Publications

Unisciences, publications: www.unil.ch/unisciences/nicoledeglon

ORCID (Open Researcher and Contributor ID): 0000-0003-4475-9476

Thomson Reuters Research ID: A-2265-2012

Cresto N, Gaillard MC, Gardier C, Gubinelli F, Diguet E, Bellet D, Legroux L, Mitja J, Auregan G, Guillermier M, Josephine C, Jan C, Dufour N, Joliot A, Hantraye P, Bonvento G, Déglon N, Bemelmans AP, Cambon K, Liot G, Brouillet E. (2020). The C-terminal domain of LRRK2 with the G2019S mutation is sufficient to produce neurodegeneration of dopaminergic neurons in vivo. Neurobiol. Dis. 134: 104614

Portal B., Delcourte S., Rovera R., Lejards C., Lorenzo N., Malnou C., Haddjeri N., Déglon N., Guiard B.P. (2020). Genetic and pharmacological inactivation of astroglial connexin 43 differentially influences the acute response of antidepressant and anxiolytic drugs. Acta Physiol. 229: e13440

Petrelli, F., Dallérac, G., Pucci, L., Cali, C., Zehnder, T., Sultan, S., Lecca, S., Chicca, A., Ivanov, A., Asensio, C. Gundersen, V., Toni, N., Knott, G., Magara, F., Gertsch, J., Kirchhoff, F., Déglon, Giros, B., Edwards, R., Mothet J.-P., Bezzi, P. (2020). Dysfunction of homeostatic control of dopamine by astrocytes in the developing prefrontal cortex leads to cognitive impairments. Mol. Psychiatry 25: 732-749

Uldry, F., Decembrini, S., Gamm, D.M., Déglon, N., Kostic, C., and Arsenijevic, Y. (2020). Lentiviral mediated RPE65 gene transfer in healthy hiPSCs-derived retinal pigment epithelial cells markedly increased RPE65 mRNA, but modestly protein level. Sci. Reports 10:8890

Droguerre, M., Duchêne, A., Picoli, C., Portal, B., Lajards, C., Guiard, B. P., Meunier, J,. Villard, V., Déglon, N., Hamon, M., Mouthon, F., Charvériat, M. (2020). Efficacy of THN201, a combination of donepezil and mefloquine, to reverse neurocognitive deficits in Alzheimer's disease. Front. Neurosci. 14: 563; DOI:10.3389/fnins.2020.00563

Hirbec, H., Déglon, N., Foo, L.C., Goshen, I., Grudzendler, J., Hangen, E., Kreisel, T., Muffat, J., Regio, S., Rion, S., Escartin, C. (2020). Emerging technologies to study glial cells. Glia 68:1692–1728

Humbel, M., Ramosaj, M., Zimmer, V., Aeby, L., Moser, S., Sipion, M., Boizot, A., Rey, M. And Déglon N. (2020). Maximizing gene transfer and therapeutic efficacy in the CNS. Gene Ther. DOI: /10.1038/s41434-020-0172-6

Jimenez-Blasco D, Busquets-Garcia A, Hebert-Chatelain E, Serrat R, Vicente-Gutierrez C, Ioannidou C, Gómez-Sotres P, Lopez-Fabuel I, Resch-Beusher M, Resel E, Arnouil D, Saraswat D, Varilh M, Cannich A, Julio-Kalajzic F, Bonilla-Del Río I, Almeida A, Puente N, Achicallende S, Lopez-Rodriguez ML, Jollé C, Déglon N, Pellerin L, Josephine C, Bonvento G, Panatier A, Lutz B, Piazza PV, Guzmán M, Bellocchio L, Bouzier-Sore AK, Grandes P, Bolaños JP, Marsicano G. (2020). Glucose metabolism links astroglial mitochondria to cannabinoid effects. Nature. Jul 8. DOI: 10.1038/s41586-020-2470-y.

