Go to: content | top | bottom | search
You are hereUNIL > Department of Biochemistry > Research > Translational research > Publications > 2002/2003

Publications 2002/2003

Articles | Reviews


  • Acestor, N., Masina, S., Walker, J., Saravia, N. G., Fasel, N., and Quadroni, M. (2002). Establishing two-dimensional gels for the analysis of Leishmania proteomes. Proteomics 2, 877-879.
  • Aganna, E., Martinon, F., Hawkins, P. N., Ross, J. B., Swan, D. C., Booth, D. R., Lachmann, H. J., Bybee, A., Gaudet, R., Woo, P., Feighery, C., Cotter, F. E., Thome, M., Hitman, G. A., Tschopp, J., and McDermott, M. F. (2002). Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis. Arthritis Rheum 46, 2445-2452.
  • Anderle, P., Rakhmanova, V., Woodford, K., Zerangue, N., and Sadee, W. (2003). Messenger RNA expression of transporter and ion channel genes in undifferentiated and differentiated Caco-2 cells compared to human intestines. Pharm Res 20, 3-15.
  • Arevalo-Herrera, M., Valencia, A. Z., Vergara, J., Bonelo, A., Fleischhauer, K., Gonzalez, J. M., Restrepo, J. C., Lopez, J. A., Valmori, D., Corradin, G., and Herrera, S. (2002). Identification of HLA-A2 restricted CD8(+) T-lymphocyte responses to Plasmodium vivax circumsporozoite protein in individuals naturally exposed to malaria. Parasite Immunol 24, 161-169.
  • Aseffa, A., Gumy, A., Launois, P., MacDonald, H. R., Louis, J. A., and Tacchini-Cottier, F. (2002). The early IL-4 response to Leishmania major and the resulting Th2 cell maturation steering progressive disease in BALB/c mice are subject to the control of regulatory CD4 CD25 T cells. J Immunol 169, 3232-3241.
  • Audran, R., Peter, K., Dannull, J., Men, Y., Scandella, E., Groettrup, M., Gander, B., and Corradin, G. (2003). Encapsulation of peptides in biodegradable microspheres prolongs their MHC class-I presentation by dendritic cells and macrophages in vitro. Vaccine 21, 1250-1255.
  • Ayyoub, M., Stevanovic, S., Sahin, U., Guillaume, P., Servis, C., Rimoldi, D., Valmori, D., Romero, P., Cerottini, J. C., Rammensee, H. G., Pfreundschuh, M., Speiser, D., and Levy, F. (2002). Proteasome-assisted identification of a SSX-2-derived epitope recognized by tumor-reactive CTL infiltrating metastatic melanoma. J Immunol 168, 1717-1722.
  • Balmelli, C., Demotz, S., Acha-Orbea, H., De Grandi, P., and Nardelli-Haefliger, D. (2002). Trachea, lung, and tracheobronchial lymph nodes are the major sites where antigenpresenting cells are detected after nasal vaccination of mice with human papillomavirus type 16 virus-like particles. J Virol 76, 12596-12602.
  • Barcelo-Batllori, S., Andre, M., Servis, C., Levy, N., Takikawa, O., Michetti, P., Reymond, M., and Felley-Bosco, E. (2002). Proteomic analysis of cytokine induced proteins in human intestinal epithelial cells: implications for inflammatory bowel diseases. Proteomics 2, 551-560.
  • Belli, S. I., Monnerat, S., Schaff, C., Masina, S., Noll, T., Myler, P. J., Stuart, K., and Fasel, N. (2003). Sense and antisense transcripts in the histone H1 (HIS-1) locus of Leishmania major. Int J Parasitol 33, 965-975.
  • Binz, P. A., Abdi, F., Affolter, M., Allard, L., Barblan, J., Bhardwaj, S., Bienvenut, W. V., Bulet, P., Burgess, J., Carrette, O., Corthals, G., Delalande, F., Diemer, H., Favreau, P., Giuliano, E., Gueguen, Y., Guillaume, E., Hahner, S., Man, P., Michalet, S., Neri, D., Noukakis, D., Palagi, P., Paroutaud, P., Carvalho Pimenta, D., Quadroni, M., Resemann, A., Richert, S., Rybak, J., Sanchez, J. C., Scherl, A., Scheurer, S., Schweiger Hufnagel, U., Siethoff, C., Suckau, D., van Dorsselaer, A., Wagner Redeker, W., Walter, N., and Stocklin, R. (2003). Proteomics application exercise of the Swiss Proteomics Society: report of the SPS'02 session. Proteomics 3, 1562-1566.
