Multiple sclerosis (MS) is an auto-inflammatory disease of the central nervous system, where all components of the immune system, innate and adaptive, are involved.In addition to genetic factors, environmental ones play a crucial role in triggering this complex disease.
In the Laboratories of neuroimmunology, we examine how environmental factors, among which Epstein-Barr virus, gut microbiome or cholesterol metabolites favor autoreactivity of B and T cells. To tackle our hypothesis, we use different approaches including animal models, namely the experimental autoimmune encephalomyelitis, human samples analysis (blood, cerebrospinal fluid, urine, stools) of MS patients and a human in vitro model of MS brain, using induced pluripotent stem cells (iPCS).
