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  • Acestor, N., Masina, S., Ives, A., Walker, J., Saravia, N.G., and Fasel, N. (2006). Resistance to oxidative stress is associated with metastasis in mucocutaneous leishmaniasis. J Infect Dis 194, 1160-1167.
  • Allenbach, C., Zufferey, C., Perez, C., Launois, P., Mueller, C., and Tacchini-Cottier, F. (2006). Macrophages induce neutrophil apoptosis through membrane TNF, a process amplified by Leishmania major. J Immunol 176, 6656-6664.
  • Arrigoni, G., Resjo, S., Levander, F., Nilsson, R., Degerman, E., Quadroni, M., Pinna, L.A., and James, P. (2006). Chemical derivatization of phosphoserine and phosphothreonine containing peptides to increase sensitivity for MALDI-based analysis and for selectivity of MS/MS analysis. Proteomics 6, 757-766.
  • Ayyanan, A., Civenni, G., Ciarloni, L., Morel, C., Mueller, N., Lefort, K., Mandinova, A., Raffoul, W., Fiche, M., Dotto, G. P., and Brisken, C. (2006). Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism. Proc Natl Acad Sci U S A 103, 3799-3804.
  • Baars, T., Petri, S., Peters, C., and Mayer, A. (2007). Role of the V-ATPase in regulation of the vacuolar fission-fusion equilibrium. Mol Biol Cell. 18, 3873-82.
  • Bongfen, S., Torgler, R., Romero, J., Renia, L., and Corradin, G. (2007). Plasmodium berghei-infected primary hepatocytes process and present the circumsporozoite protein to specific CD8+ T cells in vitro. J Immunol. 178, 7054-6.
  • Bossen, C., Tardivel, A., Cachero, T.G., Scott, M.L., Schopp J., and Schneider, P. (2007). Baff multimerization is essential for signaling b cell survival through taci, but not baff-r. Swiss Medical Weekly. 137, 17S-17S.
  • Bossen, C., Ingold, K., Tardivel, A., Bodmer, J. L., Gaide, O., Hertig, S., Ambrose, C., Tschopp, J., and Schneider, P. (2006). Interactions of tumor necrosis factor (TNF) and TNF receptor family members in the mouse and human. J Biol Chem 281, 13964-13971.
  • Bourreau, E., Ronet, C., Couppié, P., Sainte-Marie, D., Tacchini-Cottier, F., and Launois, P. (2007). IL-10 producing CD8+ T cells in human infection with Leishmania guyanensis. Microbes Infect. 9, 1034-41.
  • Brissoni, B., Agostini, L., Kropf, M., Martinon, F., Swoboda, V., Lippens, S., Everett, H., Aebi, N., Janssens, S., Meylan, E., Felberbaum-Corti, M., Hirling, H., Gruenberg, J., Tschopp, J., and Burns, K. (2006). Intracellular trafficking of interleukin-1 receptor I requires Tollip. Curr Biol 16, 2265-2270.
  • Buchegger, F., Antonescu, C., Delaloye, A.B., Helg, C., Kovacsovics, T., Kosinski, M., Mach, J.P., and Ketterer, N. (2006). Long-term complete responses after 131I-tositumomab therapy for relapsed or refractory indolent non-Hodgkin's lymphoma. Br J Cancer 94, 1770-1776.
  • Cachero, T.G., Schwartz, I.M., Qian, F., Day, E.S., Bossen, C., Ingold, K., Tardivel, A., Krushinskie, D., Eldredge, J., Silvian, L., Lugovskoy, A., Farrington, G.K., Strauch, K., Schneider, P., and Whitty, A. (2006). Formation of virus-like clusters is an intrinsic property of the tumor necrosis factor family member BAFF (B cell activating factor). Biochemistry (Mosc) 45, 2006-2013.
  • Casal, M.L., Lewis, J.R., Mauldin, E.A., Tardivel, A., Ingold, K., Favre, M., Paradies, F., Demotz, S., Gaide, O., and Schneider, P. (2007). Significant correction of disease after postnatal administration of recombinant ectodysplasin a in canine x-linked ectodermal dysplasia. American Journal of Human Genetics. 81, 1050-1056.
  • Cesson, V., Stirnemann, K., Robert, B., Luescher, I., Filleron, T., Corradin, G., Mach, J.P., and Donda, A. (2006). Active antiviral T-lymphocyte response can be redirected against tumor cells by antitumor antibody x MHC/viral peptide conjugates. Clin Cancer Res 12, 7422-7430.