  • Bourreau, E., Collet, M., Prevot, G., Milon, G., Ashimoff, D., Hasagewa, H., Parra-Lopez, C., and Launois, P. (2002). IFN-gamma-producing CD45RA CD8 and IL-10-producing CD45RA-CD4 T cells generated in response to LACK in naive subjects never exposed to Leishmania. Eur J Immunol 32, 510-520.
  • Brisken, C., Ayyannan, A., Nguyen, C., Heineman, A., Reinhardt, F., Tan, J., Dey, S. K., Dotto, G. P., Weinberg, R. A., and Jan, T. (2002). IGF-2 is a mediator of prolactin-induced morphogenesis in the breast. Dev Cell 3, 877-887.
  • Brunetti, C. R., Paulose-Murphy, M., Singh, R., Qin, J., Barrett, J. W., Tardivel, A., Schneider, P., Essani, K., and McFadden, G. (2003). A secreted high-affinity inhibitor of human TNF from Tanapox virus. Proc Natl Acad Sci U S A 100, 4831-4836.
  • Bullani, R. R., Wehrli, P., Viard-Leveugle, I., Rimoldi, D., Cerottini, J. C., Saurat, J. H., Tschopp, J., and French, L. E. (2002). Frequent downregulation of Fas (CD95) expression and function in melanoma. Melanoma Res 12, 263-270.
  • Burns, K., Janssens, S., Brissoni, B., Olivos, N., Beyaert, R., and Tschopp, J. (2003). Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J Exp Med 197, 263-268.
  • Burri, L., Servis, C., Chapatte, L., and Levy, F. (2002). A recyclable assay to analyze the NH(2)-terminal trimming of antigenic peptide precursors. Protein Expr Purif 26, 19-27.
  • Calautti, E., Grossi, M., Mammucari, C., Aoyama, Y., Pirro, M., Ono, Y., Li, J., and Dotto, G. P. (2002). Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion. J Cell Biol 156, 137-148.
  • Cerny, E. H., Levy, R., Mauel, J., Mpandi, M., Mutter, M., Henzelin-Nkubana, C., Patiny, L., Tuchscherer, G., and Cerny, T. (2002). Preclinical development of a vaccine 'against smoking'. Onkologie 25, 406-411.
  • Chakour, R., Guler, R., Bugnon, M., Allenbach, C., Garcia, I., Mauel, J., Louis, J., and Tacchini-Cottier, F. (2003). Both the Fas ligand and inducible nitric oxide synthase are needed for control of parasite replication within lesions in mice infected with Leishmania major whereas the contribution of tumor necrosis factor is minimal. Infect Immun 71, 5287-5295.
  • Chtcheglova, L., Romero, J., Corradin, G., and Dietler, G. (2002). Atomic force microscopy for imaging and force mapping of plasmodium Berghei sporozoite. Physics of Low- Dimensional Structures 5-6, 189-192.
  • Ciccia, A., Constantinou, A., and West, S. C. (2003). Identification and characterization of the human mus81-eme1 endonuclease. J Biol Chem 278, 25172-25178.
  • Cloutier, S. M., Chagas, J. R., Mach, J. P., Gygi, C. M., Leisinger, H. J., and Deperthes, D. (2002). Substrate specificity of human kallikrein 2 (hK2) as determined by phage display technology. Eur J Biochem 269, 2747-2754.
  • Constantinou, A., Chen, X. B., McGowan, C. H., and West, S. C. (2002). Holliday junction resolution in human cells: two junction endonucleases with distinct substrate specificities. Embo J 21, 5577-5585.
  • Constantinou, A., and West, S. C. (2003). Holliday junction branch migration and resolution assays. In Methods in molecular biology, A. Waldman, ed. (New Jersey, Humana Press), pp. In press.
