John Wang

Research Interests | Curriculum Vitae
 

Research Interests

I am interested in uncovering the molecular bases underlying complex insect societies. In particular, I would like to determine the molecules, pathways and genetic networks that govern social behavior in ants. Knowledge of the molecular components for a particular social behavior provides insight into the mechanism of how genes translate into behavioral phenotypes. Moreover, we may be able to address several fundamental questions:

  1. Is the set of genes and pathways that regulate a certain behavior large or small?

  2. Are these behavioral genes common to many taxa or novel to ants or hymenoptera?

  3. Are behavioral differences primarily due to changes in gene regulation or structure? Similarly, is the behavioral difference developmentally encoded?

  4. Might this behavior be evolutionarily plastic?

My focal system is a genetically-based colony dimorphism exhibited by the red imported fire ant, Solenopsis invicta. Colonies adopt either the monogyne or polygyne social form based on the willingness of workers to accept or reject queens. Interestingly, queen acceptance or rejection from a colony depends on both the genotype of the queen and the workers at a single locus, Gp-9. Gp-9 has been cloned and encodes an odorant binding protein. Gp-9 is unlikely to act in isolation, and thus, I would like to identify the other genes that may interact with or in parallel to Gp-9 to specify the monogyne or polygyne social form.

Since ants are not afforded the molecular and genetic tools of traditional model organisms, we will begin addressing the question of colony queen number with a functional genomics approach. As mRNA isolation is simple and since DNA microarrays are a proven genomics reagent for monitoring differential gene expression, a genome-wide expression analysis may be the fastest and most efficient method for identifying additional candidate effectors of colony queen number.

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Curriculum Vitae

2003 -
Postdoc, IE-ZEA, University of Lausanne. Advisor: Laurent Keller

1995 - 2002
Ph.D. Developmental Biology, Stanford University, Stanford, CA. Advisor: Stuart K. Kim

1991 - 1995
B.S. Microbiology. The Ohio State University. Columbus, OH.
Publications

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Member of Keller group
Biophore - CH-1015 Lausanne
Switzerland
Tel. +41 21 692 41 60
Fax +41 21 692 41 65