The Aging and Muscle Metabolism Lab

Aging and increased life expectancy are associated with the progression of chronic metabolic diseases, such as type 2 diabetes, obesity, hypertension, dyslipidemia and cardiovascular conditions. These multifactorial pathologies are complex, often resulting from a combination of genetic and environmental factors, such as physical inactivity and diet. The steady decline of skeletal muscle mass that comes with aging (sarcopenia) is thought to be involved in these metabolic changes, however little is known on how deranged skeletal muscle metabolism influences the development of metabolic disorders.

 

Pathophysiological framework of skeletal muscle metabolism in aging​

insulin_resistance.jpg

The Aging and Muscle Metabolism lab performs translational research projects covering multiple metabolic diseases in human and non-human models, to elucidate molecular mechanisms underlying altered muscle metabolism with aging. 

The understanding of the effect of aging and exercise on muscle metabolism is the main theme of our lab. To respond to this quest, we progress through three synchronous aims, which taken together allow an integrative vision.

Schematic representation of our research objectives 

muscle_metabolism.jpg

Follow us:      

Francesca Amati.jpg

Francesca Amati

group leader

Rue du Bugnon 7 - CH-1005 Lausanne
Switzerland
Tel. +41 21 692 55 00
Fax +41 21 692 55 05