Publications

Chtarto, A., Bockstael, O., Tshibangu, T., Dewitte, O., Levivier, M. and Tenenbaum, L. (2012). A next step in adeno-associated virus (AAV)- mediated gene therapy for neurological diseases: Regulation and targeting. British Journal of Clinical Pharmacology Jan 18. doi: 10.1111/bcp.12065

Chtarto, A., Bockstael, O., Gebara, E., Vermoesen, K., Melas, C., Pythoud, C., Levivier, M., Dewitte, O., Luthi-Carter, R., Clinkers, R. and Tenenbaum L. (2012). An adeno-associated virus-based intracellular sensor of pathological Nuclear Factor-kappa B activation for disease-inducible gene transfer. PlosOne 2013;8(1):e53156

Bockstael, O., Melas, C., Pythoud, C., Levivier, M., McCarty, D., Samulski, RJ., De Witte, O., Tenenbaum, L. (2012). Rapid transgene expression in multiple precursors cell types of adult rat subventricular zone mediated by adeno-associated type 1 vectors. Hum. Gene Ther. 23: 742-753

Driessens G, Nuttin L, Gras A, Maetens J, Mievis S, Schoore M, Velu T, Tenenbaum L, Préat V, Bruyns C. (2011). Development of a successful antitumor therapeutic model combining in vivo dendritic cell vaccination with tumor irradiation and intratumoral GM-CSF delivery. Cancer Immunology, Immunotherapy, 60:273-281.

Vanrell, L., M. di Scala, L. Blanco, I. Otano, V. Baldim, A. Paneda, P. Berraondo, S. Beattie, P. Alzuguren, R. Hernandez, A. Chtarto, L. Tenenbaum, J. Prieto, G. Gonzalez-Aseguinolaza. (2011). Development of a liver specific Tet-On inducible system for AAV vectors, Molecular Therapy, 19:1245-53.

Bockstael, O., K.Foust, B.Kaspar and L.Tenenbaum (2011) Recombinant AAV delivery to the central nervous system. Methods Mol Biol. 807:159-77.
 

Lock, M.,  S. McGorray, A.Auricchio, E. Ayuso, E. J. Beecham, V Blouin-Tavel, M F Bosch-Tubert, M Bose, B Byrne, T Caton, J Chiorini, A Chtarto, K. R Clark , Ts Conlon, C Darmon, M Doria, A Douar, T Flotte, J D. Francis, M.Giacca, M T. Korn, I Korytov, X Leon, B Leuchs, G Kroener-Lux, C Melas, Hi Mizukami, P Moullier, M Müller, K Ozawa, T Philipsberg, K Poulard, C Raupp, C Rivière, S D Roosendaal, R. J Samulski, S M. Soltys, R Surosky, L Tenenbaum, D L. Thomas, B van Montfort, G Veres, J. F Wright, Y Xu, O Zelenaia, L Zentilin and R O Snyder (2010). Characterization of a Recombinant Adeno-Associated Virus Type 2 Reference Standard Material. Hum. Gene Ther 21:1273-85.
 

Yang, X., B.Mertens, E.Lehtonen , L.Vercammen, O.Bockstael, A.Chtarto, V.Baekelandt, M. Levivier, J. Brotchi, Y.Michotte, S.Sarre and L.Tenenbaum (2009). Reversible neurochemical changes mediated by delayed intrastriatal GDNF gene delivery in a partial Parkinson’s disease rat model. J. Gene Med. 11 (899-912).
 

Lubansu, A., L.Abeloos, D.Blum, J.Brotchi, M.Levivier, L.Tenenbaum (2008). Recombinant AAV viral vectors serotype 1, 2 and 5 mediate differential gene transfer efficiency in rat striatal fetal grafts. Cell Transplant. 16(10):1013-20.

Bockstael, O., A.Chtarto, J.Wakkinnen, X.Yang, C.Melas, M.Levivier, J.Brotchi, L.Tenenbaum (2008). Differential transgene expression profiles of cross-packaged AAV2/1 vectors using the tetracycline-inducible and CMV promoters in the rat brain. Hum. Gene Ther. 19(11): 1293-1306.
 

Tenenbaum L. , J.L.Darling and E.Hooghe-Peters (1994). Adeno-associated virus (AAV) as a vector for gene transfer into glial cells of the central nervous system. Gene Ther, vol.1, suppl.1,80.

Tenenbaum L., F.Jurysta, A.Stathopoulos, Z.Puschban, C.Melas, W.T.J.M.C. Hermens, J.Verhaagen, B.Pichon, T.Velu and M.Levivier. (2000). Tropism of AAV-2 vectors for neurons of the globus pallidus. NeuroReport, 11,2277-2283.

Tenenbaum L., A. Chtarto, E. Lehtonen, D. Blum , V. Baekelandt, T.Velu, J.Brotchi and M. Levivier (2002). Neuroprotective Gene Therapy for Parkinson’s disease. Curr. Gene Ther. 2, 451-483.

Chtarto A., H.U.Bender, C.O.Hanemann, T.Kemp, E.Lehtonen, M. Levivier , J. Brotchi, T.Velu and L. Tenenbaum (2003. Tetracycline-inducible transgene expression mediated by a single AAV vector. Gene Ther. 10, 86-96.

L.Tenenbaum, E.Lehtonen and P.Monahan. (2003). Evaluation of risks related to the use of adeno-associated virus-based vectors. Curr. Gene Ther. 3: 545-565.

Tenenbaum L., A. Chtarto, E. Lehtonen, T.Velu, J.Brotchi and M. Levivier (2004). Recombinant AAV-mediated gene delivery to the Central Nervous System. J. Gene Med. 6 Suppl 1:S212-22.

Tenenbaum L., M. Peschanski, C.Melas F.Rodesh, E.Lehtonen, A.Stathopoulos, A.Chtarto, T. Velu, J.Brotchi and M. Levivier (2004). Efficient early and sustained transduction of human fetal mesencephalon using AAV2 vectors. Cell Transplant 13, 565-571.