Richetin, K., Pachoud, M., Maheswaran, M., Bégard, S., Pythoud, C., Rey, M., Caillierez, R., Leuba, G., Halliez, S., Bezzi, P., Buée, L., Colin, M., Toni, N., and Déglon, N. (2020). 1N3R tau accumulation in hilar astrocytes induces neuronal dysfunction and memory deficits in Alzheimer’s disease. Nat. Neurosci. (In Press)

Droguerre, M., Tsurugizawa, T., Duchêne, A.,Portal, B., Guiard, B.P., Déglon, N., Rouach, N., Hamon, M., Mouthon, F., Ciobanu, L., and Chavériat, M. (2019). A New Tool for In Vivo Study of Astrocyte Connexin 43 in Brain. Sci. reports 9: 18292

Jollé, C., Déglon, N., Pythoud, C., Bouzier-Sore, A.-K., Pellerin, L. (2019). Development of efficient AAV2/DJ-based viral vectors to selectively downregulate the expression of neuronal or astrocytic target proteins in the rat central nervous system. Front. Mol. Neurosci. doi: 10.3389/fnmol.2019.00201

Merienne, N., Meunier, C, Schneider, A., Seguin, J. Nair, S.S., Rocher, A. B, Le Gras, S., Keime, C., Faull, R., Pellerin, L. Chatton, J.-Y, Néri, C., Merienne, K., Déglon, N. (2019). Cell-type-specific gene expression profiling in adult mouse brain reveals normal and disease-state signatures. Cell Reports 26, 2477–2493

Blessing, D., Vachey, G., Pythoud, C., Rey, M., Padrun, V., Wurm, F.M., Schneider, B.L.*, and Déglon, N.* (2019) *Equally contributed to this work. Scalable production of AAV vectors in orbotally shaken HEK293 cells. Mol. Ther Meth Clin. Dev. 13:14-26

Dujardin, S., Bégard, S., Caillierez, R., Lachaud, C., Carrier, S., Lieger, S., Gonzalez, J.A., Deramecourt, V., Déglon, N., Maurage, C.-A., Frosch, M.P., Hyman, B.T., Colin, M., and Buée, L. (2018). Different Tau species lead to heterogeneous Tau pathology propagation and misfolding. Acta Neuropathologica Communications 6: 132

Perriot, S., Mathias, A., Perriard, G., Canales, M., Jonkmans, N., Merienne, N., Meunier, C., El Kassar, L., Perrier, A.L., Laplaud, D.-A., Schluep, M., Déglon, N., Du Pasquier, R. Human Induced Pluripotent Stem Cell-Derived Astrocytes Are Differentially Activated by Multiple Sclerosis-Associated Cytokines. Stem Cell Reports 1(5):1199-1210

Audrain, M., Souchet, B., Alves, S., Fol, R., Viode, A., Haddjeri, A., Tada, S., Orefice, N.S., Joséphine, C., Bemelmans, A.-P., Delzescaux, T., Déglon, N., Hantraye, P., Akwa, Y., Becher, F., Billard, J.-M., Potier, B., Dutar, P., Cartier, N. and Braudeau, J. (2017). βAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer’s Disease. Cerebral Cortex 28: 3976-3993

Pircs, K., Petri, R., Madsen, S., Matusiak-Brückner, M., Vuono, R., Déglon, N., Barker, R.A. & Jakobsson, J. (2018). Huntingtin aggregation impairs autophagy leading to Argonaute-2 accumulation and global microRNA dysregulation. Cell Reports 6: 397-1406

Cheng, S., Tereshchenko, J., Zimmer, V., Vachey, G., Pythoud, C., Rey, M., Liefhebber, J., Raina, A., Streit, F., Mazur, A., Bähr, M., Konstantinova, P., Déglon, N., Kügler, S. (2018). Therapeutic efficacy of regulable GDNF expression for Huntington´s and Parkinson´s disease by a high-induction, background-free "GeneSwitch" vector. Exp. Neurol. 309: 79-90

Galvan, L., Francelle, L., Gaillard, M. C., de Longprez, L., Carrillo-de Sauvage, M. A., Liot, G., Cambon, K., Stimmer, L., Luccantoni, S., Flament, J., Valette, J., de Chaldee, M., Auregan, G., Guillermier, M., Josephine, C., Petit, F., Jan, C., Jarrige, M., Dufour, N., Bonvento, G., Humbert, S., Saudou, F., Hantraye, P., Merienne, K., Bemelmans, A. P., Perrier, A. L., Déglon, N., Brouillet, E. (2018). The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin. Brain 141: 1434-1454