  • Chapatte, L., Ayyoub, M., Morel, S., Peitrequin, A.L., Levy, N., Servis, C., Van den Eynde, B.J., Valmori, D., and Levy, F. (2006). Processing of tumor-associated antigen by the proteasomes of dendritic cells controls in vivo T-cell responses. Cancer Res 66, 5461-5468.
  • Charmoy, M., Megnekou, R., Allenbach, C., Zweifel, C., Perez, C., Monnat, K., Breton, M., Ronet, C., Launois, P., and Tacchini-Cottier, F. (2007). Leishmania major induces distinct neutrophil phenotypes in mice that are resistant or susceptible to infection. J Leukoc Biol. 82, 288-99.
  • Corazza, N., Jakob, S., Schaer, C., Frese, S., Keogh, A., Stroka, D., Kassahn, D., Torgler, R., Mueller, C., Schneider, P., and Brunner, T. (2006). TRAIL receptor-mediated JNK activation and Bim phosphorylation critically regulate Fas-mediated liver damage and lethality. J Clin Invest 116, 2493-2499.
  • Corradin, G. (2007) Peptide based malaria vaccine development: personal considerations. Microbes Infect. 9, 767-71.
  • Corradin, G., Villard,, V., and Kajava, A. (2007). Protein structure based strategies for antigen discovery and vaccine development against malaria and other pathogens. Endocr Metab Immune Disord Drug Targets. 7, 259-65.
  • Devgan, V., Nguyen, B.C., Oh, H., and Dotto, G.P. (2006). p21WAF1/Cip1 suppresses keratinocyte differentiation independently of the cell cycle through transcriptional up-regulation of the IGF-I gene. J Biol Chem 281, 30463-30470.
  • Didierlaurent, A., Brissoni, B., Velin, D., Aebi, N., Tardivel, A., Kaslin, E., Sirard, J.C., Angelov, G., Tschopp, J., and Burns, K. (2006). Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide. Mol Cell Biol 26, 735-742
  • Dostert, C., Meylan, E., and Tschopp, J. (2007). Intracellular pattern-recognition receptors. Adv Drug Deliv Rev.
  • Farley, S.M., Dotson, A.D., Purdy, D.E., Sundholm, A.J., Schneider, P., Magun, B.E., and Iordanov, M.S. (2006). Fas Ligand Elicits a Caspase-Independent Proinflammatory Response in Human Keratinocytes: Implications for Dermatitis. J Invest Dermatol 126, 2438-2451.
  • Fattah, O.M., Cloutier, S.M., Kundig, C., Felber, L.M., Gygi, C.M., Jichlinski, P., Leisinger, H.J., Gauthier, E.R., Mach, J.P., and Deperthes, D. (2006). Peptabody-EGF: a novel apoptosis inducer targeting ErbB1 receptor overexpressing cancer cells. Int J Cancer 119, 2455-2463.
  • Genton, C., Wang, Y., Izui, S., Malissen, B., Delsol, G., Fournie, G.J., Malissen, M., and Acha-Orbea, H. (2006). The Th2 lymphoproliferation developing in LatY136F mutant mice triggers polyclonal B cell activation and systemic autoimmunity. J Immunol 177, 2285-2293.
  • Girgenrath, M., Weng, S., Kostek, C.A., Browning, B., Wang, M., Brown, S.A., Winkles, J.A., Michaelson, J.S., Allaire, N., Schneider, P., Scott, M.L., Hsu, Y.M., Yagita, H., Flavell, R.A., Miller, J.B., Burkly, L.C., and Zheng, T.S. (2006). TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration. EMBO J 25, 5826-5839.
  • González, I., Desponds, C., Schaff, C., Mottram, J., and Fasel, N. (2007). Leishmania major metacaspase can replace yeast metacaspase in programmed cell death and has arginine-specific cysteine peptidase activity. Int J Parasitol. 37, 161-72.
  • Gorczynski, R.M., Alexander, C., Bessler, W., Brandenburg, K., Fournier, K., Mach, J.P., Mueller, S., Rietschel, E.T., Ulmer, A.J., Waelli, T., Zahringer U., and Khatri, I. (2007). An alteration in the levels of populations of CD4(+) Treg is in part responsible for altered cytokine production by cells of aged mice which follows injection with a fetal liver extract. Immunology Letters. 109, 101-112.
  • Grutter, C., Briand, C., Capitani, G., Mittl, P.R., Papin, S., Tschopp, J., and Grutter, M.G. (2006). Structure of the PRYSPRY-domain: implications for autoinflammatory diseases. FEBS Lett 580, 99-106.
