejfar A., Tapernoux M., Moser R., Rueda D., Gaide O., Guzzardi M., Iancu E. M., Rufer N. et al., 2008. The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nature Immunology 9(3) pp. 272-281. [DOI] [Web of Science] [Pubmed]
Thome M., 2008. Multifunctional roles for MALT1 in T-cell activation. Nature Reviews Immunology 8(7) pp. 495-500. [DOI] [Web of Science] [Pubmed]
Torgler R., Bongfen S. E., Romero J. C., Tardivel A., Thome M., Corradin G., 2008. Sporozoite-mediated hepatocyte wounding limits Plasmodium parasite development via MyD88-mediated NF-kappa B activation and inducible NO synthase expression. Journal of Immunology 180(6) pp. 3990-3999. [Web of Science] [Pubmed]
Misra R.S., Russell J.Q., Koenig A., Hinshaw-Makepeace J.A., Wen R., Wang D., Huo H., Littman D.R., Ferch U., Ruland J. et al., 2007. Caspase-8 and c-FLIPL associate in lipid rafts with NF-kappaB adaptors during T cell activation. Journal of Biological Chemistry 282(27) pp. 19365-19374. [DOI] [Web of Science] [Pubmed]
Rebeaud F., Hailfinger S., Thome M., 2007. Dlgh1 and Carma1 MAGUK proteins contribute to signal specificity downstream of TCR activation. Trends in Immunology 28(5) pp. 196-200. [DOI] [Web of Science] [Pubmed]
Rueda D., Gaide O., Ho L., Lewkowicz E., Niedergang F., Hailfinger S., Rebeaud F., Guzzardi M., Conne B., Thelen M. et al., 2007. Bcl10 controls TCR- and FcgammaR-induced actin polymerization. Journal of Immunology 178(7) pp. 4373-4384. [Web of Science] [Pubmed]
Thome M., Weil R., 2007. Post-translational modifications regulate distinct functions of CARMA1 and BCL10. Trends in Immunology 28(6) pp. 281-288. [DOI] [Web of Science] [Pubmed]
Loeuillet C., Martinon F., Perez C., Munoz M., Thome M., Meylan P.R., 2006. Mycobacterium tuberculosis subverts innate immunity to evade specific effectors. Journal of Immunology 177(9) pp. 6245-6255. [Web of Science] [Pubmed]
Thurau M., Everett H., Tapernoux M., Tschopp J., Thome M., 2006. The TRAF3-binding site of human molluscipox virus FLIP molecule MC159 is critical for its capacity to inhibit Fas-induced apoptosis. Cell Death and Differentiation 13(9) pp. 1577-1585. [DOI] [Web of Science] [Pubmed]
Rueda D., Thome M., 2005. Phosphorylation of CARMA1: the link(er) to NF-kappaB activation. Immunity 23(6) pp. 551-553. [DOI] [Web of Science] [Pubmed]
Teixeiro E., Daniels M.A., Hausmann B., Schrum A.G., Naeher D., Luescher I., Thome M., Bragado R., Palmer E., 2004. T cell division and death are segregated by mutation of TCRbeta chain constant domains. Immunity 21(4) pp. 515-526. [DOI] [Web of Science] [Pubmed]
Thome M., 2004. CARMA1, BCL-10 and MALT1 in lymphocyte development and activation. Nature Reviews. Immunology 4(5) pp. 348-359. [DOI] [Web of Science] [Pubmed]
Egawa T., Albrecht B., Favier B., Sunshine M.J., Mirchandani K., O'Brien W., Thome M., Littman D.R., 2003. Requirement for CARMA1 in antigen receptor-induced NF-kappa B activation and lymphocyte proliferation. Current Biology 13(14) pp. 1252-1258. [DOI] [Web of Science] [Pubmed]
Thome M., Tschopp J., 2003. TCR-induced NF-kappaB activation: a crucial role for Carma1, Bcl10 and MALT1. Trends in Immunology 24(8) pp. 419-424. [DOI] [Web of Science] [Pubmed]
Aganna E., Martinon F., Hawkins P.N., Ross J.B., Swan D.C., Booth D.R., Lachmann H.J., Bybee A., Gaudet R., Woo P. et al., 2002. Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis. Arthritis and Rheumatism 46(9) pp. 2445-2452. [DOI] [Web of Science] [Pubmed]
Gaide O., Favier B., Legler D.F., Bonnet D., Brissoni B., Valitutti S., Bron C., Tschopp J., Thome M., 2002. CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation. Nature Immunology 3(9) pp. 836-843. [DOI] [Web of Science] [Pubmed]
Meylan E., Martinon F., Thome M., Gschwendt M., Tschopp J., 2002. RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis. EMBO Reports 3(12) pp. 1201-1208. [DOI] [Web of Science] [Pubmed]
