Metabolic Analyses in Mice

Metabolic Anasyses in Mice.png


The Mouse Metabolic Evaluation Facility (MEF) proposes to CIG users a wide repertoire of in vivo analyses in mice models of obesity/diabetes. Support to users varies on demand from a single analysis, to a full commitment from experimental design to data generation and manuscript writing.


Terms of use of the service

Services that do not require consumable are free: Assessment of Energy Homeostasis ; Injections & infusions.

For services that require consumable, please request a quote: Analysis of Biofluid Parameters ; Assessment of Glucose Homeostasis ; Assessment of Lipid Homeostasis.

General terms apply as described here. Additional terms are found here below.

Animal Guidelines

Before transmitting mice to the MEF, please make sure to fulfill all following requirements.

  1. Before any access to MEF, users must follow an introduction to the good practices of the facility.
  2. Animal experimentation Authorizations (e-tierversuche): prior to any mouse experiment at MEF, all relevant animal study protocols must be approved by the Canton Veterinary Office (SCAV).
  3. Mice inventory in PyRat: all Mice hosted at MEF must be relocated to the MEF in PyRaT, the mouse inventory online system. Change mice status in PyRat after sacrifice.


For any service request please contact to ensure proper transmission of information to the staff.

Guy Niederhauser
(Calorimetry & Biofluid Assays) 5014 021 692 39 88
Anabela Pimentel
(Glycemic Clamps & Biofluid Assays) 5014 ---
Frédéric Preitner,
Coordinator 5023 021 692 41 43


Rooms, equipment & link to other relevant facilities

  • Biofluid assays
  • Immuno/histology
  • Genotyping
  • Bioinformatics support
  • Consulting exp. Design

Informations, protocols

  • Protocols for e-tierversuche
  • Protocols for common metabolic analyses


  • Microdialysis pumps
  • Food grinder
  • Feeders for powdered food (compound supplementation or manual feeding measurement)
  • Bomb calorimeter
  • Metabolic cages for urine/feces collection (16x)
  • EchoMRI (body composition in mice)
  • Indirect calorimeter (CLAMS, Columbus, 12 cages)
  • Metabolic treadmills 2x 5 lanes
  • Online Feeding measurement/pair feeding (Phenomaster 24 cages)
  • Temperature-controlled chamber (4- 33°C) with cage rack
  • Thermic camera for infrared imageing
  • Electronic rectal thermometer for mice
  • Telemetric measurement of body temperature / locomotor activity
  • N2 flow drier for organic solvents


Publications involving MEF (with or without authorship) – Note: MEF was a faculty facility from 2007 to 2018.

58. Picard A, Metref S, Tarussio D, Dolci W, Berney X, Croizier S, Labouebe G, Thorens B. Fgf15 neurons of the dorsomedial hypothalamus control glucagon secretion and hepatic gluconeogenesis. Diabetes. 2021 Apr 21:db201121. doi: 10.2337/db20-1121. Online ahead of print. PMID: 33883213

57. Castillo-Armengol J, Barquissau V, Geller S, Ji H, Severi I, Venema W, Fenandez EA, Moret C, Huber K, Leal-Esteban LC, Nasrallah A, Martinez-Carreres L, Niederhäuser G, Seoane-Collazo P, Lagarrigue S, López M, Giordano A, Croizier S, Thorens B, Lopez-Mejia IC, Fajas L. Hypothalamic CDK4 regulates thermogenesis by modulating sympathetic innervation of adipose tissues. EMBO Rep. 2020 Sep 3;21(9):e49807. doi: 10.15252/embr.201949807. Epub 2020 Jul 12. PMID: 32657019

56. Ji H, Chen Y, Castillo-Armengol J, Dreos R, Moret C, Niederhäuser G, Delacuisine B, Lopez-Mejia IC, Denechaud PD, Fajas L. CDK7 Mediates the Beta-Adrenergic Signaling in Thermogenic Brown and White Adipose Tissues. iScience. 2020 Jun 26;23(6):101163. doi: 10.1016/j.isci.2020.101163. Epub 2020 May 15. PMID: 32464595

55. Gilardi F, Winkler C, Quignodon L, Diserens J-G, Toffoli B, Schiffrin M, Sardella C, Preitner F, Desvergne B. Systemic PPARγ deletion in mice provokes lipoatrophy, organomegaly, severe type 2 diabetes and metabolic inflexibility. Metabolism 2019 Mar 13. pii:S0026-0495(19)30051-4. Doi: 10.1016/j.metabol.2019.03.003.

