Links:
Unisciences, publications: www.unil.ch/unisciences/nicoledeglon
ORCID (Open Researcher and Contributor ID): 0000-0003-4475-9476
Thomson Reuters Research ID: A-2265-2012
Links:
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2022
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2021
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2020
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2019
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2018
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Selected Publications
Unisciences, publications: www.unil.ch/unisciences/nicoledeglon
ORCID (Open Researcher and Contributor ID): 0000-0003-4475-9476
Thomson Reuters Research ID: A-2265-2012
Leroux, E., Perbet, R., Caillerez, R., Richetin, K., Lieger, S., Espourteille, J., Bouillet, T., Bégard, S., Danis, C., Loyens, A., Toni, N., Déglon, N., Deramecourt, V., Schraen-Maschke, S., Buée, L. and Colin, M. (2022). Extracellular vesicles: major actors of heterogeneity in tau spreading among human tauopathies. Mol. Ther. 30(2):782-797.
Thiebaut, A.M., Buendia, I., Ginet, V., Lemarchand, E., Boudjadja, M.B., Hommet, Y., Lebouvier, L., Lechevallier, C., Maillasson, M., Hedou, E., Déglon, N., Oury, F., Rubio, M., Montaner, J., Puyal, J., Vivien, D., Roussel, B.D. (2021). Thrombolysis by PLAT/tPA increases serum free IGF1 leading to a decrease of deleterious autophagy following brain ischemia. Autophagy, 18: 1297-1317.
Roumes, H., Jollé, C., Blanc, J., Benkhaled, I., Chatain, C., Massot, P., Raffard, G., Bouchaud, V., Biran, M., Pythoud, C., Déglon, N., Zimmer, E.R., Pellerin, L. and Bouzier-Sore, A.-C. (2021). Lactate transpoters in the rat barrel cortex sustain whisker-dependent BOLD fMRI signal and behavioral performance. PNAS 118(47):e2112466118
Petrelli, F., Zehnder, T., Pucci, L., Cali’, C., Bondiolotti, B.M., Molinero Perez, A., Dallerac, G., Déglon, N., Giros, B., Magara, F., Magrassi, L., Mothet, J.-P., Simmler, L., and Bezzi, P. (2021). Astrocytic VMAT2 in the developing prefrontal cortex is required for normal grooming behavior in mice. bioRxiv, DOI: 10.1101/2021.01.27.428434
Zehnder, T., Petrelli, F., Romanos, J., De Oliveira Figueiredo, E.C., Lewis, T.L., Déglon N., Polleux, F., Santello, M. and Bezzi, P. (2021). Mitochondrial biogenesis in developing astrocytes regulates astrocyte maturation and synapse formation. Cell Rep. 35(2):108952.
Humbel, M., Ramosaj, M., Zimmer, V., Aeby, L., Moser, S., Sipion, M., Boizot, A., Rey, M. And Déglon N. (2021). Maximizing gene transfer and therapeutic efficacy in the CNS. Gene Ther. 28: 75-88
Cresto, N., Gaillard, M.C., Gardier, C., Gubinelli, F., Diguet, E., Bellet, D., Legroux, L., Mitja, J., Auregan, G., Guillermier, M., Josephine, C., Jan, C., Dufour, N., Joliot, A., Hantraye, P., Bonvento, G., Déglon, N., Bemelmans, A.P., Cambon, K., Liot, G., Brouillet, E. (2020). The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo. Neurobiol. Dis. 134: 104614
Portal, B., Delcourte, S., Rovera, R., Lejards, C., Lorenzo, N., Malnou, C., Haddjeri, N., Déglon, N., Guiard, B.P. (2020). Genetic and pharmacological inactivation of astroglial connexin 43 differentially influences the acute response of antidepressant and anxiolytic drugs. Acta Physiol. 229: e13440
Petrelli, F., Dallérac, G., Pucci, L., Cali, C., Zehnder, T., Sultan, S., Lecca, S., Chicca, A., Ivanov, A., Asensio, C. Gundersen, V., Toni, N., Knott, G., Magara, F., Gertsch, J., Kirchhoff, F., Déglon, Giros, B., Edwards, R., Mothet J.-P., Bezzi, P. (2020). Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments. Mol. Psychiatry 25: 732-749
Uldry, F., Decembrini, S., Gamm, D.M., Déglon, N., Kostic, C., and Arsenijevic, Y. (2020). Lentiviral mediated RPE65 gene transfer in healthy hiPSCs-derived retinal pigment epithelial cells markedly increased RPE65 mRNA, but modestly protein level. Sci. Reports 10: 8890
Droguerre, M., Duchêne, A., Picoli, C., Portal, B., Lajards, C., Guiard, B. P., Meunier, J,. Villard, V., Déglon, N., Hamon, M., Mouthon, F., Charvériat, M. (2020). Efficacy of THN201, a combination of donepezil and mefloquine, to reverse neurocognitive deficits in Alzheimer's disease. Front. Neurosci. 14: 563
Hirbec, H., Déglon, N., Foo, L.C., Goshen, I., Grudzendler, J., Hangen, E., Kreisel, T., Muffat, J., Regio, S., Rion, S., Escartin, C. (2020). Emerging technologies to study glial cells. Glia 68:1692–1728
Duarte, F. and Déglon, N. (2020). Genome Editing for CNS Disorders. Front. Neurosci. 14: 579062
Jimenez-Blasco, D., Busquets-Garcia, A., Hebert-Chatelain, E., Serrat, R., Vicente-Gutierrez, C., Ioannidou, C., Gómez-Sotres, P., Lopez-Fabuel, I,. Resch-Beusher, M., Resel, E., Arnouil, D., Saraswat, D., Varilh, M., Cannich, A., Julio-Kalajzic, F., Bonilla-Del Río, I., Almeida, A., Puente, N., Achicallende, S., Lopez-Rodriguez, M.L., Jollé, C., Déglon, N., Pellerin, L., Josephine, C., Bonvento, G., Panatier, A., Lutz, B., Piazza, P.V., Guzmán, M., Bellocchio, L., Bouzier-Sore, A.K., Grandes, P., Bolaños, J.P., Marsicano, G. (2020). Glucose metabolism links astroglial mitochondria to cannabinoid effects. Nature. 563: 603-608.