  • Corradin, S., Ransijn, A., Corradin, G., Bouvier, J., Delgado, M. B., Fernandez-Carneado, J., Mottram, J. C., Vergeres, G., and Mauel, J. (2002). Novel peptide inhibitors of Leishmania gp63 based on the cleavage site of MARCKS (myristoylated alanine-rich C kinase substrate)-related protein. Biochem J 367, 761-769.
  • Corthesy-Theulaz, I., Corthesy, B., Bachmann, D., Velin, D., and Kraehenbuhl, J. P. (2003). Passive immunity in Helicobacter-challenged neonatal mice conferred by immunized dams lasts until weaning. Infect Immun 71, 2226-2229.
  • Cunningham, A. F., Fallon, P. G., Khan, M., Vacheron, S., Acha-Orbea, H., MacLennan, I. C., McKenzie, A. N., and Toellner, K. M. (2002). Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13, and B cells. J Immunol 169, 2900-2906.
  • Donda, A., Cesson, V., Mach, J. P., Corradin, G., Primus, F. J., and Robert, B. (2003). In vivo targeting of an anti-tumor antibody coupled to antigenic MHC class I complexes induces specific growth inhibition and regression of established syngeneic tumor grafts. Cancer Immun 3, 11.
  • Doucey, M. A., Goffin, L., Naeher, D., Michielin, O., Baumgartner, P., Guillaume, P., Palmer, E., and Luescher, I. F. (2003). CD3 delta establishes a functional link between the T cell receptor and CD8. J Biol Chem 278, 3257-3264.
  • Doucey, M. A., Legler, D. F., Faroudi, M., Boucheron, N., Baumgaertner, P., Naeher, D., Cebecauer, M., Hudrisier, D., Ruegg, C., Palmer, E., Valitutti, S., Bron, C., and Luescher, I. F. (2003). The beta1 and beta3 integrins promote T cell receptor-mediated cytotoxic T lymphocyte activation. J Biol Chem 278, 26983-26991.
  • Dutoit, V., Rubio-Godoy, V., Doucey, M. A., Batard, P., Lienard, D., Rimoldi, D., Speiser, D., Guillaume, P., Cerottini, J. C., Romero, P., and Valmori, D. (2002). Functional avidity of tumor antigen-specific CTL recognition directly correlates with the stability of MHC/peptide multimer binding to TCR. J Immunol 168, 1167-1171.
  • Fasel, N., and Masina, M. S. (2003). Life after death: are trypanosomatids programmed to die for the survival of their partners? Kinetoplastid Biol Dis 2, 4.
  • Fellrath, J. M., Kettner, A., Dufour, N., Frigerio, C., Schneeberger, D., Leimgruber, A., Corradin, G., and Spertini, F. (2003). Allergen-specific T-cell tolerance induction with allergen-derived long synthetic peptides: results of a phase I trial. J Allergy Clin Immunol 111, 854-861.
  • Ferrero, I., Held, W., Wilson, A., Tacchini-Cottier, F., Radtke, F., and MacDonald, H. R. (2002). Mouse CD11c(+) B220(+) Gr1(+) plasmacytoid dendritic cells develop independently of the T-cell lineage. Blood 100, 2852-2857.
  • Finke, D., Acha-Orbea, H., Mattis, A., Lipp, M., and Kraehenbuhl, J. (2002). CD4+ CD3- cells induce Peyer's patch development: role of alpha4beta1 integrin activation by CXCR5. Immunity 17, 363-373.
  • Finke, D., Luther, S. A., and Acha-Orbea, H. (2003). The role of neutralizing antibodies for mouse mammary tumor virus transmission and mammary cancer development. Proc Natl Acad Sci U S A 100, 199-204.
  • Fotopoulos, G., Harari, A., Michetti, P., Trono, D., Pantaleo, G., and Kraehenbuhl, J. P. (2002). Transepithelial transport of HIV-1 by M cells is receptor-mediated. Proc Natl Acad Sci U S A 99, 9410-9414.
  • French, L. E., and Tschopp, J. (2002). Defective death receptor signaling as a cause of tumor immune escape. Semin Cancer Biol 12, 51-55.
  • Gaide, O., Favier, B., Legler, D. F., Bonnet, D., Brissoni, B., Valitutti, S., Bron, C., Tschopp, J., and Thome, M. (2002). CARMA1 is a critical lipid raft-associated regulator of TCRinduced NF-kappa B activation. Nat Immunol 3, 836-843.