  • Guichard, G., Trouche, N., Wieckowski, S., Sun, W., Chaloin, O., Bianco, A., Hoebeke, J., Schneider, P. and Fournel, S. (2007). Rationally-designed multivalent architectures for mimicking homotrimers of CD40L, a member of the TNF superfamily. Biopolymers. 88, 522-522.
  • Gumy, A., Aseffa, A., Rachinel, N., Breton, M., Otten, L., Tacchini-Cottier, F., Rocken, M., Doyen, N., Acha-Orbea, H., Locksley, R.M., MacDonald, H.R., Launois, P., and Louis, J. (2006). LACK-reactive CD4+ T cells require autocrine IL-2 to mediate susceptibility to Leishmania major. Eur J Immunol 36, 1465-1473.
  • Gurcel, L., Abrami, L., Girardin, S., Tschopp, J., and van der Goot, F.G. (2006). Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival. Cell 126, 1135-1145.
  • Hermsen, C.C., Verhage, D.F., Telgt, D.S., Teelen, K., Bousema, J.T., Roestenberg,M., Bolad, A., Berzins, K., Corradin, G., Leroy, O., Theisen, M., and Sauerwein, R. W. (2006). Glutamate-rich protein (GLURP) induces antibodies that inhibit in vitro growth of Plasmodium falciparum in a phase 1 malaria vaccine trial. Vaccine 25, 2930-40
  • Kariminia, A., Bourreau, E., Ronet, C., Couppie, P., Sainte-Marie, D., Tacchini-Cottier, F., and Launois, P. (2007). Selective expression of the V beta 14 T cell receptor on Leishmania guyanensis--specific CD8+ T cells during human infection. J Infect Dis. 195, 739-47.
  • Kothlow, S., Morgenroth, I., Graef, Y., Schneider, K., Riehl, I., Staeheli, P., Schneider, P., and Kaspers, B. (2007). Unique and conserved functions of B cell-activating factor of the TNF family (BAFF) in the chicken. International Immunology. 19, 203-215.
  • Kummer, J. A., Micheau, O., Schneider, P., Bovenschen, N., Broekhuizen, R. Quadir, R., Strik, M.C.M., Hack, C.E., and Tschopp, J., (2007). Ectopic expression of the serine protease inhibitor PI9 modulates death receptor-mediated apoptosis. Cell Death and Differentiation. 14, 1486-1496.
  • Launois, P., Pingel, S., Himmelrich, H., Locksley, R., and Louis, J. (2007). Different epitopes of the LACK protein are recognized by V beta 4 V alpha 8 CD4+ T cells in H-2b and H-2d mice susceptible to Leishmania major. Microbes Infect. 9, 1260-6.
  • Lefort, K., Mandinova, A., Ostano, P., Kolev, V., Calpini, V., Kolfschoten, I., V. Devgan, J. Lieb, W. Raffoul, D. Hohl, V. Neel, J. Garlick, G. Chiorino and G. Dotto (2007) Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases. Genes Dev. 21, 562-77.
  • Link, A., T. Vogt, S. Favre, M. Britschgi, H. Acha-Orbea, B. Hinz, J. Cyster and S. Luther (2007) Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells. Nat Immunol. 8, 1255-65.
  • Loeuillet, C., Martinon, F., Perez, C., Munoz, M., Thome, M., and Meylan, P. R. (2006). Mycobacterium tuberculosis subverts innate immunity to evade specific effectors. J Immunol 177, 6245-6255.
  • Luther, S., K. Serre, A. Cunningham, M. Khan, H. Acha-Orbea, I. MacLennan and K. Toellner (2007) Recirculating CD4 memory T cells mount rapid secondary responses without major contributions from follicular CD4 effectors and B cells. Eur J Immunol. 37, 1476-84.
  • Martinon, F., Petrilli, V., Mayor, A., Tardivel, A., and Tschopp, J. (2006). Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440, 237-241.
  • Masina, S., H. Zangger, D. Rivier and N. Fasel (2007) Histone H1 regulates chromatin condensation in Leishmania parasites. Exp Parasitol. 116, 83-7.
  • Mayor, A., F. Martinon, T. De Smedt, V. Pétrilli and J. Tschopp (2007) A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses. Nat Immunol. 8, 497-503.
  • Meier, D., C. Bornmann, S. Chappaz, S. Schmutz, L. Otten, R. Ceredig, H. Acha-Orbea and D. Finke (2007) Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells. Immunity. 26, 643-54.
  • Merino, D., Lalaoui, N., Morizot, A., Schneider, P., Solary, E., and Micheau, O. (2006). Differential Inhibition of TRAIL-Mediated DR5-DISC Formation by Decoy Receptors 1 and 2. Mol Cell Biol 26, 7046-7055.