54. Stuhlmann T, Planells-Cases R, Jentsch TJ. LRRC8/VRAC anion channels enhance β-cell glucose sensing and insulin secretion. Nat Commun. 2018 May 17;9(1):1974. doi: 10.1038/s41467-018-04353-y.

53. Xu C, Messina A, Somm E, Miraoui H, Kinnunen T, Acierno J Jr, Niederländer NJ, Bouilly J, Dwyer AA, Sidis Y, Cassatella D, Sykiotis GP, Quinton R, De Geyter C, Dirlewanger M, Schwitzgebel V, Cole TR, Toogood AA, Kirk JM, Plummer L, Albrecht U, Crowley WF Jr, Mohammadi M, Tena-Sempere M, Prevot V, Pitteloud N. KLB, encoding β-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism. EMBO Mol Med. 2017 Jul 28. pii: e201607376. doi: 10.15252/emmm.201607376.

52. Meens MJ, Kutkut I, Rochemont V, Dubrot J, Kaladji FR, Sabine A, Lyons O, Hendrikx S, Bernier-Latmani J, Kiefer F, Smith A, Hugues S, Petrova TV, Kwak BR. Cx47 fine-tunes the handling of serum lipids but is dispensable for lymphatic vascular function. PLoS One. 2017 Jul 21;12(7):e0181476. doi: 10.1371/journal.pone.0181476. eCollection 2017.

51. Iskender I, Cosgun T, Arni S, Trinkwitz M, Fehlings S, Yamada Y, Cesarovic N, Yu K, Frauenfelder T, Jungraithmayr W, Weder W, Inci I. Cytokine filtration modulates pulmonary metabolism and edema formation during ex vivo lung perfusion. J Heart Lung Transplant. 2017 May 20. pii: S1053-2498(17)31802-8. doi: 10.1016/j.healun.2017.05.021.

50. Lai Q, Giralt A, Le May C, Zhang L, Cariou B, Denechaud PD, Fajas L. E2F1 inhibits circulating cholesterol clearance by regulating Pcsk9 expression in the liver. JCI Insight. 2017 May 18;2(10). pii: 89729. doi: 10.1172/jci.insight.89729.

49. Somm E, Henry H, Bruce SJ, Aeby S, Rosikiewicz M, Sykiotis GP, Asrih M, Jornayvaz FR, Denechaud PD, Albrecht U, Mohammadi M, Dwyer A, Acierno JS Jr, Schoonjans K, Fajas L, Greub G, Pitteloud N. JCI Insight. β-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue. 2017 Apr 20;2(8). pii: 91809. doi: 10.1172/jci.insight.91809. [Epub ahead of print]

48. Oechslin F, Piccardi P, Mancini S, Gabard J, Moreillon P, Entenza JM, Resch G, Que YA. Synergistic Interaction Between Phage Therapy and Antibiotics Clears Pseudomonas Aeruginosa Infection in Endocarditis and Reduces Virulence. J Infect Dis. 2017 Mar 1;215(5):703-712. doi: 10.1093/infdis/jiw632.

47. Da Silva AR, Lenglet S, Carbone F, Burger F, Roth A, Liberale L, Bonaventura A, Dallegri F, Stergiopulos N, Santos RA, Mach F, Fraga-Silva RA, Montecucco F. Alamandine abrogates neutrophil degranulation in atherosclerotic mice. Eur J Clin Invest. 2017 Feb;47(2):117-128. doi: 10.1111/eci.12708. Epub 2017 Jan 4.

46. Toffoli B, Gilardi F, Winkler C, Soderberg M, Kowalczuk L, Arsenijevic Y, Bamberg K, Bonny O, Desvergne B. Nephropathy in Pparg-null mice highlights PPARγ systemic activities in metabolism and in the immune system. PLoS One. 2017 Feb 9;12(2):e0171474. doi: 10.1371/journal.pone.0171474. eCollection 2017.

