Machine learning methods to understand brain diseases

Principal Investigator: Ferath KHERIF




Our main interest in neuroimaging lies in the study of inter-individual differences in neural  activation. The understanding of the nature and extent of inter-subjects variation is critical for understanding the neural basis of cognitive processes in normal and abnormal populations.

Part of our research work is dedicated to the study of language processing using neuroimaging techniques (Structural, fMRI and DTI) in healthy controls and patients.

The other part of our research is to provide new tools, mainly using multivariate methods, for a more accurate and comprehensive investigation of neural processes in clinical populations.

From the combinatorics of distributed processing that defines cognitive anatomy, it is important, in neuropsychology and rehabilitation, to know which different combinations of brain areas can support a specific cognitive process.


Research topics

  • Brain language dysfunction.
  • Individual difference models.
  • Biological predictive models.
  • Multivariate Linear methods.
  • Spatial point pattern analysis.



Key publications

Kherif F, Josse G, Price CJ. Automatic top-down processing explains common
left occipito-temporal responses to visual words and objects. Cereb Cortex. 2011

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 Ramponi C, Barnard PJ, Kherif F, Henson RN. Voluntary explicit versus
involuntary conceptual memory are associated with dissociable fMRI responses in
hippocampus, amygdala, and parietal cortex for emotional and neutral word pairs.
J Cogn Neurosci. 2011 Aug.

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 Draganski B, Ashburner J, Hutton C, Kherif F, Frackowiak RS, Helms G, Weiskopf
N. Regional specificity of MRI contrast parameter changes in normal ageing
revealed by voxel-based quantification (VBQ). Neuroimage. 2011 Apr

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Davis MH, Ford MA, Kherif F, Johnsrude IS. Does Semantic Context Benefit
Speech Understanding through "Top-Down" Processes? Evidence from Time-resolved
Sparse fMRI. J Cogn Neurosci. 2011 Jul 11.

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Seghier ML, Kherif F, Josse G, Price CJ. Regional and hemispheric determinants
of language laterality: implications for preoperative fMRI. Hum Brain Mapp. 2011

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Ali N, Green DW, Kherif F, Devlin JT, Price CJ. The role of the left head of
caudate in suppressing irrelevant words. J Cogn Neurosci. 2010

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Centre Hospitalier Universitaire Vaudois (CHUV)