Chemically-induced animal models for Parkinson's disease and behavioural tests


Complete and partial nigrostriatal dopaminergic lesions are produced by stereotaxic injection of 6-hydroxydopamine in the medial forebrain bundle and in the striatum, respectively.
Motor behaviour is assessed using the amphetamine-induced rotation test and the forelimb asymmetry test.



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Centre Hospitalier Universitaire Vaudois (CHUV) Université de Lausanne