  • Mou, C., Jackson, B., Schneider, P., Overbeek, P. A., and Headon, D. J. (2006). Generation of the primary hair follicle pattern. Proc Natl Acad Sci U S A 103, 9075-9080.
  • Munding, C., Keller, M., Niklaus, G., Papin, S., Tschopp, J., Werner, S., and Beer, H. D. (2006). The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion. Cell Death Differ 13, 1938-1949.
  • Nguyen, B. C., Lefort, K., Mandinova, A., Antonini, D., Devgan, V., Della Gatta, G., Koster, M. I., Zhang, Z., Wang, J., di Vignano, A. T., Kitajewski, J., Chiorino, G., Roop, D. R., Missero, C., and Dotto, G. P. (2006). Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev 20, 1028-1042.
  • Ongusaha, P. P., Kim, H. G., Boswell, S. A., Ridley, A. J., Der, C. J., Dotto, G. P., Kim, Y. B., Aaronson, S. A., and Lee, S. W. (2006). RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress. Curr Biol 16, 2466-2472.
  • Otten, L. A., Leibundgut-Landmann, S., Huarte, J., Kos-Braun, I. C., Lavanchy, C., Barras, E., Borisch, B., Steimle, V., Acha-Orbea, H., and Reith, W. (2006). Revisiting the specificity of the MHC class II transactivator CIITA in vivo. Eur J Immunol 36, 1548-1558.
  • Papin, S., S. Cuenin, L. Agostini, F. Martinon, S. Werner, H. Beer, C. Grütter, M. Grütter and J. Tschopp (2007) The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing. Cell Death Differ. 14, 1457-66.
  • Pétrilli, V., C. Dostert, D. Muruve and J. Tschopp (2007a) The inflammasome: a danger sensing complex triggering innate immunity. Curr Opin Immunol. 19, 615-22.
  • Pétrilli, V., S. Papin, C. Dostert, A. Mayor, F. Martinon and J. Tschopp (2007b) Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ. 14, 1583-9.
  • Prato, S., Fleming, J., Schmidt, C. W., Corradin, G., and Lopez, J. A. (2006). Cross-presentation of a human malaria CTL epitope is conformation dependent. Mol Immunol 43, 2031-2036.
  • Pummila, M., I. Fliniaux, R. Jaatinen, M. J. James, J. Laurikkala, P. Schneider, I. Thesleff and M. L. Mikkola (2007) Ectodysplasin has a dual role in ectodermal organogenesis: inhibition of Bmp activity and induction of Shh expression. Development. 134, 117-125.
  • Rebeaud, F., S. Hailfinger and M. Thome (2007) Dlgh1 and Carma1 MAGUK proteins contribute to signal specificity downstream of TCR activation. Trends Immunol. 28, 196-200.
  • Romero, J., G. Ibrahim, J. Renggli, H. Himmelrich, P. Graber and G. Corradin (2007) IL-12p40-independent induction of protective immunity upon multiple Plasmodium berghei irradiated sporozoite immunizations. Parasite Immunol. 29, 541-8.
  • Rossi, D. C., S. Ballenegger, K. Ingold, P. Schneider and J. Tschopp (2007) Kino me siRNA screen of the human Fas pathway. Swiss Medical Weekly. 137, 29S-29S.
  • Rueda, D., O. Gaide, L. Ho, E. Lewkowicz, F. Niedergang, S. Hailfinger, F. Rebeaud, M. Guzzardi, B. Conne, M. Thelen, J. Delon, U. Ferch, T. Mak, J. Ruland, J. Schwaller and M. Thome (2007) Bcl10 controls TCR- and FcgammaR-induced actin polymerization. J Immunol. 178, 4373-84.
  • Schmidt-Ullrich, R., Tobin, D. J., Lenhard, D., Schneider, P., Paus, R., and Scheidereit, C. (2006). NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth. Development 133, 1045-1057.
  • Schwaller, J., P. Schneider, P. Mhawech-Fauceglia, T. McKee, S. Myit, T. Matthes, J. Tschopp, O. Donze, F. A. Le Gal and B. Huard (2007) Neutrophil-derived APRIL concentrated in tumor lesions by proteoglycans correlates with human B-cell lymphoma aggressiveness. Blood. 109, 331-338.
  • Sharov, A. A., Sharova, T. Y., Mardaryev, A. N., di Vignano, A. T., Atoyan, R., Weiner, L., Yang, S., Brissette, J. L., Dotto, G. P., and Botchkarev, V. A. (2006). Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes. Proc Natl Acad Sci U S A 103, 18166-18171.