45. Duszka K, Picard A, Ellero-Simatos S, Chen J, Defernez M, Paramalingam E, Pigram A, Vanoaica L, Canlet C, Parini P, Narbad A, Guillou H, Thorens B, Wahli W. Intestinal PPARγ signalling is required for sympathetic nervous system activation in response to caloric restriction. Sci Rep. 2016 Nov 17;6:36937. doi: 10.1038/srep36937.

44. Montecucco F, Bondarenko AI, Lenglet S, Burger F, Piscitelli F, Carbone F, Roth A, Liberale L, Dallegri F, Brandt KJ, Fraga-Silva RA, Stergiopulos N, Di Marzo V, Mach F. Treatment with the GPR55 antagonist CID16020046 increases neutrophil activation in mouse atherogenesis. Thromb Haemost. 2016 Oct 28;116(5):987-997. Epub 2016 Jul 28.

43. Steinbusch LK, Picard A, Bonnet MS, Basco D, Labouèbe G, Thorens B. Sex-Specific Control of Fat Mass and Counterregulation by Hypothalamic Glucokinase. Diabetes. 2016 Oct;65(10):2920-31. doi: 10.2337/db15-1514. Epub 2016 Jul 15.

42. Pellegrin M, Szostak J, Bouzourène K, Aubert JF, Berthelot A, Nussberger J, Laurant P, Mazzolai L. Running Exercise and Angiotensin II Type I Receptor Blocker Telmisartan Are Equally Effective in Preventing Angiotensin II-Mediated Vulnerable Atherosclerotic Lesions. J Cardiovasc Pharmacol Ther. 2016 May 30. pii: 1074248416652235. [Epub ahead of print]

41. Lavoie S., Steullet, P., Kulak A., Preitner F., Do K. Q. and Magistretti, P. J. Glutamate Cysteine Ligase—Modulatory Subunit Knockout Mouse Shows Normal Insulin Sensitivity but Reduced Liver Glycogen Storage. Front. Physiol., 21 April 2016 |

40. Minocha S, Sung TL, Villeneuve D, Lammers F, Herr W. Compensatory embryonic response to allele-specific inactivation of the murine X-linked gene Hcfc1. Dev Biol. 2016 Apr 1;412(1):1-17. doi: 10.1016/j.ydbio.2016.02.019. Epub 2016 Feb 24.

39. Emery M, Nanchen N, Preitner F, Ibberson M, Roduit R. Biological Characterization of Gene Response to Insulin-Induced Hypoglycemia in Mouse Retina. PLoS One. 2016 Feb 26;11(2):e0150266. doi: 10.1371/journal.pone.0150266.

38. Denechaud PD, Lopez-Mejia IC, Giralt A, Lai Q, Blanchet E, Delacuisine B, Nicolay BN, Dyson NJ, Bonner C, Pattou F, Annicotte JS, Fajas L. E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis. J Clin Invest. 2016 Jan;126(1):137-50. doi: 10.1172/JCI81542. Epub 2015 Nov 30.

37. Bernier-Latmani J, Cisarovsky C, Demir CS, Bruand M, Jaquet M, Davanture S, Ragusa S, Siegert S, Dormond O, Benedito R, Radtke F, Luther SA, Petrova DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport. J Clin Invest. 2015 Nov 3;125(12):4572-86.

36. Parapanov R, Lugrin J, Rosenblatt-Velin N, Feihl F, Waeber B, Milano G, Vergely C, Li N, Pacher P, Liaudet L. Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the mouse. Clin Sci (Lond). 2015 Jul;129(2):187-98. doi: 10.1042/CS20140444.

35. Bonhoure N, Byrnes A, Moir RD, Hodroj W, Preitner F, Praz V, Marcelin G, Chua SC Jr, Martinez-Lopez N, Singh R, Moullan N, Auwerx J, Willemin G, Shah H, Hartil K, Vaitheesvaran B, Kurland I, Hernandez N, Willis IM. Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. Genes Dev. 2015 May 1;29(9):934-47. doi: 10.1101/gad.258350.115.