  • Gaide, O., and Schneider, P. (2003). Permanent correction of an inherited ectodermal dysplasia with recombinant EDA. Nat Med 9, 614-618.
  • Gongora, R., Acestor, N., Quadroni, M., Fasel, N., Saravia, N. G., and Walker, J. (2003). Mapping the proteome of Leishmania Viannia parasites using two-dimensional polyacrylamide gel electrophoresis and associated technologies. Biomedica 23, 153-160.
  • Groom, J., Kalled, S. L., Cutler, A. H., Olson, C., Woodcock, S. A., Schneider, P., Tschopp, J., Cachero, T. G., Batten, M., Wheway, J., Mauri, D., Cavill, D., Gordon, T. P., Mackay, C. R., and Mackay, F. (2002). Association of BAFF/BLyS overexpression and altered B cell differentiation with Sjogren's syndrome. J Clin Invest 109, 59-68.
  • Hiller, S., Kohl, A., Fiorito, F., Herrmann, T., Wider, G., Tschopp, J., Grutter, M. G., and Wuthrich, K. (2003). NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain. Structure (Camb) 11, 1199-1205.
  • Holler, N., Tardivel, A., Kovacsovics-Bankowski, M., Hertig, S., Gaide, O., Martinon, F., Tinel, A., Deperthes, D., Calderara, S., Schulthess, T., Engel, J., Schneider, P., and Tschopp, J. (2003). Two adjacent trimeric Fas ligands are required for Fas signaling and formation of a death-inducing signaling complex. Mol Cell Biol 23, 1428-1440.
  • Janssens, S., Burns, K., Tschopp, J., and Beyaert, R. (2002). Regulation of interleukin-1- and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88. Curr Biol 12, 467-471.
  • Janssens, S., Burns, K., Vercammen, E., Tschopp, J., and Beyaert, R. (2003). MyD88S, a splice variant of MyD88, differentially modulates NF-kappaB- and AP-1-dependent gene expression. FEBS Lett 548, 103-107.
  • Johnson-Leger, C. A., Aurrand-Lions, M., Beltraminelli, N., Fasel, N., and Imhof, B. A. (2002). Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration. Blood 100, 2479-2486.
  • Kataoka, T., Ito, M., Budd, R. C., Tschopp, J., and Nagai, K. (2002). Expression level of c- FLIP versus Fas determines susceptibility to Fas ligand-induced cell death in murine thymoma EL-4 cells. Exp Cell Res 273, 256-264.
  • Kaufmann, M., Bozic, D., Briand, C., Bodmer, J. L., Zerbe, O., Kohl, A., Tschopp, J., and Grutter, M. G. (2002). Identification of a basic surface area of the FADD death effector domain critical for apoptotic signaling. FEBS Lett 527, 250-254.
  • Kovacsovics, M., Martinon, F., Micheau, O., Bodmer, J. L., Hofmann, K., and Tschopp, J. (2002). Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation. Curr Biol 12, 838-843.
  • Kuenzi, P., Schneider, P., and Dobbelaere, D. A. (2003). Theileria parva-transformed T cells show enhanced resistance to Fas/Fas ligand-induced apoptosis. J Immunol 171, 1224-1231.
  • Lacour, S., Micheau, O., Hammann, A., Drouineaud, V., Tschopp, J., Solary, E., and Dimanche-Boitrel, M. T. (2003). Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells. Oncogene 22, 1807-1816.
  • Launois, P., Gumy, A., Himmelrich, H., Locksley, R. M., Rocken, M., and Louis, J. A. (2002). Rapid IL-4 production by Leishmania homolog of mammalian RACK1-reactive CD4(+) T cells in resistant mice treated once with anti-IL-12 or -IFN-gamma antibodies at the onset of infection with Leishmania major instructs Th2 cell development, resulting in nonhealing lesions. J Immunol 168, 4628-4635.
  • Legler, D. F., Micheau, O., Doucey, M. A., Tschopp, J., and Bron, C. (2003). Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation. Immunity 18, 655-664.
