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Auditory Neuroscience

Principal Investigator: Melissa Saenz

 

 

Overview


How does the brain hear? 
The Auditory Neuroscience Group uses non-invasive brain imaging in humans to investigate (1) how sound information is processed by human auditory cortex and (2) how this processing is altered in audioneurological dysfunction.  Our research applies to Clinical Neuroscience (tinnitus, cochlear implants, age-related hearing disorders) as well as Fundamental and Cognitive Neuroscience (auditory systems, language, music).

 

For more information, please see the Auditory Neuroscience Group Homepage


 

 
  In the primary auditory cortex neighboring sound frequencies are processed by neighboring points in the brain - an orderly arrangement called tonotopy.  Using high-resolution functional MRI at 7 Tesla, we can image this cortical organization, non-invasively and in only a few minutes, in volunteers with normal hearing and patients with auditory disorders.

 

Publications:


Da Costa SD, Miller LM, Van der Zwaag W, Clarke S and Saenz M (2013) "Tuning in to Sound: frequency-selective attentional filter in human primary auditory cortex", Journal of Neuroscience, 33(5):1858-1863.

Da Costa S, van der Zwaag W, Marques J, Frackowiak R, Clarke S, and Saenz M. (2011) "Human Primary Auditory Cortex Follows the Shape of Heschl's Gyrus" Journal of Neuroscience 31(40), 14067-14075.  journal cover

Saenz M, Fine I (2010) Topographic Organization of V1 Projections through the Corpus Callosum in Humans, Neuroimage, 52(4), 1124-9.

Lewis LB, Saenz M, Fine I (2010) Mechanisms of cross-modal plasticity in early blind subjects, Journal of Neurophysiology, 104(6):2995-3008.

Saenz M, Koch C (2008) The Sound of Change: Visually-induced auditory synesthesia, Current Biology, 18(15), R650-1.

Saenz M, Lewis LB, Huth AG, Fine I, Koch C (2008) Visual motion area MT+/V5 responds to auditory motion in human sight-recovery subjects, Journal of Neuroscience, 28(20), 5141-5148.

Saenz M, Buracas GT, Boynton GM, (2003) Global feature-based attention for motion and color, Vision Research, 43, 629-637.

Kornylo K, Dill N, Saenz M, Krauzlis RJ (2003) Canceling of pursuit and saccadic eye movements in humans and monkeys, Journal of Neurophysiology, 89(6), 2984-99.

Saenz M, Buracas GT, Boynton GM (2002) Global effects of feature-based attention in human visual cortex, Nature Neuroscience, 5(7), 631-2. 


 

Funding

Swiss National Science Foundation Project Grant.,  P.I. Melissa Saenz, 348K for 3 years 


 

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