Laboratory Christian Widmann


 

Laboratory of cell-permeable peptide biology.

Cell-permeable peptides (CPPs) allow the intracellular delivery of cargo molecules that are hooked to them. CPPs provide an efficient mode of transfer for bioactive molecules inside cells, especially in conditions when transcription or translation of these cargo-encoding sequences is undesirable or hard to achieve. CPP sequences are ubiquitous and are often detected in both anti-cancer and anti-microbial peptides. Despite their potential practical applications, the mechanisms of CPP entry inside cells are ill-defined and even controversial. No genes have been described that regulate the intracellular delivery of CPPs. The current focus of our laboratory is to characterize the mechanism of CPPs cell entry and CPP mode of action using as an example, the anti-cancer and anti-microbial CPP TAT-RasGAP317-326. Our research is relevant to the bioengineering, oncology and microbiology fields.

See the specific research sections for further details on our work.

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Christian Widmann

Group leader

Phone : +41 21 692 51 23

christian.widmann@unil.ch

Rue du Bugnon 7 - CH-1005 Lausanne
Switzerland
Tel. +41 21 692 55 00
Fax +41 21 692 55 05