Richetin, K., Pachoud, M., Maheswaran, M., Bégard, S., Pythoud, C., Rey, M., Caillierez, R., Leuba, G., Halliez, S., Bezzi, P., Buée, L., Colin, M., Toni, N., and Déglon, N. (2020). 1N3R tau accumulation in hilar astrocytes induces neuronal dysfunction and memory deficits in Alzheimer’s disease. Nat. Neurosci. 23: 1567-1579.
Droguerre, M., Tsurugizawa, T., Duchêne, A.,Portal, B., Guiard, B.P., Déglon, N., Rouach, N., Hamon, M., Mouthon, F., Ciobanu, L., and Chavériat, M. (2019). A New Tool for In Vivo Study of Astrocyte Connexin 43 in Brain. Sci. reports 9: 18292
Jollé, C., Déglon, N., Pythoud, C., Bouzier-Sore, A.-K., Pellerin, L. (2019). Development of efficient AAV2/DJ-based viral vectors to selectively downregulate the expression of neuronal or astrocytic target proteins in the rat central nervous system. Front. Mol. Neurosci. doi: 10.3389/fnmol.2019.00201
Merienne, N., Meunier, C, Schneider, A., Seguin, J. Nair, S.S., Rocher, A. B, Le Gras, S., Keime, C., Faull, R., Pellerin, L. Chatton, J.-Y, Néri, C., Merienne, K., Déglon, N. (2019). Cell-type-specific gene expression profiling in adult mouse brain reveals normal and disease-state signatures. Cell Reports 26, 2477–2493
Blessing, D., Vachey, G., Pythoud, C., Rey, M., Padrun, V., Wurm, F.M., Schneider, B.L.*, and Déglon, N.* (2019) *Equally contributed to this work. Scalable production of AAV vectors in orbotally shaken HEK293 cells. Mol. Ther Meth Clin. Dev. 13:14-26
Dujardin, S., Bégard, S., Caillierez, R., Lachaud, C., Carrier, S., Lieger, S., Gonzalez, J.A., Deramecourt, V., Déglon, N., Maurage, C.-A., Frosch, M.P., Hyman, B.T., Colin, M., and Buée, L. (2018). Different Tau species lead to heterogeneous Tau pathology propagation and misfolding. Acta Neuropathologica Communications 6: 132
Perriot, S., Mathias, A., Perriard, G., Canales, M., Jonkmans, N., Merienne, N., Meunier, C., El Kassar, L., Perrier, A.L., Laplaud, D.-A., Schluep, M., Déglon, N., Du Pasquier, R. Human Induced Pluripotent Stem Cell-Derived Astrocytes Are Differentially Activated by Multiple Sclerosis-Associated Cytokines. Stem Cell Reports 1(5):1199-1210
Audrain, M., Souchet, B., Alves, S., Fol, R., Viode, A., Haddjeri, A., Tada, S., Orefice, N.S., Joséphine, C., Bemelmans, A.-P., Delzescaux, T., Déglon, N., Hantraye, P., Akwa, Y., Becher, F., Billard, J.-M., Potier, B., Dutar, P., Cartier, N. and Braudeau, J. (2017). βAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer’s Disease. Cerebral Cortex 28: 3976-3993
Pircs, K., Petri, R., Madsen, S., Matusiak-Brückner, M., Vuono, R., Déglon, N., Barker, R.A. & Jakobsson, J. (2018). Huntingtin aggregation impairs autophagy leading to Argonaute-2 accumulation and global microRNA dysregulation. Cell Reports 6: 397-1406
Cheng, S., Tereshchenko, J., Zimmer, V., Vachey, G., Pythoud, C., Rey, M., Liefhebber, J., Raina, A., Streit, F., Mazur, A., Bähr, M., Konstantinova, P., Déglon, N., Kügler, S. (2018). Therapeutic efficacy of regulable GDNF expression for Huntington´s and Parkinson´s disease by a high-induction, background-free "GeneSwitch" vector. Exp. Neurol. 309: 79-90