34. Montecucco F, Lenglet S, Carbone F, Boero S, Pelli G, Burger F, Roth A, Bertolotto M, Nencioni A, Cea M, Dallegri F, Fraga-Silva RA, Fougère L, Elfakir C, Gassner AL, Rudaz S, Parissaux X, Wils D, Salomé M, Vuilleumier N, Poggi A, Mach F. Treatment with KLEPTOSE® CRYSMEB reduces mouse atherogenesis by impacting on lipid profile and Th1 lymphocyte response. Vascul Pharmacol. 2015 Apr 25. pii: S1537-1891(15)00077-4. doi: 10.1016/j.vph.2015.04.008. [Epub ahead of print]

33. Wawrzyniak M, Pich C, Gross B, Schütz F, Fleury S, Quemener S, Sgandurra M, Bouchaert E, Moret C, Mury L, Rommens C, Mottaz H, Dombrowicz D, Michalik L. Endothelial, but not smooth muscle, peroxisome proliferator-activated receptor β/δ regulates vascular permeability and anaphylaxis. J Allergy Clin Immunol. 2015 Jun;135(6):1625-1635.e5. doi: 10.1016/j.jaci.2014.11.006. Epub 2014 Dec 31.

32. Fraga-Silva RA, Costa-Fraga FP, Montecucco F, Sturny M, Faye Y, Mach F, Pelli G, Shenoy V, da Silva RF, Raizada MK, Santos RA, Stergiopulos N. Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury. J Sex Med. 2015 Feb;12(2):289-302. doi: 10.1111/jsm.12757. Epub 2014 Nov 20.

31. Chalmin F, Rochemont V, Lippens C, Clottu A, Sailer AW, Merkler D, Hugues S, Pot C. Oxysterols regulate encephalitogenic CD4(+) T cell trafficking during central nervous system autoimmunity. J Autoimmun. 2015 Jan;56:45-55. doi: 10.1016/j.jaut.2014.10.001. Epub 2014 Nov 10.

30. Mang GM, Pradervand S, Du N-H, Preitner F, Wigger L, Gatfield D, Franken P. A neuron-specific deletion of the microRNA-processing enzyme DICER induces severe but transient obesity in mice. PLoS One. 2015 Jan 28;10(1):e0116760. doi: 10.1371/journal.pone.0116760. eCollection 2015.

29. Fraga-Silva RA, Savergnini SQ, Montecucco F, Nencioni A, Caffa I, Soncini D, Costa-Fraga FP, De Sousa FB, Sinisterra RD, Capettini LA, Lenglet S, Galan K, Pelli G, Bertolotto M, Pende A, Spinella G, Pane B, Dallegri F, Palombo D, Mach F, Stergiopulos N, Santos RA1, da Silva RF2. Treatment with Angiotensin-(1-7) reduces inflammation in carotid atherosclerotic plaques. Thromb Haemost. 2014 Apr 1;111(4):736-47. doi: 10.1160/TH13-06-0448. Epub 2014 Feb 6.

28. Fraga-Silva RA, Costa-Fraga FP, Faye Y, Sturny M, Santos RA, da Silva RF, Stergiopulos N. An increased arginase activity is associated with corpus cavernosum impairment induced by hypercholesterolemia. J Sex Med. 2014 May;11(5):1173-81. doi: 10.1111/jsm.12482. Epub 2014 Feb 25.

27. Winnik S, Gaul DS, Preitner F, Lohmann C, Weber J, Miranda MX, Liu Y, van Tits LJ, Mateos JM, Brokopp CE, Auwerx J, Thorens B, Lüscher TF, Matter CM. Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development. Basic Res Cardiol. 2014 Jan;109(1):399. Epub 2013 Dec 27.

26. Lengacher S, Nehiri T, Preitner F, Stehle J-C, Dix L, Pralong F, Magistretti PJ and Pellerin L. Resistance to diet-induced obesity and associated metabolic perturbations in haploinsufficient monocarboxylate transporter 1 (MCT1) mice. PLoS One 2013 Dec 18;8(12):e82505.