Novati, A., Hentrich, T., Wassouf, Z., Weber, J.J., Yu-Taeger, L., Déglon, N., Nguyen, H.P., Schultze-Hentrich, J.M. (2018). Environment-dependent striatal gene expression in the BACHD rat model for Huntington’s disease. Sci. Rep. 8: 5803

Vachey, G and Déglon, N. (2018). CRISPR/Cas9-mediated genome editing for Huntington' disease. Methods Mol Biol.1780: 463-481

Blessing D, Déglon N, Schneider BL. (2018). Scalable production and Purification of Adeno-Associated viral Vcetors (AAV). Methods Mol Biol. 1850: 259-274

Galan-Rodriguez B., Martin E., Brouillet E., Déglon N., Betuing, S. and Caboche J. (2017). Specific coupling of D2short receptor isoform to the Rho/Rock signaling pathway renders striatal neurons more vulnerable to mutant huntingtin. Eur. J. Neurochem. 45(1): 198-206

Schwab, L.C., Richetin, K., Barker, R.A. and Déglon, N. (2017). Formation of hippocampal mHTT aggregates leads to impaired spatial memory, hippocampal activation and adult neurogenesis. Neurobiol. Dis. 102:105-112

Mazuel, L., Blanc, J., LRepond, C., Bouchard, V., Raffard G., Déglon, N., Bonvento, G., Pellerin, L., and Bouzier-Sore A.-K. (2017). A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation. PlosOne 12 (4): e0174990

Déglon N. (2017). From huntingtin gene to Huntington's disease-altering strategies. Chapter 9: pp.251-276. In Disease-Modifying Targets in Neurodegenerative Disorders: paving the way for disease-modifying therapies. Elsevier Academin Press. Ed. Baekelandt V. and Lobbestael, E.

Cambon, K., Virginie Zimmer, Martineau, S., Gaillard, M.C., Jarrige. M., Bugi, A., Miniarikova, J., Rey, M., Hassig, R., Dufour, N., Auregan G., Hantraye, P., Perrier, A. L. and Déglon, N. (2017). Pre-clinical evaluation of a lentiviral vector huntingtin silencing. Mol. Ther. Meth. Clin. Dev. 5: 259-276

Merienne, N., Vachey, G., de Longprez, L., Meunier, C., Zimmer, V., Perriard, G., Canales M., Mathias, A., Hergott, L, Beltraminelli, T., Maulet, A., Dequesne, T., Pythoud, C., Rey, M., Pellerin, L., Brouillet, E., Perrier, A., du Pasquier, R., Déglon, N. (2017). The self-inactivating KamiCas9 system for the editing of CNS disease genes. Cell Reports 20: 2980-2991

Miniarikova, J.,  Zimmer, V., Martier, M., Brouwers, C.C., Pythoud, C., Richetin, K., Rey,M.,  Lubelski, J., Evers, m.M., van Deventer, S.J.,  Petry, H.,  Déglon, N., and Konstantinova, P. (2017). AAV5-miHTT gene therapy demonstrates suppression of mutant huntingtin aggregation and neuronal dysfunction in a rat model of Huntington’s disease. Gene Ther. 24: 630-639

Vázquez-Manrique, R.P., Farina, F., Cambon, K., Sequedo, M.D., Parker, A.J., Millán, J.M., Weiss, A., Déglon, N., Neri, C. (2016). AMPK activation protects from neuronal dysfunction and striatal vulnerability across nematode, cellular and mouse models of Huntington's disease. Hum. Mol. Genet. 25: 1043-1058

Lopes C., Aubert S., Bourgois-Rocha, F., Barnat M., Rego A.C., Déglon N., Perrier A. and Humbert S. (2016). Dominant-negative effects of adult-onset huntingtin mutations alter the division of human embryonic stem cells-derived neural cells. PlosOne 11(2):e0148680

