Cristina Granziera, MD Ph.D.
Research Group Leader
Ambizione Grant Recipient
Service of Neurology
Centre Hospitalier Universitaire Vaudois (CHUV)
Rue du Bugnon 46
My research interest is the structural remodeling of the human brain during pathology. Plasticity, the ability of the brain to grow and reform itself, is at the heart of my research core. Using advanced magnetic resonance imaging, I have accomplished studies aimed at identifying plasticity mechanisms for functional recuperation after acute brain injuries like stroke and pursued the investigation of microstructural brain changes in patients affected by migraine, neuroHIV and multiple sclerosis compared to healthy subjects.
My current research focus on applying high and ultra-high field advanced MRI techniques to investigate early biomarkers of Multiple Sclerosis and potential non-invasive monitoring strategies ("MS_Advanced study"). The innovative approach contemplated by this work is the development of a comprehensive tool, including the most advanced MRI markers of disease as well as serological data and clinical scores that might be used for early diagnosis and to help better predict the evolution of a disease notoriously varied in its path.
Granziera C, Daducci A, Meskaldji DE, Roche A, Maeder P, Michel P, Hadjikhani N, Sorensen AG, Frackowiak RS, Thiran JP, Meuli R, Krueger G.A new early and automated MRI-based predictor of motor improvement after stroke.Neurology. 2012 Jun 20.
MP2RAGE multiple sclerosis magnetic resonance imaging at 3 T. Kober T, Granziera C, Ribes D, Browaeys P, Schluep M, Meuli R, Frackowiak R, Gruetter R, Krueger G. Invest Radiol. 2012 Jun
Granziera C, Ay H, Koniak SP, Krueger G, Sorensen AG.Diffusion tensor imaging shows structural remodeling of stroke mirror region: results from a pilot study. Eur Neurol. 2012;67(6):370-6. Epub 2012 May 17
Granziera C., Schmahmann J., Hadjikhani N., Meyer H., Meuli R., Wedeeen V., Krueger G. In vivo
Diffusion Spectrum imaging disentangles white and gray matter connectivity in the human cerebellum. PLoS One. 2009;4(4):e5101.
Da Silva A.F.M, Granziera C., Snyder J., Hadjikhani. N. Thickening in the Somatosensory Cortex of Migraine patients. Neurology. 2007 Nov 20;69(21):1990-5.
Granziera C., D’Arceuil H., Zai. L., Magistretti P.J., Sorensen A.G., de Crespigny A.J. Long term monitoring of post-stroke recovery and plasticity after transient cerebral ischemia in mice using in vivo and ex vivo Diffusion Tensor MRI. Open Neuroimag J. 2007;1:10-7.
Granziera C., DaSilva A.F.M., Snyder J., Tuch D.S., Hadjikhani. N. Migraine with and without aura alters the anatomy of visual motion processing network. PLoS Med. 2006 Oct;3(10):e402.
Principal co-investigators "MS_advanced" study:
Advanced Clinical Imaging Technology group, Siemens-CIBM, EPFL, Lausanne
Neuroinflammatory unit, Neurology Selvice, Clinical Neurosciences Department, CHUV, Lausanne
Collaborators "MS_advanced study"
MSc Guillaume Bonnier
Mr David Romascano (master student)