  • Lens, S. M., Kataoka, T., Fortner, K. A., Tinel, A., Ferrero, I., MacDonald, R. H., Hahne, M., Beermann, F., Attinger, A., Orbea, H. A., Budd, R. C., and Tschopp, J. (2002). The caspase 8 inhibitor c-FLIP(L) modulates T-cell receptor-induced proliferation but not activationinduced cell death of lymphocytes. Mol Cell Biol 22, 5419-5433.
  • Levy, F., Burri, L., Morel, S., Peitrequin, A. L., Levy, N., Bachi, A., Hellman, U., Van den Eynde, B. J., and Servis, C. (2002). The final N-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases. J Immunol 169, 4161-4171.
  • Liu, Z. J., Shirakawa, T., Li, Y., Soma, A., Oka, M., Dotto, G. P., Fairman, R. M., Velazquez, O. C., and Herlyn, M. (2003). Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol Cell Biol 23, 14-25.
  • Lowin-Kropf, B., Kunz, B., Schneider, P., and Held, W. (2002). A role for the src family kinase Fyn in NK cell activation and the formation of the repertoire of Ly49 receptors. Eur J Immunol 32, 773-782.
  • Luther, S. A., Bidgol, A., Hargreaves, D. C., Schmidt, A., Xu, Y., Paniyadi, J., Matloubian, M., and Cyster, J. G. (2002). Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis. J Immunol 169, 424-433.
  • Luther, S.A., Ansel, K.M., Cyster, J.G. (2003). Overlapping function of CXCR5, IL-7 receptor a and CCR7 in lymph node development. J.Exp.Med 197, 1191-1198.
  • Martinon, F., Burns, K., and Tschopp, J. (2002). The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10, 417-426.
  • Masina, S., M, M. G., Demotz, S. O., and Fasel, N. J. (2003). Protection against cutaneous leishmaniasis in outbred vervet monkeys using a recombinant histone H1 antigen. J Infect Dis 188, 1250-1257.
  • Meraldi, V., Audran, R., Romero, J. F., Brossard, V., Bauer, J., Lopez, J. A., and Corradin, G. (2003). OM-174, a new adjuvant with a potential for human use, induces a protective response when administered with the synthetic C-terminal fragment 242-310 from the circumsporozoite protein of Plasmodium berghei. Vaccine 21, 2485-2491.
  • Meraldi, V., Nebie, I., Moret, R., Cuzin-Ouattara, N., Thiocone, A., Doumbo, O., Esposito, F., Traore, A. S., Corradin, G., and Terenzi, S. (2002). Recognition of synthetic polypeptides corresponding to the N- and C-terminal fragments of Plasmodium falciparum Exp-1 by T-cells and plasma from human donors from African endemic areas. Parasite Immunol 24, 141-150.
  • Meraldi, V., Romero, J. F., and Corradin, G. (2002). Peptide vaccination. Methods Mol Med 72, 335-345.
  • Meylan, E., Martinon, F., Thome, M., Gschwendt, M., and Tschopp, J. (2002). RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis. EMBO Rep 3, 1201-1208.
  • Micheau, O., Thome, M., Schneider, P., Holler, N., Tschopp, J., Nicholson, D. W., Briand, C., and Grutter, M. G. (2002). The long form of FLIP is an activator of caspase-8 at the Fas death-inducing signaling complex. J Biol Chem 277, 45162-45171.
  • Micheau, O., and Tschopp, J. (2003). Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114, 181-190.
  • Mpandi, M., Otten, L. A., Lavanchy, C., Acha-Orbea, H., and Finke, D. (2003). Passive immunization with neutralizing antibodies interrupts the mouse mammary tumor virus life cycle. J Virol 77, 9369-9377.
  • Nebie, I., Cuzin-Ouattara, N., Diallo, D. A., Cousens, S. N., Theisen, M., Corradin, G., Traore, A. S., and Esposito, F. (2003). Humoral responses to defined malaria antigens in children living since birth under insecticide treated curtains in Burkina Faso. Acta Trop 88, 17-25.
  • Nicolas, M., Wolfer, A., Raj, K., Kummer, J. A., Mill, P., van Noort, M., Hui, C. C., Clevers, H., Dotto, G. P., and Radtke, F. (2003). Notch1 functions as a tumor suppressor in mouse skin. Nat Genet 33, 416-421.