Micheau O., Thome M., Schneider P., Holler N., Tschopp J., Nicholson D.W., Briand C., Grütter M.G., 2002. The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. Journal of Biological Chemistry 277(47) pp. 45162-45171. [DOI] [Web of Science] [Pubmed]
Thome M., Tschopp J., 2002. Bcl10. Current Biology 12(2) pp. R45. [DOI] [Web of Science] [Pubmed]
Gaide O., Martinon F., Micheau O., Bonnet D., Thome M., Tschopp J., 2001. Carma1, a CARD-containing binding partner of Bcl10, induces Bcl10 phosphorylation and NF-kappaB activation. FEBS Letters 496(2-3) pp. 121-127. [DOI] [Web of Science] [Pubmed]
Siegmund D., Mauri D., Peters N., Juo P., Thome M., Reichwein M., Blenis J., Scheurich P., Tschopp J., Wajant H., 2001. Fas-associated death domain protein (FADD) and caspase-8 mediate up-regulation of c-Fos by Fas ligand and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) via a FLICE inhibitory protein (FLIP)-regulated pathway. Journal of Biological Chemistry 276(35) pp. 32585-32590. [DOI] [Web of Science] [Pubmed]
Thome M., Gaide O., Micheau O., Martinon F., Bonnet D., Gonzalez M., Tschopp J., 2001. Equine herpesvirus protein E10 induces membrane recruitment and phosphorylation of its cellular homologue, bcl-10. Journal of Cell Biology 152(5) pp. 1115-1122. [Document] [DOI] [Web of Science] [Pubmed]
Thome M., Tschopp J., 2001. Regulation of lymphocyte proliferation and death by FLIP. Nature Reviews. Immunology 1(1) pp. 50-58. [DOI] [Web of Science] [Pubmed]
Holler N., Zaru R., Micheau O., Thome M., Attinger A., Valitutti S., Bodmer J.L., Schneider P., Seed B., Tschopp J., 2000. Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule. Nature Immunology 1(6) pp. 489-495. [DOI] [Web of Science] [Pubmed]
Kataoka T., Budd R.C., Holler N., Thome M., Martinon F., Irmler M., Burns K., Hahne M., Kennedy N., Kovacsovics M. et al., 2000. The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways. Current Biology 10(11) pp. 640-648. [DOI] [Web of Science] [Pubmed]
Thome M., Martinon F., Hofmann K., Rubio V., Steiner V., Schneider P., Mattmann C., Tschopp J., 1999. Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase. Journal of Biological Chemistry 274(15) pp. 9962-9968. [DOI] [Web of Science] [Pubmed]
Kataoka T., Schröter M., Hahne M., Schneider P., Irmler M., Thome M., Froelich C.J., Tschopp J., 1998. FLIP prevents apoptosis induced by death receptors but not by perforin/granzyme B, chemotherapeutic drugs, and gamma irradiation. Journal of Immunology 161(8) pp. 3936-3942. [Web of Science] [Pubmed]
Meinl E., Fickenscher H., Thome M., Tschopp J., Fleckenstein B., 1998. Anti-apoptotic strategies of lymphotropic viruses. Immunology Today 19(10) pp. 474-479. [DOI] [Web of Science] [Pubmed]
Thome M., Hofmann K., Burns K., Martinon F., Bodmer J.L., Mattmann C., Tschopp J., 1998. Identification of CARDIAK, a RIP-like kinase that associates with caspase-1. Current Biology 8(15) pp. 885-888. [DOI] [Web of Science] [Pubmed]
Tschopp J., Irmler M., Thome M., 1998. Inhibition of fas death signals by FLIPs. Current Opinion in Immunology 10(5) pp. 552-558. [DOI] [Web of Science] [Pubmed]
Tschopp J., Thome M., Hofmann K., Meinl E., 1998. The fight of viruses against apoptosis. Current Opinion in Genetics and Development 8(1) pp. 82-87. [DOI] [Web of Science] [Pubmed]
Bodmer J.L., Burns K., Schneider P., Hofmann K., Steiner V., Thome M., Bornand T., Hahne M., Schröter M., Becker K. et al., 1997. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). Immunity 6(1) pp. 79-88. [DOI] [Web of Science] [Pubmed]
Irmler M., Thome M., Hahne M., Schneider P., Hofmann K., Steiner V., Bodmer J.L., Schröter M., Burns K., Mattmann C. et al., 1997. Inhibition of death receptor signals by cellular FLIP. Nature 388(6638) pp. 190-195. [Document] [DOI] [Web of Science] [Pubmed]
