LREN Principal Investigator
Privat Docent FBM, CHUV/UNIL
Laboratoire de recherche en Neuroimagerie - LREN
Departement des neurosciences cliniques
Centre Hospitalier Universitaire Vaudois (CHUV)
MP16 05 559, Chemin de Mont-Paisible 16
Go to: Brain function in coma
What is the extent of preserved neural functions during coma ? What is their relation with patients’ level of consciousness ? The interest in these research questions is twofold; on one side understanding brain function in coma can help the development of quantitative markers for predicting a given patient’s prognosis as early as possible; on the other side, in basic neurosciences, comatose patients offers a virtual setting for the investigation of brain functions without consciousness.
These two main research interests develop within the more general framework of the study of the neural basis of human auditory perception and cognition in healthy and clinical populations. To answer these research questions we combine functional neuroimaging with methods of machine learning and computational modeling.
Tzovara A, Rossetti AO, Juan E, Suys T, Viceic D, Rusca M, Oddo M, De Lucia M (2016) Prediction of awakening from hypothermic post anoxic coma based on auditory discrimination. Annals Neurology 2016;79:748–757.
Tzovara A, Simonin A, Oddo M, Rossetti AO, De Lucia M (2015) Neural detection of complex sound sequences in the absence of consciousness. Brain, 138(Pt 5):1160-6.
Cossy N*, Tzovara A*, Simonin A, Rossetti AO, De Lucia M (2014) Robust discrimination between EEG responses to categories of environmental sounds in early coma. Frontiers in Psychology, 5, 155 *equal contribution
Tzovara A, Rossetti AO, Spierer L, Grivel J, Murray MM, Oddo M, De Lucia M (2013) Progression of auditory discrimination based on neural decoding predicts awakening from coma. Brain, 136(Pt 1):81-9.
Tzovara A., Murray M.M., Plomp G., HerzogM.H., Michel C.M. De Lucia M (2012) Decoding stimulus-related information from single-trial EEG responses based on voltage topographies. Pattern Recognition. 45( 6): 2109–2122.
Tzovara A, Murray MM, Bourdaud N, Chavarriaga R, del R. Millán J, De Lucia M. (2012) The timing of exploratory decision-making revealed by single-trial topographic EEG analyses. Neuroimage. 60(4):1959-69.
De Lucia M, Tzovara A, Bernasconi F, Spierer L, Murray MM. (2012) Auditory perceptual decision-making based on semantic categorization of environmental sounds. Neuroimage. 60(3):1704-15.
Bernasconi F*, De Lucia M*, Tzovara A*, Manual A, Murray MM, Spierer L. (2011) Noise in brain activity engenders perception and influences discrimination sensitivity. Journal of Neuroscience 31(49):17971-17981. *equal contribution
De Lucia M*, Constantinescu I*, Sterpenich V, Pourtois G, Seeck M, Schwartz S. (2011) Decoding sequence learning from single-trial intracranial EEG in humans. Plos One 6(12):e28630. *equal contribution
De Lucia M., Cocchi L., Martuzzi R., Meuli R.A., Clarke S., Murray M.M. (2010). Perceptual and semantic contributions to repetition priming of environmental sounds Cerebral Cortex 20(7): 1676-84.
Eureka Eurostars a principal investigator for three years -starting date july 2015- (E9361-ComAlert). "COnsciousness Monitoring, Assessment, prediction and Life activities with EEG in Real Time"; (510K chf)
Grant of the Service Projets et Organisation Stratégiques (POS) of the University Hospital of Lausanne for two years as principal investigator -starting date October 2012-. "Validation d'un test pour prédire les chances de réveil de patients dans le coma basé sur le eeg"; (213K chf)
Swiss National Foundation grant (CR32I3_143780) as co-applicant for three years -starting date March 2013-. “Early electrophysiological correlates of brain injury and outcome in comatose patients after cardiac arrest”; (281K chf)