Brain plasticity in health and disease

Principal Investigator:  Bogdan DRAGANSKI

 

Overview:

We use in vivo magnetic resonance imaging (MRI) and clinical/behavioural assessment to investigate the interaction between anatomical characteristics and neural activity in cortico-subcortical brain circuits in patients with mood disorders.

Our in vivo studies of tissue property and neural activity changes associated with neuromodulation therapy will not only help understanding the missing link between current descriptive assessments of human brain plasticity and underlying neurobiological mechanisms, but will also open new fields for related research in healthy and diseased brains. The expected findings may be of clinical relevance for the development of new treatment strategies for memory decline and mood dysregulation based on patient-tailored non-invasive stimulation techniques.

 

Research topics:

• Neuromodulation-induced plasticity of hippocampal networks
• Impact of environment and social adversity on mood and cognition 
• Individual patient tailored prediction of outcome

 

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Key publications

Jastrzębowska MA, Marquis R, Melie-García L, Lutti A, Kherif F, Herzog MH, Draganski B. Dopaminergic modulation of motor network compensatory mechanisms in Parkinson's disease. Hum Brain Mapp. 2019 Jul 10. doi: 10.1002/hbm.24710. 

Marchi NA, Ramponi C, Hirotsu C, Haba-Rubio J, Lutti A, Preisig M, Marques-Vidal P, Vollenweider P, Kherif F, Heinzer R, Draganski B: Mean Oxygen Saturation during Sleep Is Related to Specific Brain Atrophy Pattern. Ann Neurol. 2020 Mar 27. doi: 10.1002/ana.25728

Taubert M, Roggenhofer E, Melie-Garcia L, Muller S, Lehmann N, Preisig M, Vollenweider P, Marques-Vidal P, Lutti A, Kherif F, Draganski B: Converging patterns of ageing-associated brain volume loss and tissue microstructure differences. Neurobiology of Aging. 2020 Apr;88:108-11

Oltedal L, Bartsch H, Sørhaug OJE, Kessler U, Abbott C, Dols A, Draganski B, Redlich R, Dannlowski U, Kugel H, Bouckaert F, Sienaert P, Anand A, Espinoza R, Narr KL, Holland D, Dale AM, Oedegaard KJ The Global ECT-MRI Research Collaboration (GEMRIC): Establishing a multi-site investigation of the neural mechanisms underlying response to electroconvulsive therapy. NeuroImage Clin 2017;14:422-432.

Draganski B, Ashburner J, Hutton C, Kherif F, Frackowiak RS, Helms G, Weiskopf N.Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ). Neuroimage. 2011 Jan 28

Draganski B, Kherif F, Kloppel S, Cook PA, Deichmann R, Alexander DC, Parker GJM, Ashburner J, and Frackowiak, RSJ. Evidence for segregated and integrative connectivity patterns in the human basal ganglia, J Neurosci. 2008 Jul 9;28(28):7143-52

Draganski B, Gaser C, Kempermann G, Kuhn HG, Winkler J, Buchel C, et al. Temporal and spatial dynamics of brain structure changes during extensive learning. J Neurosci 2006; 26: 6314-7.

Draganski B, Gaser C, Busch V, Schuierer G, Bogdahn U, May A. Neuroplasticity: changes in grey matter induced by training. Nature 2004; 427: 311-2

 

 

Funding 

Swiss National Science Foundation: project grants (320030_135679, 32003B_159780, CRSK-3_190185 and 324730_192755), SPUM and Sinergia

Fondation Leenaards

Parkinson Switzerland

Novartis Stiftung für Biologisch-Medizinische Forschung

Synapsis Foundation 

Deutsche Forschungsgemeinschaft DFG: Klinische Forschergruppe

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CHUV - Rue du Bugnon 46 - CH-1011 Lausanne
Tel. +41 21 314 95 93
Fax +41 21 314 12 56
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