  • Oh, H., Mammucari, C., Nenci, A., Cabodi, S., Cohen, S. N., and Dotto, G. P. (2002). Negative regulation of cell growth and differentiation by TSG101 through association with p21(Cip1/WAF1). Proc Natl Acad Sci U S A 99, 5430-5435.
  • Otten, L. A., Tacchini-Cottier, F., Lohoff, M., Annunziato, F., Cosmi, L., Scarpellino, L., Louis, J., Steimle, V., Reith, W., and Acha-Orbea, H. (2003). Deregulated MHC class II transactivator expression leads to a strong Th2 bias in CD4 T lymphocytes. J Immunol 170, 1150-1157.
  • Peter, K., Audran, R., Bonelo, A., Corradin, G., and Lopez, J. A. (2002). Assessment of antigen-specific CTL- and CD8(+)-dependent IFN-gamma responses in mice. Methods Mol Med 72, 437-444.
  • Peter, K., Brunda, M. J., and Corradin, G. (2002). IL-12 administration leads to a transient depletion of T cells, B cells, and APCs and concomitant abrogation of the HLA-A2.1- restricted CTL response in transgenic mice. J Immunol 169, 63-67.
  • Petit, F., Arnoult, D., Lelievre, J. D., Moutouh-de Parseval, L., Hance, A. J., Schneider, P., Corbeil, J., Ameisen, J. C., and Estaquier, J. (2002). Productive HIV-1 infection of primary CD4 T cells induces mitochondrial membrane permeabilization leading to a caspaseindependent cell death. J Biol Chem 277, 1477-1487.
  • Phalipon, A., Cardona, A., Kraehenbuhl, J. P., Edelman, L., Sansonetti, P. J., and Corthésy, B. (2002). Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo. Immunity 17, 107-115.
  • Rafati, S., Fasel, N., and Masina, S. (2003). Leishmania cysteine proteinases: from gene to subunit vaccine. Curr Genomics 4, 253-261.
  • Rafati, S., Nakhaee, A., Taheri, T., Ghashghaii, A., Salmanian, A. H., Jimenez, M., Mohebali, M., Masina, S., and Fasel, N. (2003). Expression of cysteine proteinase type I and II of Leishmania infantum and their recognition by sera during canine and human visceral leishmaniasis. Exp Parasitol 103, 143-151.
  • Ramirez, J. C., Finke, D., Esteban, M., Kraehenbuhl, J. P., and Acha-Orbea, H. (2003). Tissue distribution of the Ankara strain of vaccinia virus (MVA) after mucosal or systemic administration. Arch Virol 148, 827-839.
  • Rolink, A. G., Tschopp, J., Schneider, P., and Melchers, F. (2002). BAFF is a survival and maturation factor for mouse B cells. Eur J Immunol 32, 2004-2010.
  • Rothenberger, S., Rousseaux, M., Knecht, H., Bender, F. C., Legler, D. F., and Bron, C. (2002). Association of the Epstein-Barr virus latent membrane protein 1 with lipid rafts is mediated through its N-terminal region. Cell Mol Life Sci 59, 171-180.
  • Rothenberger, S., Burns, K., Rousseaux, M., Tschopp, J., and Bron, C. (2003). Ubiquitination of the Epstein-Barr virus-encoded latent membrane protein 1 depends on the integrity of the TRAF binding site. Oncogene 22, 5614-5618.
  • Rubio-Godoy, V., Ayyoub, M., Dutoit, V., Servis, C., Schink, A., Rimoldi, D., Romero, P., Cerottini, J. C., Simon, R., Zhao, Y., Houghten, R. A., Pinilla, C., and Valmori, D. (2002). Combinatorial peptide library-based identification of peptide ligands for tumor-reactive cytolytic T lymphocytes of unknown specificity. Eur J Immunol 32, 2292-2299.
  • Schneider, P., Olson, D., Tardivel, A., Browning, B., Lugovskoy, A., Gong, D., Dobles, M., Hertig, S., Hofmann, K., Van Vlijmen, H., Hsu, Y. M., Burkly, L. C., Tschopp, J., and Zheng, T. S. (2003). Identification of a new murine tumor necrosis factor receptor locus that contains two novel murine receptors for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). J Biol Chem 278, 5444-5454.
