Laboratoire de recherche en Neuroimagerie - LREN
Departement des neurosciences cliniques
Centre Hospitalier Universitaire Vaudois (CHUV)
Mont Paisible 16
Antoine Lutti is Head of MRI Physics at the LREN-DNC-CHUV and the technical director of the research-dedicated MRI platform of the Department of Clinical Neuroscience-CHUV. He is in charge of the technical management of the platform and of the scientific orientation of all MRI physics developments.
Antoine Lutti’s research activities are centered on the development of MRI acquisition sequences, which constitute the core of the portfolio of the acquisition techniques available on the MRI platform of the DNC-CHUV. Over 3000 scans have been completed to-date for a large range of basic and clinical neuroscience research projects.
Magnetic Resonance Imaging (MRI) is a powerful non-invasive imaging technique with wide applications in fundamental and clinical neuroscience. The main research interests of the MRI physics group at LREN lie in the development of novel structural and functional MRI acquisitions that allow for the characterization of brain structure in relation with brain function and behaviour. This includes the development of novel techniques for quantitative MRI relaxometry. In particular, the objective of the group is to develop novel biomarkers of the brain to characterize brain microstructure in-vivo. This will allow the unification of the microscopic and macroscopic descriptions of the brain in parallel with behaviour, providing new insights into the mechanisms underlying brain health and disease.
More information on the research work conducted by the MRI physics group is available here.
A complete list of publications is available here.
† Shared senior authorships
Castella R, Arn L, Dupuis E, Callaghan MF, Draganski B, Lutti A. Controlling for motion artefact levels in prospectively motion corrected MRI data. In revision. Available on BioRxiv: https://doi.org/10.1101/230490
Melie-Garcia L, Slater D, Ruef A, Sanabria-Diaz G, Kherif F, Draganski B†, Lutti A†. Networks of Myelin covariance. Human Brain Mapping (2017). doi: 10.1002/hbm.23929
Lorio S, Kherif F, Ruef A, Melie-Garcia L, Frackowiak RS, Ashburner J, Helms G, Lutti A†, Draganski B†. Neurobiological origin of spurious brain morphological changes – a quantitative MRI study. Human Brain Mapping (2016). doi: 10.1002/hbm.23137.
Lutti A, Dick F, Sereno MI, Weiskopf N.Using high-resolution quantitative mapping of R1 as an index of cortical myelination. Neuroimage (2014). doi: 10.1016/j.neuroimage.2013.06.005
Weiskopf N, Suckling J, Williams G, Correia MM, Inkster B, Tait R, Ooi C, Bullmore ET, Lutti A. Quantitative multi-parameter mapping of R1, PD*, MT and R2* at 3T: a multi-center validation. Front. Neurosci. (2013). doi: 10.3389/fnins.2013.00095
Lutti A, Thomas DL, Hutton C, Weiskopf N, High resolution functional MRI at 3T: 3D/2D echo-planar imaging (EPI) with optimized physiological correction. Magn Reson Med. (2013). doi: 10.1002/mrm.24398
Sereno MI, Lutti A, Weiskopf N, Dick F. Mapping the human cortical surface by combining quantitative T1 mapping with retinotopy. Cerebral Cortex (2013). doi:10.1093/cercor/bhs213
Dick F, Tierney, AT, Lutti A, Sereno MI, Weiskopf N, In-vivo functional and myeloarchitectonic mapping of human primary auditory areas. J Neurosci. (2012). doi: 10.1523/JNEUROSCI.1712-12.2012
Lutti A, Stadler J, Josephs O, Speck O, Bernarding J, Hutton C, Weiskopf N, Robust and Fast Whole Brain Mapping of the RF transmit field B1 at 7T. PLoS ONE (2012). doi: 10.1371/journal.pone.0032379
Lutti A, Hutton C, Finsterbusch J, Helms G, Weiskopf N, Optimization and validation of methods for mapping of the radiofrequency field B1 at 3T. Magnetic Resonance in Medicine (2010). doi: 10.1002/mrm.22421
Lutti A Callaghan PT, Using solvent diffusion as a probe to characterize lamellar systems, Applied Magnetic Resonance (2008). doi: 10.1007/s00723-008-0067-y
Lutti A, Callaghan PT. Measurement of multilamellar onion dimensions under shear using frequency domain pulsed gradient NMR, Journal of Magnetic Resonance (2007). doi: 10.1016/j.jmr.2007.05.003
Lutti A, Callaghan PT. Effect of shear on an onion texture, European Physical Journal (2007). doi: 10.1140/epje/i2007-10222-4
Lutti A, Callaghan PT. Undulations and fluctuations in a lamellar phase lyotropic liquid crystal and their suppression by weak flow, Physical Review E (2006). doi: 10.1103/PhysRevE.73.011710
Lutti A, Callaghan PT. Measurement of diffusion in the presence of shear flow, Journal of Magnetic Resonance 180:1 (2006). doi: 10.1016/j.jmr.2006.01.009