Audrain, M., Fol, R., Dutar, P., Potier, B., Billard, J.-M., Flament, J., Alves, S., Burlot, M.-A., Dufayet-Chaffaud, G., Bemelmans, A.P., Valette, J., Hantraye, P., Déglon, N., Cartier, N., Braudeau, J. (2016). Human-like APP processing in mouse hippocampus identifies early synaptic alterations as key events of Alzheimer’s disease onset. Molecular Neurodegeneration 11(1):5

Blessing, D. and Déglon, N. (2016). Adeno-associated virus and lentivirus vectors: a refined toolkit for the central nervous system. Curr. opin. Virol. 21: 61-66

Meunier, C., Merienne, N., Jolle, C., Déglon, N., Pellerin, L. (2016). Astrocytes Are Key But Indirect Contributors to the Development of the Symptomatology and Pathophysiology of Huntington’s Disease. Glia 64(11):1841-56

Merienne, N., Delzor, A., Viret, A., Dufour, N., Rey, M., Hantraye, P. and Déglon, N. (2015) Gene transfer engineering for astrocyte-specific silencing in the CNS. Gene Ther. 22: 830-839

Drouet V, Ruiz M, Zala D, Feyeux M, Auregan G, Cambon K, Troquier L, Carpentier J, Aubert S, Merienne N, Bourgois-Rocha F, Hassig R, Rey M, Dufour N, Saudou F, Perrier AL, Hantraye P, Déglon N. (2014) Allele-specific silencing of mutant huntingtin in rodent and human stem cells. PLoS One.13;9(6):e99341.

Drouet, V., Perrin, V., Hassig, R., Dufour N., Alves, S., Bonvento, G., Brouillet, E., Luthi-Carter, R., Hantraye, P. and Déglon N. (2009). Sustained effects of non-allele-specific huntingtin silencing. Ann. Neurol. 65: 276-285

Colin, A., Faideau, M., Dufour, N., Auregan, G., Hassig,R., Andrieu, T., Brouillet, E., Hantraye, P., Bonvento, G., and Déglon, N. (2009). Engineered lentiviral vector targeting astrocytes In vivo. Glia 57: 667-679

Benchoua, A., Trioulier, Y., Diguet , E., Malgorn, C., Gaillard , M.-C., Dufour, N., Elalouf , J.-M., Krajewski, S., Hantraye, P., Déglon , N. and Brouillet, E. (2008). Dopamine determines the vulnerability of striatal neurons to the N-terminal fragment of mutant huntingtin through the regulation of mitochondrial complex II. Hum. Mol. Genet. 17:1446-56

Palfi, S., Brouillet, E., Jarraya, B., Bloch, J., Jan, C., Shin, M., Condé, F., Li, X.-J., Aebischer, P., Hantraye, P., and Déglon N. (2007). Expression of an N-terminal fragment of mutated huntingtin in the lateral putamen is sufficient to produce abnormal movements in non-human primates. Mol. Ther. 15: 1444-1451

Zala, D., Benchoua, A., Brouillet, E., Perrin, V., Gaillard, M. C., Zurn, A. D., Aebischer, P. and Déglon, N. (2005). Progressive and selective striatal degeneration in primary neuronal cultures using lentiviral vector coding for a mutant huntingtin fragment. Neurobiol. Dis. 20: 785-798

de Almeida P.L., Ross C. A., Zala,D., Aebischer,P. and Déglon, N. (2002). Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression levels and protein length. J. Neurosci. 22: 3473-3483

Kordower, J. H., Emborg, M., Bloch, J., Ma, S. Y., Chu, Y., Leventhal, L., McBride, J., Chen, E.-Y., Palfi, S., Roitberg, B. Z., Brown, D., Holden, J., Pyzalski, R., Taylor, M. D., Carvey, P., Ling, Z.D., Trono, D., Hantraye, P., Déglon, N. and Aebischer, P. (2000). Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 290, 767-773

Déglon, N., Tseng, J.L., Bensadoun, J.-C., Zurn, A.D., Arsenijevic, Y., Pereira de Almeida, L., Zufferey, R., Trono and Aebischer, P. (2000). Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson’s disease. Hum. Gene Ther. 11, 179-190