  • Schneider, P., and Tschopp, J. (2003). BAFF and the regulation of B cell survival. Immunol Lett 88, 57-62.
  • Seykora, J. T., Mei, L., Dotto, G. P., and Stein, P. L. (2002). 'Srcasm: a novel Src activating and signaling molecule. J Biol Chem 277, 2812-2822.
  • Strika, M. C., Bladergroen, B. A., Wouters, D., Kisiel, W., Hooijberg, J. H., Verlaan, A. R., Hordijk, P. L., Schneider, P., Hack, C. E., and Kummer, J. A. (2002). Distribution of the human intracellular serpin protease inhibitor 8 in human tissues. J Histochem Cytochem 50, 1443-1454.
  • Talora, C., Sgroi, D. C., Crum, C. P., and Dotto, G. P. (2002). Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes Dev 16, 2252-2263.
  • Vacheron, S., Luther, S. A., and Acha-Orbea, H. (2002). Preferential infection of immature dendritic cells and B cells by mouse mammary tumor virus. J Immunol 168, 3470-3476.
  • Viard-Leveugle, I., Bullani, R. R., Meda, P., Micheau, O., Limat, A., Saurat, J. H., Tschopp, J., and French, L. E. (2003). Intracellular localization of keratinocyte Fas ligand explains lack of cytolytic activity under physiological conditions. J Biol Chem 278, 16183-16188.
  • Volle, J. N., Chambon, G., Sayah, A., Reymond, C., Fasel, N., and Gijs, M. A. (2003). Enhanced sensitivity detection of protein immobilization by fluorescent interference on oxidized silicon. Biosens Bioelectron 19, 457-464.
  • Von Garnier, C., Astori, M., Kettner, A., Dufour, N., Corradin, G., and Spertini, F. (2002). In vivo kinetics of the immunoglobulin E response to allergen: bystander effect of coimmunization and relationship with anaphylaxis. Clin Exp Allergy 32, 401-410.
  • Vuadens, F., Benay, C., Crettaz, D., Gallot, D., Sapin, V., Schneider, P., Bienvenut, W. V., Lemery, D., Quadroni, M., Dastugue, B., and Tissot, J. D. (2003). Identification of biologic markers of the premature rupture of fetal membranes: proteomic approach. Proteomics 3, 1521-1525.
  • Vuadens, F., Crettaz, D., Scelatta, C., Servis, C., Quadroni, M., Bienvenut, W. V., Schneider, P., Hohlfeld, P., Applegate, L. A., and Tissot, J. D. (2003). Plasticity of protein expression during culture of fetal skin cells. Electrophoresis 24, 1281-1291.
  • Waldburger, J. M., Rossi, S., Hollander, G. A., Rodewald, H. R., Reith, W., and Acha-Orbea, H. (2003). Promoter IV of the class II transactivator gene is essential for positive selection of CD4 T cells. Blood 101, 3550-3559.
  • Wirth, S., Bille, F., Koenig, S., Wehrli, N., Miconnet, I., Levy, F., Diggelmann, H., Romero, P., and Acha-Orbea, H. (2002). Testing mouse mammary tumor virus superantigen as adjuvant in cytotoxic T-lymphocyte responses against a melanoma tumor antigen. Int J Cancer 99, 201-206.
  • Wirth, S., Vessaz, A., Krummenacher, C., Baribaud, F., Acha-Orbea, H., and Diggelmann, H. (2002). Regions of mouse mammary tumor virus superantigen involved in interaction with the major histocompatibility complex class II I-A molecule. J Virol 76, 11172-11175.
  • Zangger, H., Mottram, J. C., and Fasel, N. (2002). Cell death in Leishmania induced by stress and differentiation: programmed cell death or necrosis? Cell Death Differ 9, 1126-1139.
  • Zhang, J., Bardos, T., Shao, Q., Tschopp, J., Mikecz, K., Glant, T. T., and Finnegan, A. (2003). IL-4 potentiates activated T cell apoptosis via an IL-2-dependent mechanism. J Immunol 170, 3495-3503.



  • Anderle, P., Duval, M., Draghici, S., Kuklin, A., Littlejohn, T. G., Medrano, J. F., Vilanova, D., and Roberts, M. A. (2003). Gene expression databases and data mining. Biotechniques Suppl, 36-44.