25. Fraga-Silva RA, Costa-Fraga FP, Montecucco F, Faye Y, Savergnini SQ, Lenglet S, Mach F, Steffens S, Stergiopulos N, dos Santos RA, da Silva RF. Treatment with CB2 agonist JWH-133 reduces histological features associated with erectile dysfunction in hypercholesterolemic mice. Clin Dev Immunol. 2013;2013:263846. doi: 10.1155/2013/263846. Epub 2013 Nov 3.

24. Nencioni A, da Silva RF, Fraga-Silva RA, Steffens S, Fabre M, Bauer I, Caffa I, Magnone M, Sociali G, Quercioli A, Pelli G, Lenglet S, Galan K, Burger F, Vázquez Calvo S, Bertolotto M, Bruzzone S, Ballestrero A, Patrone F, Dallegri F, Santos RA, Stergiopulos N, Mach F, Vuilleumier N, Montecucco F2. Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice. Thromb Haemost. 2014 Feb;111(2):308-22. doi: 10.1160/TH13-07-0531. Epub 2013 Nov 7.

23. Ding J, Loizides-Mangold U, Rando G, Zoete V, Michielin O, Reddy JK, Wahli W, Riezman H, Thorens B. The peroxisomal enzyme L-PBE is required to prevent the dietary toxicity of medium-chain fatty acids. Cell Rep. 2013 Oct 17;5(1):248-58. doi: 10.1016/j.celrep.2013.08.032.

22. Fraga-Silva RA, Costa-Fraga FP, Savergnini SQ, De Sousa FB, Montecucco F, da Silva D, Sinisterra RD, Mach F, Stergiopulos N, da Silva RF, Santos RA. An oral formulation of angiotensin-(1-7) reverses corpus cavernosum damages induced by hypercholesterolemia. J Sex Med. 2013 Oct;10(10):2430-42. doi: 10.1111/jsm.12262. Epub 2013 Jul 24.

21. Bonal CB, Baronnier DE, Pot C, Benkhoucha M, Schwab ME, Lalive PH, Herrera PL. Nogo-a downregulation improves insulin secretion in mice. Diabetes. 2013 May;62(5):1443-52.

20. Seyer P, Vallois D, Poitry-Yamate C, Schütz F, Metref S, Tarussio D, Maechler P, Staels B, Lanz B, Grueter R, Decaris J, Turner S, da Costa A, Preitner F, Minehira K, Foretz M, Thorens B. Hepatic glucose sensing is required to preserve β cell glucose competence. J Clin Invest. 2013 Apr 1;123(4):1662-76.

19. Willemin G, Roger C, Bauduret A, Minehira K. Major Histocompatibility Class II Pathway Is Not Required for the Development of Nonalcoholic Fatty Liver Disease in Mice. Int J Endocrinol. 2013;2013:972962. doi: 10.1155/2013/972962. Epub 2013 Apr 24.

18. Kostadinova R, Montagner A, Gouranton E, Fleury S, Guillou H, Dombrowicz D, Desreumaux P, Wahli W. GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation. Cell Biosci. 2012 Oct 10;2(1):34.

17. Hinard V, Mikhail C, Pradervand S, Curie T, Houtkooper RH, Auwerx J, Franken P, Tafti M. Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures. J Neurosci. 2012 Sep 5;32(36):12506-17.

16. Carvas JM, Vukolic A, Yepuri G, Xiong Y, Popp K, Schmutz I, Chappuis S, Albrecht U, Ming XF, Montani JP, Yang Z. Period2 gene mutant mice show compromised insulin-mediated endothelial nitric oxide release and altered glucose homeostasis. Front Physiol. 2012;3:337. doi: 10.3389/fphys.2012.00337. Epub 2012 Aug 23.

15. Que YA, Delodder F, Guessous I, Graf R, Bain M, Calandra T, Liaudet L, Eggimann P. Pancreatic stone protein as an early biomarker predicting mortality in a prospective cohort of patients with sepsis requiring ICU management. Crit Care. 2012 Jul 2;16(4):R114. doi: 10.1186/cc11406.

14. Ming XF, Rajapakse AG, Yepuri G, Xiong Y, Carvas JM, Ruffieux J, Scerri I, Wu Z, Popp K, Li J, Sartori C, Scherrer U, Kwak BR, Montani JP, Yang Z. Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis. J Am Heart Assoc. 2012 Aug;1(4):e000992. doi:10.1161/JAHA.112.000992. Epub 2012 Aug 24.