Schneider P., Bodmer J.L., Thome M., Hofmann K., Holler N., Tschopp J., 1997. Characterization of two receptors for TRAIL. FEBS letters 416(3) pp. 329-34. [Document] [DOI] [Web of Science] [Pubmed]
Schneider P., Thome M., Burns K., Bodmer J.L., Hofmann K., Kataoka T., Holler N., Tschopp J., 1997. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. Immunity 7(6) pp. 831-836. [Document] [DOI] [Web of Science] [Pubmed]
Thome M., Schneider P., Hofmann K., Fickenscher H., Meinl E., Neipel F., Mattmann C., Burns K., Bodmer J.L., Schröter M. et al., 1997. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 386(6624) pp. 517-521. [Document] [DOI] [Web of Science] [Pubmed]
Thome M., Germain V., DiSanto J.P., Acuto O., 09-1996. The p56lck SH2 domain mediates recruitment of CD8/p56lck to the activated T cell receptor/CD3/zeta complex. European Journal of Immunology 26(9) pp. 2093-2100. [DOI] [Web of Science] [Pubmed]
Thome M., Duplay P., Guttinger M., Acuto O., 1995. Syk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex. Journal of Experimental Medicine 181(6) pp. 1997-2006. [DOI] [Web of Science] [Pubmed]
Duplay P., Thome M., Hervé F., Acuto O., 1994. P56LCK interacts via its src homology 2 domain with the ZAP-70 kinase. Journal of Experimental Medicine 179(4) pp. 1163-1172. [DOI] [Web of Science] [Pubmed]
Thome M., Hirt W., Pfaff E., Reddehase M.J., Saalmüller A., 10-1994. Porcine T-cell receptors: molecular and biochemical characterization. Veterinary Immunology and Immunopathology 43(1-3) pp. 13-18. [DOI] [Web of Science] [Pubmed]
Phd thesis
Frera G., 2015. Characterization of the HIV protease inhibitor Nelfinavir cellular targets. 177 p., Université de Lausanne, Faculté de biologie et médecine, Martinon F., Thome M. (dir.).
Cabalzar K., 2014. Activation mechanisms of the protease MALT1 and cleavage of one of its targets - the ribonuclease Regnase-1- in lymphocytes and lymphoma cell lines. 110 p., Université de Lausanne, Faculté de biologie et médecine, Thome M. (dir.).
Staehli F., 2011. Immune regulation and function of the NOD-like receptors NLRC5 and NLRP3. 123 p., Université de Lausanne, Faculté de biologie et médecine, Guarda G., Thome-Miazza M. (dir.).
Hailfinger S., 2009. The role of Malt1 proteolytic activity in T cell activation and lymphoma development. 132 p., Université de Lausanne, Faculté de biologie et médecine, Margot T. (dir.).
Moser R., 2009. Molecular characterization of the Carma1-related protein card9. 107 p., Université de Lausanne, Faculté de biologie et médecine, Thome-Miazza M. (dir.).
Rebeaud F., 2008. Study of the proteolytic activity of the paracaspase MALT1 in T cell activation. 109 p., Université de Lausanne, Faculté de biologie et médecine, Thome M. (dir.).
Tapernoux M., 2008. Molecular insights into T cell activation : study of the TRAF, Bcl10 and Carma 1 proteins. 133 p., Université de Lausanne, Faculté de biologie et médecine, Thome-Miazza M. (dir.).
Person Position Contact
Luca Bonsignore Postdoctoral fellow Unisciences
Chantal Décaillet Technician Unisciences
Montserrat Gonzalez Technician Unisciences
Mélanie Juilland Postdoctoral fellow Unisciences
Mikhail Kuravsky Postdoctoral fellow Mikhail.Kuravsky@unil.ch
Rebekka Schairer Ph.D student Unisciences
Ivana Ubezzi Ph.D student Unisciences
Ming Zhang Postdoctoral fellow Unisciences
Mégane Bernard Apprentice Unisciences
Christelle Charbonnet Masters student Christelle.Charbonnet@unil.ch


M_Thome 2016.jpg

Margot Thome Miazza


Tel: + 41 21 692 5737

Administrative Assistant

Monique Jayet Herzstein


Tel : +41 21 692 57 34

Chemin des Boveresses 155 - CH-1066 Epalinges  - Switzerland  -  Tel. +41 21 692 5700  -  Fax +41 21 692 5705
Swiss University