  • Bodmer, J. L., Schneider, P., and Tschopp, J. (2002). The molecular architecture of the TNF superfamily. Trends Biochem Sci 27, 19-26.
  • Burns, K., Martinon, F., and Tschopp, J. (2003). New insights into the mechanism of IL- 1beta maturation. Curr Opin Immunol 15, 26-30.
  • Didierlaurent, A., Sirard, J. C., Kraehenbuhl, J. P., and Neutra, M. R. (2002). How the gut senses its content. Cell Microbiol 4, 61-72.
  • French, L. E., and Tschopp, J. (2003). Protein-based therapeutic approaches targeting death receptors. Cell Death Differ 10, 117-123.
  • Genton, B., and Corradin, G. (2002). Malaria vaccines: from the laboratory to the field. Curr Drug Targets Immune Endocr Metabol Disord 2, 255-267.
  • Jaattela, M., and Tschopp, J. (2003). Caspase-independent cell death in T lymphocytes. Nat Immunol 4, 416-423.
  • Louis, J., Gumy, A., Voigt, H., Rocken, M., and Launois, P. (2002). Experimental cutaneous Leishmaniasis: a powerful model to study in vivo the mechanisms underlying genetic differences in Th subset differentiation. Eur J Dermatol 12, 316-318.
  • Louis, J. A., Gumy, A., Voigt, H., Launois, P., and Rocken, M. (2003). The use of the murine model of infection with Leishmania major to reveal the antagonistic effects that IL-4 can exert on T helper cell development and demonstrate that these opposite effects depend upon the nature of the cells targeted for IL-4 signaling. Pathol Biol (Paris) 51, 71-73.
  • Mach, J.-P. (2002). Tumours: targeting of monoclonal antibodies for imaging and potential for therapy. In Encyclopedia of life sciences, e. a. Ronald M. Atlas, ed. (www.els.net, Nature Publishing Group).
  • Mackay, F., Schneider, P., Rennert, P., and Browning, J. (2003). BAFF AND APRIL: a tutorial on B cell survival. Annu Rev Immunol 21, 231-264.
  • Mauel, J. (2002). Vaccination against Leishmania infections. Curr Drug Targets Immune Endocr Metabol Disord 2, 201-226.
  • Neutra, M. R., and Kraehenbuhl, J.-P. (2002). The regional immune response to microbial pathogens. In Immunology of infectious diseases, A. S. S.E.H. Kaufmann, and R. Ahmed, ed. (Washington, D.C., ASM Press), pp. 191-206.
  • Neutra, M. R., Sansonetti, P., and Kraehenbuhl, J. P. (2002). Interactions of microbial pathogens with intestinal M cells. In Infections of the Gastrointestinal Tract, M. J. Blaser, P. D. Smith, J. I. Ravdin, H. B. Greenberg, and L. Guerrant, eds. (Philadelphia, Lippincott, Williams & Wilkins), pp. 141-156.
  • Neutra, M., Sansonetti, P., and Kraehenbuhl, J. P. (2003). Role of intestinal M cells in microbial pathogenesis. In Microbial pathogenesis and the intestinal epithelial cell, G. A. Hecht, ed. (Washington, D.C, ASM Press), pp. 23-42.
  • Otten, L. A., Finke, D., and Acha-Orbea, H. (2002). Can MMTV exploit TLR4? Trends Microbiol 10, 303-305; discussion 305-306.
  • Otten, L. A., Reith, W., and Acha-Orbea, H. (2003). CIITA expression and Th1-Th2 balance. J Immunol 170, 4425.
  • Thome, M., and Tschopp, J. (2002). Bcl10. Curr Biol 12, R45.
  • Thome, M., and Tschopp, J. (2003). TCR-induced NF-kappaB activation: a crucial role for Carma1, Bcl10 and MALT1. Trends Immunol 24, 419-424.
  • Tschopp, J., Martinon, F., and Burns, K. (2003). NALPs: a novel protein family involved in inflammation. Nat Rev Mol Cell Biol 4, 95-104.


Chemin des Boveresses 155 - CH-1066 Epalinges  - Switzerland  -  Tel. +41 21 692 5700  -  Fax +41 21 692 5705
Swiss University