Antimicrobial agents and experimental infection
Gram-positive bacteria (staphylococci, streptococci, enterococci, pneumococci) are major human pathogens. These organisms have progressively become resistant to almost all available antibiotics. Our group has been particularly interested in the in vitro and in vivo (rat model of experimental endocaditis) assessment of the efficacy of novel antibacterial agents, and in exploring alternative treatment strategies against such organisms.
The rat model of experimental endocarditis and the mouse model of septicaemia are employed by our group to study in vivo: (i) the role of pathogenic factors of bacteria (Staphylococcus spp.) and fungi (Candida spp.) in infection, (ii) the efficacy of novel antibiotics against multi-drug resistant organisms, and (iii) the therapeutic potential of non-antibiotic alternative strategies.