Galvan, L., Francelle, L., Gaillard, M. C., de Longprez, L., Carrillo-de Sauvage, M. A., Liot, G., Cambon, K., Stimmer, L., Luccantoni, S., Flament, J., Valette, J., de Chaldee, M., Auregan, G., Guillermier, M., Josephine, C., Petit, F., Jan, C., Jarrige, M., Dufour, N., Bonvento, G., Humbert, S., Saudou, F., Hantraye, P., Merienne, K., Bemelmans, A. P., Perrier, A. L., Déglon, N., Brouillet, E. (2018). The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin. Brain 141: 1434-1454
Novati, A., Hentrich, T., Wassouf, Z., Weber, J.J., Yu-Taeger, L., Déglon, N., Nguyen, H.P., Schultze-Hentrich, J.M. (2018). Environment-dependent striatal gene expression in the BACHD rat model for Huntington’s disease. Sci. Rep. 8: 5803
Vachey, G. and Déglon, N. (2018). CRISPR/Cas9-mediated genome editing for Huntington' disease. Methods Mol Biol.1780: 463-481
Blessing, D., Déglon, N., Schneider, B.L. (2018). Scalable production and Purification of Adeno-Associated viral Vcetors (AAV). Methods Mol Biol. 1850: 259-274
Merienne, N., Delzor, A., Viret, A., Dufour, N., Rey, M., Hantraye, P. and Déglon, N. (2015) Gene transfer engineering for astrocyte-specific silencing in the CNS. Gene Ther. 22: 830-839
Drouet V, Ruiz M, Zala D, Feyeux M, Auregan G, Cambon K, Troquier L, Carpentier J, Aubert S, Merienne N, Bourgois-Rocha F, Hassig R, Rey M, Dufour N, Saudou F, Perrier AL, Hantraye P, Déglon N. (2014) Allele-specific silencing of mutant huntingtin in rodent and human stem cells. PLoS One.13;9(6):e99341.
Drouet, V., Perrin, V., Hassig, R., Dufour N., Alves, S., Bonvento, G., Brouillet, E., Luthi-Carter, R., Hantraye, P. and Déglon N. (2009). Sustained effects of non-allele-specific huntingtin silencing. Ann. Neurol. 65: 276-285
Colin, A., Faideau, M., Dufour, N., Auregan, G., Hassig,R., Andrieu, T., Brouillet, E., Hantraye, P., Bonvento, G., and Déglon, N. (2009). Engineered lentiviral vector targeting astrocytes In vivo. Glia 57: 667-679
Benchoua, A., Trioulier, Y., Diguet , E., Malgorn, C., Gaillard , M.-C., Dufour, N., Elalouf , J.-M., Krajewski, S., Hantraye, P., Déglon , N. and Brouillet, E. (2008). Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II. Hum. Mol. Genet. 17:1446-56
Palfi, S., Brouillet, E., Jarraya, B., Bloch, J., Jan, C., Shin, M., Condé, F., Li, X.-J., Aebischer, P., Hantraye, P., and Déglon N. (2007). Expression of an N-terminal fragment of mutated huntingtin in the lateral putamen is sufficient to produce abnormal movements in non-human primates. Mol. Ther. 15: 1444-1451
Zala, D., Benchoua, A., Brouillet, E., Perrin, V., Gaillard, M. C., Zurn, A. D., Aebischer, P. and Déglon, N. (2005). Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment. Neurobiol. Dis. 20: 785-798
de Almeida P.L., Ross C. A., Zala,D., Aebischer,P. and Déglon, N. (2002). Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels and protein length. J. Neurosci. 22: 3473-3483
Kordower, J. H., Emborg, M., Bloch, J., Ma, S. Y., Chu, Y., Leventhal, L., McBride, J., Chen, E.-Y., Palfi, S., Roitberg, B. Z., Brown, D., Holden, J., Pyzalski, R., Taylor, M. D., Carvey, P., Ling, Z.D., Trono, D., Hantraye, P., Déglon, N. and Aebischer, P. (2000). Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 290, 767-773
Déglon, N., Tseng, J.L., Bensadoun, J.-C., Zurn, A.D., Arsenijevic, Y., Pereira de Almeida, L., Zufferey, R., Trono and Aebischer, P. (2000). Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson’s disease. Hum. Gene Ther. 11, 179-190