Director, Department of Clinical Neuroscience
Head of Service of Neurology
CHUV University Hospital
Service of Neurology
Centre Hospitalier Universitaire Vaudois (CHUV)
Rue du Bugnon 46
My research interest has been the functional and structural architecture of the human brain in health and disease. I have pioneered the development and introduction of positron emission tomography and magnetic resonance imaging and prosecuted a research programme dedicated to understanding the organisation of human brain functions, but my focus has been on plasticity and mechanisms for functional recuperation after brain injury and the patho-physiology of cerebral neurodegenerations. I have become interested in the use of MR-based morphometry especially in the study of genetic influences on brain disease and in a search for biomarkers and endophenotypes of neurodegenerative disorders. Most recently I have introduced computerised image classification for diagnosis and treatment monitoring into clinical science.
Klöppel S, Stonnington CM, Petrovic P, Mobbs D, Tüscher O, Craufurd D, Tabrizi SJ, Frackowiak RSJ (2010) Irritability in pre-clinical Huntington's disease. Neuropsychologia 48, 549-557.
Stonnington CM, Chu C, Klöppel S, Jack Jr CR, Ashburner J, Frackowiak RSJ. (2010) Predicting clinical scores from magnetic resonance scans in Alzheimer's disease. NeuroImage 51: 1405-1413.
Kloppel S, Mangin JF, Vongerichten A, Frackowiak RSJ, Siebner HR. (2010) Nurture versus Nature: Long-term impact of forced right-handedness on structure of pericentral cortex and basal ganglia. J Neurosci. 30; 3271-3275.
Mckay LC, Critchley HD, Murphy K, Frackowiak RSJ, Corfield DR. (2010) Sub-cortical and brainstem sites associated with chemo-stimulated increases in ventilation in humans. NeuroImage 49; 2526-2535.
Basile B, Mancini F, Macaluso E, Caltagirone C, Frackowiak RSJ, Bozzali M. (2010) Deontological and altruistic guilt : evidence for distinct neurobiological substrates. Hum Brain Mapp. e-pub Apr 16.
Ward NS, Bestmann S, Hartwigsen G, Weiss MM, Christensen LOD, Frackowiak RSJ, Rothwell JC, Siebner HR. (2010) Low-frequency transcranial magnetic stimulation over left dorsal premotor cortex improves the dynamic control of visuospatially cued actions. J Neurosci. 30, 9216-9223.
Reverberi C, Cherubini P, Frackowiak RSJ, Caltagirone C, Paulesu E, Macaluso E. (2010) Conditional and syllogistic deductive tasks dissociate functionally during premise integration. Hum. Brain. Mapp. 31, 1430-1445.
Tan GCY, Doke TF, Ashburner J, Wood NW, Frackowiak RSJ. (2010) Normal variation in fronto-occipital circuitry and cerebellar structure with an autism-associated polymorphism of CNTNAP2. NeuroImage 53, 1030-1042.
Morillon B, Lehongre K, Frackowiak RSJ, Ducorps A, Kleinschmidt A, Poeppel D, Giraud A-L. (2010) Neurophysiological origin of human brain asymmetry for speech and language. PNAS 107, 18688-93.
Draganski B, Martino D, Cavanna AE, Hutton C, Orth M, Robertson MM, Critchley HD, Frackowiak RSJ. (2010) Multispectral brain morphometry in Tourette syndrome persisting into adulthood. Brain e-pub Nov 10.
Knyazeva MG, Carmeli C, Fornari E, Meuli R, Small M, Frackowiak RSJ, Maeder P. (2010) Binding under conflict conditions: state and space analysis of multivariate EEG synchronization. J Cogn Neurosci. e-pub Oct 14.