13. Suarez PE, Rodriguez EG, Soundararajan R, Mérillat AM, Stehle JC, Rotman S, Roger T, Voirol MJ, Wang J, Gross O, Pétrilli V, Nadra K, Wilson A, Beermann F, Pralong FP, Maillard M, PearceD, Chrast R, Rossier BC, Hummler E. The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility. Mol Endocrinol. 2012 Jun;26(6):1000-13.

12. Nadra K, Médard JJ, Mul JD, Han GS, Grès S, Pende M, Metzger D, Chambon P, Cuppen E, Saulnier-Blache JS, Carman GM, Desvergne B, Chrast R. Cell autonomous lipin 1 function is essential for development and maintenance of white and brown adipose tissue. Mol Cell Biol. 2012 Dec;32(23):4794-810.

11. Ye Q, Danzer CF, Fuchs A, Krek W, Mueggler T, Baltes C, Rudin M. Longitudinal evaluation of intramyocellular lipids (IMCLs) in tibialis anterior muscle of ob/ob and ob/+ control mice using a cryogenic surface coil at 9.4 T. NMR Biomed. 2011 Dec;24(10):1295-301.

10. Thorel F, Damond N, Chera S, Wiederkehr A, Thorens B, Meda P, Wollheim CB, Herrera PL. Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice. Diabetes. 2011 Nov;60(11):2872-82.

9. Becattini B, Marone R, Zani F, Arsenijevic D, Seydoux J, Montani J-P, Dulloo A, Thorens B, Preitner F, Wymann M, Solinas, G. PI3Kγ within a Non-Hematopoietic Compartment Negatively Regulates Diet-Induced Thermogenesis, and is Key to Diet-Induced Obesity and Insulin Resistance. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):E854-63. Epub 2011 Sep 26

8. El Kochairi I, Montagner A, Rando G, Lohmann C, Matter CM, Wahli W. Beneficial effects of combinatorial micronutrition on body fat and atherosclerosis in mice. Cardiovasc Res. 2011 Sep 1;91(4):732-41.

7. Emery M, Schorderet DF, Roduit R. Acute hypoglycemia induces retinal cell death in mouse. PLoS One. 2011;6(6):e21586. Epub 2011 Jun 27.

6. Hegi ME, Diserens AC, Bady P, Kamoshima Y, Kouwenhoven MC, Delorenzi M, Lambiv WL, Hamou MF, Matter MS, Koch A, Heppner FL, Yonekawa Y, Merlo A, Frei K, Mariani L, Hofer S. Pathway Analysis of Glioblastoma Tissue after Preoperative Treatment with the EGFR Tyrosine Kinase Inhibitor Gefitinib – A Phase II Trial. Mol Cancer Ther. 2011 Jun;10(6):1102-12. Epub 2011 Apr 6.

5. L. Mounien, N. Marty, D. Tarussio, S. Metref, D. Genoux, F. Preitner, M. Foretz, and B. Thorens. Glut2-dependent Glucose Sensing Controls Thermoregulation by Enhancing the Leptin Sensitivity of NPY and POMC Neurons. . FASEB Journal, 2010 Jun;24(6):1747-58. Epub 2010 Jan 22.

4. Silva JP, von Meyenn F, Howell J, Thorens B, Wolfrum C, Stoffel M. Regulation of adaptive behaviour during fasting by hypothalamic Foxa2. Nature. 2009 Dec 3;462(7273):646-50.

3. Le Martelot G, Claudel T, Gatfield D, Schaad O, Kornmann B, Lo Sasso G, Moschetta A, Schibler U. REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. PLoS Biol. 2009 Sep;7(9):e1000181.

2. Minehira, K., Young, SG., Villanueva, CJ., Yetukuri, L., Oresic, M., Hellerstein, MK., Farese, RV. Jr, Horton, JD., Preitner, F., Thorens, B., and Tappy, L. Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res. 49(9):2038-44, 2008

1. Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, BT., and Tschopp, J. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science. 320 (5876):674-7, 2008