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2016 | 2015 | 2014 | 2013 | 2012 | Selected Publications


Barroso-Chinea P., Cruz-Muros I., Afonso-Oramas D., Castro-Hernández J., Salas-Hernández J., Chtarto A., Luis-Ravelo D., Humbert-Claude M., Tenenbaum L. and González-Hernández T. (2016).
Long-term controlled GDNF over-expression reduces dopamine transporter activity without affecting tyrosine hydroxylase expression in the rat mesostriatal system. Neurobiol. Dis. 88 : 44–54.

Chtarto A,  Humbert-Claude M and Bockstael O, Das AT, Boutry S, Breger L, Barroso-Chinea P, Klaver B, Melas C, González-Hernández T, Müller R, DeWitte O, Levivier M, Lundberg C, Berkhout B, Tenenbaum L . (2016) A regulatable AAV vector mediating GDNF biological effects at clinically-approved sub-antimicrobial doxycycline doses.  Mol. Ther. Methods and Clin. Dev.. 5, 16027; doi:10.1038.



Hanna-El-Daher, L., Béard, E., Henry, H., Tenenbaum, L. and Braissant, O. (2015). Mild elevation of guanidinoacetate under partial GAMT deficiency strongly affects brain cell development. Neurobiol. Dis. 79 :14-27



Ayuso E, Blouin V, Lock M, McGorray S, Alvira MR., Auricchio A,  Bosch F, Bucher S, Chtarto A,  Clark KR, Darmon C, Doria M, Fountain W, Gao G, Giacca M, Kleinschmidt J, Leon X, Leuchs B, Mizukami H, Normand Y, Ozawa K, Surosky R, Tenenbaum L, Van Linden I, Weins B, Wright JF, Zelenaia O, Zentilin L, Snyder  RO and Moullier P. (2014). Manufacturing and Characterization of a Recombinant Adeno-Associated Virus Type 8 Reference Standard Material.  Hum Gene Ther. 25(11):977-87.

Bockstael O, Tenenbaum L, Dalkara D, Melas C, De Witte O, Levivier M, Chtarto A. (2014). Intracisternal delivery of NFκB-inducible scAAV2/9 reveals locoregional neuroinflammation induced by systemic kainic acid treatment. Front Mol Neurosci. 2014;7:92.



Chtarto, A., Bockstael, O., Tshibangu, T., Dewitte, O., Levivier, M. and Tenenbaum, L. (2013). A next step in adeno-associated virus (AAV)- mediated gene therapy for neurological diseases: Regulation and targeting. British Journal of Clinical Pharmacology 76: 217–232

Chtarto, A., Bockstael, O., Gebara, E., Vermoesen, K., Melas, C., Pythoud, C., Levivier, M., Dewitte, O., Luthi-Carter, R., Clinkers, R. and Tenenbaum L. (2013). An adeno-associated virus-based intracellular sensor of pathological Nuclear Factor-kappa B activation for disease-inducible gene transfer. PlosOne 2013;8(1):e53156

Dismuke, D.J., Tenenbaum, L., Samulski, R.J. (2013). Biosafety of Recombinant Adeno-associated Virus Vectors. Curr Gene Ther. 13: 434-452



Bockstael, O., Melas, C., Pythoud, C., Levivier, M., McCarty, D., Samulski, RJ., De Witte, O., Tenenbaum, L. (2012). Rapid transgene expression in multiple precursors cell types of adult rat subventricular zone mediated by adeno-associated type 1 vectors. Hum. Gene Ther. 23: 742-753


Selected Publications

Tenenbaum L. , J.L.Darling and E.Hooghe-Peters (1994). Adeno-associated virus (AAV) as a vector for gene transfer into glial cells of the central nervous system. Gene Ther, vol.1, suppl.1,80.

Tenenbaum L., F.Jurysta, A.Stathopoulos, Z.Puschban, C.Melas, W.T.J.M.C. Hermens, J.Verhaagen, B.Pichon, T.Velu and M.Levivier. (2000). Tropism of AAV-2 vectors for neurons of the globus pallidus. NeuroReport, 11,2277-2283.

Tenenbaum L., A. Chtarto, E. Lehtonen, D. Blum , V. Baekelandt, T.Velu, J.Brotchi and M. Levivier (2002). Neuroprotective Gene Therapy for Parkinson’s disease. Curr. Gene Ther. 2, 451-483.

Chtarto A., H.U.Bender, C.O.Hanemann, T.Kemp, E.Lehtonen, M. Levivier , J. Brotchi, T.Velu and L. Tenenbaum (2003. Tetracycline-inducible transgene expression mediated by a single AAV vector. Gene Ther. 10, 86-96.

L.Tenenbaum, E.Lehtonen and P.Monahan. (2003). Evaluation of risks related to the use of adeno-associated virus-based vectors. Curr. Gene Ther. 3: 545-565.

Tenenbaum L., A. Chtarto, E. Lehtonen, T.Velu, J.Brotchi and M. Levivier (2004). Recombinant AAV-mediated gene delivery to the Central Nervous System. J. Gene Med. 6 Suppl 1:S212-22.

Tenenbaum L., M. Peschanski, C.Melas F.Rodesh, E.Lehtonen, A.Stathopoulos, A.Chtarto, T. Velu, J.Brotchi and M. Levivier (2004). Efficient early and sustained transduction of human fetal mesencephalon using AAV2 vectors. Cell Transplant 13, 565-571.



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