© Chris Dascher - iStockphoto
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Liens UNIL
Host laboratories in Genetics and genomics
CIG - Center for Integrative Genomics
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Structure, function and evolution of chemosensory systems. |
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Our research aims at understanding, through genomic approaches, how the interplay between various transcription factors and the corresponding regulatory networks, controls metabolic homeostasis in physiological and pathological conditions. The liver and white adipose tissue (WAT), which are important organs with respect to energy balance, are the main targets of our studies. |
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How chromatin structure impacts the stability of disease-causing trinucleotide repeats. |
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Molecular mechanisms of light-regulated growth and development in plants. |
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Reseach in the Franken lab focusses on the genetics and energetics of sleep homeostasis and circadian rhythms in the mouse using a variety of –omics (transcriptome, metabolome, epigenome, microRNAs), behavioral (activity, qEEG), imaging (life imaging of gene expression), and modelling techniques. |
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Our group explores the molecular mechanisms and physiological functions of biological timekeeping by circadian clocks in mammals. |
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Size and shape regulation during development in Drosophila. |
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Transcriptional control of skin repair and cancer. © Catherine Moret |
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Influence of genome structure on phenotypes. |
DBMV - Department of Plant Molecular Biology
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We want to understand establishment, structure and function of the endodermis, a major protective barrier in the root of higher plants. |
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The Nawrath lab studies the formation of the plant cuticle and its relevance in biotic and abiotic stress protection in different model plants; as for example the function of OsABCG31 encoding an ABC transporter involved in cutin biosynthesis in rice. |
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Study plant phosphate homeostasis and how plants respond and adapt to phosphate deficiency. |
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Molecular studies of plant-insect interactions. © Olivier Hilfiker |
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The phloem vasculature enabled plants to colonize land and is formed in a peculiar differentiation process, the formation of conductive sieve elements by selective degradation of organelles. Our research investigates this process. |
DCB - Department of Computational Biology
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We are interested in applying computational methods and evolutionary modeling to test hypotheses about the evolution and adaptation of species using both genmic, phenotypic and ecological data. |
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We develop and apply methods for the integrative analysis of large-scale biological and clinical data, as well as small regulatory systems. |
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We work on molecular genetics and genomics of hereditary retinal degeneration, an area of research that is a paradigm for both medical genetics and neurodegenerative conditions. |
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Our research by combines the predictive power of computational biology with extensive genetic and molecular analysis of candidates and aims to understand what are the contributions to homeostasis, phenotypic variation and disease of long noncoding RNAs (lincRNAs). |
DEE - Department of Ecology and Evolution
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We try to understand how the interplay of population structure, trait architecture, and selection affect evolutionnary processes. For this, we use different approaches, from theory and the development of statistical tools to data mining and field observations. Jérôme Goudet lab |
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We link genome evolution with evolution of development, using bioinformatics. © Images from Wikimedia Commons |
DMF - Department of Fundamental Microbiology
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We study how the bacterial cell cycle is temporally and spatially regulated with a particular focus on the biology of the bacterial chromosome. |
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We study microbial symbiosis with a focus on gut microbiota-host interactions. Our current work is centered on honey bees and related social bee species. |
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The Keel lab investigates molecular mechanisms used by root-colonizing beneficial bacteria to protect agricultural crop plants against pest insects and fungal pathogens. |
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The Martin lab studies how spatial intracellular organization controls cell growth and division, as well as cell-cell fusion during sexual reproduction. |
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The fundamental goal of my research is to understand how bacteria adapt to changing environmental conditions and how we can benefit from bacterial activities. |
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Our group applies synthetic biology tools to build gene regulatory networks. We then use them to study their mechanisms, properties and evolution. |
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The Veening lab uses systems and synthetic biology approaches to study chromosome segregation, mechanisms of antibiotic resistance development, and noise in gene expression in the important opportunistic human pathogen Streptococcus pneumoniae. |
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Structural maintenances of chromosomes: We use the powerful genetics, biochemistry and cell biology of bacterial model organisms to elucidate conserved mechanisms of long-range chromosome organization and genome maintenance. |
IMUL - Institute of Microbiology
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Molecular epidemiology of nosocomial infections. |
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Mechanisms of the C. albicans pathogenic fungus adaptation to its host(s) during the course of infection. |
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Genomics of Pneumocystis jirovecii, a fungus causing pneumonia in immuno-compromised humans. |
Other Departments
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In the Bioinformatics Core Facility BCF of UniL-SIB we entertain a broad range of collaborations and of bioinformatics activities with a focus on statistical-epidemiological methodology for OMICS data and on applications in medicine and oncology (explorative analyses, prognostic and predictive biomarkers, personalized medicine). Mauro Delorenzi lab - CHUV |
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Our laboratory develops fundamental, translational and clinical research focused on the molecular and cellular mechanisms of immune response to microorganisms in order to develop new diagnosis strategies, prevention and treatment of infectious diseases. Thierry Roger lab - Swiss Institute of Bioinformatics |
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Development of statistical methods for the better understanding of the genetic architecture of complex traits. Zoltan Kutalik lab - Institute of Social and Preventive Medicine |
