Plateformes - Research Core Facilities (UNIL - CHUV)

Une des caractéristiques de l'évolution de la recherche biologique et médicale est l'utilisation croissante de nouvelles technologies nécessitant parfois de larges investissements en appareils et la présence de personnel particulièrement qualifié. Pour répondre à cette demande, les centres de recherche mettent en place des platesformes communes permettant, en présence d'une masse critique de chercheurs, le partage de ressources specifiques qui ne pourraient pas être financées par un seul ou quelques groupes de recherche.

Comité des platesformes - COPLA

Ces dernières années ont vu la mise en place de diverses platesformes de recherche au sein de la FBM, que ce soit à l'UNIL ou au CHUV. Chaque plateforme, au vu de ses activités spécifiques et de l'historique de son développement, possède sa propre organisation et son propre mode de fonctionnement. Considérant pourtant que les platesformes consistent en un partage de ressources devant bénéficier à l'ensemble de la communauté des chercheurs, il est nécessaire d'exprimer un cadre général dans lequel la Faculté entend développer et gérer les platesformes technologiques.

D'une manière générale, les platesformes sont dirigées par un coordinateur assisté par un comité scientifique. Les plates-formes sont évaluées par le Comité des platesformes (COPLA) de la Commission de la recherche. Les platesformes sont administrativement rattachées au Décanat.

Animal Models

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Mouse Pathology Facility - MPF

The Mouse Pathology Facility is a histology platform with a mission to provide an in-depth histological analysis of mice which have been genetically altered (either transgenic, “knock-in” or “knock-out” mice). Following dissection and tissue preparation, slides are prepared for standard or special staining procedures. Additionally, immunohistochemical staining is also available, thus allowing an in-depth evaluation of mice. Following specimen preparation, pathologists at the Institute of Pathology examine and evaluate the results.

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Cardiovascular Assessment Facility/Experimental Microsurgery Facility (CAF/EMIF)

The Cardiovascular Assessment Facility offers to the scientific community sophisticated techniques for the physiological assessment of the cardiovascular system in rodents. Specifically, CAF provides investigators with a high-resolution ultrasound system allowing determination of cardiac dimensions and function and following of tumor growth. CAF is also equipped for blood pressure and ECG measurement. In addition, CAF offers a microsurgery service for producing pathophysiological models.

Bioinformatics, Molecular Modeling & Computational Biology

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Protein Modeling Facility - PMF

The objective of the PMF platform is to provide the researchers of the Biology and Medicine Faculty of Lausanne with a competence center for protein structure prediction and molecular modeling, as well as for the interpretation and design of relevant experiences.

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Vital-IT

Vital-IT is a Competency Centre in Bioinformatics and Computational Biology that provides infrastructure, support and technological R&D for life science and clinical research in Switzerland and internationally.

Flow Cytometry

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Flow Cytometry Facility - FCF

The Flow Cytometry Facility is equipped with 14 analytical flow cytometers (up to 20 parameters), including an ImageStream imaging flow cytometer (2 cameras) and 4 Fluorescence Activated Cell Sorters (FACS) sorting up to 6 populations at a time and using up to 20 parameters. It offers a cell sorting service as well as training and self-use of flow cytometry analysers by UNIL internal and external research groups or companies. It also provides a comprehensive consulting and training service for antibody conjugation, experiment and panel design, data analysis and trouble shooting.

Genomics

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Lausanne Genomic Technologies Facility - GTF

The Genomic Technologies Laboratory is a service laboratory whose mission is to provide the scientific research community in the Lemanic region with access to state-of-the-art instruments, methods and support for measuring quantitative and qualitative variations in nucleic acids. To this end, the GTF offers a number of leading-edge genomics technologies with a wide range of analytical applications, as well as ad hoc bioinformatics skills and infrastructure.

Human studies

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Centre de recherche clinique - CRC/Clinical Trial Unit - CTU

Le Centre de recherche clinique ou Clinical Trial Unit offre aux chercheurs et cliniciens du CHUV et de l'UNIL un support professionnel dans tous les aspects de l'investigation clinique.

Les prestations proposées aux investigateurs : support méthodologique, statistique et règlementaire, développement de bases de données, eCRF et data management, gestion de projet, prestations médico-infirmières, monitoring, et formation aux responsabilités d’investigateur et investigateur-promoteur.

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Centre d'épidémiologie clinique - CepiC

L'épidémiologie clinique est l'application de méthodes de recherche de nature épidémiologique, adaptées à l'étude des activités et des décisions médicales cliniques en ce qui concerne, notamment, le diagnostic, le pronostic, la prévention, la thérapeutique. Le Centre d'épidémiologie clinique est une structure issue de la collaboration entre plusieurs institutions partenaires du CHUV, formellement attachée à l'IUMSP, par son lien étroit avec son Unité d’évaluation des soins. Le CepiC est partenaire du Service de soutien à la recherche clinique et contribue à l’activité de Cochrane Suisse.

Imaging

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The Cellular Imaging Facility - CIF

The Cellular Imaging Facility assists researchers with imaging needs ranging from wide-field fluorescence and transmission optical microscopy, confocal microscopy, two-photon microscopy, light sheet microscopy, time-lapse and ion imaging, in vivo bioluminescence and fluorescence measurement in anesthetized animal, laser capture microscopy to digital image processing and analysis.

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Electron Microscopy Facility - EMF

The Electron Microscopy Facility welcomes users from the Departments of the Faculty of Biology and Medicine and other Faculties of the University of Lausanne as well as external academic and industrial partners.
Our centre specializes in different aspects of the ultrastructural analysis of biological samples. We provide an expertise in preparation, imaging as well as the interpretation of the obtained results. We train scientists keen to become independent in doing EM projects and help anyone willing to use our state of the art equipment.

Metabolomics

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Metabolomics & Lipidomics Platform - MEP

Metabolomics & Lipidomics Platform functions as a service and research unit. It provides the advisory, experimental and data analysis support for qualitative and quantitative analyses of metabolome & lipidome - a complete set of small molecule metabolites (including lipids) present in an organelle, a cell, an organ, a biofluid, or an organism. Our aim is to enhance the understanding of metabolite roles and activities at the system’s level, in health, ageing and disease. To this end, the state-of-the-art metabolomics & lipidomics approaches are applied to model systems and human population studies.

Proteomics

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Protein Analysis Facility - PAF

The Protein Analysis Facility is a service and research laboratory specialized in the analysis of proteins and proteomes. The primary mission of the PAF is to support the local academic community and to function as a catalyst in the application of advanced technologies to analyze protein expression and function.

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