  • Thurau, M., Everett, H., Tapernoux, M., Tschopp, J., and Thome, M. (2006). The TRAF3-binding site of human molluscipox virus FLIP molecule MC159 is critical for its capacity to inhibit Fas-induced apoptosis. Cell Death Differ 13, 1577-1585.
  • Tinel, A., S. Janssens, S. Lippens, S. Cuenin, E. Logette, B. Jaccard, M. Quadroni and J. Tschopp (2007) Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway. EMBO J. 26, 197-208.
  • Uttenweiler, A., H. Schwarz, H. Neumann and A. Mayer (2007) The vacuolar transporter chaperone (VTC) complex is required for microautophagy. Molecular Biology of the Cell. 18, 166-175.
  • Villard, V., G. Agak, G. Frank, A. Jafarshad, C. Servis, I. Nébié, S. Sirima, I. Felger, M. Arevalo-Herrera, S. Herrera, F. Heitz, V. Bäcker, P. Druilhe, A. Kajava and G. Corradin (2007) Rapid identification of malaria vaccine candidates based on alpha-helical coiled coil protein motif. PLoS ONE. 2, e645.
  • Villard, V., Kalyuzhniy, O., Riccio, O., Potekhin, S., Melnik, T. N., Kajava, A. V., Ruegg, C., and Corradin, G. (2006). Synthetic RGD-containing alpha-helical coiled coil peptides promote integrin-dependent cell adhesion. J Pept Sci 12, 206-212.
  • Vince, J. E., W. W. L. Wong, N. Khan, R. Feltham, D. Chau, A. U. Ahmed, C. A. Benetatos, S. K. Chunduru, S. M. Condon, M. McKinlay, R. Brink, M. Leverkus, V. Tergaonkar, P. Schneider, B. A. Callus, F. Koentgen, D. L. Vaux and J. Silke (2007) IAP antagonists target cIAP1 to induce TNF alpha- dependent apoptosis. Cell. 131, 682-693
  • Walker, J., Acestor, N., Gongora, R., Quadroni, M., Segura, I., Fasel, N., and Saravia, N. G. (2006). Comparative protein profiling identifies elongation factor-1beta and tryparedoxin peroxidase as factors associated with metastasis in Leishmania guyanensis. Mol Biochem Parasitol 145, 254-264.
  • Willett, B. J., E. L. McMonagle, N. Logan, O. B. Spiller, P. Schneider and M. J. Hosie (2007) Probing the interaction between feline immunodeficiency virus and CD134 by using the novel monoclonal antibody 7D6 and the CD134 (OX40) ligand. Journal of Virology. 81, 9665-9679.


  • Acha-Orbea, H., A. Shakhov and D. Finke (2007) Immune response to MMTV infection. Front Biosci. 12, 1594-609.
  • Bossen, C., and Schneider, P. (2006). BAFF, APRIL and their receptors: Structure, function and signaling. Semin Immunol 18, 263-275.
  • Budd, R. C., Yeh, W. C., and Tschopp, J. (2006). cFLIP regulation of lymphocyte activation and development. Nat Rev Immunol 6, 196-204.
  • Janssens, S., and Tschopp, J. (2006). Signals from within: the DNA-damage-induced NF-kappaB response. Cell Death Differ 13, 773-784.
  • Martinon, F. and J. Tschopp (2007) Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Differ. 14, 10-22.
  • Meylan, E., and Tschopp, J. (2006). Toll-like receptors and RNA helicases: two parallel ways to trigger antiviral responses. Mol Cell 22, 561-569.
  • Meylan, E., Tschopp, J., and Karin, M. (2006). Intracellular pattern recognition receptors in the host response. Nature 442, 39-44.
  • Pétrilli, V. and F. Martinon (2007) The inflammasome, autoinflammatory diseases, and gout. Joint Bone Spine. 74, 571-6.
  • Thome, M. and R. Weil (2007) Post-translational modifications regulate distinct functions of CARMA1 and BCL10. Trends Immunol. 28, 281-8.

Book sections

  • Acha-Orbea, H. (2007) Rolf Zinkernagel, Professor für experimentelle Immunologie und Nobelpreisträger für Medizin "Ohne den Willen sich zu informieren, verbauen wue unsere Zukunft". Swiss Guest Book. Pfändler, B. (ed.), pp 118-121, Orell Füssli Verlag Zürich.
  • Thome, M. (2006). Regulation of Fas signaling by FLIP proteins. In Fas signaling, H. Wajant, ed. (New York, Landes Bioscience, Springer Science + Business Media), pp. 38-50.
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